Extensions to lattice', providing new high-level functions, methods for existing functions, panel functions, and a theme.

Simulate phase II and/or phase III clinical trials. It supports various types of endpoints and adaptive strategies. Tools for carrying out graphical testing procedure and combination test under group sequential design are also provided.

This package provides a tidy approach to analysis of biological sequences. All processing and data-storage functions are heavily optimized to allow the fastest and most efficient data storage.

Two stage curvature identification with machine learning for causal inference in settings when instrumental variable regression is not suitable because of potentially invalid instrumental variables. Based on Guo and Buehlmann (2022) "Two Stage Curvature Identification with Machine Learning: Causal Inference with Possibly Invalid Instrumental Variables" <doi:10.48550/arXiv.2203.12808>. The vignette is available in Carl, Emmenegger, Bühlmann and Guo (2025) "TSCI: Two Stage Curvature Identification for Causal Inference with Invalid Instruments in R" <doi:10.18637/jss.v114.i07>.

Using Gaussian graphical models we propose a novel approach to perform pathway analysis using gene expression. Given the structure of a graph (a pathway) we introduce two statistical tests to compare the mean and the concentration matrices between two groups. Specifically, these tests can be performed on the graph and on its connected components (cliques). The package is based on the method described in Massa M.S., Chiogna M., Romualdi C. (2010) <doi:10.1186/1752-0509-4-121>.

The goal of tidyplots is to streamline the creation of publication-ready plots for scientific papers. It allows to gradually add, remove and adjust plot components using a consistent and intuitive syntax.

The typicality and eccentricity data analysis (TEDA) framework was put forward by Angelov (2013) <DOI:10.14313/JAMRIS_2-2014/16>. It has been further developed into multiple different techniques since, and provides a non-parametric way of determining how similar an observation, from a process that is not purely random, is to other observations generated by the process. This package provides code to use the batch and recursive TEDA methods that have been published.

Unleash the power of time-series data visualization with ease using our package. Designed with simplicity in mind, it offers three key features through the shiny package output. The first tab shows time- series charts with forecasts, allowing users to visualize trends and changes effortlessly. The second one displays Averages per country presented in tables with accompanying sparklines, providing a quick and attractive overview of the data. The last tab presents A customizable world map colored based on user-defined variables for any chosen number of countries, offering an advanced visual approach to understanding geographical data distributions. This package operates with just a few simple arguments, enabling users to conduct sophisticated analyses without the need for complex programming skills. Transform your time-series data analysis experience with our user-friendly tool.

Combine a list of taxa with a phylogeny to generate a starting tree for use in total evidence dating analyses.

This package provides a robust implementation of Topolow algorithm. It embeds objects into a low-dimensional Euclidean space from a matrix of pairwise dissimilarities, even when the data do not satisfy metric or Euclidean axioms. The package is particularly well-suited for sparse, incomplete, and censored (thresholded) datasets such as antigenic relationships. The core is a physics-inspired, gradient-free optimization framework that models objects as particles in a physical system, where observed dissimilarities define spring rest lengths and unobserved pairs exert repulsive forces. The package also provides functions specific to antigenic mapping to transform cross-reactivity and binding affinity measurements into accurate spatial representations in a phenotype space. Key features include: * Robust Embedding from Sparse Data: Effectively creates complete and consistent maps (in optimal dimensions) even with high proportions of missing data (e.g., >95%). * Physics-Inspired Optimization: Models objects (e.g., antigens, landmarks) as particles connected by springs (for measured dissimilarities) and subject to repulsive forces (for missing dissimilarities), and simulates the physical system using laws of mechanics, reducing the need for complex gradient computations. * Automatic Dimensionality Detection: Employs a likelihood-based approach to determine the optimal number of dimensions for the embedding/map, avoiding distortions common in methods with fixed low dimensions. * Noise and Bias Reduction: Naturally mitigates experimental noise and bias through its network-based, error-dampening mechanism. * Antigenic Velocity Calculation (for antigenic data): Introduces and quantifies "antigenic velocity," a vector that describes the rate and direction of antigenic drift for each pathogen isolate. This can help identify cluster transitions and potential lineage replacements. * Broad Applicability: Analyzes data from various objects that their dissimilarity may be of interest, ranging from complex biological measurements such as continuous and relational phenotypes, antibody-antigen interactions, and protein folding to abstract concepts, such as customer perception of different brands. Methods are described in the context of bioinformatics applications in Arhami and Rohani (2025a) <doi:10.1093/bioinformatics/btaf372>, and mathematical proofs and Euclidean embedding details are in Arhami and Rohani (2025b) <doi:10.48550/arXiv.2508.01733>.

