This package provides a progression model for repeated measures (PMRM) is a continuous-time nonlinear mixed-effects model for longitudinal clinical trials in progressive diseases. Unlike mixed models for repeated measures (MMRMs), which estimate treatment effects as linear combinations of additive effects on the outcome scale, PMRMs characterize treatment effects in terms of the underlying disease trajectory. This framing yields clinically interpretable quantities such as average time saved and percent reduction in decline due to treatment. This package implements frequentist PMRMs by Raket (2022) <doi:10.1002/sim.9581> using RTMB by Kristensen (2016) <doi:10.18637/jss.v070.i05>.

Optogenetics is a new tool to study neuronal circuits that have been genetically modified to allow stimulation by flashes of light. This package implements the methodological framework, Point-process Response model for Optogenetics (PRO), for analyzing data from these experiments. This method provides explicit nonlinear transformations to link the flash point-process with the spiking point-process. Such response functions can be used to provide important and interpretable scientific insights into the properties of the biophysical process that governs neural spiking in response to optogenetic stimulation.

This package provides a comprehensive, user-friendly package for label-free proteomics data analysis and machine learning-based modeling. Data generated from MaxQuant can be easily used to conduct differential expression analysis, build predictive models with top protein candidates, and assess model performance. promor includes a suite of tools for quality control, visualization, missing data imputation (Lazar et. al. (2016) <doi:10.1021/acs.jproteome.5b00981>), differential expression analysis (Ritchie et. al. (2015) <doi:10.1093/nar/gkv007>), and machine learning-based modeling (Kuhn (2008) <doi:10.18637/jss.v028.i05>).

Creation and selection of PARAllel FACtor Analysis (PARAFAC) models of longitudinal microbiome data. You can import your own data with our import functions or use one of the example datasets to create your own PARAFAC models. Selection of the optimal number of components can be done using assessModelQuality() and assessModelStability(). The selected model can then be plotted using plotPARAFACmodel(). The Parallel Factor Analysis method was originally described by Caroll and Chang (1970) <doi:10.1007/BF02310791> and Harshman (1970) <https://www.psychology.uwo.ca/faculty/harshman/wpppfac0.pdf>.

It aggregates protein panel data and metadata for protein quantitative trait locus (pQTL) analysis using pQTLtools (<https://jinghuazhao.github.io/pQTLtools/>). The package includes data from affinity-based panels such as Olink (<https://olink.com/>) and SomaScan (<https://somalogic.com/>), as well as mass spectrometry-based panels from CellCarta (<https://cellcarta.com/>), Seer (<https://seer.bio/>) and SWATH-MS (<doi:10.15252/msb.20178126>). The metadata encompasses updated annotations and publication details.

This package provides functions to estimate the kinship matrix of individuals from a large set of biallelic SNPs, and extract inbreeding coefficients and the generalized FST (Wright's fixation index). Method described in Ochoa and Storey (2021) <doi:10.1371/journal.pgen.1009241>.

All PubChem compounds are downloaded to a local computer, but for each compound, only partial records are used. The data are organized into small files referenced by PubChem CID. This package also contains functions to parse the biologically relevant compounds from all PubChem compounds, using biological database sources, pathway presence, and taxonomic relationships. Taxonomy is used to generate a lowest common ancestor taxonomy ID (NCBI) for each biological metabolite, which then enables creation of taxonomically specific metabolome databases for any taxon.

An implementation of the van Westendorp Price Sensitivity Meter in R, which is a survey-based approach to analyze consumer price preferences and sensitivity (van Westendorp 1976, isbn:9789283100386).

Most price indexes are made with a two-step procedure, where period-over-period elementary indexes are first calculated for a collection of elementary aggregates at each point in time, and then aggregated according to a price index aggregation structure. These indexes can then be chained together to form a time series that gives the evolution of prices with respect to a fixed base period. This package contains a collection of functions that revolve around this work flow, making it easy to build standard price indexes, and implement the methods described by Balk (2008, <doi:10.1017/CBO9780511720758>), von der Lippe (2007, <doi:10.3726/978-3-653-01120-3>), and the CPI manual (2020, <doi:10.5089/9781484354841.069>) for bilateral price indexes.

Generates chronological and ordered p-plots for data vectors or vectors of p-values. The p-plot visualizes the evolution of the p-value of a significance test across the sampled data. It allows for assessing the consistency of the observed effects, for detecting the presence of potential moderator variables, and for estimating the influence of outlier values on the observed results. For non-significant findings, it can diagnose patterns indicative of underpowered study designs. The p-plot can thus either back the binary accept-vs-reject decision of common null-hypothesis significance tests, or it can qualify this decision and stimulate additional empirical work to arrive at more robust and replicable statistical inferences.

