This package provides fundamental function support for SigBridgeR and its single-cell phenotypic screening algorithm, including optional functions.

This R package introduces Weighted Mean SHapley Additive exPlanations (WMSHAP), an innovative method for calculating SHAP values for a grid of fine-tuned base-learner machine learning models as well as stacked ensembles, a method not previously available due to the common reliance on single best-performing models. By integrating the weighted mean SHAP values from individual base-learners comprising the ensemble or individual base-learners in a tuning grid search, the package weights SHAP contributions according to each model's performance, assessed by multiple either R squared (for both regression and classification models). alternatively, this software also offers weighting SHAP values based on the area under the precision-recall curve (AUCPR), the area under the curve (AUC), and F2 measures for binary classifiers. It further extends this framework to implement weighted confidence intervals for weighted mean SHAP values, offering a more comprehensive and robust feature importance evaluation over a grid of machine learning models, instead of solely computing SHAP values for the best model. This methodology is particularly beneficial for addressing the severe class imbalance (class rarity) problem by providing a transparent, generalized measure of feature importance that mitigates the risk of reporting SHAP values for an overfitted or biased model and maintains robustness under severe class imbalance, where there is no universal criteria of identifying the absolute best model. Furthermore, the package implements hypothesis testing to ascertain the statistical significance of SHAP values for individual features, as well as comparative significance testing of SHAP contributions between features. Additionally, it tackles a critical gap in feature selection literature by presenting criteria for the automatic feature selection of the most important features across a grid of models or stacked ensembles, eliminating the need for arbitrary determination of the number of top features to be extracted. This utility is invaluable for researchers analyzing feature significance, particularly within severely imbalanced outcomes where conventional methods fall short. Moreover, it is also expected to report democratic feature importance across a grid of models, resulting in a more comprehensive and generalizable feature selection. The package further implements a novel method for visualizing SHAP values both at subject level and feature level as well as a plot for feature selection based on the weighted mean SHAP ratios.

The sparse online principal component can not only process the online data set, but also obtain a sparse solution of the online data set. The philosophy of the package is described in Guo G. (2022) <doi:10.1007/s00180-022-01270-z>.

This is an interface for the Python package StepMix'. It is a Python package following the scikit-learn API for model-based clustering and generalized mixture modeling (latent class/profile analysis) of continuous and categorical data. StepMix handles missing values through Full Information Maximum Likelihood (FIML) and provides multiple stepwise Expectation-Maximization (EM) estimation methods based on pseudolikelihood theory. Additional features include support for covariates and distal outcomes, various simulation utilities, and non-parametric bootstrapping, which allows inference in semi-supervised and unsupervised settings. Software paper available at <doi:10.18637/jss.v113.i08>.

Design a Bayesian seamless multi-arm biomarker-enriched phase II/III design with the survival endpoint with allowing sample size re-estimation. James M S Wason, Jean E Abraham, Richard D Baird, Ioannis Gournaris, Anne-Laure Vallier, James D Brenton, Helena M Earl, Adrian P Mander (2015) <doi:10.1038/bjc.2015.278>. Guosheng Yin, Nan Chen, J. Jack Lee (2018) <doi:10.1007/s12561-017-9199-7>. Ying Yuan, Beibei Guo, Mark Munsell, Karen Lu, Amir Jazaeri (2016) <doi:10.1002/sim.6971>.

This package provides a systematic bioinformatics tool to perform single-sample mutation-based pathway analysis by integrating somatic mutation data with the Protein-Protein Interaction (PPI) network. In this method, we use local and global weighted strategies to evaluate the effects of network genes from mutations according to the network topology and then calculate the mutation-based pathway enrichment score (ssMutPES) to reflect the accumulated effect of mutations of each pathway. Subsequently, the ssMutPES profiles are used for unsupervised spectral clustering to identify cancer subtypes.

This package provides influence function-based methods to evaluate a longitudinal surrogate marker in a censored time-to-event outcome setting, with plug-in and targeted maximum likelihood estimation options. Details are described in: Agniel D and Parast L (2025). "Robust Evaluation of Longitudinal Surrogate Markers with Censored Data." Journal of the Royal Statistical Society: Series B <doi:10.1093/jrsssb/qkae119>. A tutorial for this package can be found at <https://www.laylaparast.com/survivalsurrogate> and a Shiny App implementing the package can be found at <https://parastlab.shinyapps.io/survivalsurrogateApp/>.

Imbibition causes seeds to expand, which results in the seed coat or testa being broken. Seed germination begins with imbibition. Imbibition aids in the transport of water into the developing ovules. Imbibition is required during the first stages of root water absorption.

This package implements different kinds of bootstraps to estimate sampling variation from survey data with complex designs. Includes the rescaled bootstrap described in Rust and Rao (1996) <doi:10.1177/096228029600500305> and Rao and Wu (1988) <doi:10.1080/01621459.1988.10478591>.

This package provides functions for analysis of network objects, which are imported or simulated by the package. The non-parametric methods of analysis center on snowball and bootstrap sampling for estimating functions of network degree distribution. For other parameters of interest, see, e.g., bootnet package.

Automated unit testing of Shiny applications through a headless Chromium browser.