Density, distribution function, quantile function and random generation for the Truncated Generalised Gamma Distribution (also in log10(x) and ln(x) space).

Compile snippets of LaTeX directly into images from the R console to view in the RStudio viewer pane, Shiny apps and RMarkdown documents.

This package provides functions are collected to analyse weather data for agriculture purposes including to read weather records in multiple formats, calculate extreme climate index. Demonstration data are included the SILO daily climate data (licensed under CC BY 4.0, <https://www.longpaddock.qld.gov.au/silo/>).

Density, distribution function, quantile function, and random generation function, maximum likelihood estimation (MLE), penalized maximum likelihood estimation (PMLE), the quartiles method estimation (QM), and median rank estimation (MEDRANK) for the two-parameter exponential distribution. MLE and PMLE are based on Mengjie Zheng (2013)<https://scse.d.umn.edu/sites/scse.d.umn.edu/files/mengjie-thesis_masters-1.pdf>. QM is based on Entisar Elgmati and Nadia Gregni (2016)<doi:10.5539/ijsp.v5n5p12>. MEDRANK is based on Matthew Reid (2022)<doi:10.5281/ZENODO.3938000>.

An efficient algorithm for data twinning. This work is supported by U.S. National Science Foundation grants DMREF-1921873 and CMMI-1921646.

Sensitivity analysis using the trimmed means estimator.

The Gene Expression Omnibus (<https://www.ncbi.nlm.nih.gov/geo/>) and The Cancer Genome Atlas (<https://portal.gdc.cancer.gov/>) are widely used medical public databases. Our platform integrates routine analysis and visualization tools for expression data to provide concise and intuitive data analysis and presentation.

Trauma Mortality prediction for ICD-9, ICD-10, and AIS lexicons in long or wide format based on Dr. Alan Cook's tmpm mortality model.

This package provides tools to calculate stability indices with parametric, non-parametric and probabilistic approaches. The basic data format requirement for toolStability is a data frame with 3 columns including numeric trait values, genotype,and environmental labels. Output format of each function is the dataframe with chosen stability index for each genotype. Function "table_stability" offers the summary table of all stability indices in this package. This R package toolStability is part of the main publication: Wang, Casadebaig and Chen (2023) <doi:10.1007/s00122-023-04264-7>. Analysis pipeline for main publication can be found on github: <https://github.com/Illustratien/Wang_2023_TAAG>. Sample dataset in this package is derived from another publication: Casadebaig P, Zheng B, Chapman S et al. (2016) <doi:10.1371/journal.pone.0146385>. For detailed documentation of dataset, please see on Zenodo <doi:10.5281/zenodo.4729636>. Indices used in this package are from: Döring TF, Reckling M (2018) <doi:10.1016/j.eja.2018.06.007>. Eberhart SA, Russell WA (1966) <doi:10.2135/cropsci1966.0011183X000600010011x>. Eskridge KM (1990) <doi:10.2135/cropsci1990.0011183X003000020025x>. Finlay KW, Wilkinson GN (1963) <doi:10.1071/AR9630742>. Hanson WD (1970) Genotypic stability. <doi:10.1007/BF00285245>. Lin CS, Binns MR (1988). Nassar R, Hühn M (1987). Pinthus MJ (1973) <doi:10.1007/BF00021563>. Römer T (1917). Shukla GK (1972). Wricke G (1962).

This package provides a tm Source to create corpora from articles exported from the LexisNexis content provider as HTML files. It is able to read both text content and meta-data information (including source, date, title, author and pages). Note that the file format is highly unstable: there is no warranty that this package will work for your corpus, and you may have to adjust the code to adapt it to your particular format.

Calculate optimal Zhong's two-/three-stage Phase II designs (see Zhong (2012) <doi:10.1016/j.cct.2012.07.006>). Generate Target Toxicity decision table for Phase I dose-finding (two-/three-stage). This package also allows users to run dose-finding simulations based on customized decision table.

Compile Typst files using the typst-cli (<https://typst.app>) command line tool. Automatically falls back to rendering via embedded Typst from Quarto (<https://quarto.org>) if Typst is not installed. Includes utilities to check for typst-cli availability and run Typst commands.

Instead of nesting function calls, annotate and transform functions using "#." comments.