This package provides functions to calculate and plot event and pointer years as well as resilience indices. Designed for dendroecological applications, but also suitable to analyze patterns in other ecological time series.

This package provides analytic and simulation tools to estimate the minimum sample size required for achieving a target prediction mean-squared error (PMSE) or a specified proportional PMSE reduction (pPMSEr) in linear regression models. Functions implement the criteria of Ma (2023) <https://digital.wpi.edu/downloads/0g354j58c>, support covariance-matrix handling, and include helpers for root-finding and diagnostic plotting.

This package provides a suite of likelihood ratio test based methods to use in pharmacovigilance. Contains various testing and post-processing functions.

Phenotype study cohorts in data mapped to the Observational Medical Outcomes Partnership Common Data Model. Diagnostics are run at the database, code list, cohort, and population level to assess whether study cohorts are ready for research.

Conduct post-selection inference for regression coefficients in linear models after they have been selected by adjusted R squared. The p-values and confidence intervals are valid after model selection with the same data. This allows the user to use all data for both model selection and inference without losing control over the type I error rate. The provided tests are more powerful than data splitting, which bases inference on less data since it discards all information used for selection.

An environment to simulate the development of annual plant populations with regard to population dynamics and genetics, especially herbicide resistance. It combines genetics on the individual level (Renton et al. 2011) with a stochastic development on the population level (Daedlow, 2015). Renton, M, Diggle, A, Manalil, S and Powles, S (2011) <doi:10.1016/j.jtbi.2011.05.010> Daedlow, Daniel (2015, doctoral dissertation: University of Rostock, Faculty of Agriculture and Environmental Sciences.).

This package provides the tools needed to benchmark the R2 value corresponding to a certain acceptable noise level while also providing a rescaling function based on that noise level yielding a new value of R2 we refer to as R2k which is independent of both the number of degrees of freedom and the noise distribution function.

The probaverse is a suite of packages designed to facilitate creating advanced statistical models through probability distributions. These packages work best when loaded together because they share a common design philosophy and focus on different aspects of developing statistical models. Inspired by the tidyverse package, the probaverse package makes it easy to load the entire suite of probaverse packages together.

This package provides tools to process legacy format summary redistricting data files produced by the United States Census Bureau pursuant to P.L. 94-171. These files are generally available earlier but are difficult to work with as-is.

This package provides a lightweight message system relying purely on base R. Comes with built-in and pre styled message types and provides an easy way to create custom messages. Supports individually styled and colored text as well as timing information. Designed to make console output more informative and visually organized.

Optimal experimental designs for both population and individual studies based on nonlinear mixed-effect models. Often this is based on a computation of the Fisher Information Matrix. This package was developed for pharmacometric problems, and examples and predefined models are available for these types of systems. The methods are described in Nyberg et al. (2012) <doi:10.1016/j.cmpb.2012.05.005>, and Foracchia et al. (2004) <doi:10.1016/S0169-2607(03)00073-7>.

This package provides classes for analysing and implementing equity portfolios, including routines for generating tradelists and calculating exposures to user-specified risk factors.

This package implements Profile Analysis via Multidimensional Scaling (PAMS) for the identification of population-level core response profiles from cross-sectional and longitudinal person-score data. Each person profile is decomposed into a level component (the person mean) and a pattern component (ipsatized subscores). PAMS uses nonmetric multidimensional scaling via the SMACOF algorithm to identify a small number of core profiles that represent the central response patterns in a sample of any size. Bootstrap standard errors and bias-corrected and accelerated (BCa) confidence intervals for individual core profile coordinates are estimated, enabling significance testing of coordinates that is not available in other profile analysis methods such as cluster profile analysis or latent profile analysis. Person-level weights, R-squared values, and correlations with core profiles are also estimated, allowing individual profiles to be interpreted in terms of the core profile structure. PAMS can be applied to both cross-sectional data and longitudinal data, where core trajectory profiles describe how response patterns change over time. Methods are described in Kim and Kim (2024) <doi:10.20982/tqmp.20.3.p230>, de Leeuw and Mair (2009) <doi:10.18637/jss.v031.i03>, and Kruskal (1964) <doi:10.1007/BF02289565>.

Support Vector Machine (SVM) classification with simultaneous feature selection using penalty functions is implemented. The smoothly clipped absolute deviation (SCAD), L1-norm', Elastic Net ('L1-norm and L2-norm') and Elastic SCAD (SCAD and L2-norm') penalties are available. The tuning parameters can be found using either a fixed grid or a interval search.