Efficient sampling of truncated multivariate (scale) mixtures of normals under linear inequality constraints is nontrivial due to the analytically intractable normalizing constant. Meanwhile, traditional methods may subject to numerical issues, especially when the dimension is high and dependence is strong. Algorithms proposed by Li and Ghosh (2015) <doi: 10.1080/15598608.2014.996690> are adopted for overcoming difficulties in simulating truncated distributions. Efficient rejection sampling for simulating truncated univariate normal distribution is included in the package, which shows superiority in terms of acceptance rate and numerical stability compared to existing methods and R packages. An efficient function for sampling from truncated multivariate normal distribution subject to convex polytope restriction regions based on Gibbs sampler for conditional truncated univariate distribution is provided. By extending the sampling method, a function for sampling truncated multivariate Student's t distribution is also developed. Moreover, the proposed method and computation remain valid for high dimensional and strong dependence scenarios. Empirical results in Li and Ghosh (2015) <doi: 10.1080/15598608.2014.996690> illustrated the superior performance in terms of various criteria (e.g. mixing and integrated auto-correlation time).

This package provides a geomorphology-based hydrological modelling for transferring streamflow measurements from gauged to ungauged catchments. Inverse modelling enables to estimate net rainfall from streamflow measurements following Boudhraâ et al. (2018) <doi:10.1080/02626667.2018.1425801>. Resulting net rainfall is then estimated on the ungauged catchments by spatial interpolation in order to finally simulate streamflow following de Lavenne et al. (2016) <doi:10.1002/2016WR018716>.

This package provides a robust implementation of Topolow algorithm. It embeds objects into a low-dimensional Euclidean space from a matrix of pairwise dissimilarities, even when the data do not satisfy metric or Euclidean axioms. The package is particularly well-suited for sparse, incomplete, and censored (thresholded) datasets such as antigenic relationships. The core is a physics-inspired, gradient-free optimization framework that models objects as particles in a physical system, where observed dissimilarities define spring rest lengths and unobserved pairs exert repulsive forces. The package also provides functions specific to antigenic mapping to transform cross-reactivity and binding affinity measurements into accurate spatial representations in a phenotype space. Key features include: * Robust Embedding from Sparse Data: Effectively creates complete and consistent maps (in optimal dimensions) even with high proportions of missing data (e.g., >95%). * Physics-Inspired Optimization: Models objects (e.g., antigens, landmarks) as particles connected by springs (for measured dissimilarities) and subject to repulsive forces (for missing dissimilarities), and simulates the physical system using laws of mechanics, reducing the need for complex gradient computations. * Automatic Dimensionality Detection: Employs a likelihood-based approach to determine the optimal number of dimensions for the embedding/map, avoiding distortions common in methods with fixed low dimensions. * Noise and Bias Reduction: Naturally mitigates experimental noise and bias through its network-based, error-dampening mechanism. * Antigenic Velocity Calculation (for antigenic data): Introduces and quantifies "antigenic velocity," a vector that describes the rate and direction of antigenic drift for each pathogen isolate. This can help identify cluster transitions and potential lineage replacements. * Broad Applicability: Analyzes data from various objects that their dissimilarity may be of interest, ranging from complex biological measurements such as continuous and relational phenotypes, antibody-antigen interactions, and protein folding to abstract concepts, such as customer perception of different brands. Methods are described in the context of bioinformatics applications in Arhami and Rohani (2025a) <doi:10.1093/bioinformatics/btaf372>, and mathematical proofs and Euclidean embedding details are in Arhami and Rohani (2025b) <doi:10.48550/arXiv.2508.01733>.

Package test2norm contains functions to generate formulas for normative standards applied to cognitive tests. It takes raw test scores (e.g., number of correct responses) and converts them to scaled scores and demographically adjusted scores, using methods described in Heaton et al. (2003) <doi:10.1016/B978-012703570-3/50010-9> & Heaton et al. (2009, ISBN:9780199702800). The scaled scores are calculated as quantiles of the raw test scores, scaled to have the mean of 10 and standard deviation of 3, such that higher values always correspond to better performance on the test. The demographically adjusted scores are calculated from the residuals of a model that regresses scaled scores on demographic predictors (e.g., age). The norming procedure makes use of the mfp2() function from the mfp2 package to explore nonlinear associations between cognition and demographic variables.

Calculates Zhong's optimal two-/three-stage Phase II designs for single-arm trials, generates target-toxicity decision tables for two-/three-stage Phase I dose-finding, and supports dose-finding simulations using custom decision tables. The Phase II design is based on Zhong (2012) <doi:10.1016/j.cct.2012.07.006>.

Covers k-table control analysis using multivariate control charts for qualitative variables using fundamentals of multiple correspondence analysis and multiple factor analysis. The graphs can be shown in a flat or interactive way, in the same way all the outputs can be shown in an interactive shiny panel.

