Seamless and standardized interaction with data exported from the clinical data management system (CDMS) secuTrial'<https://www.secutrial.com>. The primary data export the package works with is a standard non-rectangular export.

This package creates complex heatmaps for single cell RNA-seq data that simultaneously display gene expression levels (as color intensity) and expression percentages (as circle sizes). Supports gene grouping, cell type annotations, and time point comparisons. Built on top of ComplexHeatmap and integrates with Seurat objects. For more details see Gu (2022) <doi:10.1002/imt2.43> and Hao (2024) <doi:10.1038/s41587-023-01767-y>.

This package provides a major challenge in estimating treatment decision rules from a randomized clinical trial dataset with covariates measured at baseline lies in detecting relatively small treatment effect modification-related variability (i.e., the treatment-by-covariates interaction effects on treatment outcomes) against a relatively large non-treatment-related variability (i.e., the main effects of covariates on treatment outcomes). The class of Single-Index Models with Multiple-Links is a novel single-index model specifically designed to estimate a single-index (a linear combination) of the covariates associated with the treatment effect modification-related variability, while allowing a nonlinear association with the treatment outcomes via flexible link functions. The models provide a flexible regression approach to developing treatment decision rules based on patients data measured at baseline. We refer to Park, Petkova, Tarpey, and Ogden (2020) <doi:10.1016/j.jspi.2019.05.008> and Park, Petkova, Tarpey, and Ogden (2020) <doi:10.1111/biom.13320> (that allows an unspecified X main effect) for detail of the method. The main function of this package is simml().

Evolutionary reconstruction based on substitutions and insertion-deletion (indels) analyses in a distance-based framework as described in Muñoz-Pajares (2013) <doi:10.1111/2041-210X.12118>.

This package contains several tools for nonlinear regression analyses and general data analysis in biology and agriculture. Contains also datasets for practicing and teaching purposes. Supports the blog: Onofri (2024) "Fixing the bridge between biologists and statisticians" <https://www.statforbiology.com> and the book: Onofri (2024) "Experimental Methods in Agriculture" <https://www.statforbiology.com/_statbookeng/>. The blog is a collection of short articles aimed at improving the efficiency of communication between biologists and statisticians, as pointed out in Kozak (2016) <doi:10.1590/0103-9016-2015-0399>, spreading a better awareness of the potential usefulness, beauty and limitations of biostatistic.

Add shiny inputs with one or more inline buttons that grow and shrink with inputs. Also add tool tips to input buttons and styling and messages for input validation.

An interface to access data from Substack publications via API. Users can fetch the latest, top, search for specific posts, or retrieve a single post by its slug. This functionality is useful for developers and researchers looking to analyze Substack content or integrate it into their applications. For more information, visit the API documentation at <https://substackapi.dev/introduction>.

An efficient implementation of Scalable Bayesian Rule Lists Algorithm, a competitor algorithm for decision tree algorithms; see Hongyu Yang, Cynthia Rudin, Margo Seltzer (2017) <https://proceedings.mlr.press/v70/yang17h.html>. It builds from pre-mined association rules and have a logical structure identical to a decision list or one-sided decision tree. Fully optimized over rule lists, this algorithm strikes practical balance between accuracy, interpretability, and computational speed.

The SPARRA risk score (Scottish Patients At Risk of admission and Re-Admission) estimates yearly risk of emergency hospital admission using electronic health records on a monthly basis for most of the Scottish population. This package implements a suite of functions used to analyse the behaviour and performance of the score, focusing particularly on differential performance over demographically-defined groups. It includes useful utility functions to plot receiver-operator-characteristic, precision-recall and calibration curves, draw stock human figures, estimate counterfactual quantities without the need to re-compute risk scores, to simulate a semi-realistic dataset. Our manuscript can be found at: <doi:10.1371/journal.pdig.0000675>.

This package provides functions to access and collect data from the Brazilian Federal Senate open data API and website. Covers senators, legislative materials, committees, voting records, speeches, provisional measures, vetoes, and legislative agendas, returning results as tidy data frames ready for analysis.

Fits linear regression models on datasets residing in SQL databases without pulling data into R memory. Computes sufficient statistics inside the database engine via a single aggregation query and solves the normal equations in R.

Simulate parametric and semi-parametric survival times through a consistent, reusable interface for each distribution, using an object-oriented design. Supported distributions include Exponential, Weibull, Gompertz, Log-Logistic, Log-Normal, and Piecewise Exponential. Random variates can be generated under Proportional Hazards, Accelerated Failure Time, and Extended Hazards models, as well as under renewal and non-homogeneous Poisson recurrent event processes, following the methods described by Bender (2003) <doi:10.5282/UBM/EPUB.1716> and Leemis (1987) in Operations Research, 35(6), 892-894.

