Construct and evaluate directed tree structures that model the process of occurrence of genetic alterations during carcinogenesis as described in Szabo, A. and Boucher, K (2002) <doi:10.1016/S0025-5564(02)00086-X>.

Model mixed integer linear programs in an algebraic way directly in R. The model is solver-independent and thus offers the possibility to solve a model with different solvers. It currently only supports linear constraints and objective functions. See the ompr website <https://dirkschumacher.github.io/ompr/> for more information, documentation and examples.

This package provides tools for converting Open-Source Tools for Training Resources (OTTR) courses into Leanpub or Coursera courses. ottrpal is for use with the OTTR Template repository to create courses.

Machine learning estimator specifically optimized for predictive modeling of ordered non-numeric outcomes. ocf provides forest-based estimation of the conditional choice probabilities and the covariatesâ marginal effects. Under an "honesty" condition, the estimates are consistent and asymptotically normal and standard errors can be obtained by leveraging the weight-based representation of the random forest predictions. Please reference the use as Di Francesco (2025) <doi:10.1080/07474938.2024.2429596>.

Outcome-dependent sampling (ODS) schemes are cost-effective ways to enhance study efficiency. In ODS designs, one observes the exposure/covariates with a probability that depends on the outcome variable. Popular ODS designs include case-control for binary outcome, case-cohort for time-to-event outcome, and continuous outcome ODS design (Zhou et al. 2002) <doi: 10.1111/j.0006-341X.2002.00413.x>. Because ODS data has biased sampling nature, standard statistical analysis such as linear regression will lead to biases estimates of the population parameters. This package implements four statistical methods related to ODS designs: (1) An empirical likelihood method analyzing the primary continuous outcome with respect to exposure variables in continuous ODS design (Zhou et al., 2002). (2) A partial linear model analyzing the primary outcome in continuous ODS design (Zhou, Qin and Longnecker, 2011) <doi: 10.1111/j.1541-0420.2010.01500.x>. (3) Analyze a secondary outcome in continuous ODS design (Pan et al. 2018) <doi: 10.1002/sim.7672>. (4) An estimated likelihood method analyzing a secondary outcome in case-cohort data (Pan et al. 2017) <doi: 10.1111/biom.12838>.

This package provides tools to segment fire scars and assess severity and vegetation regeneration using Otsu thresholding on Relative Burn Ratio (RBR) and differenced Normalized Burn Ratio (dNBR) image composites. Includes support for mosaic handling, polygon metrics, post-fire regeneration detection, day-of-year flagging, and validation against reference datasets. Designed for analysis of fire history in the Iberian Peninsula. Input Landsat composites follow the methodology described in Quintero et al. (2025) <doi:10.2139/ssrn.4929831>.

Solves linear systems of form Ax=b via Gauss elimination, LU decomposition, Gauss-Seidel, Conjugate Gradient Method (CGM) and Cholesky methods.

This package provides functions for estimating the overlapping area of two or more kernel density estimations from empirical data.

Tetra-allele cross often referred as four-way cross or double cross or four-line cross are those type of mating designs in which every cross is obtained by mating amongst four inbred lines. A tetra-allele cross can be obtained by crossing the resultant of two unrelated diallel crosses. A common triallel cross involving four inbred lines A, B, C and D can be symbolically represented as (A X B) X (C X D) or (A, B, C, D) or (A B C D) etc. Tetra-allele cross can be broadly categorized as Complete Tetra-allele Cross (CTaC) and Partial Tetra-allele Crosses (PTaC). Rawlings and Cockerham (1962)<doi:10.2307/2527461> firstly introduced and gave the method of analysis for tetra-allele cross hybrids using the analysis method of single cross hybrids under the assumption of no linkage. The set of all possible four-way mating between several genotypes (individuals, clones, homozygous lines, etc.) leads to a CTaC. If there are N number of inbred lines involved in a CTaC, the the total number of crosses, T = N*(N-1)*(N-2)*(N-3)/8. When more number of lines are to be considered, the total number of crosses in CTaC also increases. Thus, it is almost impossible for the investigator to carry out the experimentation with limited available resource material. This situation lies in taking a fraction of CTaC with certain underlying properties, known as PTaC.

