Our method introduces mathematically well-defined measures for tightness of branches in a hierarchical tree. Statistical significance of the findings is determined, for all branches of the tree, by performing permutation tests, optionally with generalized Pareto p-value estimation.

This package provides a new measure of similarity between a pair of mass spectrometry (MS) experiments, called truncated rank correlation (TRC). To provide a robust metric of similarity in noisy high-dimensional data, TRC uses truncated top ranks (or top m-ranks) for calculating correlation. Truncated rank correlation as a robust measure of test-retest reliability in mass spectrometry data. For more details see Lim et al. (2019) <doi:10.1515/sagmb-2018-0056>.

Conditional logistic regression with longitudinal follow up and individual-level random coefficients: A stable and efficient two-step estimation method.

This package provides a global-local approximation framework for large-scale Gaussian process modeling. Please see Vakayil and Joseph (2024) <doi:10.1080/00401706.2023.2296451> for details. This work is supported by U.S. NSF grants CMMI-1921646 and DMREF-1921873.

Calculates total survey error (TSE) for a survey under multiple, different weighting schemes, using both scale-dependent and scale-independent metrics. Package works directly from the data set, with no hand calculations required: just upload a properly structured data set (see TESTWGT and its documentation), properly input column names (see functions documentation), and run your functions. For more on TSE, see: Weisberg, Herbert (2005, ISBN:0-226-89128-3); Biemer, Paul (2010) <doi:10.1093/poq/nfq058>; Biemer, Paul et.al. (2017, ISBN:9781119041672); etc.

Performing the hypothesis tests for the two sample problem based on order statistics and power comparisons. Calculate the test statistic, density, distribution function, quantile function, random number generation and others.

Finding the best values for user-specified arguments of a prediction algorithm can be difficult, particularly if there is an interaction between argument levels. This package automates the testing of any user-defined prediction algorithm over an arbitrary number of arguments. It includes functions for testing the algorithm over the given arguments with respect to an arbitrary number of user-defined diagnostics, visualising the results of these tests, and finding the optimal argument combinations with respect to each diagnostic.

This package provides a pipeline of tools for analysing circadian time-series data using functional data analysis (FDA). The package supports smoothing of rhythmic time series, functional principle component analysis (FPCA), and extraction of group-level traits from functional representations. Analyses can incorporate multiple curve derivatives and optional temporal segmentation, enabling comparative analysis of circadian dynamics across experimental groups and time windows.

Visualize your Tidyverse data analysis pipelines via the Tidy Data Tutor'(<https://tidydatatutor.com/>) web application.

Integrates several popular high-dimensional methods based on Linear Discriminant Analysis (LDA) and provides a comprehensive and user-friendly toolbox for linear, semi-parametric and tensor-variate classification as mentioned in Yuqing Pan, Qing Mai and Xin Zhang (2019) <arXiv:1904.03469>. Functions are included for covariate adjustment, model fitting, cross validation and prediction.

Computes the solution path of the Terminating-LARS (T-LARS) algorithm. The T-LARS algorithm is a major building block of the T-Rex selector (see R package TRexSelector'). The package is based on the papers Machkour, Muma, and Palomar (2022) <arXiv:2110.06048>, Efron, Hastie, Johnstone, and Tibshirani (2004) <doi:10.1214/009053604000000067>, and Tibshirani (1996) <doi:10.1111/j.2517-6161.1996.tb02080.x>.

Includes: (i) tests and visualisations that can help the modeller explore time series components and perform decomposition; (ii) modelling shortcuts, such as functions to construct lagmatrices and seasonal dummy variables of various forms; (iii) an implementation of the Theta method; (iv) tools to facilitate the design of the forecasting process, such as ABC-XYZ analyses; and (v) "quality of life" functions, such as treating time series for trailing and leading values.

This package provides functions for admin needs of employees of Thomas Jefferson University and Thomas Jefferson University Hospital, Philadelphia, PA.

This package provides extended data frames, with a special data frame column which contains two indexes, with potentially a nesting structure, and support for tibbles and methods for dplyr'.

