The commonly used methods for relative quantification of gene expression levels obtained in real-time PCR (Polymerase Chain Reaction) experiments are the delta Ct methods, encompassing 2^-dCt and 2^-ddCt methods, originally proposed by Kenneth J. Livak and Thomas D. Schmittgen (2001) <doi:10.1006/meth.2001.1262>. The main idea is to normalise gene expression values using endogenous control gene, present gene expression levels in linear form by using the 2^-(value)^ transformation, and calculate differences in gene expression levels between groups of samples (or technical replicates of a single sample). The RQdeltaCT package offers functions that cover both methods for comparison of either independent groups of samples or groups with paired samples, together with importing expression datasets, performing multi-step quality control of data, enabling numerous data visualisations, enrichment of the standard workflow with additional useful analyses (correlation analysis, Receiver Operating Characteristic analysis, logistic regression), and conveniently export obtained results in table and image formats. The package has been designed to be friendly to non-experts in R programming.

Estimates the total, between-, and within-cluster Spearman rank correlations for continuous and ordinal clustered data. See Tu et al. (2024) <DOI:10.1002/sim.10326> for details.

Linguistic Descriptions of Complex Phenomena (LDCP) is an architecture and methodology that allows us to model complex phenomena, interpreting input data, and generating automatic text reports customized to the user needs (see <doi:10.1016/j.ins.2016.11.002> and <doi:10.1007/s00500-016-2430-5>). The proposed package contains a set of methods that facilitates the development of LDCP systems. It main goal is increasing the visibility and practical use of this research line.

An interface to the Integrated Taxonomic Information System ('ITIS') (<https://www.itis.gov>). Includes functions to work with the ITIS REST API methods (<https://www.itis.gov/ws_description.html>), as well as the Solr web service (<https://www.itis.gov/solr_documentation.html>).

Test for effects of both individual factors and their interaction on replicated spatial patterns in a two factorial design, as explained in Ramon et al. (2016) <doi:10.1111/ecog.01848>.

This package provides fast implementations of Random Forests, Gradient Boosting, and Linear Random Forests, with an emphasis on inference and interpretability. Additionally contains methods for variable importance, out-of-bag prediction, regression monotonicity, and several methods for missing data imputation.

Allows work with Management API for load counters, segments, filters, user permissions and goals list from Yandex Metrica, Reporting API allows you to get information about the statistics of site visits and other data without using the web interface, Logs API allows to receive non-aggregated data and Compatible with Google Analytics Core Reporting API v3 allows receive information about site traffic and other data using field names from Google Analytics Core API. For more information see official documents <https://yandex.ru/dev/metrika/doc/api2/concept/about-docpage>.

This package provides fast procedures for exploring all pairs of cutpoints of a single covariate with respect to survival and determining optimal cutpoints using a hierarchical method and various ordered logrank tests.

For whole-genome analysis, idiograms are virtually the most intuitive and effective way to map and visualize the genome-wide information. RIdeogram was developed to visualize and map whole-genome data on idiograms with no restriction of species.

In data science, it is a common practice to compute a series of columns (e.g. features) against a common response vector. Various metrics are provided with efficient computation implemented with Rcpp'.

Ports the Ripser <doi:10.48550/arXiv.1908.02518> and Cubical Ripser <doi:10.48550/arXiv.2005.12692> persistent homology calculation engines from C++. Can be used as a rapid calculation tool in topological data analysis pipelines.

An R implementation of ChASM (Chromosomal Aneuploidy Screening Methodology): a statistically rigorous Bayesian approach for screening data sets for autosomal and sex chromosomal aneuploidies. This package takes as input the number of (deduplicated) reads mapping to chromosomes 1-22 and the X and Y chromosomes, and models these using a Dirichlet-multinomial distribution. From this, This package returns posterior probabilities of sex chromosomal karyotypes (XX, XY, XXY, XYY, XXX and X) and full autosomal aneuploidies (trisomy 13, trisomy 18 and trisomy 21). This package also returns two diagnostic statistics: (i) a posterior probability addressing whether contamination between XX and XY may explain the observed sex chromosomal aneuploidy, and (ii) a chi-squared statistic measuring whether the observed read counts are too divergent from the underlying distribution (and may represent abnormal sequencing/quality issues).

