This package provides nonparametric Steinian shrinkage estimators of the covariance matrix that are suitable in high dimensional settings, that is when the number of variables is larger than the sample size.

Determine sample sizes, draw samples, and conduct data analysis using data frames. It specifically enables you to determine simple random sample sizes, stratified sample sizes, and complex stratified sample sizes using a secondary variable such as population; draw simple random samples and stratified random samples from sampling data frames; determine which observations are missing from a random sample, missing by strata, duplicated within a dataset; and perform data analysis, including proportions, margins of error and upper and lower bounds for simple, stratified and cluster sample designs.

An R implementation of the Self-Organising Migrating Algorithm, a general-purpose, stochastic optimisation algorithm. The approach is similar to that of genetic algorithms, although it is based on the idea of a series of ``migrations by a fixed set of individuals, rather than the development of successive generations. It can be applied to any cost-minimisation problem with a bounded parameter space, and is robust to local minima.

Select best combination of auxiliary variables with certain criterion.

This package implements two iterative techniques called T3Clus and 3Fkmeans, aimed at simultaneously clustering objects and a factorial dimensionality reduction of variables and occasions on three-mode datasets developed by Vichi et al. (2007) <doi:10.1007/s00357-007-0006-x>. Also, we provide a convex combination of these two simultaneous procedures called CT3Clus and based on a hyperparameter alpha (alpha in [0,1], with 3FKMeans for alpha=0 and T3Clus for alpha= 1) also developed by Vichi et al. (2007) <doi:10.1007/s00357-007-0006-x>. Furthermore, we implemented the traditional tandem procedures of T3Clus (TWCFTA) and 3FKMeans (TWFCTA) for sequential clustering-factorial decomposition (TWCFTA), and vice-versa (TWFCTA) proposed by P. Arabie and L. Hubert (1996) <doi:10.1007/978-3-642-79999-0_1>.

This package provides a seamless design that combines phase I dose escalation based on toxicity with phase II dose expansion and dose comparison based on efficacy.

This package provides tools for applying Sklar's Omega (Hughes, 2022) <doi:10.1007/s11222-022-10105-2> methodology to nominal scores, ordinal scores, percentages, counts, amounts (i.e., non-negative real numbers), and balances (i.e., any real number). The framework can accommodate any number of units, any number of coders, and missingness; and can be used to measure agreement with a gold standard, intra-coder agreement, and/or inter-coder agreement. Frequentist inference is supported for all levels of measurement. Bayesian inference is supported for continuous scores only.

Fit Cox non-proportional hazards models with time-varying coefficients. Both unpenalized procedures (Newton and proximal Newton) and penalized procedures (P-splines and smoothing splines) are included using B-spline basis functions for estimating time-varying coefficients. For penalized procedures, cross validations, mAIC, TIC or GIC are implemented to select tuning parameters. Utilities for carrying out post-estimation visualization, summarization, point-wise confidence interval and hypothesis testing are also provided. For more information, see Wu et al. (2022) <doi: 10.1007/s10985-021-09544-2> and Luo et al. (2023) <doi:10.1177/09622802231181471>.

Pauly et al. (2008) <http://legacy.seaaroundus.s3.amazonaws.com/doc/Researcher+Publications/dpauly/PDF/2008/Books%26Chapters/FisheriesInLargeMarineEcosystems.pdf> created (and coined the name) Stock Status Plots for a UNEP compendium on Large Marine Ecosystems(LMEs, Sherman and Hempel (2009)<https://marineinfo.org/imis?module=ref&refid=142061&printversion=1&dropIMIStitle=1>). Stock status plots are bivariate graphs summarizing the status (e.g., developing, fully exploited, overexploited, etc.), through time, of the multispecies fisheries of a fished area or ecosystem. This package contains three functions to generate stock status plots viz., SSplots_pauly() (as per the criteria proposed by Pauly et al.,2008), SSplots_kleisner() (as per the criteria proposed by Kleisner and Pauly (2011) <http://www.ecomarres.com/downloads/regional.pdf> and Kleisner et al. (2013) <doi:10.1111/j.1467-2979.2012.00469.x>)and SSplots_EPI() (as per the criteria proposed by Jayasankar et al.,2021 <https://eprints.cmfri.org.in/11364/>).

Rapidly build accurate genetic prediction models for genome-wide association or whole-genome sequencing study data by smooth-threshold multivariate genetic prediction (STMGP) method. Variable selection is performed using marginal association test p-values with an optimal p-value cutoff selected by Cp-type criterion. Quantitative and binary traits are modeled respectively via linear and logistic regression models. A function that works through PLINK software (Purcell et al. 2007 <DOI:10.1086/519795>, Chang et al. 2015 <DOI:10.1186/s13742-015-0047-8>) <https://www.cog-genomics.org/plink2> is provided. Covariates can be included in regression model.

This package provides estimations of the Receiver Operating Characteristic (ROC) curve and the Area Under the Curve (AUC) based on the two-stages mixed-subjects ROC curve estimator (Diaz-Coto et al. (2020) <doi:10.1515/ijb-2019-0097> and Diaz-Coto et al. (2020) <doi:10.1080/00949655.2020.1736071>).

