This package provides an expectation maximization (EM) algorithm to fit a mixture of continuous time Markov models for use with clickstream or other sequence type data. Gallaugher, M.P.B and McNicholas, P.D. (2018) <arXiv:1802.04849>.

This package provides functionality for the analysis of clustered data using the cluster bootstrap.

Compute Chinese capital stocks in provinces level, based on Zhang (2008) <DOI:10.1080/14765280802028302>.

Search across R files with contextual results, highlights and clickable links. Includes an add-in for further workflow enhancement.

Computing comorbidity indices and scores such as the weighted Charlson score (Charlson, 1987 <doi:10.1016/0021-9681(87)90171-8>) and the Elixhauser comorbidity score (Elixhauser, 1998 <doi:10.1097/00005650-199801000-00004>) using ICD-9-CM or ICD-10 codes (Quan, 2005 <doi:10.1097/01.mlr.0000182534.19832.83>). Australian and Swedish modifications of the Charlson Comorbidity Index are available as well (Sundararajan, 2004 <doi:10.1016/j.jclinepi.2004.03.012> and Ludvigsson, 2021 <doi:10.2147/CLEP.S282475>), together with different weighting algorithms for both the Charlson and Elixhauser comorbidity scores.

This package implements the semiparametric efficient estimators of continuous-time causal models for time-varying treatments and confounders in the presence of dependent censoring (including structural failure time model and Cox proportional hazards marginal structural model). S. Yang, K. Pieper, and F. Cools (2019) <doi:10.1111/biom.12845>.

The cov.nnve() function implements robust covariance estimation by the nearest neighbor variance estimation (NNVE) method of Wang and Raftery (2002) <DOI:10.1198/016214502388618780>.

The Codemeta Project defines a JSON-LD format for describing software metadata, as detailed at <https://codemeta.github.io>. This package provides core utilities to generate this metadata with a minimum of dependencies.

Convolute probabilistic distributions using the random generator function of each distribution. A new random number generator function is created that perform the mathematical operation on the individual random samples from the random generator function of each distribution. See the documentation for examples.

This package provides tools for assessing data quality, performing exploratory analysis, and semi-automatic preprocessing of messy data with change tracking for integral dataset cleaning.

Estimation of sparse nonlinear functions in nonparametric regression using component selection and smoothing. Designed for the analysis of high-dimensional data, the models support various data types, including exponential family models and Cox proportional hazards models. The methodology is based on Lin and Zhang (2006) <doi:10.1214/009053606000000722>.

This package provides comprehensive cytokine profiling analysis through quality control using biologically meaningful cutoffs on raw cytokine measurements and by testing for distributional symmetry to recommend appropriate transformations. Offers exploratory data analysis with summary statistics, enhanced boxplots, and barplots, along with univariate and multivariate analytical capabilities for in-depth cytokine profiling such as Principal Component Analysis based on Andrzej MaÄ kiewicz and Waldemar Ratajczak (1993) <doi:10.1016/0098-3004(93)90090-R>, Sparse Partial Least Squares Discriminant Analysis based on Lê Cao K-A, Boitard S, and Besse P (2011) <doi:10.1186/1471-2105-12-253>, Random Forest based on Breiman, L. (2001) <doi:10.1023/A:1010933404324>, and Extreme Gradient Boosting based on Tianqi Chen and Carlos Guestrin (2016) <doi:10.1145/2939672.2939785>.

In statistical modeling, multiple models need to be compared based on certain criteria. The method described here uses eight metrics from AllMetrics package. â input_dfâ is the data frame (at least two columns for comparison) containing metrics values in different rows of a column (which denotes a particular modelâ s performance). First five metrics are expected to be minimum and last three metrics are expected to be maximum for a model to be considered good. Firstly, every metric value (among first five) is searched in every columns and minimum values are denoted as â MINâ and other values are denoted as â NAâ . Secondly, every metric (among last three) is searched in every columns and maximum values are denoted as â MAXâ and other values are denoted as â NAâ . â output_dfâ contains the similar number of rows (which is 8) and columns (which is number of models to be compared) as of â input_dfâ . Values in â output_dfâ are corresponding â NAâ , â MINâ or â MAXâ . Finally, the column containing minimum number of â NAâ values is denoted as the best column. â min_NA_colâ gives the name of the best column (model). â min_NA_valuesâ are the corresponding metrics values. âBestColumn_metricsâ is the data frame (dimension: 1*8) containing different metrics of the best column (model). â best_column_resultsâ is the final result (a list) containing all of these output elements. In special case, if two columns having equal NA', it will be checked among these two column which one is having least NA in first five rows and will be inferred as the best. More details about AllMetrics can be found in Garai (2023) <doi:10.13140/RG.2.2.18688.30723>.

