This package performs inference for C of risk prediction models with censored survival data, using the method proposed by Uno et al. (2011) <doi:10.1002/sim.4154>. Inference for the difference in C between two competing prediction models is also implemented.

Create short sprint acceleration-velocity (AVP) and force-velocity (FVP) profiles and predict kinematic and kinetic variables using the timing-gate split times, laser or radar gun data, tether devices data, as well as the data provided by the GPS and LPS monitoring systems. The modeling method utilized in this package is based on the works of Furusawa K, Hill AV, Parkinson JL (1927) <doi: 10.1098/rspb.1927.0035>, Greene PR. (1986) <doi: 10.1016/0025-5564(86)90063-5>, Chelly SM, Denis C. (2001) <doi: 10.1097/00005768-200102000-00024>, Clark KP, Rieger RH, Bruno RF, Stearne DJ. (2017) <doi: 10.1519/JSC.0000000000002081>, Samozino P. (2018) <doi: 10.1007/978-3-319-05633-3_11>, Samozino P. and Peyrot N., et al (2022) <doi: 10.1111/sms.14097>, Clavel, P., et al (2023) <doi: 10.1016/j.jbiomech.2023.111602>, Jovanovic M. (2023) <doi: 10.1080/10255842.2023.2170713>, and Jovanovic M., et al (2024) <doi: 10.3390/s24092894>.

Implementations of the Single Transferable Vote counting system. By default, it uses the Cambridge method for surplus allocation and Droop method for quota calculation. Fractional surplus allocation and the Hare quota are available as options.

An efficient sensitivity analysis for stochastic models based on Monte Carlo samples. Provides weights on simulated scenarios from a stochastic model, such that stressed random variables fulfil given probabilistic constraints (e.g. specified values for risk measures), under the new scenario weights. Scenario weights are selected by constrained minimisation of the relative entropy to the baseline model. The SWIM package is based on Pesenti S.M., Millossovich P., Tsanakas A. (2019) "Reverse Sensitivity Testing: What does it take to break the model" <openaccess.city.ac.uk/id/eprint/18896/> and Pesenti S.M. (2021) "Reverse Sensitivity Analysis for Risk Modelling" <https://www.ssrn.com/abstract=3878879>.

Scale invariant version of the original PNN proposed by Specht (1990) <doi:10.1016/0893-6080(90)90049-q> with the added functionality of allowing for smoothing along multiple dimensions while accounting for covariances within the data set. It is written in the R statistical programming language. Given a data set with categorical variables, we use this algorithm to estimate the probabilities of a new observation vector belonging to a specific category. This type of neural network provides the benefits of fast training time relative to backpropagation and statistical generalization with only a small set of known observations.

This package provides a collection of Radix Tree and Trie algorithms for finding similar sequences and calculating sequence distances (Levenshtein and other distance metrics). This work was inspired by a trie implementation in Python: "Fast and Easy Levenshtein distance using a Trie." Hanov (2011) <https://stevehanov.ca/blog/index.php?id=114>.

Compute the position of the sun, and local solar time using Meeus formulae. Compute day and/or night length using different twilight definitions or arbitrary sun elevation angles. This package is part of the r4photobiology suite, Aphalo, P. J. (2015) <doi:10.19232/uv4pb.2015.1.14>. Algorithms from Meeus (1998, ISBN:0943396611).

Create and format tables and APA statistics for scientific publication. This includes making a Table 1 to summarize demographics across groups, correlation tables with significance indicated by stars, and extracting formatted statistical summarizes from simple tests for in-text notation. The package also includes functions for Winsorizing data based on a Z-statistic cutoff.

This package provides functions to perform stepwise split regularized regression. The approach first uses a stepwise algorithm to split the variables into the models with a goodness of fit criterion, and then regularization is applied to each model. The weights of the models in the ensemble are determined based on a criterion selected by the user.

Launch a shiny application for tidymodels results. For classification or regression models, the app can be used to determine if there is lack of fit or poorly predicted points.

Fast computation of multivariate analyses of small (10s to 100s markers) to big (1000s to 100000s) genotype data. Runs Principal Component Analysis allowing for centering, z-score standardization and scaling for genetic drift, projection of ancient samples to modern genetic space and multivariate tests for differences in group location (Permutation-Based Multivariate Analysis of Variance) and dispersion (Permutation-Based Multivariate Analysis of Dispersion).

This package provides elastic net penalized maximum likelihood estimator for structural equation models (SEM). The package implements `lasso` and `elastic net` (l1/l2) penalized SEM and estimates the model parameters with an efficient block coordinate ascent algorithm that maximizes the penalized likelihood of the SEM. Hyperparameters are inferred from cross-validation (CV). A Stability Selection (STS) function is also available to provide accurate causal effect selection. The software achieves high accuracy performance through a `Network Generative Pre-trained Transformer` (Network GPT) Framework with two steps: 1) pre-trains the model to generate a complete (fully connected) graph; and 2) uses the complete graph as the initial state to fit the `elastic net` penalized SEM.

