This package provides a robust implementation of Topolow algorithm. It embeds objects into a low-dimensional Euclidean space from a matrix of pairwise dissimilarities, even when the data do not satisfy metric or Euclidean axioms. The package is particularly well-suited for sparse, incomplete, and censored (thresholded) datasets such as antigenic relationships. The core is a physics-inspired, gradient-free optimization framework that models objects as particles in a physical system, where observed dissimilarities define spring rest lengths and unobserved pairs exert repulsive forces. The package also provides functions specific to antigenic mapping to transform cross-reactivity and binding affinity measurements into accurate spatial representations in a phenotype space. Key features include: * Robust Embedding from Sparse Data: Effectively creates complete and consistent maps (in optimal dimensions) even with high proportions of missing data (e.g., >95%). * Physics-Inspired Optimization: Models objects (e.g., antigens, landmarks) as particles connected by springs (for measured dissimilarities) and subject to repulsive forces (for missing dissimilarities), and simulates the physical system using laws of mechanics, reducing the need for complex gradient computations. * Automatic Dimensionality Detection: Employs a likelihood-based approach to determine the optimal number of dimensions for the embedding/map, avoiding distortions common in methods with fixed low dimensions. * Noise and Bias Reduction: Naturally mitigates experimental noise and bias through its network-based, error-dampening mechanism. * Antigenic Velocity Calculation (for antigenic data): Introduces and quantifies "antigenic velocity," a vector that describes the rate and direction of antigenic drift for each pathogen isolate. This can help identify cluster transitions and potential lineage replacements. * Broad Applicability: Analyzes data from various objects that their dissimilarity may be of interest, ranging from complex biological measurements such as continuous and relational phenotypes, antibody-antigen interactions, and protein folding to abstract concepts, such as customer perception of different brands. Methods are described in the context of bioinformatics applications in Arhami and Rohani (2025a) <doi:10.1093/bioinformatics/btaf372>, and mathematical proofs and Euclidean embedding details are in Arhami and Rohani (2025b) <doi:10.48550/arXiv.2508.01733>.

This package provides test statistics, p-value, and confidence intervals based on 9 hypothesis tests for dependence.

Using The Free Evocation of Words Technique method with some functions, this package will make a social representation and other analysis. The Free Evocation of Words Technique consists of collecting a number of words evoked by a subject facing exposure to an inducer term. The purpose of this technique is to understand the relationships created between words evoked by the individual and the inducer term. This technique is included in the theory of social representations, therefore, on the information transmitted by an individual, seeks to create a profile that define a social group.

This package performs fast variable selection in high-dimensional settings while controlling the false discovery rate (FDR) at a user-defined target level. The package is based on the paper Machkour, Muma, and Palomar (2022) <arXiv:2110.06048>.

The model estimates air pollution removal by dry deposition on trees. It also estimates or uses hourly values for aerodynamic resistance, boundary layer resistance, canopy resistance, stomatal resistance, cuticular resistance, mesophyll resistance, soil resistance, friction velocity and deposition velocity. It also allows plotting graphical results for a specific time period. The pollutants are nitrogen dioxide, ozone, sulphur dioxide, carbon monoxide and particulate matter. Baldocchi D (1994) <doi:10.1093/treephys/14.7-8-9.1069>. Farquhar GD, von Caemmerer S, Berry JA (1980) Planta 149: 78-90. Hirabayashi S, Kroll CN, Nowak DJ (2015) i-Tree Eco Dry Deposition Model. Nowak DJ, Crane DE, Stevens JC (2006) <doi:10.1016/j.ufug.2006.01.007>. US EPA (1999) PCRAMMET User's Guide. EPA-454/B-96-001. Weiss A, Norman JM (1985) Agricultural and Forest Meteorology 34: 205â 213.

Gives the required 2^n treatment combinations in a 2^n symmetric factorial experiment in their respective standard order.

Translate R control flow expressions into Tensorflow graphs.

Transformer is a Deep Neural Network Architecture based i.a. on the Attention mechanism (Vaswani et al. (2017) <doi:10.48550/arXiv.1706.03762>).

Find similarities between texts using the Smith-Waterman algorithm. The algorithm performs local sequence alignment and determines similar regions between two strings. The Smith-Waterman algorithm is explained in the paper: "Identification of common molecular subsequences" by T.F.Smith and M.S.Waterman (1981), available at <doi:10.1016/0022-2836(81)90087-5>. This package implements the same logic for sequences of words and letters instead of molecular sequences.

Interface to TensorFlow <https://www.tensorflow.org/>, an open source software library for numerical computation using data flow graphs. Nodes in the graph represent mathematical operations, while the graph edges represent the multidimensional data arrays (tensors) communicated between them. The flexible architecture allows you to deploy computation to one or more CPUs or GPUs in a desktop, server, or mobile device with a single API'. TensorFlow was originally developed by researchers and engineers working on the Google Brain Team within Google's Machine Intelligence research organization for the purposes of conducting machine learning and deep neural networks research, but the system is general enough to be applicable in a wide variety of other domains as well.

