Implementation of the scregclust algorithm described in Larsson, Held, et al. (2024) <doi:10.1038/s41467-024-53954-3> which reconstructs regulatory programs of target genes in scRNA-seq data. Target genes are clustered into modules and each module is associated with a linear model describing the regulatory program.

Extends the classical SSIM method proposed by Wang', Bovik', Sheikh', and Simoncelli'(2004) <doi:10.1109/TIP.2003.819861>. for irregular lattice-based maps and raster images. The geographical SSIM method incorporates well-developed geographically weighted summary statistics'('Brunsdon', Fotheringham and Charlton 2002) <doi:10.1016/S0198-9715(01)00009-6> with an adaptive bandwidth kernel function for irregular lattice-based maps.

Manage a collection/library of R source packages. Discover, document, load, test source packages. Enable to use those packages as if they were actually installed. Quickly reload only what is needed on source code change. Run tests and checks in parallel.

This package provides functions to perform robust variable selection and regression using the Fast and Scalable Cellwise-Robust Ensemble (FSCRE) algorithm. The approach establishes a robust foundation using the Detect Deviating Cells (DDC) algorithm and robust correlation estimates. It then employs a competitive ensemble architecture where a robust Least Angle Regression (LARS) engine proposes candidate variables and cross-validation arbitrates their assignment. A final robust MM-estimator is applied to the selected predictors.

All data in the book "Statistical Methods in Biology" by Welham et al. (2015) <doi:10.1201/b17336> with a corresponding documentation and illustrative analysis of the data.

Pleiotropy-informed significance analysis of genome-wide association studies with surrogate functional false discovery rates (sfFDR). The sfFDR framework adapts the fFDR to leverage informative data from multiple sets of GWAS summary statistics to increase power in study while accommodating for linkage disequilibrium. sfFDR provides estimates of key FDR quantities in a significance analysis such as the functional local FDR and $q$-value, and uses these estimates to derive a functional $p$-value for type I error rate control and a functional local Bayes factor for post-GWAS analyses (e.g., fine mapping and colocalization).

Dictionary-like reference for computing scoring rules in a wide range of situations. Covers both parametric forecast distributions (such as mixtures of Gaussians) and distributions generated via simulation. Further details can be found in the package vignettes <doi:10.18637/jss.v090.i12>, <doi:10.18637/jss.v110.i08>.

Sparse-group boosting to be used in conjunction with the mboost for modeling grouped data. Applicable to all sparse-group lasso type problems where within-group and between-group sparsity is desired. Interprets and visualizes individual variables and groups.

This package provides functions for simplified emulation of time series computer model output in model parameter space using Gaussian processes. Stilt can be used more generally for Kriging of spatio-temporal fields. There are functions to predict at new parameter settings, to test the emulator using cross-validation (which includes information on 95% confidence interval empirical coverage), and to produce contour plots over 2D slices in model parameter space.

Algorithms for fitting scaled sparse linear regression and estimating precision matrices.

Designed for estimating variants of hidden (latent) Markov models (HMMs), mixture HMMs, and non-homogeneous HMMs (NHMMs) for social sequence data and other categorical time series. Special cases include feedback-augmented NHMMs, Markov models without latent layer, mixture Markov models, and latent class models. The package supports models for one or multiple subjects with one or multiple parallel sequences (channels). External covariates can be added to explain cluster membership in mixture models as well as initial, transition and emission probabilities in NHMMs. The package provides functions for evaluating and comparing models, as well as functions for visualizing of multichannel sequence data and HMMs. For NHMMs, methods for computing average causal effects and marginal state and emission probabilities are available. Models are estimated using maximum likelihood via the EM algorithm or direct numerical maximization with analytical gradients. Documentation is available via several vignettes, and Helske and Helske (2019, <doi:10.18637/jss.v088.i03>). For methodology behind the NHMMs, see Helske (2025, <doi:10.48550/arXiv.2503.16014>).

Constructs a yield curve by the Smith-Wilson method from a table of libor and swap rates. Now updated to take bond coupons and prices in the same table.

This implementation of the Empirical Mode Decomposition (EMD) works in 2 dimensions simultaneously, and can be applied on spatial data. It can handle both gridded or un-gridded datasets.

This package provides a method to explore the treatment-covariate interactions in survival or generalized linear model (GLM) for continuous, binomial and count data arising from two or more treatment arms of a clinical trial. A permutation distribution approach to inference is implemented, based on permuting the covariate values within each treatment group.

An implementation of image processing effects that convert a photo into a line drawing image. For details, please refer to Tsuda, H. (2020). sketcher: An R package for converting a photo into a sketch style image. <doi:10.31234/osf.io/svmw5>.

The cartogram heatmaps generated by the included methods are an alternative to choropleth maps for the United States and are based on work by the Washington Post graphics department in their report on "The states most threatened by trade" (<http://www.washingtonpost.com/wp-srv/special/business/states-most-threatened-by-trade/>). "State bins" preserve as much of the geographic placement of the states as possible but have the look and feel of a traditional heatmap. Functions are provided that allow for use of a binned, discrete scale, a continuous scale or manually specified colors depending on what is needed for the underlying data.

SOHPIE (pronounced as SOFIE) is a novel pseudo-value regression approach for differential co-abundance network analysis of microbiome data, which can include additional clinical covariate in the model. The full methodological details can be found in Ahn S and Datta S (2023) <arXiv:2303.13702v1>.

This package provides functions for making particle-size analysis. Sieve tests are widely used to obtain particle-size distribution of powders or granular materials.

Tidies up the forecasting modeling and prediction work flow, extends the broom package with sw_tidy', sw_glance', sw_augment', and sw_tidy_decomp functions for various forecasting models, and enables converting forecast objects to "tidy" data frames with sw_sweep'.

An implementation of interpreted string literals. Based on the glue package by Hester & Bryan (2024) <doi:10.32614/CRAN.package.glue> but with a focus on efficiency and simplicity at a cost of flexibility.

This package provides functions for creating and manipulating 12-tone (i.e., dodecaphonic) musical matrices using Arnold Schoenberg's (1923) serialism technique. This package can generate random 12-tone matrices and can generate matrices using a pre-determined sequence of notes.

Builds regression trees and random forests for longitudinal or functional data using a spline projection method. Implements and extends the work of Yu and Lambert (1999) <doi:10.1080/10618600.1999.10474847>. This method allows trees and forests to be built while considering either level and shape or only shape of response trajectories.

Survival analysis for unbalanced clusters using Archimedean copulas (Prenen et al. (2016) <DOI:10.1111/rssb.12174>).

This package contains methods for simulation and for evaluating the pdf, cdf, and quantile functions for symmetric stable, symmetric classical tempered stable, and symmetric power tempered stable distributions.