Personalize drug regimens using individual pharmacokinetic (PK) and pharmacokinetic-pharmacodynamic (PK-PD) profiles. By combining therapeutic drug monitoring (TDM) data with a population model, posologyr offers accurate posterior estimates and helps compute optimal individualized dosing regimens. The empirical Bayes estimates are computed following the method described by Kang et al. (2012) <doi:10.4196/kjpp.2012.16.2.97>.

This package provides a dataset of Pokemon information in both English and Brazilian Portuguese. The dataset contains 949 rows and 22 columns, including information such as the Pokemon's name, ID, height, weight, stats, type, and more.

It enables sparklyr to integrate with Spark Connect', and Databricks Connect by providing a wrapper over the PySpark python library.

This package provides a simple implementation of the Predictive Information Index ('PII').

This package performs genomic prediction of hybrid performance using eight GS methods including GBLUP, BayesB, RKHS, PLS, LASSO, Elastic net, XGBoost and LightGBM. GBLUP: genomic best liner unbiased prediction, RKHS: reproducing kernel Hilbert space, PLS: partial least squares regression, LASSO: least absolute shrinkage and selection operator, XGBoost: extreme gradient boosting, LightGBM: light gradient boosting machine. It also provides fast cross-validation and mating design scheme for training population (Xu S et al (2016) <doi:10.1111/tpj.13242>; Xu S (2017) <doi:10.1534/g3.116.038059>). A complete manual for this package is provided in the manual folder of the package installation directory. You can locate the manual by running the following command in R: system.file("manual", package = "predhy.GUI").

Create the density contour plot for bivariate inverse Gaussian distribution for given non negative random variables.

Create phantom variables, which are variables that were not observed, for the purpose of sensitivity analyses for structural equation models. The package makes it easier for a user to test different combinations of covariances between the phantom variable(s) and observed variables. The package may be used to assess a model's or effect's sensitivity to temporal bias (e.g., if cross-sectional data were collected) or confounding bias.

Based on different statistical definitions of discrimination, several methods have been proposed to detect and mitigate social inequality in machine learning models. This package aims to provide an alternative to fairness treatment in predictive models. The ROC method implemented in this package is described by Kamiran, Karim and Zhang (2012) <https://ieeexplore.ieee.org/document/6413831/>.

Post-selection inference in linear regression models, constructing simultaneous confidence intervals across a user-specified universe of models. Implements the methodology described in Kuchibhotla, Kolassa, and Kuffner (2022) "Post-Selection Inference" <doi:10.1146/annurev-statistics-100421-044639> to ensure valid inference after model selection, with applications in high-dimensional settings like Lasso selection.

We consider the network structure detection for variables Y with auxiliary variables X accommodated, which are possibly subject to measurement error. The following three functions are designed to address various structures by different methods : one is NP_Graph() that is used for handling the nonlinear relationship between the responses and the covariates, another is Joint_Gaussian() that is used for correction in linear regression models via the Gaussian maximum likelihood, and the other Cond_Gaussian() is for linear regression models via conditional likelihood function.

This package provides a collection of privacy-preserving distributed algorithms (PDAs) for conducting federated statistical learning across multiple data sites. The PDA framework includes models for various tasks such as regression, trial emulation, causal inference, design-specific analysis, and clustering. The PDA algorithms run on a lead site and only require summary statistics from collaborating sites, with one or few iterations. The package can be used together with the online data transfer system (<https://pda-ota.pdamethods.org/>) for safe and convenient collaboration. For more information, please visit our software websites: <https://github.com/Penncil/pda>, and <https://pdamethods.org/>.

Implementation of an oligonucleotide primer and probe design algorithm using a linearly scaling approximation of set coverage. A detailed description available at Smolander and Tamminen, 2021; <doi:10.1101/2021.09.06.459073>.

This package provides a visualization toolkit for preferential data, such as ranked-choice election results, tournament outcomes, and survey responses. The package provides methods to visualise the preference distribution of one contest with bar charts and pairwise comparisons of two contestants, as well as methods to visualise multiple contests through 2D and high-dimensional simplex plots both statically and interactively. HD simplex displays are implemented via projection methods using the tourr and detourr packages, enabling dynamic exploration of high-dimensional preference structure. For more details on HD simplex projection, see Wickham et al. (2011) <doi:10.21105/joss.03419>.

