Run other estimation and simulation software via the nlmixr2 (Fidler et al (2019) <doi:10.1002/psp4.12445>) interface including PKNCA', NONMEM and Monolix'. While not required, you can get/install the lixoftConnectors package in the Monolix installation, as described at the following url <https://monolixsuite.slp-software.com/r-functions/2024R1/installation-and-initialization>. When lixoftConnectors is available, Monolix can be run directly instead of setting up command line usage.

Verification of continually updating time series data where we expect new values, but want to ensure previous data remains unchanged. Data previously recorded could change for a number of reasons, such as discovery of an error in model code, a change in methodology or instrument recalibration. Monitoring data sources for these changes is not always possible. Other unnoticed changes could include a jump in time or measurement frequency, due to instrument failure or software updates. Functionality is provided that can be used to check and flag changes to previous data to prevent changes going unnoticed, as well as unexpected jumps in time.

Build decision trees and random forests for classification and regression. The implementation strikes a balance between minimizing computing efforts and maximizing the expected predictive accuracy, thus scales well to large data sets. Multi-threading is available through OpenMP <https://gcc.gnu.org/wiki/openmp>.

Spike and slab regression with a variety of residual error distributions corresponding to Gaussian, Student T, probit, logit, SVM, and a few others. Spike and slab regression is Bayesian regression with prior distributions containing a point mass at zero. The posterior updates the amount of mass on this point, leading to a posterior distribution that is actually sparse, in the sense that if you sample from it many coefficients are actually zeros. Sampling from this posterior distribution is an elegant way to handle Bayesian variable selection and model averaging. See <DOI:10.1504/IJMMNO.2014.059942> for an explanation of the Gaussian case.

This package provides a fast, lightweight, and vectorized base 64 engine to encode and decode character and raw vectors as well as files stored on disk. Common base 64 alphabets are supported out of the box including the standard, URL-safe, bcrypt, crypt, BinHex', and IMAP-modified UTF-7 alphabets. Custom engines can be created to support unique base 64 encoding and decoding needs.

Calculate robust measures of effect sizes using the bootstrap.

This package provides tools for identifying subgroups within populations based on individual response patterns to specific interventions or treatments. Designed to support researchers and clinicians in exploring heterogeneous treatment effects and developing personalized therapeutic strategies. Offers functionality for analyzing and visualizing the interplay between two variables, thereby enhancing the interpretation of social sustainability metrics. The package focuses on bivariate discriminant analysis and aims to clarify relationships between indicator variables.

This package provides a Bayesian regression model for discrete response, where the conditional distribution is modelled via a discrete Weibull distribution. This package provides an implementation of Metropolis-Hastings and Reversible-Jumps algorithms to draw samples from the posterior. It covers a wide range of regularizations through any two parameter prior. Examples are Laplace (Lasso), Gaussian (ridge), Uniform, Cauchy and customized priors like a mixture of priors. An extensive visual toolbox is included to check the validity of the results as well as several measures of goodness-of-fit.

This package provides an efficient and robust implementation for estimating marginal Hazard Ratio (HR) and Restricted Mean Survival Time (RMST) with covariate adjustment using Daniel et al. (2021) <doi:10.1002/bimj.201900297> and Karrison et al. (2018) <doi:10.1177/1740774518759281>.

This package implements an S3 class based on data.table to store and process efficiently ethomics (high-throughput behavioural) data.

Bayes factors and posterior probabilities in Linear models, aimed at provide a formal Bayesian answer to testing and variable selection problems.

An implementation of best subset selection in generalized linear model and Cox proportional hazard model via the primal dual active set algorithm proposed by Wen, C., Zhang, A., Quan, S. and Wang, X. (2020) <doi:10.18637/jss.v094.i04>. The algorithm formulates coefficient parameters and residuals as primal and dual variables and utilizes efficient active set selection strategies based on the complementarity of the primal and dual variables.

The Bootstrap framework lets you add some JavaScript functionality to your web site by adding attributes to your HTML tags - Bootstrap takes care of the JavaScript <https://getbootstrap.com/docs/3.3/javascript/>. If you are using R Markdown or Shiny, you can use these functions to create collapsible sections, accordion panels, modals, tooltips, popovers, and an accordion sidebar framework (not described at Bootstrap site). Please note this package was designed for Bootstrap 3.3.

This package provides tools for the calculation of common biodiversity indices from count data. Additionally, it incorporates bootstrapping techniques to generate multiple samples, facilitating the estimation of confidence intervals around these indices. Furthermore, the package allows for the exploration of how variation in these indices changes with differing numbers of sites, making it a useful tool with which to begin an ecological analysis. Methods are based on the following references: Chao et al. (2014) <doi:10.1890/13-0133.1>, Chao and Colwell (2022) <doi:10.1002/9781119902911.ch2>, Hsieh, Ma,` and Chao (2016) <doi:10.1111/2041-210X.12613>.

