This version of the permutational algorithm generates a dataset in which event and censoring times are conditional on an user-specified list of covariates, some or all of which are time-dependent.

The main attribute of PopVar is the prediction of genetic variance in bi-parental populations, from which the package derives its name. PopVar contains a set of functions that use phenotypic and genotypic data from a set of candidate parents to 1) predict the mean, genetic variance, and superior progeny value of all, or a defined set of pairwise bi-parental crosses, and 2) perform cross-validation to estimate genome-wide prediction accuracy of multiple statistical models. More details are available in Mohammadi, Tiede, and Smith (2015, <doi:10.2135/cropsci2015.01.0030>). A dataset think_barley.rda is included for reference and examples.

Fast, flexible framework for implementing Bayesian optimization of model hyperparameters according to the methods described in Snoek et al. (2012) <doi:10.48550/arXiv.1206.2944>. The package allows the user to run scoring function in parallel, save intermediary results, and tweak other aspects of the process to fully utilize the computing resources available to the user.

This package implements partition-assisted clustering and multiple alignments of networks. It 1) utilizes partition-assisted clustering to find robust and accurate clusters and 2) discovers coherent relationships of clusters across multiple samples. It is particularly useful for analyzing single-cell data set. Please see Li et al. (2017) <doi:10.1371/journal.pcbi.1005875> for detail method description.

This package contains statistical inference tools applied to Partial Linear Regression (PLR) models. Specifically, point estimation, confidence intervals estimation, bandwidth selection, goodness-of-fit tests and analysis of covariance are considered. Kernel-based methods, combined with ordinary least squares estimation, are used and time series errors are allowed. In addition, these techniques are also implemented for both parametric (linear) and nonparametric regression models.

Enables computation of epidemiological statistics, including those where counts or mortality rates of the reference population are used. Currently supported: excess hazard models (Dickman, Sloggett, Hills, and Hakulinen (2012) <doi:10.1002/sim.1597>), rates, mean survival times, relative/net survival (in particular the Ederer II (Ederer and Heise (1959)) and Pohar Perme (Pohar Perme, Stare, and Esteve (2012) <doi:10.1111/j.1541-0420.2011.01640.x>) estimators), and standardized incidence and mortality ratios, all of which can be easily adjusted for by covariates such as age. Fast splitting and aggregation of Lexis objects (from package Epi') and other computations achieved using data.table'.

Implementation of commonly used penalized functional linear regression models, including the Smooth and Locally Sparse (SLoS) method by Lin et al. (2016) <doi:10.1080/10618600.2016.1195273>, Nested Group bridge Regression (NGR) method by Guan et al. (2020) <doi:10.1080/10618600.2020.1713797>, Functional Linear Regression That's interpretable (FLIRTI) by James et al. (2009) <doi:10.1214/08-AOS641>, and the Penalized B-spline regression method.

Infer causation from observational data through pattern causality analysis (PC), with original algorithm for time series data from Stavroglou et al. (2020) <doi:10.1073/pnas.1918269117>, as well as methodological extensions for spatial cross-sectional data introduced by Zhang & Wang (2025) <doi:10.1080/13658816.2025.2581207>, together with a systematic description proposed in Lyu et al. (2026) <doi:10.1016/j.compenvurbsys.2026.102435>.

Includes JavaScript files that allow plotly maps to render without an internet connection.

This package provides access to the Philippine Standard Geographic Code (PSGC), an official classification system for geographic areas in the Philippines published by the Philippine Statistics Authority (PSA). Includes area names, geographic levels (Region, Province, City, Municipality, Sub-Municipality, and Barangay), and census population figures across multiple PSA publication releases. Offers utilities to look up individual codes, filter by geographic level, track code changes across releases via a built-in crosswalk, and retrieve population data in long or wide format.

This package provides a focused implementation of the Public Suffix List (PSL). Bundles a reproducible, pinned PSL snapshot and implements the official prevailing-rule algorithm to answer public-suffix (eTLD) and registrable-domain (eTLD+1) queries. Distinguishes ICANN and PRIVATE rule sections, accepts Unicode and ASCII hostnames via punycoder canonicalization, and supports an explicit, validated offline refresh path. The matcher is compiled with cpp11 and requires no external system library. Used as the PSL engine by the rurl package.

Includes functions implementing the conditionally optimal matching algorithm, which can be used to generate matched samples in designs with multiple groups. The algorithm is described in Nattino, Song and Lu (2022) <doi:10.1016/j.csda.2021.107364>.

