Compute relative or absolute population trends across space and time using predictions from models fitted to ecological population abundance data, as described in Knape (2025) <doi:10.1016/j.ecolind.2025.113435>. The package supports models fitted by mgcv or brms', and draws from posterior predictive distributions.

Easily calculate precession and obliquity from an orbital solution (defaults to ZB18a from Zeebe and Lourens (2019) <doi:10.1126/science.aax0612>) and assumed or reconstructed values for tidal dissipation (Td) and dynamical ellipticity (Ed). This is a translation and adaptation of the C'-code in the supplementary material to Zeebe and Lourens (2022) <doi:10.1029/2021PA004349>, with further details on the methodology described in Zeebe (2022) <doi:10.3847/1538-3881/ac80f8>. The name of the C'-routine is snvec', which refers to the key units of computation: spin vector s and orbit normal vector n.

Formulates a sparse distance weighted discrimination (SDWD) for high-dimensional classification and implements a very fast algorithm for computing its solution path with the L1, the elastic-net, and the adaptive elastic-net penalties. More details about the methodology SDWD is seen on Wang and Zou (2016) (<doi:10.1080/10618600.2015.1049700>).

The heterogeneity of spatial data presenting a finite number of categories can be measured via computation of spatial entropy. Functions are available for the computation of the main entropy and spatial entropy measures in the literature. They include the traditional version of Shannon's entropy (Shannon, 1948 <doi:10.1002/j.1538-7305.1948.tb01338.x>), Batty's spatial entropy (Batty, 1974 <doi:10.1111/j.1538-4632.1974.tb01014.x>), O'Neill's entropy (O'Neill et al., 1998 <doi:10.1007/BF00162741>), Li and Reynolds contagion index (Li and Reynolds, 1993 <doi:10.1007/BF00125347>), Karlstrom and Ceccato's entropy (Karlstrom and Ceccato, 2002 <https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-61351>), Leibovici's entropy (Leibovici, 2009 <doi:10.1007/978-3-642-03832-7_24>), Parresol and Edwards entropy (Parresol and Edwards, 2014 <doi:10.3390/e16041842>) and Altieri's entropy (Altieri et al., 2018, <doi:10.1007/s10651-017-0383-1>). Full references for all measures can be found under the topic SpatEntropy'. The package is able to work with lattice and point data. The updated version works with the updated spatstat package (>= 3.0-2).

This package implements a three-dimensional stochastic model of cancer growth and mutation similar to the one described in Waclaw et al. (2015) <doi:10.1038/nature14971>. Allows for interactive 3D visualizations of the simulated tumor. Provides a comprehensive summary of the spatial distribution of mutants within the tumor. Contains functions which create synthetic sequencing datasets from the generated tumor.

Implement a promising, and yet little explored protocol for bioacoustical analysis, the eigensound method by MacLeod, Krieger and Jones (2013) <doi:10.4404/hystrix-24.1-6299>. Eigensound is a multidisciplinary method focused on the direct comparison between stereotyped sounds from different species. SoundShape', in turn, provide the tools required for anyone to go from sound waves to Principal Components Analysis, using tools extracted from traditional bioacoustics (i.e. tuneR and seewave packages), geometric morphometrics (i.e. geomorph package) and multivariate analysis (e.g. stats package). For more information, please see Rocha and Romano (2021) and check SoundShape repository on GitHub for news and updates <https://github.com/p-rocha/SoundShape>.

This package performs two-sample comparisons using the restricted mean survival time (RMST) as a summary measure of the survival time distribution. Three kinds of between-group contrast metrics (i.e., the difference in RMST, the ratio of RMST and the ratio of the restricted mean time lost (RMTL)) are computed. It performs an ANCOVA-type covariate adjustment as well as unadjusted analyses for those measures.

Pathway Analysis is statistically linking observations on the molecular level to biological processes or pathways on the systems(i.e., organism, organ, tissue, cell) level. Traditionally, pathway analysis methods regard pathways as collections of single genes and treat all genes in a pathway as equally informative. However, this can lead to identifying spurious pathways as statistically significant since components are often shared amongst pathways. SIGORA seeks to avoid this pitfall by focusing on genes or gene pairs that are (as a combination) specific to a single pathway. In relying on such pathway gene-pair signatures (Pathway-GPS), SIGORA inherently uses the status of other genes in the experimental context to identify the most relevant pathways. The current version allows for pathway analysis of human and mouse datasets. In addition, it contains pre-computed Pathway-GPS data for pathways in the KEGG and Reactome pathway repositories and mechanisms for extracting GPS for user-supplied repositories.

