The SAVVY (Survival Analysis for AdVerse Events with VarYing Follow-Up Times) project is a consortium of academic and pharmaceutical industry partners that aims to improve the analyses of adverse event (AE) data in clinical trials through the use of survival techniques appropriately dealing with varying follow-up times and competing events, see Stegherr, Schmoor, Beyersmann, et al. (2021) <doi:10.1186/s13063-021-05354-x>. Although statistical methodologies have advanced, in AE analyses often the incidence proportion, the incidence density or a non-parametric Kaplan-Meier estimator are used, which either ignore censoring or competing events. This package contains functions to easily conduct the proposed improved AE analyses.

Contract helpers built with S7 for expressing runtime protocols around ordinary S7 dispatch. Structural interfaces describe small sets of required S7 generics, while explicit traits record registered implementations with optional default methods and associated metadata. Optional runtime checks can validate argument and return specifications in contract-scoped evaluation.

This is a graph database in SQLite'. It is inspired by Denis Papathanasiou's Python simple-graph project on GitHub'.

Static analysis for R scientific data analysis code. Flags patterns that often correspond to hidden scientific commitments -- silent error swallowing, smuggled defaults, label leakage in selection-stage code, magic-eps floors in BIC formulas, and shadow-overwrite of sourced helpers. Designed for agentic coding workflows; high recall over precision; structured ANALYSIS_OK waivers as the audit trail.

Data sets used by Krause et al. (2022) <doi:10.1101/2022.04.11.487885>. It comprises phenotypic records obtained from the USDA Northern Region Uniform Soybean Tests from 1989 to 2019 for maturity groups II and III. In addition, soil and weather variables are provided for the 591 observed environments (combination of locations and years).

This package provides a collection of recycled and modified R functions to aid in file manipulation, data exploration, wrangling, optimization, and object manipulation. Other functions aid in convenient data visualization, loop progression, software packaging, and installation.

This package produces various measures of expected treatment effect heterogeneity under an assumption of homogeneity across subgroups. Graphical presentations are created to compare these expected differences with the observed differences.

This package provides a modification of the preventive vaccine efficacy trial design of Gilbert, Grove et al. (2011, Statistical Communications in Infectious Diseases) is implemented, with application generally to individual-randomized clinical trials with multiple active treatment groups and a shared control group, and a study endpoint that is a time-to-event endpoint subject to right-censoring. The design accounts for the issues that the efficacy of the treatment/vaccine groups may take time to accrue while the multiple treatment administrations/vaccinations are given; there is interest in assessing the durability of treatment efficacy over time; and group sequential monitoring of each treatment group for potential harm, non-efficacy/efficacy futility, and high efficacy is warranted. The design divides the trial into two stages of time periods, where each treatment is first evaluated for efficacy in the first stage of follow-up, and, if and only if it shows significant treatment efficacy in stage one, it is evaluated for longer-term durability of efficacy in stage two. The package produces plots and tables describing operating characteristics of a specified design including an unconditional power for intention-to-treat and per-protocol/as-treated analyses; trial duration; probabilities of the different possible trial monitoring outcomes (e.g., stopping early for non-efficacy); unconditional power for comparing treatment efficacies; and distributions of numbers of endpoint events occurring after the treatments/vaccinations are given, useful as input parameters for the design of studies of the association of biomarkers with a clinical outcome (surrogate endpoint problem). The code can be used for a single active treatment versus control design and for a single-stage design.

This package contains more modern tools for causal inference using regression standardization. Four general classes of models are implemented; generalized linear models, conditional generalized estimating equation models, Cox proportional hazards models, and shared frailty gamma-Weibull models. Methodological details are described in Sjölander, A. (2016) <doi:10.1007/s10654-016-0157-3>. Also includes functionality for doubly robust estimation for generalized linear models in some special cases, and the ability to implement custom models.

This package contains methods for the simulation of positive tempered stable distributions and related subordinators. Including classical tempered stable, rapidly deceasing tempered stable, truncated stable, truncated tempered stable, generalized Dickman, truncated gamma, generalized gamma, and p-gamma. For details, see Dassios et al (2019) <doi:10.1017/jpr.2019.6>, Dassios et al (2020) <doi:10.1145/3368088>, Grabchak (2021) <doi:10.1016/j.spl.2020.109015>.

Estimates the population average controlled difference for a given outcome between levels of a binary treatment, exposure, or other group membership variable of interest for clustered, stratified survey samples where sample selection depends on the comparison group. Provides three methods for estimation, namely outcome modeling and two factorizations of inverse probability weighting. Under stronger assumptions, these methods estimate the causal population average treatment effect. Salerno et al., (2024) <doi:10.48550/arXiv.2406.19597>.

