This package provides a fast integrative genetic association test for rare diseases based on a model for disease status given allele counts at rare variant sites. Probability of association, mode of inheritance and probability of pathogenicity for individual variants are all inferred in a Bayesian framework - A Fast Association Test for Identifying Pathogenic Variants Involved in Rare Diseases', Greene et al 2017 <doi:10.1016/j.ajhg.2017.05.015>.

Making probabilistic projections of life expectancy for all countries of the world, using a Bayesian hierarchical model <doi:10.1007/s13524-012-0193-x>. Subnational projections are also supported.

Perform fundamental analyses using Bayesian parametric and non-parametric inference (regression, anova, 1 and 2 sample inference, non-parametric tests, etc.). (Practically) no Markov chain Monte Carlo (MCMC) is used; all exact finite sample inference is completed via closed form solutions or else through posterior sampling automated to ensure precision in interval estimate bounds. Diagnostic plots for model assessment, and key inferential quantities (point and interval estimates, probability of direction, region of practical equivalence, and Bayes factors) and model visualizations are provided. Bayes factors are computed either by the Savage Dickey ratio given in Dickey (1971) <doi:10.1214/aoms/1177693507> or by Chib's method as given in xxx. Interpretations are from Kass and Raftery (1995) <doi:10.1080/01621459.1995.10476572>. ROPE bounds are based on discussions in Kruschke (2018) <doi:10.1177/2515245918771304>. Methods for determining the number of posterior samples required are described in Doss et al. (2014) <doi:10.1214/14-EJS957>. Bayesian model averaging is done in part by Feldkircher and Zeugner (2015) <doi:10.18637/jss.v068.i04>. Methods for contingency table analysis is described in Gunel et al. (1974) <doi:10.1093/biomet/61.3.545>. Variational Bayes (VB) methods are described in Salimans and Knowles (2013) <doi:10.1214/13-BA858>. Mediation analysis uses the framework described in Imai et al. (2010) <doi:10.1037/a0020761>. The loss-likelihood bootstrap used in the non-parametric regression modeling is described in Lyddon et al. (2019) <doi:10.1093/biomet/asz006>. Non-parametric survival methods are described in Qing et al. (2023) <doi:10.1002/pst.2256>. Methods used for the Bayesian Wilcoxon signed-rank analysis is given in Chechile (2018) <doi:10.1080/03610926.2017.1388402> and for the Bayesian Wilcoxon rank sum analysis in Chechile (2020) <doi:10.1080/03610926.2018.1549247>. Correlation analysis methods are carried out by Barch and Chechile (2023) <doi:10.32614/CRAN.package.DFBA>, and described in Lindley and Phillips (1976) <doi:10.1080/00031305.1976.10479154> and Chechile and Barch (2021) <doi:10.1016/j.jmp.2021.102638>. See also Chechile (2020, ISBN: 9780262044585).

This package provides a selection of distances measures for bioinformatics data. Other important distance measures for bioinformatics data are selected from the R package parallelDist'. A special distance measure for the Gene Ontology is available.

Bayesian models to estimate causal effects of biological treatments on time-to-event endpoints in clinical trials with principal strata defined by the occurrence of antidrug antibodies. The methodology is based on Frangakis and Rubin (2002) <doi:10.1111/j.0006-341x.2002.00021.x> and Imbens and Rubin (1997) <doi:10.1214/aos/1034276631>, and here adapted to a specific time-to-event setting.

Bayesian analysis for exponential random graph models using advanced computational algorithms. More information can be found at: <https://acaimo.github.io/Bergm/>.

Included are two main interfaces, bentcable.ar() and bentcable.dev.plot(), for fitting and diagnosing bent-cable regressions for autoregressive time-series data (Chiu and Lockhart 2010, <doi:10.1002/cjs.10070>) or independent data (time series or otherwise - Chiu, Lockhart and Routledge 2006, <doi:10.1198/016214505000001177>). Some components in the package can also be used as stand-alone functions. The bent cable (linear-quadratic-linear) generalizes the broken stick (linear-linear), which is also handled by this package. Version 0.2 corrected a glitch in the computation of confidence intervals for the CTP. References that were updated from Versions 0.2.1 and 0.2.2 appear in Version 0.2.3 and up. Version 0.3.0 improved robustness of the error-message producing mechanism. Version 0.3.1 improves the NAMESPACE file of the package. It is the author's intention to distribute any future updates via GitHub.

Simulation, estimation and forecasting of first-order Beta-Skew-t-EGARCH models with leverage (one-component, two-component, skewed versions).

Fits a piecewise exponential hazard to survival data using a Hierarchical Bayesian model with an Intrinsic Conditional Autoregressive formulation for the spatial dependency in the hazard rates for each piece. This function uses Metropolis- Hastings-Green MCMC to allow the number of split points to vary and also uses Stochastic Search Variable Selection to determine what covariates drive the risk of the event. This function outputs trace plots depicting the number of split points in the hazard and the number of variables included in the hazard. The function saves all posterior quantities to the desired path.

An automated graphical exploratory data analysis (EDA) tool that introduces: a.) wideplot graphics for exploring the structure of a dataset through a grid of variables and graphic types. b.) longplot graphics, which present the entire catalog of available graphics for representing a particular variable using a grid of graphic types and variations on these types. c.) plotup function, which presents a particular graphic for a specific variable of a dataset. The plotup() function also makes it possible to obtain the code used to generate the graphic, meaning that the user can adjust its properties as needed. d.) matrixplot graphics that is a grid of a particular graphic showing bivariate relationships between all pairs of variables of a certain(s) type(s) in a multivariate data set.

