Fits a wide variety of multivariate spatio-temporal models with simultaneous and lagged interactions among variables (including vector autoregressive spatio-temporal ('VAST') dynamics) for areal, continuous, or network spatial domains. It includes time-variable, space-variable, and space-time-variable interactions using dynamic structural equation models ('DSEM') as expressive interface, and the mgcv package to specify splines via the formula interface. See Thorson et al. (2025) <doi:10.1111/geb.70035> for more details.

Up-and-Down (UD) is the most popular design approach for dose-finding, but it has been severely under-served by the statistical and computing communities. This is the first package that comprehensively addresses UD's needs. Recent applied UD tutorial: Oron et al., 2022 <doi:10.1097/ALN.0000000000004282>. Recent methodological overview: Oron and Flournoy, 2024 <doi:10.51387/24-NEJSDS74>.

Efficient Bayesian implementations of probit, logit, multinomial logit and binomial logit models. Functions for plotting and tabulating the estimation output are available as well. Estimation is based on Gibbs sampling where the Markov chain Monte Carlo algorithms are based on the latent variable representations and marginal data augmentation algorithms described in "Gregor Zens, Sylvia Frühwirth-Schnatter & Helga Wagner (2023). Ultimate Pólya Gamma Samplers â Efficient MCMC for possibly imbalanced binary and categorical data, Journal of the American Statistical Association <doi:10.1080/01621459.2023.2259030>".

Most universities use specific color combinations to express their unique brand identity. The unicol package provides the colors and color palettes of various universities for easy plotting and printing in R. We collect and provide a diverse range of color palettes for creating scientific visualizations.

This package provides a framework for estimating difference-in-differences with unpoolable data, based on Karim, Webb, Austin, and Strumpf (2025) <doi:10.48550/arXiv.2403.15910>. Supports common or staggered adoption, multiple groups, and the inclusion of covariates. Also computes p-values for the aggregate average treatment effect on the treated via the randomization inference procedure described in MacKinnon and Webb (2020) <doi:10.1016/j.jeconom.2020.04.024>.

UpSet.js is a re-implementation of UpSetR to create interactive set visualizations for more than three sets. This is a htmlwidget wrapper around the JavaScript library UpSet.js'.

Calculates the Urban Centrality Index (UCI) as in Pereira et al., (2013) <doi:10.1111/gean.12002>. The UCI measures the extent to which the spatial organization of a city or region varies from extreme polycentric to extreme monocentric in a continuous scale from 0 to 1. Values closer to 0 indicate more polycentric patterns and values closer to 1 indicate a more monocentric urban form.

An implementation of Lind and Mehlum's (2010) <doi:10.1111/j.1468-0084.2009.00569.x> Utest to test for the presence of a U shaped or inverted U shaped relationship between variables in (generalized) linear models. It also implements a test of upward/downward sloping relationships at the lower and upper boundary of the data range.

Uniform sampling of Directed Acyclic Graphs (DAG) using exact enumeration by relating each DAG to a sequence of outpoints (nodes with no incoming edges) and then to a composition of integers as suggested by Kuipers, J. and Moffa, G. (2015) <doi:10.1007/s11222-013-9428-y>.

Define and use graphical elements of corporate design manuals in R. The unikn package provides color functions (by defining dedicated colors and color palettes, and commands for finding, changing, viewing, and using them) and styled text elements (e.g., for marking, underlining, or plotting colored titles). The pre-defined range of colors and text decoration functions is based on the corporate design of the University of Konstanz <https://www.uni-konstanz.de/>, but can be adapted and extended for other purposes or institutions.

Does uniformly most powerful (UMP) and uniformly most powerful unbiased (UMPU) tests. At present only distribution implemented is binomial distribution. Also does fuzzy tests and confidence intervals (following Geyer and Meeden, 2005, <doi:10.1214/088342305000000340>) for the binomial distribution (one-tailed procedures based on UMP test and two-tailed procedures based on UMPU test).

Predicts a smooth and continuous (individual) utility function from utility points, and computes measures of intensity for risk and higher-order risk measures (or any other measure computed with user-written function) based on this utility function and its derivatives according to the method introduced in Schneider (2017) <http://hdl.handle.net/21.11130/00-1735-0000-002E-E306-0>.

Algorithms for checking the accuracy of a clustering result with known classes, computing cluster validity indices, and generating plots for comparing them. The package is compatible with K-means, fuzzy C means, EM clustering, and hierarchical clustering (single, average, and complete linkage). The details of the indices in this package can be found in: J. C. Bezdek, M. Moshtaghi, T. Runkler, C. Leckie (2016) <doi:10.1109/TFUZZ.2016.2540063>, T. Calinski, J. Harabasz (1974) <doi:10.1080/03610927408827101>, C. H. Chou, M. C. Su, E. Lai (2004) <doi:10.1007/s10044-004-0218-1>, D. L. Davies, D. W. Bouldin (1979) <doi:10.1109/TPAMI.1979.4766909>, J. C. Dunn (1973) <doi:10.1080/01969727308546046>, F. Haouas, Z. Ben Dhiaf, A. Hammouda, B. Solaiman (2017) <doi:10.1109/FUZZ-IEEE.2017.8015651>, M. Kim, R. S. Ramakrishna (2005) <doi:10.1016/j.patrec.2005.04.007>, S. H. Kwon (1998) <doi:10.1049/EL:19981523>, S. H. Kwon, J. Kim, S. H. Son (2021) <doi:10.1049/ell2.12249>, G. W. Miligan (1980) <doi:10.1007/BF02293907>, M. K. Pakhira, S. Bandyopadhyay, U. Maulik (2004) <doi:10.1016/j.patcog.2003.06.005>, M. Popescu, J. C. Bezdek, T. C. Havens, J. M. Keller (2013) <doi:10.1109/TSMCB.2012.2205679>, S. Saitta, B. Raphael, I. Smith (2007) <doi:10.1007/978-3-540-73499-4_14>, A. Starczewski (2017) <doi:10.1007/s10044-015-0525-8>, Y. Tang, F. Sun, Z. Sun (2005) <doi:10.1109/ACC.2005.1470111>, N. Wiroonsri (2024) <doi:10.1016/j.patcog.2023.109910>, N. Wiroonsri, O. Preedasawakul (2023) <doi:10.48550/arXiv.2308.14785>, C. H. Wu, C. S. Ouyang, L. W. Chen, L. W. Lu (2015) <doi:10.1109/TFUZZ.2014.2322495>, X. Xie, G. Beni (1991) <doi:10.1109/34.85677> and Rousseeuw (1987) and Kaufman and Rousseeuw(2009) <doi:10.1016/0377-0427(87)90125-7> and <doi:10.1002/9780470316801> C. Alok. (2010).

