Simulate complex traits given a SNP genotype matrix and model parameters (the desired heritability, number of causal loci, and either the true ancestral allele frequencies used to generate the genotypes or the mean kinship for a real dataset). Emphasis on avoiding common biases due to the use of estimated allele frequencies. The code selects random loci to be causal, constructs coefficients for these loci and random independent non-genetic effects, and can optionally generate random group effects. Traits can follow three models: random coefficients, fixed effect sizes, and infinitesimal (multivariate normal). GWAS method benchmarking functions are also provided. Described in Yao and Ochoa (2022) <doi:10.1101/2022.03.25.485885>.

We implement functions to estimate and perform sensitivity analysis to unobserved confounding of direct and indirect effects introduced in Lindmark, de Luna and Eriksson (2018) <doi:10.1002/sim.7620> and Lindmark (2022) <doi:10.1007/s10260-021-00611-4>. The estimation and sensitivity analysis are parametric, based on probit and/or linear regression models. Sensitivity analysis is implemented for unobserved confounding of the exposure-mediator, mediator-outcome and exposure-outcome relationships.

This package provides indices such as Manly's alpha, foraging ratio, and Ivlev's selectivity to allow for analysis of dietary selectivity and preference. Can accommodate multiple experimental designs such as constant prey number of prey depletion. Please contact the package maintainer with any publications making use of this package in an effort to maintain a repository of dietary selections studies.

Estimate the size of a networked population based on respondent-driven sampling data. The package is part of the "RDS Analyst" suite of packages for the analysis of respondent-driven sampling data. See Handcock, Gile and Mar (2014) <doi:10.1214/14-EJS923>, Handcock, Gile and Mar (2015) <doi:10.1111/biom.12255>, Kim and Handcock (2021) <doi:10.1093/jssam/smz055>, and McLaughlin, et. al. (2023) <doi:10.1214/23-AOAS1807>.

This package provides an R interface to SymEngine <https://github.com/symengine/>, a standalone C++ library for fast symbolic manipulation. The package has functionalities for symbolic computation like calculating exact mathematical expressions, solving systems of linear equations and code generation.

This package provides easy to use functions to create all-sky grid plots of widely used astronomical coordinate systems (equatorial, ecliptic, galactic) and scatter plots of data on any of these systems including on-the-fly system conversion. It supports any type of spherical projection to the plane defined by the mapproj package.

This package provides tools for power and sample size calculation as well as design diagnostics for longitudinal mixed model settings, with a focus on stepped wedge designs. All calculations are oracle estimates i.e. assume random effect variances to be known (or guessed) in advance. The method is introduced in Hussey and Hughes (2007) <doi:10.1016/j.cct.2006.05.007>, extensions are discussed in Li et al. (2020) <doi:10.1177/0962280220932962>.

Plots that illustrate the flow of information or material.

This package provides a set of tools dedicated to modeling food web transfer based on an initial ground raster. It provides a directed acyclic graph structure for a set of rasters representing the flow of elements (e.g., food, energy, contaminants). It also includes tools for working with dispersal algorithms, enabling the combination of flux data with population movement.

This package provides a systematic bioinformatics tool to perform single-sample mutation-based pathway analysis by integrating somatic mutation data with the Protein-Protein Interaction (PPI) network. In this method, we use local and global weighted strategies to evaluate the effects of network genes from mutations according to the network topology and then calculate the mutation-based pathway enrichment score (ssMutPES) to reflect the accumulated effect of mutations of each pathway. Subsequently, the ssMutPES profiles are used for unsupervised spectral clustering to identify cancer subtypes.

Build and run metaheuristic optimization algorithms as serializable component graphs executed by a Rust core, with reproducible, bit-exact trajectories shared across the R and Python frontends. Includes population and local-search algorithm presets, standard benchmark suites (BBOB, CEC 2014/2017/2022, TSP), multi-objective indicators, structural-bias diagnostics and statistical comparison tools.

Toolbox containing a variety of spectral clustering tools functions. Among the tools available are the hierarchical spectral clustering algorithm, the Shi and Malik clustering algorithm, the Perona and Freeman algorithm, the non-normalized clustering, the Von Luxburg algorithm, the Partition Around Medoids clustering algorithm, a multi-level clustering algorithm, recursive clustering and the fast method for all clustering algorithm. As well as other tools needed to run these algorithms or useful for unsupervised spectral clustering. This toolbox aims to gather the main tools for unsupervised spectral classification. See <http://mawenzi.univ-littoral.fr/> for more information and documentation.

Fast k-nearest neighbors (K-NN) and principal component analysis (PCA) imputation algorithms for missing values in epigenetic data or other high-dimensional numeric matrices. For PCA, a locally optimal block preconditioned conjugate gradient (LOBPCG) eigensolver with warm starts of both the eigenblock and search direction is also supported. Two complementary imputation strategies are available. Group-wise imputation (e.g., by chromosome) is recommended for Illumina DNA methylation microarrays (e.g., 450K, EPIC) and other matrices with groupable columns. A sliding window approach for K-NN or PCA imputation is recommended only for whole-genome methylation data such as whole-genome bisulfite sequencing (WGBS) or Enzymatic Methyl-seq (EM-seq). The package also supports hyperparameter tuning via repeated cross-validation. The K-NN algorithm is described in: Hastie, T., Tibshirani, R., Sherlock, G., Eisen, M., Brown, P. and Botstein, D. (1999) "Imputing Missing Data for Gene Expression Arrays". The PCA imputation is an optimized reimplementation of the imputePCA() function from the missMDA package described in: Josse, J. and Husson, F. (2016) <doi:10.18637/jss.v070.i01> "missMDA: A Package for Handling Missing Values in Multivariate Data Analysis".

