Analysis of multivariate environmental high frequency data by Self-Organizing Map and k-means clustering algorithms. By means of the graphical user interface it provides a comfortable way to elaborate by self-organizing map algorithm rather big datasets (txt files up to 100 MB ) obtained by environmental high-frequency monitoring by sensors/instruments. The functions present in the package are based on kohonen and openair packages implemented by functions embedding Vesanto et al. (2001) <http://www.cis.hut.fi/projects/somtoolbox/package/papers/techrep.pdf> heuristic rules for map initialization parameters, k-means clustering algorithm and map features visualization. Cluster profiles visualization as well as graphs dedicated to the visualization of time-dependent variables Licen et al. (2020) <doi:10.4209/aaqr.2019.08.0414> are provided.

Summary ellipses superimposed on a scatter plot contain all bi-variate summary statistics for regression analysis. Furthermore, the outer ellipse flags potential outliers. Multiple groups can be compared in terms of centers and spreads as illustrated in the examples.

Transforms or simulates data with a target empirical covariance matrix supplied by the user. The method to obtain the data with the target empirical covariance matrix is described in Section 5.1 of Christidis, Van Aelst and Zamar (2019) <arXiv:1812.05678>.

For making Trellis-type conditioning plots without strip labels. This is useful for displaying the structure of results from factorial designs and other studies when many conditioning variables would clutter the display with layers of redundant strip labels. Settings of the variables are encoded by layout and spacing in the trellis array and decoded by a separate legend. The functionality is implemented by a single S3 generic strucplot() function that is a wrapper for the Lattice package's xyplot() function. This allows access to all Lattice graphics capabilities in the usual way.

An interactive charting library built on Svelte and D3 to easily produce SVG charts in R. Designed to simplify shiny development by eliminating the need for renderUI(), insertUI(), removeUI(), and shiny proxy functions, using Svelte''s reactive state system instead.

Density, distribution function, quantile function and random generation for the skewed t distribution of Fernandez and Steel.

This package provides a collection of functions for estimating spatial regimes, aggregations of neighboring spatial units that are homogeneous in functional terms. The term spatial regime, therefore, should not be understood as a synonym for cluster. More precisely, the term cluster does not presuppose any functional relationship between the variables considered, while the term regime is linked to a regressive relationship underlying the spatial process.

Designed for estimating variants of hidden (latent) Markov models (HMMs), mixture HMMs, and non-homogeneous HMMs (NHMMs) for social sequence data and other categorical time series. Special cases include feedback-augmented NHMMs, Markov models without latent layer, mixture Markov models, and latent class models. The package supports models for one or multiple subjects with one or multiple parallel sequences (channels). External covariates can be added to explain cluster membership in mixture models as well as initial, transition and emission probabilities in NHMMs. The package provides functions for evaluating and comparing models, as well as functions for visualizing of multichannel sequence data and HMMs. For NHMMs, methods for computing average causal effects and marginal state and emission probabilities are available. Models are estimated using maximum likelihood via the EM algorithm or direct numerical maximization with analytical gradients. Documentation is available via several vignettes, and Helske and Helske (2019, <doi:10.18637/jss.v088.i03>). For methodology behind the NHMMs, see Helske (2025, <doi:10.48550/arXiv.2503.16014>).

For Multi Parent Populations (MPP) Identity By Descend (IBD) probabilities are computed using Hidden Markov Models. These probabilities are then used in a mixed model approach for QTL Mapping as described in Li et al. (<doi:10.1007/s00122-021-03919-7>).

Evolutionary reconstruction based on substitutions and insertion-deletion (indels) analyses in a distance-based framework as described in Muñoz-Pajares (2013) <doi:10.1111/2041-210X.12118>.

This package provides a test for the existence of a subgroup with enhanced treatment effect. And, a sample size calculation procedure for the subgroup detection test.

Assigns a score projection from 0 to 1 between a given in vivo stage and each single cluster from an in vitro dataset. The score is assigned based on the the fraction of specific markers of the in vivo stage that are conserved in the in vitro clusters <https://github.com/ScialdoneLab>.

This package provides a tool to interactively explore the embeddings created by dimension reduction methods such as Principal Components Analysis (PCA), Multidimensional Scaling (MDS), T-distributed Stochastic Neighbour Embedding (t-SNE), Uniform Manifold Approximation and Projection (UMAP) or any other.

Implementations self-normalization (SN) based algorithms for change-points estimation in time series data. This comprises nested local-window algorithms for detecting changes in both univariate and multivariate time series developed in Zhao, Jiang and Shao (2022) <doi:10.1111/rssb.12552>.