An implementation of the selectboost algorithm (Bertrand et al. 2020, Bioinformatics', <doi:10.1093/bioinformatics/btaa855>), which is a general algorithm that improves the precision of any existing variable selection method. This algorithm is based on highly intensive simulations and takes into account the correlation structure of the data. It can either produce a confidence index for variable selection or it can be used in an experimental design planning perspective.

This package provides a web-based shiny interface for the StepReg package enables stepwise regression analysis across linear, generalized linear (including logistic, Poisson, Gamma, and negative binomial), and Cox models. It supports forward, backward, bidirectional, and best-subset selection under a range of criteria. The package also supports stepwise regression to multivariate settings, allowing multiple dependent variables to be modeled simultaneously. Users can explore and combine multiple selection strategies and criteria to optimize model selection. For enhanced robustness, the package offers optional randomized forward selection to reduce overfitting, and a data-splitting workflow for more reliable post-selection inference. Additional features include logging and visualization of the selection process, as well as the ability to export results in common formats.

Select the most suitable shape to describe the relationship between the exposure and the outcome among increasing, decreasing, convex, and concave shapes (Yin et al. (2021) <DOI:10.1007/s13571-020-00246-7>); estimate the direct and indirect effects with prior knowledge on the relationship between the mediator and the outcome with binary exposure (Yin et al. (2024) <DOI:10.1007/s13571-024-00336-w>); estimate the direct and indirect effects using linear regression-based approach (VanderWeele (2015, ISBN:9780199325870)).

Output colors used in literal vectors, palettes and plot objects (ggplot).

This package provides several datasets useful for processing and analysis of text in Turkish from an online shopping platform.

Training and validation of a custom (or data-driven) Structural Equation Models using Deep Neural Networks or Machine Learning algorithms, which extend the fitting procedures of the SEMgraph R package <doi:10.32614/CRAN.package.SEMgraph>.

Fits Bayesian linear mixed models for spatial and space-time data with fixed effects, independent and identically distributed (iid) grouped random effects, and structured latent processes. The formula interface supports first-order autoregressive (AR(1)) effects, dense Gaussian processes, nearest-neighbor Gaussian processes, proper and Leroux conditional autoregressive (CAR) effects, ordered directed acyclic graph autoregressive (DAGAR) effects, separable CAR-time and DAGAR-time effects, and spatially varying coefficients. The sampler uses sparse precision matrix calculations when available and includes post-fitting tools for latent process recovery, fitted values, prediction, pointwise log likelihoods, and posterior sample extraction. Method details include Datta et al. (2016) <doi:10.1080/01621459.2015.1044091>, Finley et al. (2019) <doi:10.1080/10618600.2018.1537924>, Datta et al. (2019) <doi:10.1214/19-BA1177>, and May and Finley (2025) <doi:10.1016/j.spasta.2025.100917>.

Sensitivity analysis in structural equation modeling using influence measures and diagnostic plots. Support leave-one-out casewise sensitivity analysis presented by Pek and MacCallum (2011) <doi:10.1080/00273171.2011.561068> and approximate casewise influence using scores and casewise likelihood. An introduction to the package can be found in Cheung and Lai (2026) <doi:10.1080/00273171.2026.2634293>.

This package provides three basic functions that support an implementation of Case 2 (profile case) best-worst scaling. The first is to convert an orthogonal main-effect design into questions, the second is to create a dataset suitable for analysis, and the third is to calculate count-based scores. For details, see Aizaki and Fogarty (2019) <doi:10.1016/j.jocm.2019.100171>.

Statistical models for specific coronavirus disease 2019 use cases at German local health authorities. All models of Statistical modelling for infectious disease management smidm are part of the decision support toolkit in the EsteR project. More information is published in Sonja Jäckle, Rieke Alpers, Lisa Kühne, Jakob Schumacher, Benjamin Geisler, Max Westphal "'EsteR â A Digital Toolkit for COVID-19 Decision Support in Local Health Authorities" (2022) <doi:10.3233/SHTI220799> and Sonja Jäckle, Elias Röger, Volker Dicken, Benjamin Geisler, Jakob Schumacher, Max Westphal "A Statistical Model to Assess Risk for Supporting COVID-19 Quarantine Decisions" (2021) <doi:10.3390/ijerph18179166>.

This package provides a set of segregation-based indices and randomization methods to make robust environmental inequality assessments, as described in Schaeffer and Tivadar (2019) "Measuring Environmental Inequalities: Insights from the Residential Segregation Literature" <doi:10.1016/j.ecolecon.2019.05.009>.

Design and evaluate phase I dose-finding trials that use the Bayesian optimal interval (BOIN) design of Liu and Yuan (2015) <doi:10.1111/rssc.12089>. Functions are provided to tabulate the decision boundaries, to simulate trials, to estimate the dose-toxicity curve under a monotonicity constraint and to select the maximum tolerated dose. The simulation engine is written in C++ and draws one random variate per patient in enrollment order, which reproduces the reference implementation in the BOIN package trial by trial for a given seed. The traditional 3+3 design is provided as a comparator, with operating characteristics obtained in closed form rather than by simulation.

This package provides a meta-package that aims to make R easier for everyone, especially programmers who have a background in SAS® software. This set of packages brings many useful concepts to R', including data libraries, data dictionaries, formats and format catalogs, a data step, and a traceable log. The system also includes a package that replicates several commonly-used SAS® procedures, like PROC FREQ', PROC MEANS', and PROC REG'.