This package provides a process-oriented and trajectory-based Discrete-Event Simulation (DES) package for R. It is designed as a generic yet powerful framework. The architecture encloses a robust and fast simulation core written in C++ with automatic monitoring capabilities. It provides a rich and flexible R API that revolves around the concept of trajectory, a common path in the simulation model for entities of the same type. Documentation about simmer is provided by several vignettes included in this package, via the paper by Ucar, Smeets & Azcorra (2019, <doi:10.18637/jss.v090.i02>), and the paper by Ucar, Hernández, Serrano & Azcorra (2018, <doi:10.1109/MCOM.2018.1700960>); see citation("simmer") for details.

This package implements the bootstrap-calibrated local-influence goodness-of-fit test for simplex regression models with constant or varying dispersion, following the local influence approach of Zhu and Zhang (2004) <doi:10.1093/biomet/91.3.579> and the simplex regression model of Barndorff-Nielsen and Jorgensen (1991) <doi:10.1016/0047-259X(91)90008-P>. The test statistic aggregates individual local-influence measures under case-weight perturbation. Because the first-order asymptotic normal calibration is severely liberal in finite samples, a parametric bootstrap calibration is provided that restores accurate size control and delivers high power against omitted covariates, neglected dispersion, and distributional misspecification. Plotting functions reproduce the figures and tables of the companion methodological paper. Computational kernels are implemented in C++ via Rcpp and RcppArmadillo for speed, and two real datasets are bundled.

This package provides utilities for cleaning survey data, computing weights, and performing descriptive statistical analysis. Methods follow Lohr (2019, ISBN:978-0367272454) "Sampling: Design and Analysis" and Lumley (2010) <doi:10.1002/9780470580066>.

This package provides a scalable Gibbs sampling implementation for high dimensional Bayesian regression with the continuous spike-and-slab prior. Niloy Biswas, Lester Mackey and Xiao-Li Meng, "Scalable Spike-and-Slab" (2022) <arXiv:2204.01668>.

Perform a Bayesian estimation of the exploratory Sparse Latent Class Model for Binary Data described by Chen, Y., Culpepper, S. A., and Liang, F. (2020) <doi:10.1007/s11336-019-09693-2>.

This package produces LaTeX code, HTML/CSS code and ASCII text for well-formatted tables that hold regression analysis results from several models side-by-side, as well as summary statistics.

SCEPtER pipeline for estimating the stellar age for double-lined detached binary systems. The observational constraints adopted in the recovery are the effective temperature, the metallicity [Fe/H], the mass, and the radius of the two stars. The results are obtained adopting a maximum likelihood technique over a grid of pre-computed stellar models.

This package provides tools to simulate and analyze survival data with interval-, left-, right-, and uncensored observations under common parametric distributions, including "Weibull", "Exponential", "Log-Normal", "Log-Logistic", "Gamma", "Gompertz", "Normal", "Logistic", and "EMV". The package supports both direct maximum likelihood estimation and imputation-based methods, making it suitable for methodological research, simulation benchmarking, and teaching. A web-based companion app is also available for demonstration purposes.

This package provides tools for spatial data analysis. Emphasis on kriging. Provides functions for prediction and simulation. Intended to be relatively straightforward, fast, and flexible.

We develop a novel matrix factorization tool named scINSIGHT to jointly analyze multiple single-cell gene expression samples from biologically heterogeneous sources, such as different disease phases, treatment groups, or developmental stages. Given multiple gene expression samples from different biological conditions, scINSIGHT simultaneously identifies common and condition-specific gene modules and quantify their expression levels in each sample in a lower-dimensional space. With the factorized results, the inferred expression levels and memberships of common gene modules can be used to cluster cells and detect cell identities, and the condition-specific gene modules can help compare functional differences in transcriptomes from distinct conditions. Please also see Qian K, Fu SW, Li HW, Li WV (2022) <doi:10.1186/s13059-022-02649-3>.

This package provides functions common to members of the SISTM team.

Utilities for injecting search engine optimization (SEO), Open Graph, Twitter, site verification, and schema.org metadata into Shiny applications from YAML files or named lists.

Allow to identify motifs in spatial-time series. A motif is a previously unknown subsequence of a (spatial) time series with relevant number of occurrences. For this purpose, the Combined Series Approach (CSA) is used.