Implementation of sequential trial emulation for the analysis of observational databases. The SEQTaRget software accommodates time-varying treatments and confounders, as well as binary and failure time outcomes. SEQTaRget allows to compare both static and dynamic strategies, can be used to estimate observational analogs of intention-to-treat and per-protocol effects, and can adjust for potential selection bias induced by losses-to-follow-up. (Paper to come).

We implement functions to estimate and perform sensitivity analysis to unobserved confounding of direct and indirect effects introduced in Lindmark, de Luna and Eriksson (2018) <doi:10.1002/sim.7620> and Lindmark (2022) <doi:10.1007/s10260-021-00611-4>. The estimation and sensitivity analysis are parametric, based on probit and/or linear regression models. Sensitivity analysis is implemented for unobserved confounding of the exposure-mediator, mediator-outcome and exposure-outcome relationships.

This is a user-friendly way to run a parallel factor (PARAFAC) analysis (Harshman, 1971) <doi:10.1121/1.1977523> on excitation emission matrix (EEM) data from dissolved organic matter (DOM) samples (Murphy et al., 2013) <doi:10.1039/c3ay41160e>. The analysis includes profound methods for model validation. Some additional functions allow the calculation of absorbance slope parameters and create beautiful plots.'.

Create correlation networks using St. Nicolas House Analysis ('SNHA'). The package can be used for visualizing multivariate data similar to Principal Component Analysis or Multidimensional Scaling using a ranking approach. In contrast to MDS and PCA', SNHA uses a network approach to explore interacting variables. For details see Hermanussen et. al. 2021', <doi:10.3390/ijerph18041741>.

This package implements Additive Logistic Transformation (alr) for Small Area Estimation under Fay Herriot Model. Small Area Estimation is used to borrow strength from auxiliary variables to improve the effectiveness of a domain sample size. This package uses Empirical Best Linear Unbiased Prediction (EBLUP). The Additive Logistic Transformation (alr) are based on transformation by Aitchison J (1986). The covariance matrix for multivariate application is based on covariance matrix used by Esteban M, Lombardà a M, López-Vizcaà no E, Morales D, and Pérez A <doi:10.1007/s11749-019-00688-w>. The non-sampled models are modified area-level models based on models proposed by Anisa R, Kurnia A, and Indahwati I <doi:10.9790/5728-10121519>, with univariate model using model-3, and multivariate model using model-1. The MSE are estimated using Parametric Bootstrap approach. For non-sampled cases, MSE are estimated using modified approach proposed by Haris F and Ubaidillah A <doi:10.4108/eai.2-8-2019.2290339>.

Efficient implementation of sparse group lasso with optional bound constraints on the coefficients; see <doi:10.18637/jss.v110.i06>. It supports the use of a sparse design matrix as well as returning coefficient estimates in a sparse matrix. Furthermore, it correctly calculates the degrees of freedom to allow for information criteria rather than cross-validation with very large data. Finally, the interface to compiled code avoids unnecessary copies and allows for the use of long integers.

An R shiny user interface for the nlmixr2 (Fidler et al (2019) <doi:10.1002/psp4.12445>) package, designed to simplify the modeling process for users. Additionally, this package includes supplementary functions to further enhances the usage of nlmixr2'.

This package provides a scrolling chat interface with multiline input, suitable for creating chatbot apps based on Large Language Models (LLMs). Designed to work particularly well with the ellmer R package for calling LLMs.

It's a Super K-Nearest Neighbor(SKNN) classification method with using kernel density to describe weight of the distance between a training observation and the testing sample. Comparison of performance between SKNN and KNN shows that SKNN is significantly superior to KNN.

The sdrt() function is designed for estimating subspaces for Sufficient Dimension Reduction (SDR) in time series, with a specific focus on the Time Series Central Mean subspace (TS-CMS). The package employs the Fourier transformation method proposed by Samadi and De Alwis (2023) <doi:10.48550/arXiv.2312.02110> and the Nadaraya-Watson kernel smoother method proposed by Park et al. (2009) <doi:10.1198/jcgs.2009.08076> for estimating the TS-CMS. The package provides tools for estimating distances between subspaces and includes functions for selecting model parameters using the Fourier transformation method.

Implementation of deep learningâ based changepoint detection algorithm designed for time series with smooth local fluctuations. The method fits localized feedâ forward neural networks to approximate the underlying smooth component and constructs a residualâ based detector that isolates abrupt structural changes. A fully dataâ adaptive empirical cumulative distribution function (ECDF) based thresholding rule and refinement procedures yield accurate changepoint localization without parametric assumptions on noise or trend structure.

Utility functions for survey-weighted regression, diagnostics, and visualization.