Fit a variety of models to two-way tables with ordered categories. Most of the models are appropriate to apply to tables of that have correlated ordered response categories. There is a particular interest in rater data and models for rescore tables. Some utility functions (e.g., Cohen's kappa and weighted kappa) support more general work on rater agreement. Because the names of the models are very similar, the functions that implement them are organized by last name of the primary author of the article or book that suggested the model, with the name of the function beginning with that author's name and an underscore. This may make some models more difficult to locate if one doesn't have the original sources. The vignettes and tests can help to locate models of interest. For more dertaiils see the following references: Agresti, A. (1983) <doi:10.1016/0167-7152(83)90051-2> "A Simple Diagonals-Parameter Symmetry And Quasi-Symmetry Model", Agrestim A. (1983) <doi:10.2307/2531022> "Testing Marginal Homogeneity for Ordinal Categorical Variables", Agresti, A. (1988) <doi:10.2307/2531866> "A Model For Agreement Between Ratings On An Ordinal Scale", Agresti, A. (1989) <doi:10.1016/0167-7152(89)90104-1> "An Agreement Model With Kappa As Parameter", Agresti, A. (2010 ISBN:978-0470082898) "Analysis Of Ordinal Categorical Data", Bhapkar, V. P. (1966) <doi:10.1080/01621459.1966.10502021> "A Note On The Equivalence Of Two Test Criteria For Hypotheses In Categorical Data", Bhapkar, V. P. (1979) <doi:10.2307/2530344> "On Tests Of Marginal Symmetry And Quasi-Symmetry In Two And Three-Dimensional Contingency Tables", Bowker, A. H. (1948) <doi:10.2307/2280710> "A Test For Symmetry In Contingency Tables", Clayton, D. G. (1974) <doi:10.2307/2335638> "Some Odds Ratio Statistics For The Analysis Of Ordered Categorical Data", Cliff, N. (1993) <doi:10.1037/0033-2909.114.3.494> "Dominance Statistics: Ordinal Analyses To Answer Ordinal Questions", Cliff, N. (1996 ISBN:978-0805813333) "Ordinal Methods For Behavioral Data Analysis", Goodman, L. A. (1979) <doi:10.1080/01621459.1979.10481650> "Simple Models For The Analysis Of Association In Cross-Classifications Having Ordered Categories", Goodman, L. A. (1979) <doi:10.2307/2335159> "Multiplicative Models For Square Contingency Tables With Ordered Categories", Ireland, C. T., Ku, H. H., & Kullback, S. (1969) <doi:10.2307/2286071> "Symmetry And Marginal Homogeneity Of An r à r Contingency Table", Ishi-kuntz, M. (1994 ISBN:978-0803943766) "Ordinal Log-linear Models", McCullah, P. (1977) <doi:10.2307/2345320> "A Logistic Model For Paired Comparisons With Ordered Categorical Data", McCullagh, P. (1978) <doi:10.2307/2335224> A Class Of Parametric Models For The Analysis Of Square Contingency Tables With Ordered Categories", McCullagh, P. (1980) <doi:10.1111/j.2517-6161.1980.tb01109.x> "Regression Models For Ordinal Data", Penn State: Eberly College of Science (undated) <https://online.stat.psu.edu/stat504/lesson/11> "Stat 504: Analysis of Discrete Data, 11. Advanced Topics I", Schuster, C. (2001) <doi:10.3102/10769986026003331> "Kappa As A Parameter Of A Symmetry Model For Rater Agreement", Shoukri, M. M. (2004 ISBN:978-1584883210). "Measures Of Interobserver Agreement", Stuart, A. (1953) <doi:10.2307/2333101> "The Estimation Of And Comparison Of Strengths Of Association In Contingency Tables", Stuart, A. (1955) <doi:10.2307/2333387> "A Test For Homogeneity Of The Marginal Distributions In A Two-Way Classification", von Eye, A., & Mun, E. Y. (2005 ISBN:978-0805849677) "Analyzing Rater Agreement: Manifest Variable Methods".