Computation of robust standard errors of Poisson fixed effects models, following Wooldridge (1999).

This package provides a scalable and accurate tool for Killer-cell Immunoglobulin-like Receptor (KIR) genotype imputation directly from SNP array data using supervised machine learning models trained across five continental ancestry groups. Uses attribute bagging and an ensemble classifier method with haplotype inference for SNPs and KIR types. Models are built from global populations in the 1000 Genomes Project and validated across diverse biobank cohorts. Methods are based on Zheng et al. (2014) <doi:10.1016/j.ajhg.2013.12.015> and Sadeeq et al. (2026) <https://github.com/NormanLabUCD/PONG2>.

Conducts hierarchical partitioning to calculate individual contributions of phylogenetic tree and predictors (groups) towards total R2 for phylogenetic linear regression models.

Combine probabilistic forecasts using CRPS learning algorithms proposed in Berrisch, Ziel (2021) <doi:10.48550/arXiv.2102.00968> <doi:10.1016/j.jeconom.2021.11.008>. The package implements multiple online learning algorithms like Bernstein online aggregation; see Wintenberger (2014) <doi:10.48550/arXiv.1404.1356>. Quantile regression is also implemented for comparison purposes. Model parameters can be tuned automatically with respect to the loss of the forecast combination. Methods like predict(), update(), plot() and print() are available for convenience. This package utilizes the optim C++ library for numeric optimization <https://github.com/kthohr/optim>.

Use Prime Factorization for simplifying computations, for instance for ratios of large factorials.

An embedded proximal interior point quadratic programming solver, which can solve dense and sparse quadratic programs, described in Schwan, Jiang, Kuhn, and Jones (2023) <doi:10.48550/arXiv.2304.00290>. Combining an infeasible interior point method with the proximal method of multipliers, the algorithm can handle ill-conditioned convex quadratic programming problems without the need for linear independence of the constraints. The solver is written in header only C++ 14 leveraging the Eigen library for vectorized linear algebra. For small dense problems, vectorized instructions and cache locality can be exploited more efficiently. Allocation free problem updates and re-solves are also provided.

Fast functions for dealing with prime numbers, such as testing whether a number is prime and generating a sequence prime numbers. Additional functions include finding prime factors and Ruth-Aaron pairs, finding next and previous prime numbers in the series, finding or estimating the nth prime, estimating the number of primes less than or equal to an arbitrary number, computing primorials, prime k-tuples (e.g., twin primes), finding the greatest common divisor and smallest (least) common multiple, testing whether two numbers are coprime, and computing Euler's totient function. Most functions are vectorized for speed and convenience.

PI-Change is a prior-informed multiple change point detection method that incorporates prespecified plausible change point locations through a time-varying penalized likelihood. The method extends multiple change point detection beyond purely data-driven segmentation by allowing external knowledge about plausible change point locations to enter the objective function; see Jacobs and Chen (2026) <doi:10.48550/arXiv.2605.01003>.

This package provides a simple package to grab a Bible proverb corresponding to the day of the month.

Estimates DNA target concentration by classifying digital PCR (polymerase chain reaction) droplets as positive, negative, or rain, using Expectation-Maximization Clustering. The fitting is accomplished using the EMMIXskew R package (v. 1.0.3) by Kui Wang, Angus Ng, and Geoff McLachlan (2018) as based on their paper "Multivariate Skew t Mixture Models: Applications to Fluorescence-Activated Cell Sorting Data" <doi:10.1109/DICTA.2009.88>.

This package provides a phylogenetic comparative method for finding associations between biological traits and molecular evolutionary rates. The method samples pairs from a phylogeny such that each pair has non-overlapping edge paths, and can therefore be treated as statistically independent observations. Linear regression is performed on the pair contrasts. This approach is similar to phylogenetically independent contrasts (PIC) but without reconstructing the traits at internal nodes, and is better suited for finding trait-rate associations than phylogenetic generalised least squares (PGLS). Refer to Douglas and Bromham (2026) <doi:10.64898/2026.08.13.744736> for further details.

Compute detailed and aggregated performance spectrum for event data. The detailed performance spectrum describes the event data in terms of segments, where the performance of each segment is measured and plotted for any occurrences of this segment over time and can be classified, e.g., regarding the overall population. The aggregated performance spectrum visualises the amount of cases of particular performance over time. Denisov, V., Fahland, D., & van der Aalst, W. M. P. (2018) <doi:10.1007/978-3-319-98648-7_9>.