Automate specification search for identifying noninvariant items in factorial invariance analyses, as described in Yoon & Millsap (2007) <doi:10.1080/10705510701301677>. Models are specified in lavaan syntax. Supports continuous indicators with loadings, intercepts, residuals (uniqueness), and residual covariances invariance, and ordered categorical indicators with loadings, thresholds, and residual covariances invariance.

Generation of multiple count, binary and ordinal variables simultaneously given the marginal characteristics and association structure. Throughout the package, the word Poisson is used to imply count data under the assumption of Poisson distribution. The details of the method are explained in Amatya, A. and Demirtas, H. (2015) <DOI:10.1080/00949655.2014.953534>.

Seq2seq time-feature analysis based on variational model, with a wide range of distributions available for the latent variable.

This package provides tools for visual exploratory data analysis with nested data. Includes functions for creating bivariate plots, dot plots, histograms, and violin plots for each group or unit in nested data. Methods are described in Crabtree and Nelson (2017) "Plotrr: Functions for making visual exploratory data analysis with nested data easier" <doi:10.21105/joss.00190>.

Pattern Sequence Based Forecasting (PSF) takes univariate time series data as input and assist to forecast its future values. This algorithm forecasts the behavior of time series based on similarity of pattern sequences. Initially, clustering is done with the labeling of samples from database. The labels associated with samples are then used for forecasting the future behaviour of time series data. The further technical details and references regarding PSF are discussed in Vignette.

This package provides functions for processing Shimadzu gas chromatography-mass spectrometry (GC-MS) exported text files, extracting Chemical Abstracts Service (CAS) numbers and peak areas, building abundance matrices, annotating compounds, and screening based on occurrence frequency. The package is designed for organizing, identifying, and screening volatile compounds in metabolomics and environmental studies.

This package provides a wrapper for Paddle - The Merchant of Record for digital products API (Application Programming Interface) <https://developer.paddle.com/api-reference/overview>. Provides functions to manage and analyze products, customers, invoices and many more.

This package provides a simple interface for extracting various elements from the publicly available PubMed XML files, incorporating PubMed's regular updates, and combining the data with the NIH Open Citation Collection. See Schoenbachler and Hughey (2021) <doi:10.7717/peerj.11071>.

This package provides a comprehensive framework for model fitting and simulation of drug release kinetics, pharmacokinetics (PK), and pharmacodynamics (PD). The package implements widely used mechanistic and empirical models for in vitro drug release, including zero-order, first-order, Higuchi, Korsmeyer-Peppas, Hixson-Crowell, and Weibull models. Pharmacokinetic functionality includes linear and nonlinear functions for one- and two-compartment models for intravenous bolus and oral administration, Michaelis-Menten kinetics, and non-compartmental analysis (NCA). Pharmacodynamic and dose-response modeling is supported through Emax-based models, including stimulatory (sigmoid Emax) and inhibitory (sigmoid Imax) Hill models, four- and five-parameter logistic models, as well as median toxic dose (TD50) and lethal dose (LD50) models. The package is intended to support parameter estimation, simulation, and model comparison in pharmaceutical research, drug development, and pharmacometrics education. For more details, see Gabrielsson & Weiner (2000) <ISBN:9186274929>, Holford & Sheiner (1981) <doi:10.2165/00003088-198106060-00002>, and Manlapaz (2025) <doi:10.32614/CRAN.package.adsoRptionCMF>.

This package provides tools to sort, edit and prune pedigrees and to extract the inbreeding coefficients and the relationship matrix (includes code for pedigrees from self-pollinated species). The use of pedigree data is central to genetics research within the animal and plant breeding communities to predict breeding values. The relationship matrix between the individuals can be derived from pedigree structure ('Vazquez et al., 2010') <doi:10.2527/jas.2009-1952>.

Intended for larger-than-memory tabular data, prt objects provide an interface to read row and/or column subsets into memory as data.table objects. Data queries, constructed as R expressions, are evaluated using the non-standard evaluation framework provided by rlang and file-backing is powered by the fast and efficient fst package.