The main function of the package aims to update lmer()'/'glmer() models depending on their warnings, so trying to avoid convergence and singularity problems.

Calculates trait moments from trait and community data using the methods developed in Maitner et al (2021) <doi:10.22541/au.162196147.76797968/v1>.

Fast calculation of the Subtree Prune and Regraft (SPR), Tree Bisection and Reconnection (TBR) and Replug distances between unrooted trees, using the algorithms of Whidden and Matsen (2017) <doi:10.48550/arXiv.1511.07529>.

ARIMA-model-based decomposition of quarterly and monthly time series data. The methodology is developed and described, among others, in Burman (1980) <DOI:10.2307/2982132> and Hillmer and Tiao (1982) <DOI:10.2307/2287770>.

Tests one hypothesis with several test statistics, correcting for multiple testing. The central function in the package is testtwice(). In a sensitivity analysis, the method has the largest design sensitivity of its component tests. The package implements the method and examples in Rosenbaum, P. R. (2012) <doi:10.1093/biomet/ass032> Testing one hypothesis twice in observational studies. Biometrika, 99(4), 763-774.

This package provides tools to import, clean, validate, and analyze freshwater quality data in Brazil. Implements water quality indices including the Water Quality Index (WQI/IQA), the Trophic State Index (TSI/IET) after Carlson (1977) <doi:10.4319/lo.1977.22.2.0361> and Lamparelli (2004) <https://www.teses.usp.br/teses/disponiveis/41/41134/tde-20032006-075813/publico/TeseLamparelli2004.pdf>, and the National Sanitation Foundation Water Quality Index (NSF WQI) <doi:10.1007/s11157-023-09650-7>. The package also checks compliance with Brazilian standard CONAMA Resolution 357/2005 <https://conama.mma.gov.br/?id=450&option=com_sisconama&task=arquivo.download> and generates reproducible reports for routine monitoring workflows. The example dataset (`wq_demo`) is now a real subset from monitoring data (BURANHEM river, 2020-2024, 4 points, 20 rows, 14 columns including extra `rio`, `lat`, `lon`). All core examples and vignettes use this realistic sample, improving reproducibility and documentation value for users.

This package provides a collection of true type and open type Star Trek-themed fonts.

Utilities for text analysis.

Set of tools to estimate the probability in the upper tail of the aggregate loss distribution using different methods: Panjer recursion, Monte Carlo simulations, Markov bound, Cantelli bound, Moment bound, and Chernoff bound.

Set of functions designed to help in the analysis of TDP sensors. Features includes dates and time conversion, weather data interpolation, daily maximum of tension analysis and calculations required to convert sap flow density data to sap flow rates at the tree and plot scale (For more information see : Granier (1985) <DOI:10.1051/forest:19850204> & Granier (1987) <DOI:10.1093/treephys/3.4.309>).

Third order response surface designs (M. Hemavathi, Shashi Shekhar, Eldho Varghese, Seema Jaggi, Bikas Sinha & Nripes Kumar Mandal (2022) <DOI:10.1080/03610926.2021.1944213>."Theoretical developments in response surface designs: an informative review and further thoughts") are classified into two types viz., designs which are suitable for sequential experimentation and designs for non-sequential experimentation (M. Hemavathi, Eldho Varghese, Shashi Shekhar & Seema Jaggi (2022)<DOI:10.1080/02664763.2020.1864817>." Sequential asymmetric third order rotatable designs (SATORDs)"). The sequential experimentation approach involves conducting the trials step by step whereas, in the non-sequential experimentation approach, the entire runs are executed in one go.This package contains functions named STORDs() and NSTORDs() for generating sequential/non-sequential TORDs given in Das, M. N., and V. L. Narasimham (1962). <DOI:10.1214/aoms/1177704374>. "Construction of rotatable designs through balanced incomplete block designs" along with the randomized layout. It also contains another function named Pred3.var() for generating the variance of predicted response as well as the moment matrix based on a third order response surface model.

Graphic interface for text analysis, implement a few methods such as biplots, correspondence analysis, co-occurrence, clustering, topic models, correlations and sentiments.

Custom template and output formats for use with rmarkdown. Produce Edward Tufte-style handouts in html formats with full support for rmarkdown features.

Mixed models for repeated measures (MMRM) are a popular choice for analyzing longitudinal continuous outcomes in randomized clinical trials and beyond; see for example Cnaan, Laird and Slasor (1997) <doi:10.1002/(SICI)1097-0258(19971030)16:20%3C2349::AID-SIM667%3E3.0.CO;2-E>. This package provides an interface for fitting MMRM within the tern <https://cran.r-project.org/package=tern> framework by Zhu et al. (2023) and tabulate results easily using rtables <https://cran.r-project.org/package=rtables> by Becker et al. (2023). It builds on mmrm <https://cran.r-project.org/package=mmrm> by Sabanés Bové et al. (2023) for the actual MMRM computations.