This package provides a user interface to create or modify pharmacometric models for various modeling and simulation software platforms.

Translating messages in R packages is managed using the po top-level directory and the gettext program. This package provides some helper functions for building this support in R packages, e.g. common validation & I/O tasks.

Makes it easier to create a Quarto website for an R package. Converts R documentation ('Rd') files into Quarto Markdown documents individually. Supports configuration via the _quarto.yml file and groups functions using roxygen2 family tags.

We extend dplyr and fuzzyjoin join functions with features to preprocess the data, apply various data checks, and deal with conflicting columns.

This package provides a collection of utilities and ggplot2 extensions to assist with visualisations in genomic epidemiology. This includes the phylepic chart, a visual combination of a phylogenetic tree and a matched epidemic curve. The included ggplot2 extensions such as date axes binned by week are relevant for other applications in epidemiology and beyond. The approach is described in Suster et al. (2024) <doi:10.1101/2024.04.02.24305229>.

Computational infrastructure for biogeography, community ecology, and biodiversity conservation (Daru et al. 2020) <doi:10.1111/2041-210X.13478>. It is based on the methods described in Daru et al. (2020) <doi:10.1038/s41467-020-15921-6>. The original conceptual work is described in Daru et al. (2017) <doi:10.1016/j.tree.2017.08.013> on patterns and processes of biogeographical regionalization. Additionally, the package contains fast and efficient functions to compute more standard conservation measures such as phylogenetic diversity, phylogenetic endemism, evolutionary distinctiveness and global endangerment, as well as compositional turnover (e.g., beta diversity).

This package provides generalized linear models for panel data, including pooled, fixed-effects, and random-effects estimators for continuous, binary, and count outcomes. Offers a unified interface for fitting and analysing panel regression models, with efficient computation for large datasets. Estimators and tests follow standard panel-data references, including Hausman (1978) <doi:10.2307/1913827>, Chamberlain (1980) <doi:10.2307/2297110>, Allison and Waterman (2002) <doi:10.1111/1467-9531.00117>, and Croissant and Millo (2008) <doi:10.18637/jss.v027.i02>. Core numerical routines are implemented using Rcpp', RcppArmadillo', and RcppParallel'.

Descriptive statistics (mean rank, pairwise frequencies, and marginal matrix), Analytic Hierarchy Process models (with Saaty's and Koczkodaj's inconsistencies), probability models (Luce models, distance-based models, and rank-ordered logit models) and visualization with multidimensional preference analysis for ranking data are provided. Current, only complete rankings are supported by this package.

Makes output files from select PreSens Fiber Optic Oxygen Transmitters easier to work with in R. See <http://www.presens.de> for more information about PreSens (Precision Sensing GmbH). Note: this package is neither created nor maintained by PreSens.

Obtener listado de datos, acceder y extender series del Portal de Datos de Hacienda.Las proyecciones se realizan con forecast', Hyndman RJ, Khandakar Y (2008) <doi:10.18637/jss.v027.i03>. Search, download and forecast time-series from the Ministry of Economy of Argentina. Forecasts are built with the forecast package, Hyndman RJ, Khandakar Y (2008) <doi:10.18637/jss.v027.i03>.

Given an arbitrary set of spatial regions and road networks, generate a set of representative points, or pseudohouseholds, that can be used for travel burden analysis. Parallel processing is supported.

Reconstruction of paleoclimate niches using phylogenetic comparative methods and projection reconstructed niches onto paleoclimate maps. The user can specify various models of trait evolution or estimate the best fit model, include fossils, use one or multiple phylogenies for inference, and make animations of shifting suitable habitat through time. This model was first used in Lawing and Polly (2011), and further implemented in Lawing et al (2016) and Rivera et al (2020). Lawing and Polly (2011) <doi:10.1371/journal.pone.0028554> "Pleistocene climate, phylogeny and climate envelope models: An integrative approach to better understand species response to climate change" Lawing et al (2016) <doi:10.1086/687202> "Including fossils in phylogenetic climate reconstructions: A deep time perspective on the climatic niche evolution and diversification of spiny lizards (Sceloporus)" Rivera et al (2020) <doi:10.1111/jbi.13915> "Reconstructing historical shifts in suitable habitat of Sceloporus lineages using phylogenetic niche modelling.".

Converts TXT and XML data curated by the United States Patent and Trademark Office (USPTO). Allows conversion of bulk data after downloading directly from the USPTO bulk data website, eliminating need for users to wrangle multiple data formats to get large patent databases in tidy, rectangular format. Data details can be found on the USPTO website <https://bulkdata.uspto.gov/>. Currently, all 3 formats: 1. TXT data (1976-2001); 2. XML format 1 data (2002-2004); and 3. XML format 2 data (2005-current) can be converted to rectangular, CSV format. Relevant literature that uses data from USPTO includes Wada (2020) <doi:10.1007/s11192-020-03674-4> and Plaza & Albert (2008) <doi:10.1007/s11192-007-1763-3>.

