This package provides wrappers for common activity patterns in simmer trajectories.

This package provides functions to calculate exact critical values, statistical power, expected time to signal, and required sample sizes for performing exact sequential analysis. All these calculations can be done for either Poisson or binomial data, for continuous or group sequential analyses, and for different types of rejection boundaries. In case of group sequential analyses, the group sizes do not have to be specified in advance and the alpha spending can be arbitrarily settled. For regression versions of the methods, Monte Carlo and asymptotic methods are used.

Efficient estimation of multivariate skew-normal distribution in closed form.

This implementation of the Empirical Mode Decomposition (EMD) works in 2 dimensions simultaneously, and can be applied on spatial data. It can handle both gridded or un-gridded datasets.

Computation of sparse eigenvectors of a matrix (aka sparse PCA) with running time 2-3 orders of magnitude lower than existing methods and better final performance in terms of recovery of sparsity pattern and estimation of numerical values. Can handle covariance matrices as well as data matrices with real or complex-valued entries. Different levels of sparsity can be specified for each individual ordered eigenvector and the method is robust in parameter selection. See vignette for a detailed documentation and comparison, with several illustrative examples. The package is based on the paper: K. Benidis, Y. Sun, P. Babu, and D. P. Palomar (2016). "Orthogonal Sparse PCA and Covariance Estimation via Procrustes Reformulation," IEEE Transactions on Signal Processing <doi:10.1109/TSP.2016.2605073>.

This package provides helper functions to compute linear predictors, time-dependent ROC curves, and Harrell's concordance index for Cox proportional hazards models as described in Therneau (2024) <https://CRAN.R-project.org/package=survival>, Therneau and Grambsch (2000, ISBN:0-387-98784-3), Hung and Chiang (2010) <doi:10.1002/cjs.10046>, Uno et al. (2007) <doi:10.1198/016214507000000149>, Blanche, Dartigues, and Jacqmin-Gadda (2013) <doi:10.1002/sim.5958>, Blanche, Latouche, and Viallon (2013) <doi:10.1007/978-1-4614-8981-8_11>, Harrell et al. (1982) <doi:10.1001/jama.1982.03320430047030>, Peto and Peto (1972) <doi:10.2307/2344317>, Schemper (1992) <doi:10.2307/2349009>, and Uno et al. (2011) <doi:10.1002/sim.4154>.

Compiles and displays the available data sets regarding the Italian school system, with a focus on the infrastructural aspects. Input datasets are downloaded from the web, with the aim of updating everything to real time. The functions are divided in four main modules, namely Get', to scrape raw data from the web Util', various utilities needed to process raw data Group', to aggregate data at the municipality or province level Map', to visualize the output datasets.

Speeds up the process of loading raw data from MBA (Multiplex Bead Assay) examinations, performs quality control checks, and automatically normalises the data, preparing it for more advanced, downstream tasks. The main objective of the package is to create a simple environment for a user, who does not necessarily have experience with R language. The package is developed within the project PvSTATEM', which is an international project aiming for malaria elimination.

This package provides tools for analyzing spatial cell-cell interactions based on ligand-receptor pairs, including functions for local, regional, and global analysis using spatial transcriptomics data. Integrates with databases like CellChat <http://www.cellchat.org/>, CellPhoneDB <https://www.cellphonedb.org/>, Cellinker <https://www.rna-society.org/cellinker/index.html>, ICELLNET <https://github.com/soumelis-lab/ICELLNET>, and ConnectomeDB <https://humanconnectome.org/software/connectomedb/> to identify ligand-receptor pairs, visualize interactions through heatmaps, chord diagrams, and infer interactions on different spatial scales.

This package provides a fast implementation of the SWAG algorithm for Generalized Linear Models which allows to perform a meta-learning procedure that combines screening and wrapper methods to find a set of extremely low-dimensional attribute combinations. The package then performs test on the network of selected models to identify the variables that are highly predictive by using entropy-based network measures.

