Allows for building drug response models using screening data between bulk RNA-Seq and a drug response metric and two additional tools for biomarker discovery that have been developed by the Huang Laboratory at University of Minnesota. There are 3 main functions within this package. (1) calcPhenotype() is used to build drug response models on RNA-Seq data and impute them on any other RNA-Seq dataset given to the model. (2) GLDS() is used to calculate the general level of drug sensitivity, which can improve biomarker discovery. (3) IDWAS() can take the results from calcPhenotype() and link the imputed response back to available genomic (mutation and CNV alterations) to identify biomarkers. Each of these functions comes from a paper from the Huang research laboratory. Below gives the relevant paper for each function. The package is described in Maeser et al. (2021) "oncoPredict: an R package for predicting in vivo or cancer patient drug response and biomarkers from cell line screening data" <doi:10.1093/bib/bbab260>. calcPhenotype() - Geeleher et al, Clinical drug response can be predicted using baseline gene expression levels and in vitro drug sensitivity in cell lines. GLDS() - Geeleher et al, Cancer biomarker discovery is improved by accounting for variability in general levels of drug sensitivity in pre-clinical models. IDWAS() - Geeleher et al, Discovering novel pharmacogenomic biomarkers by imputing drug response in cancer patients from large genomics studies.

Data processing, visualisation and analysis of Limit Order Book event data.

Predictive scores must be updated with care, because actions taken on the basis of existing risk scores causes bias in risk estimates from the updated score. A holdout set is a straightforward way to manage this problem: a proportion of the population is held-out from computation of the previous risk score. This package provides tools to estimate a size for this holdout set and associated errors. Comprehensive vignettes are included. Please see: Haidar-Wehbe S, Emerson SR, Aslett LJM, Liley J (2022) <doi:10.48550/arXiv.2202.06374> (in Annals of Applied Statistics) for details of methods.

Computes A-, MV-, D- and E-optimal or near-optimal row-column designs for two-colour cDNA microarray experiments using the linear fixed effects and mixed effects models where the interest is in a comparison of all pairwise treatment contrasts. The algorithms used in this package are based on the array exchange and treatment exchange algorithms adopted from Debusho, Gemechu and Haines (2018) <doi:10.1080/03610918.2018.1429617> algorithms after adjusting for the row-column designs setup. The package also provides an optional method of using the graphical user interface (GUI) R package tcltk to ensure that it is user friendly.

This package provides a tidy, long-format dataset of every athlete-event participation in the modern Olympic Games, spanning Athens 1896 through Milano-Cortina 2026 (about 315,000 rows). Extends the rgriff23 Olympic_history dataset (1896-2016) with five additional editions scraped from Olympedia (<https://www.olympedia.org>): PyeongChang 2018, Tokyo 2020, Beijing 2022, Paris 2024, and Milano-Cortina 2026. Companion datasets cover edition-level metadata and verified medal tables for every edition from 1896 to 2026.

This package provides functions to access and download data from the Open Case Studies <https://www.opencasestudies.org/> repositories on GitHub <https://github.com/opencasestudies>. Different functions enable users to grab the data they need at different sections in the case study, as well as download the whole case study repository. All the user needs to do is input the name of the case study being worked on. The package relies on the httr::GET() function to access files through the GitHub API. The functions usethis::use_zip() and usethis::create_from_github() are used to clone and/or download the case study repositories. To cite an individual case study, please see the respective README file at <https://github.com/opencasestudies/>. <https://github.com/opencasestudies/ocs-bp-rural-and-urban-obesity> <https://github.com/opencasestudies/ocs-bp-air-pollution> <https://github.com/opencasestudies/ocs-bp-vaping-case-study> <https://github.com/opencasestudies/ocs-bp-opioid-rural-urban> <https://github.com/opencasestudies/ocs-bp-RTC-wrangling> <https://github.com/opencasestudies/ocs-bp-RTC-analysis> <https://github.com/opencasestudies/ocs-bp-youth-disconnection> <https://github.com/opencasestudies/ocs-bp-youth-mental-health> <https://github.com/opencasestudies/ocs-bp-school-shootings-dashboard> <https://github.com/opencasestudies/ocs-bp-co2-emissions> <https://github.com/opencasestudies/ocs-bp-diet>.

Automated reporting in Word and PowerPoint can require customization for each organizational template. This package works around this by adding standard reporting functions and an abstraction layer to facilitate automated reporting workflows that can be replicated across different organizational templates.

Set of tools to generate samples of k-th order statistics and others quantities of interest from new families of distributions. The main references for this package are: C. Kleiber and S. Kotz (2003) Statistical size distributions in economics and actuarial sciences; Gentle, J. (2009), Computational Statistics, Springer-Verlag; Naradajah, S. and Rocha, R. (2016), <DOI:10.18637/jss.v069.i10> and Stasinopoulos, M. and Rigby, R. (2015), <DOI:10.1111/j.1467-9876.2005.00510.x>. The families of distributions are: Benini distributions, Burr distributions, Dagum distributions, Feller-Pareto distributions, Generalized Pareto distributions, Inverse Pareto distributions, The Inverse Paralogistic distributions, Marshall-Olkin G distributions, exponentiated G distributions, beta G distributions, gamma G distributions, Kumaraswamy G distributions, generalized beta G distributions, beta extended G distributions, gamma G distributions, gamma uniform G distributions, beta exponential G distributions, Weibull G distributions, log gamma G I distributions, log gamma G II distributions, exponentiated generalized G distributions, exponentiated Kumaraswamy G distributions, geometric exponential Poisson G distributions, truncated-exponential skew-symmetric G distributions, modified beta G distributions, exponentiated exponential Poisson G distributions, Poisson-inverse gaussian distributions, Skew normal type 1 distributions, Skew student t distributions, Singh-Maddala distributions, Sinh-Arcsinh distributions, Sichel distributions, Zero inflated Poisson distributions.