Identifies a bicluster, a submatrix of the data such that the features and observations within the submatrix differ from those not contained in submatrix, using a two-step method. In the first step, observations in the bicluster are identified to maximize the sum of weighted between cluster feature differences. The method is described in Helgeson et al. (2020) <doi:10.1111/biom.13136>. SCBiclust can be used to identify biclusters which differ based on feature means, feature variances, or more general differences.

Graphical and computational methods that can be used to assess the stability of results from supervised statistical learning.

This package provides a set of tools inspired by Stata to explore data.frames ('summarize', tabulate', xtile', pctile', binscatter', elapsed quarters/month, lead/lag).

This package provides functions for analyzing stocks or other investments. Main features are loading and aligning historical data for ticker symbols, calculating performance metrics for individual funds or portfolios (e.g. annualized growth, maximum drawdown, Sharpe/Sortino ratio), and creating graphs. C++ code is used to improve processing speed where possible.

Univariate and multivariate normal data simulation. They also supply a brief summary of the analysis for each experiment/design: - Independent samples. - One-way and two-way Anova. - Paired samples (T-Test & Regression). - Repeated measures (Anova & Multiple Regression). - Clinical Assay.

This package provides an R interface for SSW (Striped Smith-Waterman) via its Python binding ssw-py'. SSW is a fast C and C++ implementation of the Smith-Waterman algorithm for pairwise sequence alignment using Single-Instruction-Multiple-Data (SIMD) instructions. SSW enhances the standard algorithm by efficiently returning alignment information and suboptimal alignment scores. The core SSW library offers performance improvements for various bioinformatics tasks, including protein database searches, short-read alignments, primary and split-read mapping, structural variant detection, and read-overlap graph generation. These features make SSW particularly useful for genomic applications. Zhao et al. (2013) <doi:10.1371/journal.pone.0082138> developed the original C and C++ implementation.

This package contains statistical methods to analyze graphs, such as graph parameter estimation, model selection based on the Graph Information Criterion, statistical tests to discriminate two or more populations of graphs, correlation between graphs, and clustering of graphs. References: Takahashi et al. (2012) <doi:10.1371/journal.pone.0049949>, Fujita et al. (2017) <doi:10.3389/fnins.2017.00066>, Fujita et al. (2017) <doi:10.1016/j.csda.2016.11.016>, Fujita et al. (2019) <doi:10.1093/comnet/cnz028>.

Allows a Simile model saved as a compiled binary to be loaded, parameterized, executed and interrogated. This version works with Simile v6 on.

This package provides a toolkit for stratified medicine, subgroup identification, and precision medicine. Current tools include (1) filtering models (reduce covariate space), (2) patient-level estimate models (counterfactual patient-level quantities, such as the conditional average treatment effect), (3) subgroup identification models (find subsets of patients with similar treatment effects), and (4) treatment effect estimation and inference (for the overall population and discovered subgroups). These tools can be customized and are directly used in PRISM (patient response identifiers for stratified medicine; Jemielita and Mehrotra 2019 <arXiv:1912.03337>. This package is in beta and will be continually updated.

Constructs gene regulatory networks from single-cell gene expression data using the PANDA (Passing Attributes between Networks for Data Assimilation) algorithm.

This package provides an S4 class for representing and interacting with sparse plus rank matrices. At the moment the implementation is quite spare, but the plan is eventually subclass Matrix objects.

Substitution matrices are important parameters in protein alignment algorithms. These matrices represent the likelihood that an amino acid will be substituted for another during mutation. This tool allows users to apply predefined and custom matrices and then explore the resulting alignments with interactive visualizations. SubVis requires the availability of a web browser.

Collection of shiny application styling that are the based on the GOV.UK Design System. See <https://design-system.service.gov.uk/components/> for details.

Implementation of Small Area Estimation (SAE) using Hierarchical Bayesian (HB) Method when auxiliary variable measured with error under Beta Distribution. The rjags package is employed to obtain parameter estimates. For the references, see J.N.K & Molina (2015) <doi:10.1002/9781118735855>, Ybarra and Sharon (2008) <doi:10.1093/biomet/asn048>, and Ntzoufras (2009, ISBN-10: 1118210352).

Characterize daily stream discharge and water quality data and subsample water quality data. Provide dates, discharge, and water quality measurements and streamsampler can find gaps, get summary statistics, and subsample according to common stream sampling protocols. Stream sampling protocols are described in Lee et al. (2016) <doi:10.1016/j.jhydrol.2016.08.059> and Lee et al. (2019) <doi:10.3133/sir20195084>.

This package provides a set of tools for examining the design and analysis aspects of stepped wedge cluster randomized trials (SW CRT) based on a repeated cross-sectional or cohort sampling scheme (Hussey MA and Hughes JP (2007) Contemporary Clinical Trials 28:182-191).