Reversion mutations are secondary mutations that reverse the deleterious effects of an original pathogenic mutation, partially or fully restoring the gene's function. The revert package detects reversion mutations for a specific pathogenic mutation from DNA-seq bam files.

Shiny-based interactive gadgets of radial visualization methods and extensions thereof.

This package provides functions to implement the parametric and non-parametric bootstrap confidence interval methods described in Morrison and Simon (2017) <arXiv:1702.06986>.

This package provides tools to automate the morphological delineation of riverside urban areas based on a method introduced in Forgaci (2018) <doi:10.7480/abe.2018.31>. Delineation entails the identification of corridor boundaries, segmentation of the corridor, and delineation of the river space using two-dimensional spatial information from street network data and digital elevation data in a projected CRS. The resulting delineation can be used to characterise spatial phenomena that can be related to the river as a central element.

Build regular expressions piece by piece using human readable code. This package contains Unicode functionality, and is primarily intended to be used by package developers.

This package provides tools for response surface analysis, using a comparative framework that identifies best-fitting solutions across 37 families of polynomials. Many of these tools are based upon and extend the RSA package, by testing a larger scope of polynomials (+27 families), more diverse response surface probing techniques (+acceleration points), more plots (+line of congruence, +line of incongruence, both with extrema), and other useful functions for exporting results.

This package provides a simple implementation of Binary Indexed Tree by R. The BinaryIndexedTree class supports construction of Binary Indexed Tree from a vector, update of a value in the vector and query for the sum of a interval of the vector.

Providing just one primary function, readit uses a set of reasonable heuristics to apply the appropriate reader function to the given file path. As long as the data file has an extension, and the data is (or can be coerced to be) rectangular, readit() can probably read it.

Vector Graphics devices for Microsoft PowerPoint and Microsoft Excel'. Functions extending package officer are provided to embed DrawingML graphics into Microsoft PowerPoint presentations and Microsoft Excel workbooks.

Minirhizotrons are widely used to observe and explore roots and their growth. This package provides the means to stitch images and divide them into depth layers. Please note that this R package was developed alongside the following manuscript: Stitching root scans and extracting depth layer information -- a workflow and practical examples, S. Kersting, L. Knüver, and M. Fischer. The manuscript is currently in preparation and should be citet as soon as it is available. This project was supported by the project ArtIGROW, which is a part of the WIR!-Alliance ArtIFARM â Artificial Intelligence in Farming funded by the German Federal Ministry of Research, Technology and Space (No. 03WIR4805).

Datasets and utility functions to support the book "R for Plant Disease Epidemiology" (R4PDE). It includes functions for quantifying disease, assessing spatial patterns, and modeling plant disease epidemics based on weather predictors. These tools are intended for teaching and research in plant disease epidemiology. Several functions are based on classical and contemporary methods, including those discussed in Laurence V. Madden, Gareth Hughes, and Frank van den Bosch (2007) <doi:10.1094/9780890545058>.

This package provides access to a suite of geospatial data layers for wildfire management, fuel modeling, ecology, natural resource management, climate, conservation, etc., via the LANDFIRE (<https://www.landfire.gov/>) Product Service ('LFPS') API.

Translation of the MATLAB program Carb (Nathan and Mauz 2008 <DOI:10.1016/j.radmeas.2007.12.012>; Mauz and Hoffmann 2014) for dose rate modelling for carbonate-rich samples in the context of trapped charged dating (e.g., luminescence dating) applications.

This package provides randomization tests and graphical diagnostics for assessing randomized assignment and covariate balance for a binary treatment variable. See Branson (2021) <arXiv:1804.08760> for details.

This package provides a RESTful API wrapper for accessing the GENESIS database of the German Federal Statistical Office (Destatis) as well as its Census Database and the database of Germany's regional statistics. Supports data search functions, credential management, result caching, and handling remote background jobs for large datasets.

This package implements the Robust Scoring Equations estimator to fit linear mixed effects models robustly. Robustness is achieved by modification of the scoring equations combined with the Design Adaptive Scale approach.