This package provides functions and a Shiny application for downloading, analyzing and visualizing datasets from UCSC Xena (<http://xena.ucsc.edu/>), which is a collection of UCSC-hosted public databases such as TCGA, ICGC, TARGET, GTEx, CCLE, and others.

Construct and plot objective hierarchies and associated value and utility functions. Evaluate the values and utilities and visualize the results as colored objective hierarchies or tables. Visualize uncertainty by plotting median and quantile intervals within the nodes of objective hierarchies. Get numerical results of the evaluations in standard R data types for further processing.

The framework proposed in Jenul et al., (2022) <doi:10.1007/s10994-022-06221-9>, together with an interactive Shiny dashboard. UBayFS is an ensemble feature selection technique embedded in a Bayesian statistical framework. The method combines data and user knowledge, where the first is extracted via data-driven ensemble feature selection. The user can control the feature selection by assigning prior weights to features and penalizing specific feature combinations. UBayFS can be used for common feature selection as well as block feature selection.

In many phase I trials, the design goal is to find the dose associated with a certain target toxicity rate. In some trials, the goal can be to find the dose with a certain weighted sum of rates of various toxicity grades. For others, the goal is to find the dose with a certain mean value of a continuous response. This package provides the setup and calculations needed to run a dose-finding trial with non-binary endpoints and performs simulations to assess designâ s operating characteristics under various scenarios. Three dose finding designs are included in this package: unified phase I design (Ivanova et al. (2009) <doi:10.1111/j.1541-0420.2008.01045.x>), Quasi-CRM/Robust-Quasi-CRM (Yuan et al. (2007) <doi:10.1111/j.1541-0420.2006.00666.x>, Pan et al. (2014) <doi:10.1371/journal.pone.0098147>) and generalized BOIN design (Mu et al. (2018) <doi:10.1111/rssc.12263>). The toxicity endpoints can be handled with these functions including equivalent toxicity score (ETS), total toxicity burden (TTB), general continuous toxicity endpoints, with incorporating ordinal grade toxicity information into dose-finding procedure. These functions allow customization of design characteristics to vary sample size, cohort sizes, target dose-limiting toxicity (DLT) rates, discrete or continuous toxicity score, and incorporate safety and/or stopping rules.

Top-down and bottom-up algorithms for nonparametric function estimation in Gaussian noise using Unbalanced Haar wavelets.

Uniform Error Index is the weighted average of different error measures. Uniform Error Index utilizes output from different error function and gives more robust and stable error values. This package has been developed to compute Uniform Error Index from ten different loss function like Error Square, Square of Square Error, Quasi Likelihood Error, LogR-Square, Absolute Error, Absolute Square Error etc. The weights are determined using Principal Component Analysis (PCA) algorithm of Yeasin and Paul (2024) <doi:10.1007/s11227-023-05542-3>.

Clustering and classification inference for high dimension low sample size (HDLSS) data with U-statistics. The package contains implementations of nonparametric statistical tests for sample homogeneity, group separation, clustering, and classification of multivariate data. The methods have high statistical power and are tailored for data in which the dimension L is much larger than sample size n. See Gabriela B. Cybis, Marcio Valk and SÃ lvia RC Lopes (2018) <doi:10.1080/00949655.2017.1374387>, Marcio Valk and Gabriela B. Cybis (2020) <doi:10.1080/10618600.2020.1796398>, Debora Z. Bello, Marcio Valk and Gabriela B. Cybis (2021) <arXiv:2106.09115>.

The Unmanned Aerial Vehicle Mission Planner provides an easy to use work flow for planning autonomous obstacle avoiding surveys of ready to fly unmanned aerial vehicles to retrieve aerial or spot related data. It creates either intermediate flight control files for the DJI-Litchi supported series or ready to upload control files for the pixhawk-based flight controller. Additionally it contains some useful tools for digitizing and data manipulation.

This package provides tools for assigning molecular formulas from exact masses obtained by ultrahigh-resolution mass spectrometry. The methodology follows the workflow described in Leefmann et al. (2019) <doi:10.1002/rcm.8315>. The package supports the inspection, filtering and visualization of molecular formula data and includes utilities for calculating common molecular parameters (e.g., double bond equivalents, DBE). A graphical user interface is available via the shiny'-based ume application.

This package provides a time series of the national grid demand (high-voltage electric power transmission network) in the UK since 2011.

This package provides functions for building customized ready-to-export tables for publication.