Analysis and measurement of promotion effectiveness on a given target variable (e.g. daily sales). After converting promotion schedule into dummy or smoothed predictor variables, the package estimates the effects of these variables controlled for trend/periodicity/structural change using prophet by Taylor and Letham (2017) <doi:10.7287/peerj.preprints.3190v2> and some prespecified variables (e.g. start of a month).

Fits Emax models to pharmacokinetic/pharmacodynamic (PK/PD) data, estimate key parameters, and visualise model fits for multiple PK/PD indices. Methods are described in Macdougall J (2006) <doi:10.1007/0-387-33706-7_9>, Spiess AN, Neumeyer N (2010) <doi:10.1186/1471-2210-10-6>, and Burnham KP, Anderson DR (2004) <doi:10.1177/0049124104268644>.

This package provides a system for fast, accurate, and flexible whole genome bisulfite sequencing (WGBS) data analysis of two-condition comparisons. Principal Component BiSulfite, PCBS', assigns methylated loci eigenvector values from the treatment-delineating principal component in lieu of running millions of pairwise statistical tests, which dramatically increases analysis flexibility and reduces computational requirements. Methods: <https://katlande.github.io/PCBS/articles/Differential_Methylation.html>.

This package provides functions and data-sets that are helpful for teaching statistics and data analysis. It was originally designed for use when teaching students in the Psychology Department at Nottingham Trent University.

Procedures for testing for group-wide signal in clusters of variables. Tests can be performed for single groups in isolation (univariate) or multiple groups together (multivariate). Specific tests include the exact and approximate (un)selective likelihood ratio tests described in Reid et al (2015), the selective F test and marginal screening prototype test of Reid and Tibshirani (2015). User may pre-specify columns to be included in prototype formation, or allow the function to select them itself. A mixture of these two is also possible. Any variable selection is accounted for using the selective inference framework. Options for non-sampling and hit-and-run null reference distributions.

This package creates and manages a provenance graph corresponding to the provenance created by the rdtLite package, which collects provenance from R scripts. rdtLite is available on CRAN. The provenance format is an extension of the W3C PROV JSON format (<https://www.w3.org/Submission/2013/SUBM-prov-json-20130424/>). The extended JSON provenance format is described in <https://github.com/End-to-end-provenance/ExtendedProvJson>.

Estimates corrected Procrustean correlation between matrices for removing overfitting effect. Coissac Eric and Gonindard-Melodelima Christelle (2019) <doi:10.1101/842070>.

Computes the D', Wn, and conditional asymmetric linkage disequilibrium (ALD) measures for pairs of genetic loci. Performs these linkage disequilibrium (LD) calculations on phased genotype data recorded using Genotype List (GL) String or columnar formats. Alternatively, generates expectation-maximization (EM) estimated haplotypes from phased data, or performs LD calculations on EM estimated haplotypes. Performs sign tests comparing LD values for phased and unphased datasets, and generates heat-maps for each LD measure. Described by Osoegawa et al. (2019a) <doi:10.1016/j.humimm.2019.01.010>, and Osoegawa et. al. (2019b) <doi:10.1016/j.humimm.2019.05.018>.

Programmatic interface to the PhenoCam web services (<https://phenocam.nau.edu/webcam>). Allows for easy downloading of PhenoCam data directly to your R workspace or your computer and provides post-processing routines for consistent and easy timeseries outlier detection, smoothing and estimation of phenological transition dates. Methods for this package are described in detail in Hufkens et. al (2018) <doi:10.1111/2041-210X.12970>.

This package provides a package for selecting the most relevant features (genes) in the high-dimensional binary classification problems. The discriminative features are identified using analyzing the overlap between the expression values across both classes. The package includes functions for measuring the proportional overlapping score for each gene avoiding the outliers effect. The used measure for the overlap is the one defined in the "Proportional Overlapping Score (POS)" technique for feature selection. A gene mask which represents a gene's classification power can also be produced for each gene (feature). The set size of the selected genes might be set by the user. The minimum set of genes that correctly classify the maximum number of the given tissue samples (observations) can be also produced.

Estimates principal causal effects under principal stratification using a margin-free, conditional odds ratio sensitivity parameter. This framework unifies the monotonicity assumption and the counterfactual intermediate independence assumption, allowing for robust analysis when monotonicity may not hold. Computes point estimates, standard errors, and confidence intervals for conditionally doubly robust and debiased machine learning estimators. The methodological details are described in Tong, Kahan, Harhay, and Li (2025) <doi:10.48550/arXiv.2501.17514>.

An implementation of the parameter cascade method in Ramsay, J. O., Hooker,G., Campbell, D., and Cao, J. (2007) for estimating ordinary differential equation models with missing or complete observations. It combines smoothing method and profile estimation to estimate any non-linear dynamic system. The package also offers variance estimates for parameters of interest based on either bootstrap or Delta method.

R's implementation of the JavaScript library path-to-regexp', it aims to provide R web frameworks features such as parameter handling among other URL path utilities.

Computes the exact probability density function of X/Y conditioned on positive quadrant for series of bivariate distributions,for more details see Nadarajah,Song and Si (2019) <DOI:10.1080/03610926.2019.1576893>.

In causal mediation analysis with multiple causally ordered mediators, a set of path-specific effects are identified under standard ignorability assumptions. This package implements an imputation approach to estimating these effects along with a set of bias formulas for conducting sensitivity analysis (Zhou and Yamamoto <doi:10.31235/osf.io/2rx6p>). It contains two main functions: paths() for estimating path-specific effects and sens() for conducting sensitivity analysis. Estimation uncertainty is quantified using the nonparametric bootstrap.

This package provides a collection of tools for approximating the PDQ functions (respectively, the cumulative distribution, density, and quantile) of probability distributions via classical expansions involving moments and cumulants.

Parallelized version of the "segment" function from Bioconductor package "DNAcopy", utilizing multi-core computation on host CPU.

Enables the removal of training data from fitted R models while retaining predict functionality. The purged models are more portable as their memory footprints do not scale with the training sample size.

This package provides a portfolio of tools for economic complexity analysis and industrial upgrading navigation. The package implements essential measures in international trade and development economics, including the relative comparative advantage (RCA), economic complexity index (ECI) and product complexity index (PCI). It enables users to analyze export structures, explore product relatedness, and identify potential upgrading paths grounded in economic theory, following the framework in Hausmann et al. (2014) <doi:10.7551/mitpress/9647.001.0001>.

The Poisson-lognormal model and variants (Chiquet, Mariadassou and Robin, 2021 <doi:10.3389/fevo.2021.588292>) can be used for a variety of multivariate problems when count data are at play, including principal component analysis for count data, discriminant analysis, model-based clustering and network inference. Implements variational algorithms to fit such models accompanied with a set of functions for visualization and diagnostic.

This package provides a project infrastructure with a focus on manuscript creation. Creates a project folder with a single command, containing subdirectories for specific components, templates for manuscripts, and so on.

Computes probabilities of the bivariate normal distribution in a vectorized R function (Drezner & Wesolowsky, 1990, <doi:10.1080/00949659008811236>).

Run population simulations using an Individual-Based Model (IBM) compiled in C.

This package provides some easy-to-use functions for time series analyses of (plant-) phenological data sets. These functions mainly deal with the estimation of combined phenological time series and are usually wrappers for functions that are already implemented in other R packages adapted to the special structure of phenological data and the needs of phenologists. Some date conversion functions to handle Julian dates are also provided.