This package provides functions for modeling Soil Organic Matter decomposition in terrestrial ecosystems with linear and nonlinear systems of differential equations. The package implements models according to the compartmental system representation described in Sierra and others (2012) <doi:10.5194/gmd-5-1045-2012> and Sierra and others (2014) <doi:10.5194/gmd-7-1919-2014>.

Fast and regularized version of GWR for large dataset, detailed in Murakami, Tsutsumida, Yoshida, Nakaya, and Lu (2019) <arXiv:1905.00266>.

Computes confidence intervals for variance using the Chi-Square distribution, without requiring raw data. Wikipedia (2025) <https://en.wikipedia.org/wiki/Chi-squared_distribution>. All-in-One Chi Distribution CI provides functions to calculate confidence intervals for the population variance based on a chi-squared distribution, utilizing a sample variance and sample size. It offers only a simple all-in-one method for quick calculations to find the CI for Chi Distribution.

This package provides SPSS- and SAS-like output for least squares multiple regression, logistic regression, and count variable regressions. Detailed output is also provided for OLS moderated regression, interaction plots, and Johnson-Neyman regions of significance. The output includes standardized coefficients, partial and semi-partial correlations, collinearity diagnostics, plots of residuals, and detailed information about simple slopes for interactions. The output for some functions includes Bayes Factors and, if requested, regression coefficients from Bayesian Markov Chain Monte Carlo analyses. There are numerous options for model plots. The REGIONS_OF_SIGNIFICANCE function also provides Johnson-Neyman regions of significance and plots of interactions for both lm and lme models. There is also a function for partial and semipartial correlations and a function for conducting Cohen's set correlation analyses.

This package implements methods for obtaining kernel density estimates subject to a variety of shape constraints (unimodality, bimodality, symmetry, tail monotonicity, bounds, and constraints on the number of inflection points). Enforcing constraints can eliminate unwanted waves or kinks in the estimate, which improves its subjective appearance and can also improve statistical performance. The main function scdensity() is very similar to the density() function in stats', allowing shape-restricted estimates to be obtained with little effort. The methods implemented in this package are described in Wolters and Braun (2017) <doi:10.1080/03610918.2017.1288247>, Wolters (2012) <doi:10.18637/jss.v047.i06>, and Hall and Huang (2002) <https://www3.stat.sinica.edu.tw/statistica/j12n4/j12n41/j12n41.htm>. See the scdensity() help for for full citations.

Efficient variational inference methods for fully Bayesian univariate and multivariate Gaussian and t-process regression models. Hierarchical shrinkage priors, including the triple gamma prior, are used for effective variable selection and covariance shrinkage in high-dimensional settings. The package leverages normalizing flows to approximate complex posterior distributions. For details on implementation, see Knaus (2025) <doi:10.48550/arXiv.2501.13173>.

Renders plots to a temporary image using the ragg graphics device and returns knitr::include_graphics() output. Optionally saves the image to a specified path. This helps ensure consistent appearance across interactive sessions, saved files, and knitted documents. For more details see Pedersen and Shemanarev (2025) <doi: 10.32614/CRAN.package.ragg>.

Modeling spatial dependencies in dependent variables, extending traditional spatial regression approaches. It allows for the joint modeling of both the mean and the variance of the dependent variable, incorporating semiparametric effects in both models. Based on generalized additive models (GAM), the package enables the inclusion of non-parametric terms while maintaining the classical theoretical framework of spatial regression. Additionally, it implements the Generalized Spatial Autoregression (GSAR) model, which extends classical methods like logistic Spatial Autoregresive Models (SAR), probit Spatial Autoregresive Models (SAR), and Poisson Spatial Autoregresive Models (SAR), offering greater flexibility in modeling spatial dependencies and significantly improving computational efficiency and the statistical properties of the estimators. Related work includes: a) J.D. Toloza-Delgado, Melo O.O., Cruz N.A. (2024). "Joint spatial modeling of mean and non-homogeneous variance combining semiparametric SAR and GAMLSS models for hedonic prices". <doi:10.1016/j.spasta.2024.100864>. b) Cruz, N. A., Toloza-Delgado, J. D., Melo, O. O. (2024). "Generalized spatial autoregressive model". <doi:10.48550/arXiv.2412.00945>.

This package provides functions to access and collect data from the Brazilian Federal Senate open data API and website. Covers senators, legislative materials, committees, voting records, speeches, provisional measures, vetoes, and legislative agendas, returning results as tidy data frames ready for analysis.

This package provides drop-in replacements for functions from the stringr package, with the same user interface. These functions have no external dependencies and can be copied directly into your package code using the staticimports package.

Automates the creation of Dockerfiles for deploying Shiny applications. By integrating with renv for dependency management and leveraging Docker-based solutions, it simplifies the process of containerizing Shiny apps, ensuring reproducibility and consistency across different environments. Additionally, it facilitates the setup of CI/CD pipelines for building Docker images on both GitLab and GitHub.