Estimate the correlation between two irregular time series that are not necessarily sampled on identical time points. This program is also applicable to the situation of two evenly spaced time series that are not on the same time grid. BINCOR is based on a novel estimation approach proposed by Mudelsee (2010, 2014) to estimate the correlation between two climate time series with different timescales. The idea is that autocorrelation (AR1 process) allows to correlate values obtained on different time points. BINCOR contains four functions: bin_cor() (the main function to build the binned time series), plot_ts() (to plot and compare the irregular and binned time series, cor_ts() (to estimate the correlation between the binned time series) and ccf_ts() (to estimate the cross-correlation between the binned time series). A description of the method and package is provided in Polanco-Martà nez et al. (2019), <doi:10.32614/RJ-2019-035>.

This R package offers block Gibbs samplers for the Bayesian (adaptive) graphical lasso, ridge, and naive elastic net priors. These samplers facilitate the simulation of the posterior distribution of precision matrices for Gaussian distributed data and were originally proposed by: Wang (2012) <doi:10.1214/12-BA729>; Smith et al. (2022) <doi:10.48550/arXiv.2210.16290> and Smith et al. (2023) <doi:10.48550/arXiv.2306.14199>, respectively.

This package provides tools to create, validate, and export BioCompute Objects described in King et al. (2019) <doi:10.17605/osf.io/h59uh>. Users can encode information in data frames, and compose BioCompute Objects from the domains defined by the standard. A checksum validator and a JSON schema validator are provided. This package also supports exporting BioCompute Objects as JSON, PDF, HTML, or Word documents, and exporting to cloud-based platforms.

This package provides functions to construct efficient block designs for 3-level factorial experiments in block size 3. The designs ensure the estimation of all main effects and two-factor interactions in minimum number of replications. For more details, see Dey and Mukerjee (2012) <doi:10.1016/j.spl.2012.06.014> and Dash, S., Parsad, R. and Gupta, V.K. (2013) <doi:10.1007/s40003-013-0059-5>.

Latent and Stochastic Block Model estimation by a Variational EM algorithm. Various probability distribution are provided (Bernoulli, Poisson...), with or without covariates.

Constructs treatment and block designs for linear treatment models with crossed or nested block factors. The treatment design can be any feasible linear model and the block design can be any feasible combination of crossed or nested block factors. The block design is a sum of one or more block factors and the block design is optimized sequentially with the levels of each successive block factor optimized conditional on all previously optimized block factors. D-optimality is used throughout except for square or rectangular lattice block designs which are constructed algebraically using mutually orthogonal Latin squares. Crossed block designs with interaction effects are optimized using a weighting scheme which allows for differential weighting of first and second-order block effects. Outputs include a table showing the allocation of treatments to blocks and tables showing the achieved D-efficiency factors for each block and treatment design. Edmondson, R.N. Multi-level Block Designs for Comparative Experiments. JABES 25, 500â 522 (2020) <doi:10.1007/s13253-020-00416-0>.

This package provides functions for exploring and visualising estimation results obtained with BayesX, a free software for estimating structured additive regression models (<https://www.uni-goettingen.de/de/bayesx/550513.html>). In addition, functions that allow to read, write and manipulate map objects that are required in spatial analyses performed with BayesX.

Computes uniform bounds on the distance between the cumulative distribution function of a standardized sum of random variables and its first-order Edgeworth expansion, following the article Derumigny, Girard, Guyonvarch (2023) <doi:10.1007/s13171-023-00320-y>.

Calculate Bayesian marginal effects, average marginal effects, and marginal coefficients (also called population averaged coefficients) for models fit using the brms package including fixed effects, mixed effects, and location scale models. These are based on marginal predictions that integrate out random effects if necessary (see for example <doi:10.1186/s12874-015-0046-6> and <doi:10.1111/biom.12707>).

Functional differences between the cerebral hemispheres are a fundamental characteristic of the human brain. Researchers interested in studying these differences often infer underlying hemispheric dominance for a certain function (e.g., language) from laterality indices calculated from observed performance or brain activation measures . However, any inference from observed measures to latent (unobserved) classes has to consider the prior probability of class membership in the population. The provided functions implement a Bayesian model for predicting hemispheric dominance from observed laterality indices (Sorensen and Westerhausen, Laterality: Asymmetries of Body, Brain and Cognition, 2020, <doi:10.1080/1357650X.2020.1769124>).