This package provides comprehensive tools for the implementation of Structural Latent Class Models (SLCM), including Latent Transition Analysis (LTA; Linda M. Collins and Stephanie T. Lanza, 2009) <doi:10.1002/9780470567333>, Latent Class Profile Analysis (LCPA; Hwan Chung et al., 2010) <doi:10.1111/j.1467-985x.2010.00674.x>, and Joint Latent Class Analysis (JLCA; Saebom Jeon et al., 2017) <doi:10.1080/10705511.2017.1340844>, and any other extended models involving multiple latent class variables.

This package provides methods focused in performing the OSGB36/ETRS89 transformation (Great Britain and the Isle of Man only) by using the Ordnance Survey's OSTN15/OSGM15 transformation model. Calculation of distances and areas from sets of points defined in any of the supported Coordinated Systems is also available.

This package provides functions to estimate the proportion of treatment effect explained by the surrogate marker using a Bayesian Model Averaging approach. Duan and Parast (2023) <doi:10.1002/sim.9986>.

An Electronic Data Capture system (EDC) and Data Standard agnostic solution that enables the pharmaceutical programming community to develop Clinical Data Interchange Standards Consortium (CDISC) Study Data Tabulation Model (SDTM) datasets in R. The reusable algorithms concept in sdtm.oak provides a framework for modular programming and can potentially automate the conversion of raw clinical data to SDTM through standardized SDTM specifications. SDTM is one of the required standards for data submission to the Food and Drug Administration (FDA) in the United States and Pharmaceuticals and Medical Devices Agency (PMDA) in Japan. SDTM standards are implemented following the SDTM Implementation Guide as defined by CDISC <https://www.cdisc.org/standards/foundational/sdtmig>.

This package provides methods for spatial and spatio-temporal smoothing of demographic and health indicators using survey data, with particular focus on estimating and projecting under-five mortality rates, described in Mercer et al. (2015) <doi:10.1214/15-AOAS872>, Li et al. (2019) <doi:10.1371/journal.pone.0210645>, Wu et al. (DHS Spatial Analysis Reports No. 21, 2021), and Li et al. (2023) <doi:10.48550/arXiv.2007.05117>.

Processing and analysis of field collected or simulated sprinkler system catch data (depths) to characterize irrigation uniformity and efficiency using standard and other measures. Standard measures include the Christiansen coefficient of uniformity (CU) as found in Christiansen, J.E.(1942, ISBN:0138779295, "Irrigation by Sprinkling"); and distribution uniformity (DU), potential efficiency of the low quarter (PELQ), and application efficiency of the low quarter (AELQ) that are implementations of measures of the same notation in Keller, J. and Merriam, J.L. (1978) "Farm Irrigation System Evaluation: A Guide for Management" <https://pdf.usaid.gov/pdf_docs/PNAAG745.pdf>. spreval::DU.lh is similar to spreval::DU but is the distribution uniformity of the low half instead of low quarter as in DU. spreval::PELQT is a version of spreval::PELQ adapted for traveling systems instead of lateral move or solid-set sprinkler systems. The function spreval::eff is analogous to the method used to compute application efficiency for furrow irrigation presented in Walker, W. and Skogerboe, G.V. (1987,ISBN:0138779295, "Surface Irrigation: Theory and Practice"),that uses piecewise integration of infiltrated depth compared against soil-moisture deficit (SMD), when the argument "target" is set equal to SMD. The other functions contained in the package provide graphical representation of sprinkler system uniformity, and other standard univariate parametric and non-parametric statistical measures as applied to sprinkler system catch depths. A sample data set of field test data spreval::catchcan (catch depths) is provided and is used in examples and vignettes. Agricultural systems emphasized, but this package can be used for landscape irrigation evaluation, and a landscape (turf) vignette is included as an example application.

An automatic cluster-based annotation pipeline based on evidence-based score by matching the marker genes with known cell markers in tissue-specific cell taxonomy reference database for single-cell RNA-seq data. See Shao X, et al (2020) <doi:10.1016/j.isci.2020.100882> for more details.

Provide model averaging-based approaches that can be used to predict personalized survival probabilities. The key underlying idea is to approximate the conditional survival function using a weighted average of multiple candidate models. Two scenarios of candidate models are allowed: (Scenario 1) partial linear Cox model and (Scenario 2) time-varying coefficient Cox model. A reference of the underlying methods is Li and Wang (2023) <doi:10.1016/j.csda.2023.107759>.

Stochastic Newton Sampler (SNS) is a Metropolis-Hastings-based, Markov Chain Monte Carlo sampler for twice differentiable, log-concave probability density functions (PDFs) where the proposal density function is a multivariate Gaussian resulting from a second-order Taylor-series expansion of log-density around the current point. The mean of the Gaussian proposal is the full Newton-Raphson step from the current point. A Boolean flag allows for switching from SNS to Newton-Raphson optimization (by choosing the mean of proposal function as next point). This can be used during burn-in to get close to the mode of the PDF (which is unique due to concavity). For high-dimensional densities, mixing can be improved via state space partitioning strategy, in which SNS is applied to disjoint subsets of state space, wrapped in a Gibbs cycle. Numerical differentiation is available when analytical expressions for gradient and Hessian are not available. Facilities for validation and numerical differentiation of log-density are provided. Note: Formerly available versions of the MfUSampler can be obtained from the archive <https://cran.r-project.org/src/contrib/Archive/MfUSampler/>.

