Complete work flow for the analysis of pharmacokinetic pharmacodynamic (PKPD), physiologically-based pharmacokinetic (PBPK) and systems pharmacology models including: creation of ordinary differential equation-based models, pooled parameter estimation, individual/population based simulations, rule-based simulations for clinical trial design and modeling assays, deployment with a customizable Shiny app, and non-compartmental analysis. System-specific analysis templates can be generated and each element includes integrated reporting with PowerPoint and Word'.

When updating major or minor R versions all packages should be re-installed. The utilities in this package assist in getting a user up-and-running again by installing all previously installed R packages. The package uses renv to install; immediately replenishing your renv package cache.

Clustering and classification inference for high dimension low sample size (HDLSS) data with U-statistics. The package contains implementations of nonparametric statistical tests for sample homogeneity, group separation, clustering, and classification of multivariate data. The methods have high statistical power and are tailored for data in which the dimension L is much larger than sample size n. See Gabriela B. Cybis, Marcio Valk and SÃ lvia RC Lopes (2018) <doi:10.1080/00949655.2017.1374387>, Marcio Valk and Gabriela B. Cybis (2020) <doi:10.1080/10618600.2020.1796398>, Debora Z. Bello, Marcio Valk and Gabriela B. Cybis (2021) <arXiv:2106.09115>.

Fits hierarchical signal detection theory (SDT) models to paired direct and indirect measures, the design used to test for unconscious processing. Continuous indirect measures (typically response times) are dichotomized with the within-subject median split of Meyen et al. (2022) <doi:10.1037/xge0001065> so that both tasks are placed on a common sensitivity scale. The package estimates a binomial probit mixed model in which the two sensitivities are correlated random effects, and tests the three hypotheses of interest: the group-level difference between sensitivities, their latent correlation, and the latent regression of the indirect on the direct measure, whose intercept is the test for unconscious processing. Frequentist estimation uses lme4'.

Wraps the unrtf utility <https://www.gnu.org/software/unrtf/> to extract text from RTF files. Supports document conversion to HTML, LaTeX or plain text. Output in HTML is recommended because unrtf has limited support for converting between character encodings.

This package provides a fast and simple URL parser package for R'. This package provides functions to parse URLs into their components, such as scheme, user, password, host, port, path, query, and fragment.

This package provides a simple interface to the Geographic Header information from the "2010 US Census Summary File 2". The entire Summary File 2 is described at <https://catalog.data.gov/dataset/census-2000-summary-file-2-sf2>, but note that this package only provides access to parts of the geographic header ('geoheader') of the file. In particular, only the first 101 columns of the geoheader are included and, more importantly, only rows with summary levels (SUMLEVs) 010 through 050 (nation down through county level) are included. In addition to access to (part of) the geoheader, the package also provides a decode function that takes a column name and value and, for certain columns, returns "the meaning" of that column (i.e., a "SUMLEV" value of 40 means "State"); without a value, the decode function attempts to describe the column itself.

Spreadsheets silently turn entries such as 30.3 into dates, so the imported data carry date serials instead of the numbers that were typed. Reading the workbook directly recovers those numbers without guesswork: an xlsx file states its own date system, and records which cells are formatted as dates and in which field order, so the values to repair are identified from the file rather than inferred from their magnitude. Functions are also provided for data already imported, where that evidence is no longer available, using conservative and configurable detection.

Algorithms for checking the accuracy of a clustering result with known classes, computing cluster validity indices, and generating plots for comparing them. The package is compatible with K-means, fuzzy C means, EM clustering, and hierarchical clustering (single, average, and complete linkage). The details of the indices in this package can be found in: J. C. Bezdek, M. Moshtaghi, T. Runkler, C. Leckie (2016) <doi:10.1109/TFUZZ.2016.2540063>, T. Calinski, J. Harabasz (1974) <doi:10.1080/03610927408827101>, C. H. Chou, M. C. Su, E. Lai (2004) <doi:10.1007/s10044-004-0218-1>, D. L. Davies, D. W. Bouldin (1979) <doi:10.1109/TPAMI.1979.4766909>, J. C. Dunn (1973) <doi:10.1080/01969727308546046>, F. Haouas, Z. Ben Dhiaf, A. Hammouda, B. Solaiman (2017) <doi:10.1109/FUZZ-IEEE.2017.8015651>, M. Kim, R. S. Ramakrishna (2005) <doi:10.1016/j.patrec.2005.04.007>, S. H. Kwon (1998) <doi:10.1049/EL:19981523>, S. H. Kwon, J. Kim, S. H. Son (2021) <doi:10.1049/ell2.12249>, G. W. Miligan (1980) <doi:10.1007/BF02293907>, M. K. Pakhira, S. Bandyopadhyay, U. Maulik (2004) <doi:10.1016/j.patcog.2003.06.005>, M. Popescu, J. C. Bezdek, T. C. Havens, J. M. Keller (2013) <doi:10.1109/TSMCB.2012.2205679>, S. Saitta, B. Raphael, I. Smith (2007) <doi:10.1007/978-3-540-73499-4_14>, A. Starczewski (2017) <doi:10.1007/s10044-015-0525-8>, Y. Tang, F. Sun, Z. Sun (2005) <doi:10.1109/ACC.2005.1470111>, N. Wiroonsri (2024) <doi:10.1016/j.patcog.2023.109910>, N. Wiroonsri, O. Preedasawakul (2023) <doi:10.48550/arXiv.2308.14785>, C. H. Wu, C. S. Ouyang, L. W. Chen, L. W. Lu (2015) <doi:10.1109/TFUZZ.2014.2322495>, X. Xie, G. Beni (1991) <doi:10.1109/34.85677> and P.J. Rousseeuw (1987) and L. Kaufman and P.J. Rousseeuw(2009) <doi:10.1016/0377-0427(87)90125-7> and <doi:10.1002/9780470316801> C. Alok. (2010).