Allows forecasting time series using nearest neighbors regression Francisco Martinez, Maria P. Frias, Maria D. Perez-Godoy and Antonio J. Rivera (2019) <doi:10.1007/s10462-017-9593-z>. When the forecasting horizon is higher than 1, two multi-step ahead forecasting strategies can be used. The model built is autoregressive, that is, it is only based on the observations of the time series. The nearest neighbors used in a prediction can be consulted and plotted.

Loads the 5 packages in the Tidy Consultant Universe. This collection of packages is useful for anyone doing data science, data analysis, or quantitative consulting. The functions in these packages range from data cleaning, data validation, data binning, statistical modeling, and file exporting.

Unsupervised text tokenizer focused on computational efficiency. Wraps the YouTokenToMe library <https://github.com/VKCOM/YouTokenToMe> which is an implementation of fast Byte Pair Encoding (BPE) <https://aclanthology.org/P16-1162/>.

This package provides new layer functions to tmap for drawing glyphs. A glyph is a small chart (e.g., donut chart) shown at specific map locations to visualize multivariate or time-series data. The functions work with the syntax of tmap and allow flexible control over size, layout, and appearance.

TensorFlow Hub is a library for the publication, discovery, and consumption of reusable parts of machine learning models. A module is a self-contained piece of a TensorFlow graph, along with its weights and assets, that can be reused across different tasks in a process known as transfer learning. Transfer learning train a model with a smaller dataset, improve generalization, and speed up training.

Fit two-part regression models for zero-inflated data. The models and their components are represented using S4 classes and methods. Average Marginal effects and predictive margins with standard errors and confidence intervals can be calculated from two-part model objects. Belotti, F., Deb, P., Manning, W. G., & Norton, E. C. (2015) <doi:10.1177/1536867X1501500102>.

Nonlinear growth models are extremely useful in gaining insight into the underlying mechanism. These models are generally mechanistic, with parameters that have biological meaning. This package allows you to fit and forecast time series data using nonlinear growth models.

Topological data analysis studies structure and shape of the data using topological features. We provide a variety of algorithms to learn with persistent homology of the data based on functional summaries for clustering, hypothesis testing, visualization, and others. We refer to Wasserman (2018) <doi:10.1146/annurev-statistics-031017-100045> for a statistical perspective on the topic.

Compute arbitrary non-parametric bootstrap statistics on data in tidy data frames.

Additive hazards models with two stage residual inclusion method are fitted under either survival data or competing risks data. The estimator incorporates an instrumental variable and therefore can recover causal estimand in the presence of unmeasured confounding under some assumptions. A.Ying, R. Xu and J. Murphy. (2019) <doi:10.1002/sim.8071>.

This package provides a novel feature-wise normalization method based on a zero-inflated negative binomial model. This method assumes that the effects of sequencing depth vary for each taxon on their mean and also incorporates a rational link of zero probability and taxon dispersion as a function of sequencing depth. Ziyue Wang, Dillon Lloyd, Shanshan Zhao, Alison Motsinger-Reif (2023) <doi:10.1101/2023.10.31.563648>.

Transformer is a Deep Neural Network Architecture based i.a. on the Attention mechanism (Vaswani et al. (2017) <doi:10.48550/arXiv.1706.03762>).

This package provides functions and example files to calculate the tRNA adaptation index, a measure of the level of co-adaptation between the set of tRNA genes and the codon usage bias of protein-coding genes in a given genome. The methodology is described in dos Reis, Wernisch and Savva (2003) <doi:10.1093/nar/gkg897>, and dos Reis, Savva and Wernisch (2004) <doi:10.1093/nar/gkh834>.

This package provides a system for personalized exercise plan recommendations for T2D (Type 2 Diabetes) patients based on the primary outcome of HbA1c (Glycated Hemoglobin). You provide the individual's information, and T2DFitTailor details the exercise plan and predicts the intervention's effectiveness.

Calculates total survey error (TSE) for one or more surveys, using common scale-dependent and/or scale-independent metrics. On TSE, see: Weisberg, Herbert (2005, ISBN:0-226-89128-3); Biemer, Paul (2010) <doi:10.1093/poq/nfq058>.

The tdROC package facilitates the estimation of time-dependent ROC (Receiver Operating Characteristic) curves and the Area Under the time-dependent ROC Curve (AUC) in the context of survival data, accommodating scenarios with right censored data and the option to account for competing risks. In addition to the ROC/AUC estimation, the package also estimates time-dependent Brier score and survival difference. Confidence intervals of various estimated quantities can be obtained from bootstrap. The package also offers plotting functions for visualizing time-dependent ROC curves.

Fit a threshold regression model based on the first-hitting-time of a boundary by the sample path of a Wiener diffusion process. The threshold regression methodology is well suited to applications involving survival and time-to-event data.

The trapezoid package provides dtrapezoid', ptrapezoid', qtrapezoid', and rtrapezoid functions for the trapezoidal distribution.