Set of functions to perform various bootstrap unit root tests for both individual time series (including augmented Dickey-Fuller test and union tests), multiple time series and panel data; see Smeekes and Wilms (2023) <doi:10.18637/jss.v106.i12>, Palm, Smeekes and Urbain (2008) <doi:10.1111/j.1467-9892.2007.00565.x>, Palm, Smeekes and Urbain (2011) <doi:10.1016/j.jeconom.2010.11.010>, Moon and Perron (2012) <doi:10.1016/j.jeconom.2012.01.008>, Smeekes and Taylor (2012) <doi:10.1017/S0266466611000387> and Smeekes (2015) <doi:10.1111/jtsa.12110> for key references.

This package provides a collection of R functions were implemented from published and available analytic solutions for the One-Dimensional Boussinesq Equation (ground-water). In particular, the function "beq.lin()" is the analytic solution of the linearized form of Boussinesq Equation between two different head-based boundary (Dirichlet) conditions; "beq.song" is the non-linear power-series analytic solution of the motion of a wetting front over a dry bedrock (Song at al, 2007, see complete reference on function documentation). Bugs/comments/questions/collaboration of any kind are warmly welcomed.

This package performs logistic regression for binary longitudinal data, allowing for serial dependence among observations from a given individual and a random intercept term. Estimation is via maximization of the exact likelihood of a suitably defined model. Missing values and unbalanced data are allowed, with some restrictions. M. Helena Goncalves et al.(2007) <DOI: 10.18637/jss.v046.i09>.

Estimate population average treatment effects from a primary data source with borrowing from supplemental sources. Causal estimation is done with either a Bayesian linear model or with Bayesian additive regression trees (BART) to adjust for confounding. Borrowing is done with multisource exchangeability models (MEMs). For information on BART, see Chipman, George, & McCulloch (2010) <doi:10.1214/09-AOAS285>. For information on MEMs, see Kaizer, Koopmeiners, & Hobbs (2018) <doi:10.1093/biostatistics/kxx031>.

Comprehensive Business Process Analysis toolkit. Creates S3-class for event log objects, and related handler functions. Imports related packages for filtering event data, computation of descriptive statistics, handling of Petri Net objects and visualization of process maps. See also packages edeaR','processmapR', eventdataR and processmonitR'.

Reads several formats of 13C data (IRIS/Wagner, BreathID) and CSV. Creates artificial sample data for testing. Fits Maes/Ghoos, Bluck-Coward self-correcting formula using nls', nlme'. Methods to fit breath test curves with Bayesian Stan methods are refactored to package breathteststan'. For a Shiny GUI, see package dmenne/breathtestshiny on github.

This package implements Bayesian inference to detect signal from blinded clinical trial when total number of adverse events of special concerns and total risk exposures from all patients are available in the study. For more details see the article by Mukhopadhyay et. al. (2018) titled Bayesian Detection of Potential Risk Using Inference on Blinded Safety Data', in Pharmaceutical Statistics (to appear).

This package provides a simple tool to quantify the amount of transmission of an infectious disease of interest occurring within and between population groups. bumblebee uses counts of observed directed transmission pairs, identified phylogenetically from deep-sequence data or from epidemiological contacts, to quantify transmission flows within and between population groups accounting for sampling heterogeneity. Population groups might include: geographical areas (e.g. communities, regions), demographic groups (e.g. age, gender) or arms of a randomized clinical trial. See the bumblebee website for statistical theory, documentation and examples <https://magosil86.github.io/bumblebee/>.

An R interface to the Stark-Parker implementation of an algorithm for bounded-variable least squares.

The main purpose of this package is to propose a transparent methodological framework to compare bioregionalization methods based on hierarchical and non-hierarchical clustering algorithms (Kreft & Jetz (2010) <doi:10.1111/j.1365-2699.2010.02375.x>) and network algorithms (Lenormand et al. (2019) <doi:10.1002/ece3.4718> and Leroy et al. (2019) <doi:10.1111/jbi.13674>).

Interface to the Python package BERTopic <https://maartengr.github.io/BERTopic/index.html> for transformer-based topic modeling. Provides R wrappers to fit BERTopic models, transform new documents, update and reduce topics, extract topic- and document-level information, and generate interactive visualizations. Python backends and dependencies are managed via the reticulate package.

Generate urls and hyperlinks to commonly used biological databases and resources based on standard identifiers. This is primarily useful when writing dynamic reports that reference things like gene symbols in text or tables, allowing you to, for example, convert gene identifiers to hyperlinks pointing to their entry in the NCBI Gene database. Currently supports NCBI Gene, PubMed', Gene Ontology, KEGG', CRAN and Bioconductor.

Extend lasso and elastic-net model fitting for large data sets that cannot be loaded into memory. Designed to be more memory- and computation-efficient than existing lasso-fitting packages like glmnet and ncvreg', thus allowing the user to analyze big data with limited RAM <doi:10.32614/RJ-2021-001>.

This package creates an area-proportional Venn diagram of 2 or 3 circles. BioVenn is the only R package that can automatically generate an accurate area-proportional Venn diagram by having only lists of (biological) identifiers as input. Also offers the option to map Entrez and/or Affymetrix IDs to Ensembl IDs. In SVG mode, text and numbers can be dragged and dropped. Based on the BioVenn web interface available at <https://www.biovenn.nl>. Hulsen (2021) <doi:10.3233/DS-210032>.