This package provides support for linear order and unimodal order (univariate) isotonic regression and bivariate isotonic regression with linear order on both variables.

This package provides a bunch of functions to deal with circular data under order restrictions.

This package provides ISoLDE a new method for identifying imprinted genes. This method is dedicated to data arising from RNA sequencing technologies. The ISoLDE package implements original statistical methodology described in the publication below.

Clustering algorithm developed for use with plot inventories of species. It groups plots by subsets of diagnostic species rather than overall species composition. There is an unsupervised and a supervised mode, the latter accepting suggestions for species with greater weight and cluster medoids.

isobar provides methods for preprocessing, normalization, and report generation for the analysis of quantitative mass spectrometry proteomics data labeled with isobaric tags, such as iTRAQ and TMT. Features modules for integrating and validating PTM-centric datasets (isobar-PTM). More information on http://www.ms-isobar.org.

This package provides a set of functions to run simple and composite box-models to describe the dynamic or static distribution of stable isotopes in open or closed systems. The package also allows the sweeping of many parameters in both static and dynamic conditions. The mathematical models used in this package are derived from Albarede, 1995, Introduction to Geochemical Modelling, Cambridge University Press, Cambridge <doi:10.1017/CBO9780511622960>.

This package is for building isoscapes using mixed models and inferring the geographic origin of samples based on their isotopic ratios. This package is essentially a simplified interface to several other packages which implements a new statistical framework based on mixed models. It uses spaMM for fitting and predicting isoscapes, and assigning an organism's origin depending on its isotopic ratio. IsoriX also relies heavily on the package rasterVis for plotting the maps produced with terra using lattice'.

This resource provides tools to create, compare, and post-process spatial isotope assignment models of animal origin. It generates probability-of-origin maps for individuals based on user-provided tissue and environment isotope values (e.g., as generated by IsoMAP, Bowen et al. [2013] <doi:10.1111/2041-210X.12147>) using the framework established in Bowen et al. (2010) <doi:10.1146/annurev-earth-040809-152429>). The package isocat can then quantitatively compare and cluster these maps to group individuals by similar origin. It also includes techniques for applying four approaches (cumulative sum, odds ratio, quantile only, and quantile simulation) with which users can summarize geographic origins and probable distance traveled by individuals. Campbell et al. [2020] establishes several of the functions included in this package <doi:10.1515/ami-2020-0004>.

Analyzing Inductively Coupled Plasma - Mass Spectrometry (ICP-MS) measurement data to evaluate isotope ratios (IRs) is a complex process. The IsoCor package facilitates this process and renders it reproducible by providing a function to run a Shiny'-App locally in any web browser. In this App the user can upload data files of various formats, select ion traces, apply peak detection and perform calculation of IRs and delta values. Results are provided as figures and tables and can be exported. The App, therefore, facilitates data processing of ICP-MS experiments to quickly obtain optimal processing parameters compared to traditional Excel worksheet based approaches. A more detailed description can be found in the corresponding article <doi:10.1039/D2JA00208F>. The most recent version of IsoCor can be tested online at <https://apps.bam.de/shn00/IsoCor/>.

Nonparametric estimation on survival analysis under order-restrictions.

Characterization of miRNAs and isomiRs, clustering and differential expression.

Read and process isotopocule data from an Orbitrap Isotope Solutions mass spectrometer. Citation: Kantnerova et al. (Nature Protocols, 2024).

This package provides a fast C++ implementation to generate contour lines (isolines) and contour polygons (isobands) from regularly spaced grids containing elevation data.

API wrapper that contains functions to retrieve data from the IsoMemo partnership databases. Web services for API: <https://isomemodb.com/api/v1/iso-data>.

This package provides functions to parse strings with ISO8601 dates, times, and date-times into R-objects. Additionally, there are functions to determine the type of ISO8601 string and to standardise ISO8601 strings.

This is an substitute for the %V and %u formats which are not implemented on Windows. In addition, the package offers functions to convert from standard calender format yyyy-mm-dd to and from ISO 8601 week format yyyy-Www-d.

This package contains two main functions: one for solving general isotone regression problems using the pool-adjacent-violators algorithm (PAVA); another one provides a framework for active set methods for isotone optimization problems with arbitrary order restrictions. Various types of loss functions are prespecified.

Fast and multi-threaded implementation of isolation forest (Liu, Ting, Zhou (2008) <doi:10.1109/ICDM.2008.17>), extended isolation forest (Hariri, Kind, Brunner (2018) <doi:10.48550/arXiv.1811.02141>), SCiForest (Liu, Ting, Zhou (2010) <doi:10.1007/978-3-642-15883-4_18>), fair-cut forest (Cortes (2021) <doi:10.48550/arXiv.2110.13402>), robust random-cut forest (Guha, Mishra, Roy, Schrijvers (2016) <http://proceedings.mlr.press/v48/guha16.html>), and customizable variations of them, for isolation-based outlier detection, clustered outlier detection, distance or similarity approximation (Cortes (2019) <doi:10.48550/arXiv.1910.12362>), isolation kernel calculation (Ting, Zhu, Zhou (2018) <doi:10.1145/3219819.3219990>), and imputation of missing values (Cortes (2019) <doi:10.48550/arXiv.1911.06646>), based on random or guided decision tree splitting, and providing different metrics for scoring anomalies based on isolation depth or density (Cortes (2021) <doi:10.48550/arXiv.2111.11639>). Provides simple heuristics for fitting the model to categorical columns and handling missing data, and offers options for varying between random and guided splits, and for using different splitting criteria.

Deconvolution of mixed tumour profiles into normal and cancer for each patient, using the ISOpure algorithm in Quon et al. Genome Medicine, 2013 5:29. Deconvolution requires mixed tumour profiles and a set of unmatched "basis" normal profiles.

In classification problems a monotone relation between some predictors and the classes may be assumed. In this package isoboost we propose new boosting algorithms, based on LogitBoost, that incorporate this isotonicity information, yielding more accurate and easily interpretable rules.

Perform common calculations based on published stable isotope theory, such as calculating carbon isotope discrimination and intrinsic water use efficiency from wood or leaf carbon isotope composition. See Mathias and Hudiburg (2022) in Global Change Biology <doi:10.1111/gcb.16407>.

This package contains functions to check the isomorphism of multi-stage factorial designs with randomisation restrictions based on balanced spreads and balanced covering stars of PG(n-1,2) as described in Spencer, Ranjan and Mendivil (2019) <doi:10.1007/s42519-019-0064-5>.

This package provides ISO language, territory, currency, script and character codes. It provides ISO 639 language codes, ISO 3166 territory codes, ISO 4217 currency codes, ISO 15924 script codes, and the ISO 8859 character codes as well as the UN M.49 area codes.

The wiDB...() functions provide an interface to the public API of the wiDB <https://github.com/SPATIAL-Lab/isoWater/blob/master/Protocol.md>: build, check and submit queries, and receive and unpack responses. Data analysis functions support Bayesian inference of the source and source isotope composition of water samples that may have experienced evaporation. Algorithms adapted from Bowen et al. (2018, <doi:10.1007/s00442-018-4192-5>).