This package provides a model-agnostic framework for selecting dataset-specific imputation methods for missing values in numerical data related to pain. Lotsch J, Ultsch A (2025) "A model-agnostic framework for dataset-specific selection of missing value imputation methods in pain-related numerical data" Canadian Journal of Pain (in minor revision).

Defines thresholds for breaking data into a number of discrete levels, minimizing the (mean) squared error within all bins.

This package provides an Interface to Open Collaboration Services OCS (<https://www.open-collaboration-services.org/>) REST API.

DNA methylation is an important epigenetic process that regulates gene activity through chemical modifications of DNA without changing its sequence. OpEnCAMeO is a organism based ensemble model for prediction of 4mC, 6mA and No methylation sites directly from DNA sequences. It combines multiple machine learning algorithms trained on Bacteria (Escherichia coli), Fungi (Saccharomyces cerevisiae) and Nematode (Caenorhabditis elegans) as reference models to deliver accurate predictions. This methodology is being inspired by the ensemble algorithm for methylation prediction developed by Sinha et al. (2025) <doi:10.1101/2025.11.10.687509>.

This package provides a utility to quickly obtain clean and tidy sports odds from The Odds API <https://the-odds-api.com>. Provides wrappers for every version 4 endpoint -- featured-market and single-event odds (including player props and alternate lines), historical odds snapshots, scores, events, participants, and usage-quota reporting -- returning tidy tibbles ready for analysis.

Solves penalized least squares problems for big tall data using the orthogonalizing EM algorithm of Xiong et al. (2016) <doi:10.1080/00401706.2015.1054436>. The main fitting function is oem() and the functions cv.oem() and xval.oem() are for cross validation, the latter being an accelerated cross validation function for linear models. The big.oem() function allows for out of memory fitting. A description of the underlying methods and code interface is described in Huling and Chien (2022) <doi:10.18637/jss.v104.i06>.

An RStudio addin to assist with removing objects from the global environment. Features include removing objects according to name patterns and object type. During the course of an analysis, temporary objects are often created and this tool assists with removing them quickly. This can be useful when memory management within R is important.

This package provides functions to calculate the out-of-bag learning curve for random forests for any measure that is available in the mlr package. Supported random forest packages are randomForest and ranger and trained models of these packages with the train function of mlr'. The main function is OOBCurve() that calculates the out-of-bag curve depending on the number of trees. With the OOBCurvePars() function out-of-bag curves can also be calculated for mtry', sample.fraction and min.node.size for the ranger package.

This package creates mock data for testing and package development for the Observational Medical Outcomes Partnership common data model. The package offers functions crafted with pipeline-friendly implementation, enabling users to effortlessly include only the necessary tables for their testing needs.

Estimates ordered probit switching regression models - a Heckman type selection model with an ordinal selection and continuous outcomes. Different model specifications are allowed for each treatment/regime. For more details on the method, see Wang & Mokhtarian (2024) <doi:10.1016/j.tra.2024.104072> or Chiburis & Lokshin (2007) <doi:10.1177/1536867X0700700202>.

This package provides a function for fitting cumulative link, adjacent category, forward and backward continuation ratio, and stereotype ordinal response models when the number of parameters exceeds the sample size, using the the generalized monotone incremental forward stagewise method.

The openFDA API facilitates access to Federal Drug Agency (FDA) data on drugs, devices, foodstuffs, tobacco, and more with httr2'. This package makes the API easily accessible, returning objects which the user can convert to JSON data and parse. Kass-Hout TA, Xu Z, Mohebbi M et al. (2016) <doi:10.1093/jamia/ocv153>.

Social media sites often embed cards when links are shared, based on metadata in the Open Graph Protocol (<https://ogp.me/>). This supports extracting that metadata from a website. It further allows for the creation of tags to add to a website to support the Open Graph Protocol and provides a list of the standard tags and their required properties.

This tool was designed to assess the sensitivity of research findings to omitted variables when estimating causal effects using propensity score (PS) weighting. This tool produces graphics and summary results that will enable a researcher to quantify the impact an omitted variable would have on their results. Burgette et al. (2021) describe the methodology behind the primary function in this package, ov_sim. The method is demonstrated in Griffin et al. (2020) <doi:10.1016/j.jsat.2020.108075>.