This package provides a collection of sparse and regularized discriminant analysis methods intended for small-sample, high-dimensional data sets. The package features the High-Dimensional Regularized Discriminant Analysis classifier from Ramey et al. (2017) <arXiv:1602.01182>. Other classifiers include those from Dudoit et al. (2002) <doi:10.1198/016214502753479248>, Pang et al. (2009) <doi:10.1111/j.1541-0420.2009.01200.x>, and Tong et al. (2012) <doi:10.1093/bioinformatics/btr690>.

An implementation of neural networks trained with flow-sorted gene expression data to classify cellular phenotypes in single cell RNA-sequencing data. See Chamberlain M et al. (2021) <doi:10.1101/2021.02.01.429207> for more details.

Handling of behavioural data from the Ethoscope platform (Geissmann, Garcia Rodriguez, Beckwith, French, Jamasb and Gilestro (2017) <DOI:10.1371/journal.pbio.2003026>). Ethoscopes (<https://giorgiogilestro.notion.site/Ethoscope-User-Manual-a9739373ae9f4840aa45b277f2f0e3a7>) are an open source/open hardware framework made of interconnected raspberry pis (<https://www.raspberrypi.org>) designed to quantify the behaviour of multiple small animals in a distributed and real-time fashion. The default tracking algorithm records primary variables such as xy coordinates, dimensions and speed. This package is part of the rethomics framework <https://rethomics.github.io/>.

An ADMM implementation of SDP-1, a semidefinite programming relaxation of the maximum likelihood estimator for fitting a block model. SDP-1 has a tendency to produce equal-sized blocks and is ideal for producing a form of network histogram approximating a nonparametric graphon model. Alternatively, it can be used for community detection. (This is experimental code, proceed with caution.).

This package implements a method to combine multiple levels of multiple sequence alignment to uncover the structure of complex DNA rearrangements.

This package provides functions for fitting discrete distribution models to count data. Included are the Poisson, the negative binomial, the Poisson-inverse gaussian and, most importantly, a new implementation of the Poisson-beta distribution (density, distribution and quantile functions, and random number generator) together with a needed new implementation of Kummer's function (also: confluent hypergeometric function of the first kind). Three different implementations of the Gillespie algorithm allow data simulation based on the basic, switching or bursting mRNA generating processes. Moreover, likelihood functions for four variants of each of the three aforementioned distributions are also available. The variants include one population and two population mixtures, both with and without zero-inflation. The package depends on the MPFR libraries (<https://www.mpfr.org/>) which need to be installed separately (see description at <https://github.com/fuchslab/scModels>). This package is supplement to the paper "A mechanistic model for the negative binomial distribution of single-cell mRNA counts" by Lisa Amrhein, Kumar Harsha and Christiane Fuchs (2019) <doi:10.1101/657619> available on bioRxiv.

The goal of SIHR is to provide inference procedures in the high-dimensional generalized linear regression setting for: (1) linear functionals <doi:10.48550/arXiv.1904.12891> <doi:10.48550/arXiv.2012.07133>, (2) conditional average treatment effects, (3) quadratic functionals <doi:10.48550/arXiv.1909.01503>, (4) inner product, (5) distance.

Connecting to databases requires boilerplate code to specify connection parameters and to set up sessions properly with the DBMS. This package provides a simple tool to fill two purposes: abstracting connection details, including secret credentials, out of your source code and managing configuration for frequently-used database connections in a persistent and flexible way, while minimizing requirements on the runtime environment.

Create a hexagon tile map display from spatial polygons. Each polygon is represented by a hexagon tile, placed as close to it's original centroid as possible, with a focus on maintaining spatial relationship to a focal point. Developed to aid visualisation and analysis of spatial distributions across Australia, which can be challenging due to the concentration of the population on the coast and wide open interior.

This package provides functions to speed up the exploratory analysis of simple datasets using dplyr'. Functions are provided to do the common tasks of calculating confidence intervals.

We build an Susceptible-Infectious-Recovered (SIR) model where the rate of infection is the sum of the household rate and the community rate. We estimate the posterior distribution of the parameters using the Metropolis algorithm. Further details may be found in: F Scott Dahlgren, Ivo M Foppa, Melissa S Stockwell, Celibell Y Vargas, Philip LaRussa, Carrie Reed (2021) "Household transmission of influenza A and B within a prospective cohort during the 2013-2014 and 2014-2015 seasons" <doi:10.1002/sim.9181>.

This package implements spatial error estimation and permutation-based variable importance measures for predictive models using spatial cross-validation and spatial block bootstrap.

