Implementation of an algorithm in two steps to estimate parameters of a model whose latent dynamics are inferred through latent processes, jointly regularized. This package uses Monolix software (<https://monolixsuite.slp-software.com/>), which provide robust statistical method for non-linear mixed effects modeling. Monolix must have been installed prior to use.

This package provides a direct interface to the underlying XML representation of DDI Codebook 2.5 with flexible API creation.

The goal of ralger is to facilitate web scraping in R.

This package provides a robust and powerful approach is developed for replicability analysis of two Genome-wide association studies (GWASs) accounting for the linkage disequilibrium (LD) among genetic variants. The LD structure in two GWASs is captured by a four-state hidden Markov model (HMM). The unknowns involved in the HMM are estimated by an efficient expectation-maximization (EM) algorithm in combination with a non-parametric estimation of functions. By incorporating information from adjacent locations via the HMM, this approach identifies the entire clusters of genotype-phenotype associated signals, improving the power of replicability analysis while effectively controlling the false discovery rate.

Design and analysis of confirmatory adaptive clinical trials with continuous, binary, and survival endpoints according to the methods described in the monograph by Wassmer and Brannath (2025) <doi:10.1007/978-3-031-89669-9>. This includes classical group sequential as well as multi-stage adaptive hypotheses tests that are based on the combination testing principle.

Scalable implementation of classification and regression forests, as described by Breiman (2001), <DOI:10.1023/A:1010933404324>.

Compiles C++ code using Rcpp <doi:10.18637/jss.v040.i08>, Eigen <doi:10.18637/jss.v052.i05> and CppAD to produce first and second order partial derivatives. Also provides an implementation of Faa di Bruno's formula to combine the partial derivatives of composed functions.

This package provides a very lightweight package that writes out log messages in an opinionated way. Simpler and lighter than other logging packages, rlog provides a compact feature set that focuses on getting the job done in a Unix-like way.

Client for the web service methods provided by DataCite (<https://www.datacite.org/>), including functions to interface with their RESTful search API. The API is backed by Elasticsearch', allowing expressive queries, including faceting.

KEEL is a popular Java software for a large number of different knowledge data discovery tasks. Furthermore, RKEEL is a package with a R code layer between R and KEEL', for using KEEL in R code. This package includes the datasets from KEEL in .dat format for its use in RKEEL package. For more information about KEEL', see <http://www.keel.es/>.

This package provides methods to compute chemical similarity between two or more reactions and molecules. Allows masking of chemical substructures for weighted similarity computations. Uses packages rCDK and fingerprint for cheminformatics functionality. Methods for reaction similarity and sub-structure masking are as described in: Giri et al. (2015) <doi:10.1093/bioinformatics/btv416>.

ROSE (RObust Semiparametric Efficient) random forests for robust semiparametric efficient estimation in partially parametric models (containing generalised partially linear models). Details can be found in the paper by Young and Shah (2024) <doi:10.48550/arXiv.2410.03471>.

An implementation of calculating the R-squared measure as a total mediation effect size measure and its confidence interval for moderate- or high-dimensional mediator models. It gives an option to filter out non-mediators using variable selection methods. The original R package is directly related to the paper Yang et al (2021) "Estimation of mediation effect for high-dimensional omics mediators with application to the Framingham Heart Study" <doi:10.1101/774877>. The new version contains a choice of using cross-fitting, which is computationally faster. The details of the cross-fitting method are available in the paper Xu et al (2023) "Speeding up interval estimation for R2-based mediation effect of high-dimensional mediators via cross-fitting" <doi:10.1101/2023.02.06.527391>.

This package provides data structures and functions for file input/output in the ribios software suite, supporting common bioinformatics and computational biology file formats, designed for fast loading and high performance with minimal dependencies.

This package provides a toolkit for making antigenic maps from immunological assay data, in order to quantify and visualize antigenic differences between different pathogen strains as described in Smith et al. (2004) <doi:10.1126/science.1097211> and used in the World Health Organization influenza vaccine strain selection process. Additional functions allow for the diagnostic evaluation of antigenic maps and an interactive viewer is provided to explore antigenic relationships amongst several strains and incorporate the visualization of associated genetic information.

Client for Rserve, allowing to connect to Rserve instances and issue commands.

Generation of univariate and multivariate data that follow the generalized Poisson distribution. The details of the univariate part are explained in Demirtas (2017) <doi: 10.1080/03610918.2014.968725>, and the multivariate part is an extension of the correlated Poisson data generation routine that was introduced in Yahav and Shmueli (2012) <doi: 10.1002/asmb.901>.

This package provides a set of functions to facilitate building formatted strings under various replacement rules: C-style formatting, variable-based formatting, and number-based formatting. C-style formatting is basically identical to built-in function sprintf'. Variable-based formatting allows users to put variable names in a formatted string which will be replaced by variable values. Number-based formatting allows users to use index numbers to represent the corresponding argument value to appear in the string.

Visualize your favorite XKCD comic strip directly from R. XKCD <https://xkcd.com> web comic content is provided under the Creative Commons Attribution-NonCommercial 2.5 License.

Helps users in quickly visualizing risk-of-bias assessments performed as part of a systematic review. It allows users to create weighted bar-plots of the distribution of risk-of-bias judgments within each bias domain, in addition to traffic-light plots of the specific domain-level judgments for each study. The resulting figures are of publication quality and are formatted according the risk-of-bias assessment tool use to perform the assessments. Currently, the supported tools are ROB2.0 (for randomized controlled trials; Sterne et al (2019) <doi:10.1136/bmj.l4898>), ROBINS-I (for non-randomised studies of interventions; Sterne et al (2016) <doi:10.1136/bmj.i4919>), and QUADAS-2 (for diagnostic accuracy studies; Whiting et al (2011) <doi:10.7326/0003-4819-155-8-201110180-00009>).

Convert REDCap exports into tidy tables for easy handling of REDCap repeat instruments and event arms.

An implementation of a number of Global Trend models for time series forecasting that are Bayesian generalizations and extensions of some Exponential Smoothing models. The main differences/additions include 1) nonlinear global trend, 2) Student-t error distribution, and 3) a function for the error size, so heteroscedasticity. The methods are particularly useful for short time series. When tested on the well-known M3 dataset, they are able to outperform all classical time series algorithms. The models are fitted with MCMC using the rstan package.

This package provides functions for calculating life history metrics using matrix population models ('MPMs'). Described in Jones et al. (2021) <doi:10.1101/2021.04.26.441330>.

This package provides a unified framework for designing, simulating, and analyzing implementation rollout trials, including stepped wedge, sequential rollout, head-to-head, multi-condition, and rollout implementation optimization designs. The package enables users to flexibly specify rollout schedules, incorporate site-level and nested data structures, generate outcomes under rich hierarchical models, and evaluate analytic strategies through simulation-based power analysis. By separating data generation from model fitting, the tools support assessment of bias, Type I error, and robustness to model misspecification. The workflow integrates with standard mixed-effects modeling approaches and the tidyverse ecosystem, offering transparent and reproducible tools for implementation scientists and applied statisticians.