Density, distribution function, quantile function and random generation for the Odd Log-Logistic Generalized Gamma proposed in Prataviera, F. et al (2017) <doi:10.1080/00949655.2016.1238088>.

Install and control Open Source Routing Machine ('OSRM') backend executables to prepare routing data and run/stop a local OSRM server. For computations with the running server use the osrm package for R (<https://cran.r-project.org/package=osrm>).

Enables the usage of the OpenDota API from <https://www.opendota.com/>, get game lists, and download JSON's of parsed replays from the OpenDota API. Also has functionality to execute own code to extract the specific parts of the JSON file.

Read, validate, and load Open Knowledge Format (OKF) bundles (a directory of markdown files with YAML frontmatter) into a portable DuckDB catalog, build the concept graph, render to HTML, and optionally embed concept bodies for semantic search. Deterministic and agent-free: the same bundle always yields the same catalog, graph, and render, with no LLM calls in the core. Conformant and permissive per the OKF v0.1 specification.

Allows users to download and analyze official data on Brazil's federal budget through the SPARQL endpoint provided by the Integrated Budget and Planning System ('SIOP'). This package enables access to detailed information on budget allocations and expenditures of the federal government, making it easier to analyze and visualize these data. Technical information on the Brazilian federal budget is available (Portuguese only) at <https://www1.siop.planejamento.gov.br/mto/>. The SIOP endpoint is available at <https://www1.siop.planejamento.gov.br/sparql/>.

This package provides a tool for visualizing numerical data (e.g., gene expression, protein abundance) on predefined anatomical maps of human/mouse organs and subcellular organelles. It supports customization of color schemes, filtering by organ systems (for organisms) or organelle types, and generation of optional bar charts for quantitative comparison. The package integrates coordinate data for organs and organelles to plot anatomical/subcellular contours, mapping data values to specific structures for intuitive visualization of biological data distribution.The underlying method was described in the preprint by Zhou et al. (2022) <doi:10.1101/2022.09.07.506938>.

Growing collection of helper functions for point pattern analysis. Most functions are designed to work with the spatstat (<http://spatstat.org>) package. The focus of most functions are either null models or summary functions for spatial point patterns. For a detailed description of all null models and summary functions, see Wiegand and Moloney (2014, ISBN:9781420082548).

This package provides a framework for organizing R projects with a standardized structure. Most analyses consist of three main components: code, results, and data, each with different requirements such as version control, sharing, and encryption. This package provides tools to set up and manage project directories, handle file paths consistently across operating systems, organize results using date-based structures, source code from specified directories, and perform file operations safely. It ensures consistency across projects while accommodating different requirements for various types of content.

Two-part system for first collecting then managing direct observation data, as described by Hibbing PR, Ellingson LD, Dixon PM, & Welk GJ (2018) <doi:10.1249/MSS.0000000000001486>.

Packages data about the victims of the Pinochet regime as compiled by the Chilean National Commission for Truth and Reconciliation Report (1991, ISBN:9780268016463).

This package provides a focused implementation of the Public Suffix List (PSL). Bundles a reproducible, pinned PSL snapshot and implements the official prevailing-rule algorithm to answer public-suffix (eTLD) and registrable-domain (eTLD+1) queries. Distinguishes ICANN and PRIVATE rule sections, accepts Unicode and ASCII hostnames via punycoder canonicalization, and supports an explicit, validated offline refresh path. The matcher is compiled with cpp11 and requires no external system library. Used as the PSL engine by the rurl package.

This package contains a graphical user interface to generate the diagnostic plots proposed by Bauer (2005; <doi:10.1207/s15328007sem1204_1>), Pek & Chalmers (2015; <doi:10.1080/10705511.2014.937790>), and Pek, Chalmers, R. Kok, & Losardo (2015; <doi:10.3102/1076998615589129>) to investigate nonlinear bivariate relationships in latent regression models using structural equation mixture models (SEMMs).

This package provides tools for the practical management of financial portfolios: backtesting investment and trading strategies, computing profit/loss and returns, analysing trades, handling lists of transactions, reporting, and more. The package provides a small set of reliable, efficient and convenient tools for processing and analysing trade/portfolio data. The manual provides all the details; it is available from <https://enricoschumann.net/R/packages/PMwR/manual/PMwR.html>. Examples and descriptions of new features are provided at <https://enricoschumann.net/notes/PMwR/>.

An interface to compute poverty and inequality indicators for more than 160 countries and regions from the World Bank's database of household surveys, through the Poverty and Inequality Portal (PIP).

This package implements principal component analysis, orthogonal rotation and multiple factor analysis for a mixture of quantitative and qualitative variables.

This package provides a tidy interface to Pakistan's official administrative boundary data from the United Nations Office for the Coordination of Humanitarian Affairs (OCHA). Spatial data at country, province, district, and tehsil levels are embedded in the package as sf objects compatible with the tidyverse and geospatial ecosystem. Includes utilities for geographic dictionary lookup, coordinate reference system selection, spatial measurement, and neighbour structure construction for use with spdep', ggplot2', leaflet', and related packages.