This package creates simulated clinical trial data with realistic correlation structures and assumed efficacy levels by using a tilted bootstrap resampling approach. Samples are drawn from observed data with some samples appearing more frequently than others. May also be used for simulating from a joint Bayesian distribution along with clinical trials based on the Bayesian distribution.

This package provides the estimation of a time-dependent covariance matrix of returns with the intended use for portfolio optimization. The package offers methods for determining the optimal number of factors to be used in the covariance estimation, a hypothesis test of time-varying covariance, and user-friendly functions for portfolio optimization and rolling window evaluation. The local PCA method, method for determining the number of factors, and associated hypothesis test are based on Su and Wang (2017) <doi:10.1016/j.jeconom.2016.12.004>. The approach to time-varying portfolio optimization follows Fan et al. (2024) <doi:10.1016/j.jeconom.2022.08.007>. The regularisation applied to the residual covariance matrix adopts the technique introduced by Chen et al. (2019) <doi:10.1016/j.jeconom.2019.04.025>.

Fast, reproducible detection and quantitative analysis of tertiary lymphoid structures (TLS) in multiplexed tissue imaging. Implements Independent Component Analysis Trace (ICAT) index, local Ripley's K scanning, automated K Nearest Neighbor (KNN)-based TLS detection, and T-cell clusters identification as described in Amiryousefi et al. (2025) <doi:10.1101/2025.09.21.677465>.

Utilities for rapidly loading specified rows and/or columns of data from large tab-separated value (tsv) files (large: e.g. 1 GB file of 10000 x 10000 matrix). tsvio is an R wrapper to C code that creates an index file for the rows of the tsv file, and uses that index file to collect rows and/or columns from the tsv file without reading the whole file into memory.

Uses the optimal test design approach by Birnbaum (1968, ISBN:9781593119348) and van der Linden (2018) <doi:10.1201/9781315117430> to construct fixed, adaptive, and parallel tests. Supports the following mixed-integer programming (MIP) solver packages: Rsymphony', highs', gurobi', lpSolve', and Rglpk'. The gurobi package is not available from CRAN; see <https://www.gurobi.com/downloads/>.

This package provides methods for generating .dat files for use with the AMPL software using spatial data, particularly rasters. It includes support for various spatial data formats and different problem types. By automating the process of generating AMPL datasets, this package can help streamline optimization workflows and make it easier to solve complex optimization problems. The methods implemented in this package are described in detail in a publication by Fourer et al. (<doi:10.1287/mnsc.36.5.519>).

Reconstruct phylogenetic trees from discrete data. Inapplicable character states are handled using the algorithm of Brazeau, Guillerme and Smith (2019) <doi:10.1093/sysbio/syy083> with the "Morphy" library, under equal or implied step weights. Contains a "shiny" user interface for interactive tree search and exploration of results, including character visualization, rogue taxon detection, tree space mapping, and cluster consensus trees (Smith 2022a, b) <doi:10.1093/sysbio/syab099>, <doi:10.1093/sysbio/syab100>. Profile Parsimony (Faith and Trueman, 2001) <doi:10.1080/10635150118627>, Successive Approximations (Farris, 1969) <doi:10.2307/2412182> and custom optimality criteria are implemented.

This package provides functions for the computationally efficient simulation of dynamic networks estimated with the statistical framework of temporal exponential random graph models, implemented in the tergm package.

Implement the alternating algorithm for supervised tensor decomposition with interactive side information. Details can be found in the publication Hu, Jiaxin, Chanwoo Lee, and Miaoyan Wang. "Generalized Tensor Decomposition with features on multiple modes." Journal of Computational and Graphical Statistics, Vol. 31, No. 1, 204-218, 2022 <doi:10.1080/10618600.2021.1978471>.

Analyse time to event data with two time scales by estimating a smooth hazard that varies over two time scales and also, if covariates are available, to estimate a proportional hazards model with such a two-dimensional baseline hazard. Functions are provided to prepare the raw data for estimation, to estimate and to plot the two-dimensional smooth hazard. Extension to a competing risks model are implemented. For details about the method please refer to Carollo et al. (2024) <doi:10.1002/sim.10297>.