Fits a semiparametric spatiotemporal model for data with mixed frequencies, specifically where the response variable is observed at a lower frequency than some covariates. The estimation uses an iterative backfitting algorithm that combines a non-parametric smoothing spline for high-frequency data, parametric estimation for low-frequency and spatial neighborhood effects, and an autoregressive error structure. Methodology based on Malabanan, Lansangan, and Barrios (2022) <https://scienggj.org/2022/SciEnggJ%202022-vol15-no02-p90-107-Malabanan%20et%20al.pdf>.

This package produces various measures of expected treatment effect heterogeneity under an assumption of homogeneity across subgroups. Graphical presentations are created to compare these expected differences with the observed differences.

Simulates the cultural evolution of quantitative traits of bird song. SongEvo is an individual- (agent-) based model. SongEvo is spatially-explicit and can be parameterized with, and tested against, measured song data. Functions are available for model implementation, sensitivity analyses, parameter optimization, model validation, and hypothesis testing.

Implementation of the SAM prior and generation of its operating characteristics for dynamically borrowing information from historical data. For details, please refer to Yang et al. (2023) <doi:10.1111/biom.13927>.

Implementation for sparse logistic functional principal component analysis (SLFPCA). SLFPCA is specifically developed for functional binary data, and the estimated eigenfunction can be strictly zero on some sub-intervals, which is helpful for interpretation. The crucial function of this package is SLFPCA().

Estimates split-half reliabilities for scoring algorithms of cognitive tasks and questionnaires. The splithalfr supports researcher-provided scoring algorithms, with six vignettes illustrating how on included datasets. The package provides four splitting methods (first-second, odd-even, permutated, Monte Carlo), the option to stratify splits by task design, a number of reliability coefficients, the option to sub-sample data, and bootstrapped confidence intervals.

This package contains all the formulae of the growth and trace element uptake model described in the equally-named Geoscientific Model Development paper (de Winter, 2017, <doi:10.5194/gmd-2017-137>). The model takes as input a file with X- and Y-coordinates of digitized growth increments recognized on a longitudinal cross section through the bivalve shell, as well as a BMP file of an elemental map of the cross section surface with chemically distinct phases separated by phase analysis. It proceeds by a step-by-step process described in the paper, by which digitized growth increments are used to calculate changes in shell height, shell thickness, shell volume, shell mass and shell growth rate through the bivalve's life time. Then, results of this growth modelling are combined with the trace element mapping results to trace the incorporation of trace elements into the bivalve shell. Results of various modelling parameters can be exported in the form of XLSX files.

This package provides a function sfc() to compute the substance flow with the input files --- "data" and "model". If sample.size is set more than 1, uncertainty analysis will be executed while the distributions and parameters are supplied in the file "data".

Includes an interactive application designed to support educators in wide-ranging disciplines, with a particular focus on those teaching introductory statistical methods (descriptive and/or inferential) for data analysis. Users are able to randomly generate data, make new versions of existing data through common adjustments (e.g., add random normal noise and perform transformations), and check the suitability of the resulting data for statistical analyses.

Computes bounds and sensitivity parameters as part of sensitivity analysis for selection bias. Different bounds are provided: the SV (Smith and VanderWeele), sharp bounds, AF (assumption-free) bound, GAF (generalized AF), and CAF (counterfactual AF) bounds. The calculation of the sensitivity parameters for the SV, sharp, and GAF bounds assume an additional dependence structure in form of a generalized M-structure. The bounds can be calculated for any structure as long as the necessary assumptions hold. See Smith and VanderWeele (2019) <doi:10.1097/EDE.0000000000001032>, Zetterstrom, Sjölander, and Waernabum (2025) <doi:10.1177/09622802251374168>, Zetterstrom and Waernbaum (2022) <doi:10.1515/em-2022-0108>, and Zetterstrom (2024) <doi:10.1515/em-2023-0033>.

Provide utilities to work with solar time, i.e. where noon is exactly when sun culminates. Provides functions for computing sun position and times of sunrise and sunset.

Spatial stratified heterogeneity (SSH) denotes the coexistence of within-strata homogeneity and between-strata heterogeneity. Information consistency-based methods provide a rigorous approach to quantify SSH and evaluate its role in spatial processes, grounded in principles of geographical stratification and information theory (Bai, H. et al. (2023) <doi:10.1080/24694452.2023.2223700>; Wang, J. et al. (2024) <doi:10.1080/24694452.2023.2289982>).