Series of algorithms to translate users mental models of seascapes, landscapes and, more generally, of geographic features into computer representations (classifications). Spaces and geographic objects are classified with user-defined rules taking into account spatial data as well as spatial relationships among different classes and objects.

This package provides a robust and powerful empirical Bayesian approach is developed for replicability analysis of two large-scale experimental studies. The method controls the false discovery rate by using the joint local false discovery rate based on the replicability null as the test statistic. An EM algorithm combined with a shape constraint nonparametric method is used to estimate unknown parameters and functions. [Li, Y. et al., (2024), <doi:10.1371/journal.pgen.1011423>].

Fits single-species (univariate) and multi-species (multivariate) non-spatial and spatial abundance models in a Bayesian framework using Markov Chain Monte Carlo (MCMC). Spatial models are fit using Nearest Neighbor Gaussian Processes (NNGPs). Details on NNGP models are given in Datta, Banerjee, Finley, and Gelfand (2016) <doi:10.1080/01621459.2015.1044091> and Finley, Datta, and Banerjee (2022) <doi:10.18637/jss.v103.i05>. Fits single-species and multi-species spatial and non-spatial versions of generalized linear mixed models (Gaussian, Poisson, Negative Binomial), N-mixture models (Royle 2004 <doi:10.1111/j.0006-341X.2004.00142.x>) and hierarchical distance sampling models (Royle, Dawson, Bates (2004) <doi:10.1890/03-3127>). Multi-species spatial models are fit using a spatial factor modeling approach with NNGPs for computational efficiency.

Hierarchical models for the analysis of species-area relationships (SARs) by combining several data sets and covariates; with a global data set combining individual SAR studies; as described in Solymos and Lele (2012) <doi:10.1111/j.1466-8238.2011.00655.x>.

This package provides tools for reading and writing biological sequences in multiple formats, including FASTA', PHYLIP', CLUSTAL', STOCKHOLM', MEGA and GenBank'. Supports interleaved and sequential layouts where applicable, converts between formats, and manipulates sequence sets (e.g., filtering by patterns and computing consensus sequences from alignments). Also includes functions to download nucleotide records from NCBI by accession.

This package provides deep learning models for right-censored survival data using the torch backend. Supports multiple loss functions, including Cox partial likelihood, L2-penalized Cox, time-dependent Cox, and accelerated failure time (AFT) loss. Offers a formula-based interface, built-in support for cross-validation, hyperparameter tuning, survival curve plotting, and evaluation metrics such as the C-index, Brier score, and integrated Brier score. For methodological details, see Kvamme et al. (2019) <https://www.jmlr.org/papers/v20/18-424.html>.

This package provides a flexible framework combining variable screening and random projection techniques for fitting ensembles of predictive generalized linear models to high-dimensional data. Designed for extensibility, the package implements key techniques as S3 classes with user-friendly constructors, enabling easy integration and development of new procedures for high-dimensional applications. For more details see Parzer et al (2024a) <doi:10.48550/arXiv.2312.00130> and Parzer et al (2024b) <doi:10.48550/arXiv.2410.00971>.

Density, distribution function, quantile function and random generation for the skewed generalized t distribution. This package also provides a function that can fit data to the skewed generalized t distribution using maximum likelihood estimation.

Visualizes sulcal morphometry data derived from BrainVisa <https://brainvisa.info/> including width, depth, surface area, and length. The package enables mapping of statistical group results or subject-level values onto cortical surface maps, with options to focus on all sulci or only selected regions of interest. Users can display all four measures simultaneously or restrict plots to chosen measures, creating composite, publication-quality brain visualizations in R to support the analysis and interpretation of sulcal morphology.

Single-index mixture cure models allow estimating the probability of cure and the latency depending on a vector (or functional) covariate, avoiding the curse of dimensionality. The vector of parameters that defines the model can be estimated by maximum likelihood. A nonparametric estimator for the conditional density of the susceptible population is provided. For more details, see Piñeiro-Lamas (2024) (<https://ruc.udc.es/dspace/handle/2183/37035>). Funding: This work, integrated into the framework of PERTE for Vanguard Health, has been co-financed by the Spanish Ministry of Science, Innovation and Universities with funds from the European Union NextGenerationEU, from the Recovery, Transformation and Resilience Plan (PRTR-C17.I1) and from the Autonomous Community of Galicia within the framework of the Biotechnology Plan Applied to Health.