This package provides a useful statistical tool for the construction and analysis of Honeycomb Selection Designs. More information about this type of designs: Fasoula V. (2013) <doi:10.1002/9781118497869.ch6> Fasoula V.A., and Tokatlidis I.S. (2012) <doi:10.1007/s13593-011-0034-0> Fasoulas A.C., and Fasoula V.A. (1995) <doi:10.1002/9780470650059.ch3> Tokatlidis I. (2016) <doi:10.1017/S0014479715000150> Tokatlidis I., and Vlachostergios D. (2016) <doi:10.3390/d8040029>.

R wrapper for the JPMML-R library <https://github.com/jpmml/jpmml-r>, which converts R models to Predictive Model Markup Language ('PMML').

Access to Boost Date_Time functionality for dates, durations (both for days and date time objects), time zones, and posix time ('ptime') is provided by using Rcpp modules'. The posix time implementation can support high-resolution of up to nano-second precision by using 96 bits (instead of 64 with R) to present a ptime object (but this needs recompilation with a #define set).

Offers bathymetric interpolation using Inverse Distance Weighted and Ordinary Kriging via the gstat and terra packages. Other functions focus on quantifying physical aquatic habitats (e.g., littoral, epliminion, metalimnion, hypolimnion) from interpolated digital elevation models (DEMs). Functions were designed to calculate these metrics across water levels for use in reservoirs but can be applied to any DEM and will provide values for fixed conditions. Parameters like Secchi disk depth or estimated photic zone, thermocline depth, and water level fluctuation depth are included in most functions.

Minimally adjust the values of numerical records in a data.frame, such that each record satisfies a predefined set of equality and/or inequality constraints. The constraints can be defined using the validate package. The core algorithms have recently been moved to the lintools package, refer to lintools for a more basic interface and access to a version of the algorithm that works with sparse matrices.

Suite of utilities for accessing and manipulating data from the KoboToolbox API. KoboToolbox is a robust platform designed for field data collection in various disciplines. This package aims to simplify the process of fetching and handling data from the API. Detailed documentation for the KoboToolbox API can be found at <https://support.kobotoolbox.org/api.html>.

Calculate rarefaction-based alpha- and beta-diversity. Offer parametric extrapolation to estimate the total expected species in a single community and the total expected shared species between two communities. Visualize the curve-fitting for these estimators.

Implementation of the tests for rotational symmetry on the hypersphere proposed in Garcà a-Portugués, Paindaveine and Verdebout (2020) <doi:10.1080/01621459.2019.1665527>. The package also implements the proposed distributions on the hypersphere, based on the tangent-normal decomposition, and allows for the replication of the data application considered in the paper.

The Brazilian Central Bank API delivers many datasets which regard economic activity, regional economy, international economy, public finances, credit indicators and many more. For more information please see <http://dadosabertos.bcb.gov.br/>. These datasets can be accessed through rbcb functions and can be obtained in different data structures common to R ('tibble', data.frame', xts', ...).

Efficient CRUD interface for the Airtable API <https://airtable.com/developers/web/api>, supporting batch requests and parallel encoding of large data sets.

Random univariate and multivariate finite mixture model generation, estimation, clustering, latent class analysis and classification. Variables can be continuous, discrete, independent or dependent and may follow normal, lognormal, Weibull, gamma, Gumbel, binomial, Poisson, Dirac, uniform or circular von Mises parametric families.

This package provides a comprehensive suite of utilities for univariate continuous probability distributions and reliability models. Includes functions to compute the probability density, cumulative distribution, quantile, reliability, and hazard functions, along with random variate generation. Also offers diagnostic and model assessment tools such as Quantile-Quantile (Q-Q) and Probability-Probability (P-P) plots, the Kolmogorov-Smirnov goodness-of-fit test, and model selection criteria including the Akaike Information Criterion (AIC) and Bayesian Information Criterion (BIC). Currently implements the following distributions: Burr X, Chen, Exponential Extension, Exponentiated Logistic, Exponentiated Weibull, Exponential Power, Flexible Weibull, Generalized Exponential, Gompertz, Generalized Power Weibull, Gumbel, Inverse Generalized Exponential, Linear Failure Rate, Log-Gamma, Logistic-Exponential, Logistic-Rayleigh, Log-log, Marshall-Olkin Extended Exponential, Marshall-Olkin Extended Weibull, and Weibull Extension distributions. Serves as a valuable resource for teaching and research in probability theory, reliability analysis, and applied statistical modeling.