Accesses raw data via API and calculates social determinants of health measures for user-specified locations in the US, returning them in tidyverse- and sf-compatible data frames.

This package performs support vectors analysis for data sets with survival outcome. Three approaches are available in the package: The regression approach takes censoring into account when formulating the inequality constraints of the support vector problem. In the ranking approach, the inequality constraints set the objective to maximize the concordance index for comparable pairs of observations. The hybrid approach combines the regression and ranking constraints in the same model.

This package provides functions to estimate kernel-smoothed spatial and spatio-temporal densities and relative risk functions, and perform subsequent inference. Methodological details can be found in the accompanying tutorial: Davies et al. (2018) <DOI:10.1002/sim.7577>.

This package provides a framework for evaluating drug combination effects in preclinical in vivo studies. SynergyLMM provides functions to analyze longitudinal tumor growth experiments using mixed-effects models, perform time-resolved analyses of synergy and antagonism, evaluate model diagnostics and performance, and assess both post-hoc and a priori statistical power. The calculation of drug combination synergy follows the statistical framework provided by Demidenko and Miller (2019, <doi:10.1371/journal.pone.0224137>). The implementation and analysis of linear mixed-effect models is based on the methods described by Pinheiro and Bates (2000, <doi:10.1007/b98882>), and GaÅ ecki and Burzykowski (2013, <doi:10.1007/978-1-4614-3900-4>).

This package provides tools to compute and analyze the set of statistically-equivalent (Gaussian, linear) path models which generate the input precision or (partial) correlation matrix. This procedure is useful for understanding how statistical network models such as the Gaussian Graphical Model (GGM) perform as causal discovery tools. The statistical-equivalence set of a given GGM expresses the uncertainty we have about the sign, size and direction of directed relationships based on the weights matrix of the GGM alone. The derivation of the equivalence set and its use for understanding GGMs as causal discovery tools is described by Ryan, O., Bringmann, L.F., & Schuurman, N.K. (2022) <doi: 10.31234/osf.io/ryg69>.

This package provides a subgroup identification method for precision medicine based on quantitative objectives. This method can handle continuous, binary and survival endpoint for both prognostic and predictive case. For the predictive case, the method aims at identifying a subgroup for which treatment is better than control by at least a pre-specified or auto-selected constant. For the prognostic case, the method aims at identifying a subgroup that is at least better than a pre-specified/auto-selected constant. The derived signature is a linear combination of predictors, and the selected subgroup are subjects with the signature > 0. The false discover rate when no true subgroup exists is controlled at a user-specified level.

This package implements the S-type estimators, novel robust estimators for general linear regression models, addressing challenges such as outlier contamination and leverage points. This package introduces robust regression techniques to provide a robust alternative to classical methods and includes diagnostic tools for assessing model fit and performance. The methodology is based on the study, "Comparison of the Robust Methods in the General Linear Regression Model" by Sazak and Mutlu (2023). This package is designed for statisticians and applied researchers seeking advanced tools for robust regression analysis.

Empirical likelihood methods for asymptotically efficient estimation of models based on conditional or unconditional moment restrictions; see Kitamura, Tripathi & Ahn (2004) <doi:10.1111/j.1468-0262.2004.00550.x> and Owen (2013) <doi:10.1002/cjs.11183>. Kernel-based non-parametric methods for density/regression estimation and numerical routines for empirical likelihood maximisation are implemented in Rcpp for speed.

Create in-app purchasing and subscriptions through Servicebot payment using the Stripe framework.

Package performs Cox regression and survival distribution function estimation when the survival times are subject to double truncation. In case that the survival and truncation times are quasi-independent, the estimation procedure for each method involves inverse probability weighting, where the weights correspond to the inverse of the selection probabilities and are estimated using the survival times and truncation times only. A test for checking this independence assumption is also included in this package. The functions available in this package for Cox regression, survival distribution function estimation, and testing independence under double truncation are based on the following methods, respectively: Rennert and Xie (2018) <doi:10.1111/biom.12809>, Shen (2010) <doi:10.1007/s10463-008-0192-2>, Martin and Betensky (2005) <doi:10.1198/016214504000001538>. When the survival times are dependent on at least one of the truncation times, an EM algorithm is employed to obtain point estimates for the regression coefficients. The standard errors are calculated using the bootstrap method. See Rennert and Xie (2022) <doi:10.1111/biom.13451>. Both the independent and dependent cases assume no censoring is present in the data. Please contact Lior Rennert <liorr@clemson.edu> for questions regarding function coxDT and Yidan Shi <yidan.shi@pennmedicine.upenn.edu> for questions regarding function coxDTdep.

It provides easy internationalization of Shiny applications. It can be used as standalone translation package to translate reports, interactive visualizations or graphical elements as well.

Message translation is often managed with po files and the gettext programme, but sometimes another solution is needed. In contrast to po files, a more flexible approach is used as in the Fluent <https://projectfluent.org/> project with R Markdown snippets. The key-value approach allows easier handling of the translated messages.