This package implements convex regression with interpretable sharp partitions (CRISP), which considers the problem of predicting an outcome variable on the basis of two covariates, using an interpretable yet non-additive model. CRISP partitions the covariate space into blocks in a data-adaptive way, and fits a mean model within each block. Unlike other partitioning methods, CRISP is fit using a non-greedy approach by solving a convex optimization problem, resulting in low-variance fits. More details are provided in Petersen, A., Simon, N., and Witten, D. (2016). Convex Regression with Interpretable Sharp Partitions. Journal of Machine Learning Research, 17(94): 1-31 <http://jmlr.org/papers/volume17/15-344/15-344.pdf>.

This package provides a daily counts of the Coronavirus (COVID19) cases by districts and country. Data source: Epidemiological Unit, Ministry of Health, Sri Lanka <https://www.epid.gov.lk/web/>.

Explore and normalize American campaign finance data. Created by the Investigative Reporting Workshop to facilitate work on The Accountability Project, an effort to collect public data into a central, standard database that is more easily searched: <https://publicaccountability.org/>.

Datasets for the book entitled "Modelling Survival Data in Medical Research" by Collett (2023) <doi:10.1201/9781003282525>. The datasets provide extensive examples of time-to-event data.

This package implements the adaptive designs for integrated phase I/II trials of drug combinations via continual reassessment method (CRM) to evaluate toxicity and efficacy simultaneously for each enrolled patient cohort based on Bayesian inference. It supports patients assignment guidance in a single trial using current enrolled data, as well as conducting extensive simulation studies to evaluate operating characteristics before the trial starts. It includes various link functions such as empiric, one-parameter logistic, two-parameter logistic, and hyperbolic tangent, as well as considering multiple prior distributions of the parameters like normal distribution, gamma distribution and exponential distribution to accommodate diverse clinical scenarios. Method using Bayesian framework with empiric link function is described in: Wages and Conaway (2014) <doi:10.1002/sim.6097>.

This is a one-function package that will pass only unique values to a computationally-expensive function that returns an output of the same length as the input. In importing and working with tidy data, it is common to have index columns, often including time stamps that are far from unique. Some functions to work with these such as text conversion to other variable types (e.g. as.POSIXct()), various grep()-based functions, and often the cut() function are relatively slow when working with tens of millions of rows or more.

Plots calibration curves and computes statistics for assessing calibration performance. See Lasai et al. (2025) <doi:10.48550/arXiv.2503.08389>, De Cock Campo (2023) <doi:10.48550/arXiv.2309.08559> and Van Calster et al. (2016) <doi:10.1016/j.jclinepi.2015.12.005>.

Computes Chernoff's distribution based on the method in Piet Groeneboom & Jon A Wellner (2001) Computing Chernoff's Distribution, Journal of Computational and Graphical Statistics, 10:2, 388-400, <doi:10.1198/10618600152627997>. Chernoff's distribution is defined as the distribution of the maximizer of the two-sided Brownian motion minus quadratic drift. That is, Z = argmax (B(t)-t^2).

Model-based clustering of mixed data (i.e. data which consist of continuous, binary, ordinal or nominal variables) using a parsimonious mixture of latent Gaussian variable models.

Iterate and repel visually similar colors away in various ggplot2 plots. When many groups are plotted at the same time on multiple axes, for instance stacked bars or scatter plots, effectively ordering colors becomes difficult. This tool iterates through color combinations to find the best solution to maximize visual distinctness of nearby groups, so plots are more friendly toward colorblind users. This is achieved by two distance measurements, distance between groups within the plot, and CIELAB color space distances between colors as described in Carter et al., (2018) <doi:10.25039/TR.015.2018>.

This package implements a basis function or functional data analysis framework for several techniques of multivariate analysis in continuous-time setting. Specifically, we introduced continuous-time analogues of several classical techniques of multivariate analysis, such as principal component analysis, canonical correlation analysis, Fisher linear discriminant analysis, K-means clustering, and so on. Details are in Biplab Paul, Philip T. Reiss, Erjia Cui and Noemi Foa (2025) "Continuous-time multivariate analysis" <doi: 10.1080/10618600.2024.2374570>.