This package provides functions for constructing dashboards for business process monitoring. Building on the event log objects class from package bupaR'. Allows the use to assemble custom shiny dashboards based on process data.

Computes the minimum sample size required for the external validation of an existing multivariable prediction model using the criteria proposed by Archer (2020) <doi:10.1002/sim.8766> and Riley (2021) <doi:10.1002/sim.9025>.

This package provides tools for clustering, consensus meta-clustering, validation, exploratory interpretation, cluster prediction, and plotting. The package provides a clustering workflow with consensus clustering following Strehl and Ghosh (2002) <https://www.jmlr.org/papers/v3/strehl02a.html>.

This package provides tools for analyzing and optimizing PTSD (Post-Traumatic Stress Disorder) diagnostic criteria using PCL-5 (PTSD Checklist for DSM-5) and CAPS-5 (Clinician-Administered PTSD Scale for DSM-5) data. Functions identify optimal subsets of PCL-5 items that maintain diagnostic accuracy while reducing assessment burden. Includes tools for both hierarchical (cluster-based) and non-hierarchical symptom combinations, calculation of diagnostic metrics, and comparison with standard DSM-5 criteria. Redundancy analysis quantifies how many item subsets perform equivalently, through plateau sizes and bootstrap stability, and reports item selection against the chance baseline of the searched candidate space. A transport layer allows a site to evaluate subsets derived elsewhere and return only aggregate summaries, supporting multi-site validation without sharing individual-level data. Model validation is conducted using holdout and cross-validation methods to assess robustness and generalizability of the results. For more details see Weidmann et al. (2025) <doi:10.31219/osf.io/6rk72_v1>.

Optimal experimental designs for both population and individual studies based on nonlinear mixed-effect models. Often this is based on a computation of the Fisher Information Matrix. This package was developed for pharmacometric problems, and examples and predefined models are available for these types of systems. The methods are described in Nyberg et al. (2012) <doi:10.1016/j.cmpb.2012.05.005>, and Foracchia et al. (2004) <doi:10.1016/S0169-2607(03)00073-7>.

Algorithms to implement various Bayesian penalized survival regression models including: semiparametric proportional hazards models with lasso priors (Lee et al., Int J Biostat, 2011 <doi:10.2202/1557-4679.1301>) and three other shrinkage and group priors (Lee et al., Stat Anal Data Min, 2015 <doi:10.1002/sam.11266>); parametric accelerated failure time models with group/ordinary lasso prior (Lee et al. Comput Stat Data Anal, 2017 <doi:10.1016/j.csda.2017.02.014>).

Generates plain Markdown reference documentation for any R package, installed or a local development source tree, optimized for rendering in the GitHub'/'Gitea browser UI and for use as LLM context (e.g. Claude Code'). Reads Rd documentation via tools::Rd_db() (installed packages) or directly from man/*.Rd (development packages, no installation required) and renders one file per topic plus a navigable index.

Prepare pharmacokinetic/pharmacodynamic (PK/PD) data for PK/PD analyses. This package provides functions to standardize infusion and bolus dose data while linking it to drug level or concentration data.

This package implements univariate polynomial operations in R, including polynomial arithmetic, finding zeros, plotting, and some operations on lists of polynomials.

We aim for fitting a multinomial regression model with Lasso penalty and doing statistical inference (calculating confidence intervals of coefficients and p-values for individual variables). It implements 1) the coordinate descent algorithm to fit an l1-penalized multinomial regression model (parameterized with a reference level); 2) the debiasing approach to obtain the inference results, which is described in "Tian, Y., Rusinek, H., Masurkar, A. V., & Feng, Y. (2024). L1â Penalized Multinomial Regression: Estimation, Inference, and Prediction, With an Application to Risk Factor Identification for Different Dementia Subtypes. Statistics in Medicine, 43(30), 5711-5747.".

This package provides functions for generating pseudo-random numbers that follow a uniform distribution [0,1]. Randomness tests were conducted using the National Institute of Standards and Technology test suite<https://csrc.nist.gov/pubs/sp/800/22/r1/upd1/final>, along with additional tests. The sequence generated depends on the initial values and parameters. The package includes a linear congruence map as the decision map and three chaotic maps to generate the pseudo-random sequence, which follow a uniform distribution. Other distributions can be generated from the uniform distribution using the Inversion Principle Method and BOX-Muller transformation. Small perturbations in seed values result in entirely different sequences of numbers due to the sensitive nature of the maps being used. The chaotic nature of the maps helps achieve randomness in the generator. Additionally, the generator is capable of producing random bits.