Toolbox for chemometrics analysis of bidimensional gas chromatography data. This package import data for common scientific data format (NetCDF) and fold it to 2D chromatogram. Then, it can perform preprocessing and multivariate analysis. In the preprocessing algorithms, baseline correction, smoothing, and peak alignment are available. While in multivariate analysis, multiway principal component analysis is incorporated.

Rogue ("wildcard") taxa are leaves with uncertain phylogenetic position. Their position may vary from tree to tree under inference methods that yield a tree set (e.g. bootstrapping, Bayesian tree searches, maximum parsimony). The presence of rogue taxa in a tree set can potentially remove all information from a consensus tree. The information content of a consensus tree - a function of its resolution and branch support values - can often be increased by removing rogue taxa. Rogue provides an explicitly information-theoretic approach to rogue detection (Smith 2022) <doi:10.1093/sysbio/syab099>, and an interface to RogueNaRok (Aberer et al. 2013) <doi:10.1093/sysbio/sys078>.

This package provides functions and methods for manipulating SNOMED CT concepts. The package contains functions for loading the SNOMED CT release into a convenient R environment, selecting SNOMED CT concepts using regular expressions, and navigating the SNOMED CT ontology. It provides the SNOMEDconcept S3 class for a vector of SNOMED CT concepts (stored as 64-bit integers) and the SNOMEDcodelist S3 class for a table of concepts IDs with descriptions. The package can be used to construct sets of SNOMED CT concepts for research (<doi:10.1093/jamia/ocac158>). For more information about SNOMED CT visit <https://www.snomed.org/>.

This package performs multinomial goodness-of-fit test on multinomially distributed data using the Randomized phi-divergence test statistics. Details of this kind of statistics can be found at Nikita Puchkin, Vladimir Ulyanov (2023) <doi:10.1214/22-AIHP1299>.

This package provides tools for RFM (recency, frequency and monetary value) analysis. Generate RFM score from both transaction and customer level data. Visualize the relationship between recency, frequency and monetary value using heatmap, histograms, bar charts and scatter plots. Includes a shiny app for interactive segmentation. References: i. Blattberg R.C., Kim BD., Neslin S.A (2008) <doi:10.1007/978-0-387-72579-6_12>.

Higher-order spectra or polyspectra of time series, such as bispectrum and bicoherence, have been investigated in abundant literature and applied to problems of signal detection in a wide range of fields. This package aims to provide a simple API to estimate and analyze them. The current implementation is based on Brillinger and Irizarry (1998) <doi:10.1016/S0165-1684(97)00217-X> for estimating bispectrum or bicoherence, Lii and Helland (1981) <doi:10.1145/355958.355961> for cross-bispectrum, and Kim and Powers (1979) <doi:10.1109/TPS.1979.4317207> for cross-bicoherence.

This package performs robust estimation and inference when using covariate adjustment and/or covariate-adaptive randomization in randomized controlled trials. This package is trimmed to reduce the dependencies and validated to be used across industry. See "FDA's final guidance on covariate adjustment"<https://www.regulations.gov/docket/FDA-2019-D-0934>, Tsiatis (2008) <doi:10.1002/sim.3113>, Bugni et al. (2018) <doi:10.1080/01621459.2017.1375934>, Ye, Shao, Yi, and Zhao (2023)<doi:10.1080/01621459.2022.2049278>, Ye, Shao, and Yi (2022)<doi:10.1093/biomet/asab015>, Rosenblum and van der Laan (2010)<doi:10.2202/1557-4679.1138>, Wang et al. (2021)<doi:10.1080/01621459.2021.1981338>, Ye, Bannick, Yi, and Shao (2023)<doi:10.1080/24754269.2023.2205802>, and Bannick, Shao, Liu, Du, Yi, and Ye (2024)<doi:10.48550/arXiv.2306.10213>.

ViennaCL is a free open-source linear algebra library for computations on many-core architectures (GPUs, MIC) and multi-core CPUs. The library is written in C++ and supports CUDA', OpenCL', and OpenMP (including switches at runtime). I have placed these libraries in this package as a more efficient distribution system for CRAN. The idea is that you can write a package that depends on the ViennaCL library and yet you do not need to distribute a copy of this code with your package.