Determining potential output and the output gap - two inherently unobservable variables - is a major challenge for macroeconomists. sectorgap features a flexible modeling and estimation framework for a multivariate Bayesian state space model identifying economic output fluctuations consistent with subsectors of the economy. The proposed model is able to capture various correlations between output and a set of aggregate as well as subsector indicators. Estimation of the latent states and parameters is achieved using a simple Gibbs sampling procedure and various plotting options facilitate the assessment of the results. For details on the methodology and an illustrative example, see Streicher (2024) <https://www.research-collection.ethz.ch/handle/20.500.11850/653682>.

Spatial transcriptomics iterative hierarchical clustering ('stIHC'), is a method for identifying spatial gene co-expression modules, defined as groups of genes with shared spatial expression patterns. The method is applicable across spatial transcriptomics technologies with differing spatial resolution, and provides a framework for investigating the spatial organisation of gene expression in tissues. For further details, see Higgins C., Li J.J., Carey M. <doi:10.1002/qub2.70011>.

Vignettes for the survival package. Split from the survival package since the vignettes were getting large. Also, since survival is a recommended package it cannot make use of other packages outside of base+recommended (e.g. rmarkdown').

Collection of functions to connect the structure of the data with the information on the samples. Three types of associations are covered: 1. linear model of principal components. 2. hierarchical clustering analysis. 3. distribution of features-sample annotation associations. Additionally, the inter-relation between sample annotations can be analyzed. Simple methods are provided for the correction of batch effects and removal of principal components.

Implementation of the wavelet-based spatial verification method of Buschow and Friederichs "SAD: Verifying the Scale, Anisotropy and Direction of precipitation forecasts" (2020, submitted to QJRMS). Forecasts and Observations are transformed by a decimated or redundant dual-tree complex wavelet transform to analyze the spatial scale, degree of anisotropy and preferred direction in each field. These structural attributes are compared by a series of scores. An experimental algorithm for the correction of these errors is included as well.

This package provides basic functionality for labeling iso- & anisotropic percolation clusters on 2D & 3D square lattices with various lattice sizes, occupation probabilities, von Neumann & Moore (1,d)-neighborhoods, and random variables weighting the percolation lattice sites.

Computes segregation indices, including the Index of Dissimilarity, as well as the information-theoretic indices developed by Theil (1971) <isbn:978-0471858454>, namely the Mutual Information Index (M) and Theil's Information Index (H). The M, further described by Mora and Ruiz-Castillo (2011) <doi:10.1111/j.1467-9531.2011.01237.x> and Frankel and Volij (2011) <doi:10.1016/j.jet.2010.10.008>, is a measure of segregation that is highly decomposable. The package provides tools to decompose the index by units and groups (local segregation), and by within and between terms. The package also provides a method to decompose differences in segregation as described by Elbers (2021) <doi:10.1177/0049124121986204>. The package includes standard error estimation by bootstrapping, which also corrects for small sample bias. The package also contains functions for visualizing segregation patterns.

Generalized additive models under shape constraints on the component functions of the linear predictor. Models can include multiple shape-constrained (univariate and bivariate) and unconstrained terms. Routines of the package mgcv are used to set up the model matrix, print, and plot the results. Multiple smoothing parameter estimation by the Generalized Cross Validation or similar. See Pya and Wood (2015) <doi:10.1007/s11222-013-9448-7> for an overview. A broad selection of shape-constrained smoothers, linear functionals of smooths with shape constraints, and Gaussian models with AR1 residuals.

The sparse vector field consensus (SparseVFC) algorithm (Ma et al., 2013 <doi:10.1016/j.patcog.2013.05.017>) for robust vector field learning. Largely translated from the Matlab functions in <https://github.com/jiayi-ma/VFC>.

Calculates constant structure parameters of endocrine homeostatic systems from equilibrium hormone concentrations. Methods and equations have been described in Dietrich et al. (2012) <doi:10.1155/2012/351864> and Dietrich et al. (2016) <doi:10.3389/fendo.2016.00057>.

This package implements self-organising maps combined with hierarchical cluster analysis (SOM-HCA) for clustering and visualization of high-dimensional data. The package includes functions to estimate the optimal map size based on various quality measures and to generate a model using the selected dimensions. It also performs hierarchical clustering on the map nodes to group similar units. Documentation about the SOM-HCA method is provided in Pastorelli et al. (2024) <doi:10.1002/xrs.3388>.

Statistical tools for analyzing time-to-event data using machine learning. Implements survival stacking for conditional survival estimation, standardized survival function estimation for current status data, and methods for algorithm-agnostic variable importance. See Wolock CJ, Gilbert PB, Simon N, and Carone M (2024) <doi:10.1080/10618600.2024.2304070>.

Allow to identify motifs in spatial-time series. A motif is a previously unknown subsequence of a (spatial) time series with relevant number of occurrences. For this purpose, the Combined Series Approach (CSA) is used.