This package provides a fast and consistent general-purpose wrapper for arranging microdata and generating interactive and static visualizations. Offers a library of graphical functions with a highly configurable and simple syntax. Features include HTML tables, time series, bar and pie charts, and maps supported by various JavaScript libraries. Allows seamless transitions between interactive and static graphics without changing the core syntax. Originally developed to standardize the publication of official statistics at the National University of Colombia <https://unal.edu.co>. Spanish: Proporciona una herramienta de propósito general rápida y consistente para organizar microdatos y generar visualizaciones interactivas y estáticas. Ofrece una biblioteca de funciones gráficas con una sintaxis simple y altamente configurable. Permite transiciones fluidas entre gráficos interactivos y estáticos sin cambiar la sintaxis base. Desarrollado originalmente para estandarizar la publicación de estadà sticas oficiales en la Universidad Nacional de Colombia <https://unal.edu.co>.

Retrieve data from the UNESCO Institute for Statistics (UIS) API <https://api.uis.unesco.org/api/public/documentation/>. UIS provides public access to more than 4,000 indicators focusing on education, science and technology, culture, and communication.

This package performs a test for second-order stationarity of time series based on unsystematic sub-samples.

This package provides a variational mapping approach that reveals and expands future temporal dynamics from folded high-dimensional geometric distance spaces, unfold turns a set of time series into a 4D block of pairwise distances between reframed windows, learns a variational mapper that maps those distances to the next reframed window, and produces horizon-wise predictive functions for each input series. In short: it unfolds the future path of each series from a folded geometric distance representation.

This package implements the Gaussian method of first and second order, the Kragten numerical method and the Monte Carlo simulation method for uncertainty estimation and analysis.

This package provides functions for converting between UK and US spellings of English words.

This package provides a comprehensive educational package combining clustering algorithms with detailed step-by-step explanations. Provides implementations of both traditional (hierarchical, k-means) and modern (Density-Based Spatial Clustering of Applications with Noise (DBSCAN), Gaussian Mixture Models (GMM), genetic k-means) clustering methods as described in Ezugwu et. al., (2022) <doi:10.1016/j.engappai.2022.104743>. Includes educational datasets highlighting different clustering challenges, based on scikit-learn examples (Pedregosa et al., 2011) <https://jmlr.csail.mit.edu/papers/v12/pedregosa11a.html>. Features detailed algorithm explanations, visualizations, and weighted distance calculations for enhanced learning.

If a procedure consists of several stages and there are several models that can be selected for each stage, uncertainty of the procedure can be decomposed by stages or models. This package includes the ANOVA-based method, the cumulative uncertainty-based method, and the balanced decomposition method. Yongdai Kim et al. (2019) <doi:10.1016/j.hydroa.2019.100024> is a related paper which is accessible via the URL below.

This package provides convenience functions for user experience research with an emphasis on quantitative user experience testing and reporting. The functions are designed to translate statistical approaches to applied user experience research.

Download and explore datasets from UCSC Xena data hubs, which are a collection of UCSC-hosted public databases such as TCGA, ICGC, TARGET, GTEx, CCLE, and others. Databases are normalized so they can be combined, linked, filtered, explored and downloaded.

Conduct unit root tests based on EViews (<https://eviews.com>) routines and report them in tables. EViews (Econometric Views) is a commercial software for econometrics.

This package provides a unified framework for unit root and stationarity testing including quantile ADF tests (Koenker and Xiao, 2004) <doi:10.1198/016214504000001114>, GARCH-based unit root tests with endogenous structural breaks (Narayan and Liu, 2015) <doi:10.1016/j.eneco.2014.11.021>, and comprehensive Dickey-Fuller, Phillips-Perron, KPSS, ERS/DF-GLS, Zivot-Andrews, and Kobayashi-McAleer tests with an Elder-Kennedy decision strategy (Elder and Kennedy, 2001) <doi:10.1080/00220480109595179>.

UpSet.js is a re-implementation of UpSetR to create interactive set visualizations for more than three sets. This is a htmlwidget wrapper around the JavaScript library UpSet.js'.

Allows users to access live UK energy market information via various APIs.

Using matrix layout to visualize the unique, common, or individual contribution of each predictor (or matrix of predictors) towards explained variation on different models. These contributions were derived from variation partitioning (VP) and hierarchical partitioning (HP), applying the algorithm of "Lai et al. (2022) Generalizing hierarchical and variation partitioning in multiple regression and canonical analyses using the rdacca.hp R package.Methods in Ecology and Evolution, 13: 782-788 <doi:10.1111/2041-210X.13800>".