Fitting dimension reduction methods to data lying on two-dimensional sphere. This package provides principal geodesic analysis, principal circle, principal curves proposed by Hauberg, and spherical principal curves. Moreover, it offers the method of locally defined principal geodesics which is underway. The detailed procedures are described in Lee, J., Kim, J.-H. and Oh, H.-S. (2021) <doi:10.1109/TPAMI.2020.3025327>. Also see Kim, J.-H., Lee, J. and Oh, H.-S. (2020) <arXiv:2003.02578>.

Description: Provides functions for simulation and inference for stochastic differential equations (SDEs). It accompanies the book "Simulation and Inference for Stochastic Differential Equations: With R Examples" (Iacus, 2008, Springer; ISBN: 978-0-387-75838-1).

An English language syllable counter, plus readability score measure-er. For readability, we support Flesch Reading Ease and Flesch-Kincaid Grade Level ('Kincaid et al'. 1975) <https://stars.library.ucf.edu/cgi/viewcontent.cgi?article=1055&context=istlibrary>, Automated Readability Index ('Senter and Smith 1967) <https://apps.dtic.mil/sti/citations/AD0667273>, Simple Measure of Gobbledygook (McLaughlin 1969), and Coleman-Liau (Coleman and Liau 1975) <doi:10.1037/h0076540>. The package has been carefully optimized and should be very efficient, both in terms of run time performance and memory consumption. The main methods are vectorized by document, and scores for multiple documents are computed in parallel via OpenMP'.

Explains the behavior of a time series by decomposing it into its trend, seasonality and residuals. It is built to perform very well in the presence of significant level shifts. It is designed to play well with any breakpoint algorithm and any smoothing algorithm. Currently defaults to lowess for smoothing and strucchange for breakpoint identification. The package is useful in areas such as trend analysis, time series decomposition, breakpoint identification and anomaly detection.

This package contains chart code for monitoring clinical trial safety. Charts can be used as standalone output, but are also designed for use with the safetyGraphics package, which makes it easy to load data and customize the charts using an interactive web-based interface created with Shiny.

Uses a novel rank-based nonparametric approach to evaluate a surrogate marker in a small sample size setting. Details are described in Parast et al (2024) <doi:10.1093/biomtc/ujad035> and Hughes A et al (2025) <doi:10.1002/sim.70241>. A tutorial for this package can be found at <https://www.laylaparast.com/surrogaterank> and a Shiny App implementing the package can be found at <https://parastlab.shinyapps.io/SurrogateRankApp/>.

Allows users to easily build custom docker images <https://docs.docker.com/> from Amazon Web Service Sagemaker <https://aws.amazon.com/sagemaker/> using Amazon Web Service CodeBuild <https://aws.amazon.com/codebuild/>.

By binding R functions and the Highcharts <http://www.highcharts.com/> charting library, sankeywheel package provides a simple way to draw dependency wheels and sankey diagrams.

Allows search and visualisation of a collection of uniformly processed skeletal transcriptomic datasets. Includes methods to identify datasets where genes of interest are differentially expressed and find datasets with a similar gene expression pattern to a query dataset Soul J, Hardingham TE, Boot-Handford RP, Schwartz JM (2019) <doi:10.1093/bioinformatics/bty947>.

Add functionality to create drag and drop div elements in shiny.

Bayesian clustering of spatial regions with similar functional shapes using spanning trees and latent Gaussian models. The method enforces spatial contiguity within clusters and supports a wide range of latent Gaussian models, including non-Gaussian likelihoods, via the R-INLA framework. The algorithm is based on Zhong, R., Chacón-Montalván, E. A., and Moraga, P. (2024) <doi:10.48550/arXiv.2407.12633>, extending the approach of Zhang, B., Sang, H., Luo, Z. T., and Huang, H. (2023) <doi:10.1214/22-AOAS1643>. The package includes tools for model fitting, convergence diagnostics, visualization, and summarization of clustering results.

Wrapper for the non-validating SQL parser Python module sqlparse <https://github.com/andialbrecht/sqlparse>. It allows parsing, splitting, and formatting SQL statements.

Short and understandable commands that generate tabulated, formatted, and rounded survey estimates. Mostly a wrapper for the survey package (Lumley (2004) <doi:10.18637/jss.v009.i08> <https://CRAN.R-project.org/package=survey>) that identifies low-precision estimates using the National Center for Health Statistics (NCHS) presentation standards (Parker et al. (2017) <https://www.cdc.gov/nchs/data/series/sr_02/sr02_175.pdf>, Parker et al. (2023) <doi:10.15620/cdc:124368>).

Network meta-analysis for survival outcome data often involves several studies only involve dichotomized outcomes (e.g., the numbers of event and sample sizes of individual arms). To combine these different outcome data, Woods et al. (2010) <doi:10.1186/1471-2288-10-54> proposed a Bayesian approach using complicated hierarchical models. Besides, frequentist approaches have been alternative standard methods for the statistical analyses of network meta-analysis, and the methodology has been well established. We proposed an easy-to-implement method for the network meta-analysis based on the frequentist framework in Noma and Maruo (2025) <doi:10.1101/2025.01.23.25321051>. This package involves some convenient functions to implement the simple synthesis method.

Algorithms of nonparametric sequential test and online change-point detection for streams of univariate (sub-)Gaussian, binary, and bounded random variables, introduced in following publications - Shin et al. (2024) <doi:10.48550/arXiv.2203.03532>, Shin et al. (2021) <doi:10.48550/arXiv.2010.08082>.