Fits a semiparametric spatiotemporal model for data with mixed frequencies, specifically where the response variable is observed at a lower frequency than some covariates. The estimation uses an iterative backfitting algorithm that combines a non-parametric smoothing spline for high-frequency data, parametric estimation for low-frequency and spatial neighborhood effects, and an autoregressive error structure. Methodology based on Malabanan, Lansangan, and Barrios (2022) <https://scienggj.org/2022/SciEnggJ%202022-vol15-no02-p90-107-Malabanan%20et%20al.pdf>.

Implementation of the original Sequence Globally Unique Identifier (SEGUID) algorithm [Babnigg and Giometti (2006) <doi:10.1002/pmic.200600032>] and SEGUID v2 (<https://www.seguid.org>), which extends SEGUID v1 with support for linear, circular, single- and double-stranded biological sequences, e.g. DNA, RNA, and proteins.

Apply the spectral residual algorithm to data, such as a time series, to detect anomalies. Anomaly scores can be used to determine outliers based upon a threshold or fed into more sophisticated prediction models. Methods are based upon "Time-Series Anomaly Detection Service at Microsoft", Ren, H., Xu, B., Wang, Y., et al., (2019) <doi:10.48550/arXiv.1906.03821>.

This package provides an XY pad input for the Shiny framework. An XY pad is like a bivariate slider. It allows to pick up a pair of numbers.

It allows to rapidly compute, bootstrap and plot up to fourth-order Sobol'-based sensitivity indices using several state-of-the-art first and total-order estimators. Sobol indices can be computed either for models that yield a scalar as a model output or for systems of differential equations. The package also provides a suit of benchmark tests functions and several options to obtain publication-ready figures of the model output uncertainty and sensitivity-related analysis. An overview of the package can be found in Puy et al. (2022) <doi:10.18637/jss.v102.i05>.

This package provides a framework for modeling cellular metabolic states and continuous metabolic trajectories from single-cell RNA-seq data using pathway-level scoring. Enables lineage-restricted metabolic analysis, metabolic pseudotime inference, module-level trend analysis, and visualization of metabolic state transitions.

Compute various common mean squared predictive error (MSPE) estimators, as well as several existing variance component predictors as a byproduct, for FH model (Fay and Herriot, 1979) and NER model (Battese et al., 1988) in small area estimation.

Reliability and agreement analyses often have limited software support. Therefore, this package was created to make agreement and reliability analyses easier for the average researcher. The functions within this package include simple tests of agreement, agreement analysis for nested and replicate data, and provide robust analyses of reliability. In addition, this package contains a set of functions to help when planning studies looking to assess measurement agreement.

Simulate complex data from a given directed acyclic graph and information about each individual node. Root nodes are simply sampled from the specified distribution. Child Nodes are simulated according to one of many implemented regressions, such as logistic regression, linear regression, poisson regression or any other function. Also includes a comprehensive framework for discrete-time simulation, discrete-event simulation, and networks-based simulation which can generate even more complex longitudinal and dependent data. For more details, see Robin Denz, Nina Timmesfeld (2025) <doi:10.48550/arXiv.2506.01498>.

Data on the Spy vs. Spy comic strip of Mad magazine, created and written by Antonio Prohias.

Constructs gene regulatory networks from single-cell gene expression data using the PANDA (Passing Attributes between Networks for Data Assimilation) algorithm.

The package is used for calibrating the design parameters for single-to-double arm transition design proposed by Shi and Yin (2017). The calibration is performed via numerical enumeration to find the optimal design that satisfies the constraints on the type I and II error rates.

Extract the signed backbones of intrinsically dense weighted networks based on the significance filter and vigor filter as described in the following paper. Please cite it if you find this software useful in your work. Furkan Gursoy and Bertan Badur. "Extracting the signed backbone of intrinsically dense weighted networks." Journal of Complex Networks. <arXiv:2012.05216>.

This package provides methods for constructing and maintaining a database of presentations in R. The presentations are either ones that the user gives or gave or presentations at a particular event or event series. The package also provides a plot method for the interactive mapping of the presentations using leaflet by grouping them according to country, city, year and other presentation attributes. The markers on the map come with popups providing presentation details (title, institution, event, links to materials and events, and so on).