This package provides a suite of tools designed to build attractive command line interfaces (CLIs). It includes tools for drawing rules, boxes, trees, and Unicode symbols with ASCII alternatives.

This package provides simple utility functions to read from and write to the system clipboards.

Execute command line programs and format results for interactive use. It is based on the package processx so it does not use shell to start up the process like system() and system2(). It also provides a simpler and cleaner interface than processx::run().

This package provides a robust constrained L1 minimization method for estimating a large sparse inverse covariance matrix (aka precision matrix), and recovering its support for building graphical models. The computation uses linear programming. The method was published in TT Cai, W Liu, X Luo (2011) <doi:10.1198/jasa.2011.tm10155>.

This package provides a fast and general implementation of the Elston-Stewart algorithm that can calculate the likelihoods of large and complex pedigrees. References for the Elston-Stewart algorithm are Elston & Stewart (1971) <doi:10.1159/000152448>, Lange & Elston (1975) <doi:10.1159/000152714> and Cannings et al. (1978) <doi:10.2307/1426718>.

Collection of indices and tools relating to cardiovascular, nephrology, and hepatic research that aid epidemiological chort or retrospective chart review with big data. All indices and tools take commonly used lab values and patient demographics and measurements to compute various risk and predictive values for survival. References to original literature and validation contained in each function documentation.

The developed function is a comprehensive tool for the analysis of India Meteorological Department (IMD) NetCDF rainfall data. Specifically designed to process high-resolution daily gridded rainfall datasets. It provides four key functions to process IMD NetCDF rainfall data and create rasters for various temporal scales, including annual, seasonal, monthly, and weekly rainfall. For method details see, Malik, A. (2019).<DOI:10.1007/s12517-019-4454-5>. It supports different aggregation methods, such as sum, min, max, mean, and standard deviation. These functions are designed for spatio-temporal analysis of rainfall patterns, trend analysis,geostatistical modeling of rainfall variability, identifying rainfall anomalies and extreme events and can be an input for hydrological and agricultural models.

This package provides tools for assessing data quality, performing exploratory analysis, and semi-automatic preprocessing of messy data with change tracking for integral dataset cleaning.

Create rich command line applications, with colors, headings, lists, alerts, progress bars, etc. It uses CSS for custom themes. This package is now superseded by the cli package. Please use cli instead in new projects.

This package provides equations commonly used in clinical pharmacokinetics and clinical pharmacology, such as equations for dose individualization, compartmental pharmacokinetics, drug exposure, anthropomorphic calculations, clinical chemistry, and conversion of common clinical parameters. Where possible and relevant, it provides multiple published and peer-reviewed equations within the respective R function.

Designed for web usage data analysis, it implements tools to process web sequences and identify web browsing profiles through sequential classification. Sequences clusters are identified by using a model-based approach, specifically mixture of discrete time first-order Markov models for categorical web sequences. A Bayesian approach is used to estimate model parameters and identify sequences classification as proposed by Fruehwirth-Schnatter and Pamminger (2010) <doi:10.1214/10-BA606>.

Bayesian and ML Emax model fitting, graphics and simulation for clinical dose response. The summary data from the dose response meta-analyses in Thomas, Sweeney, and Somayaji (2014) <doi:10.1080/19466315.2014.924876> and Thomas and Roy (2016) <doi:10.1080/19466315.2016.1256229> Wu, Banerjee, Jin, Menon, Martin, and Heatherington(2017) <doi:10.1177/0962280216684528> are included in the package. The prior distributions for the Bayesian analyses default to the posterior predictive distributions derived from these references.

CliFlo is a web portal to the New Zealand National Climate Database and provides public access (via subscription) to around 6,500 various climate stations (see <https://cliflo.niwa.co.nz/> for more information). Collating and manipulating data from CliFlo (hence clifro) and importing into R for further analysis, exploration and visualisation is now straightforward and coherent. The user is required to have an internet connection, and a current CliFlo subscription (free) if data from stations, other than the public Reefton electronic weather station, is sought.

This package provides functions for calculating clinical significance.

Every research team have their own script for calculation of hemodynamic indexes. This package makes it possible to insert a long-format dataframe, and add both periods of interest (trigger-periods), and delete artifacts with deleter-files.

Utilities to make your clinical collaborations easier if not fun. It contains functions for designing studies such as Simon 2-stage and group sequential designs and for data analysis such as Jonckheere-Terpstra test and estimating survival quantiles.

This package contains functions to detect and visualise periods of climate sensitivity (climate windows) for a given biological response. Please see van de Pol et al. (2016) <doi:10.1111/2041-210X.12590> and Bailey and van de Pol (2016) <doi:10.1371/journal.pone.0167980> for details.

The primary motivation of this package is to take the things that are great about the R packages flextable <https://davidgohel.github.io/flextable/> and officer <https://davidgohel.github.io/officer/>, take the standard and complex pieces of formatting clinical tables for regulatory use, and simplify the tedious pieces.

This package provides methods for the nalysis of data from clinical proteomic profiling studies. The focus is on the studies of human subjects, which are often observational case-control by design and have technical replicates. A method for sample size determination for planning these studies is proposed. It incorporates routines for adjusting for the expected heterogeneities and imbalances in the data and the within-sample replicate correlations.

Automatize downloading of meteorological and hydrological data from publicly available repositories: OGIMET (<http://ogimet.com/index.phtml.en>), University of Wyoming - atmospheric vertical profiling data (<http://weather.uwyo.edu/upperair/>), Polish Institute of Meteorology and Water Management - National Research Institute (<https://danepubliczne.imgw.pl>), and National Oceanic & Atmospheric Administration (NOAA). This package also allows for searching geographical coordinates for each observation and calculate distances to the nearest stations.

This package implements topological gene set analysis using a two-step empirical approach. It exploits graph decomposition theory to create a junction tree and reconstruct the most relevant signal path. In the first step clipper selects significant pathways according to statistical tests on the means and the concentration matrices of the graphs derived from pathway topologies. Then, it "clips" the whole pathway identifying the signal paths having the greatest association with a specific phenotype.

Computes 138 standard climate indices at monthly, seasonal and annual resolution. These indices were selected, based on their direct and significant impacts on target sectors, after a thorough review of the literature in the field of extreme weather events and natural hazards. Overall, the selected indices characterize different aspects of the frequency, intensity and duration of extreme events, and are derived from a broad set of climatic variables, including surface air temperature, precipitation, relative humidity, wind speed, cloudiness, solar radiation, and snow cover. The 138 indices have been classified as follow: Temperature based indices (42), Precipitation based indices (22), Bioclimatic indices (21), Wind-based indices (5), Aridity/ continentality indices (10), Snow-based indices (13), Cloud/radiation based indices (6), Drought indices (8), Fire indices (5), Tourism indices (5).

This package provides a profile likelihood based method of estimation and inference on the correlation coefficient of bivariate data with different types of censoring and missingness.

Implementation of Hurst exponent estimators based on complex-valued lifting wavelet energy from Knight, M. I and Nunes, M. A. (2018) <doi:10.1007/s11222-018-9820-8>.