Electronic health records (EHR) linked with biorepositories are a powerful platform for translational studies. A major bottleneck exists in the ability to phenotype patients accurately and efficiently. Towards that end, we developed an automated high-throughput phenotyping method integrating International Classification of Diseases (ICD) codes and narrative data extracted using natural language processing (NLP). Specifically, our proposed method, called MAP (Map Automated Phenotyping algorithm), fits an ensemble of latent mixture models on aggregated ICD and NLP counts along with healthcare utilization. The MAP algorithm yields a predicted probability of phenotype for each patient and a threshold for classifying subjects with phenotype yes/no (See Katherine P. Liao, et al. (2019) <doi:10.1093/jamia/ocz066>.).

This package provides an R module for display of maps. Projection code and larger maps are in separate packages (mapproj and mapdata).

Mapping Averaged Pairwise Information (MAPI) is an exploratory method providing graphical representations summarizing the spatial variation of pairwise metrics (eg. distance, similarity coefficient, ...) computed between georeferenced samples.

This package provides functions and wrappers for using the Multiple Aggregation Prediction Algorithm (MAPA) for time series forecasting. MAPA models and forecasts time series at multiple temporal aggregation levels, thus strengthening and attenuating the various time series components for better holistic estimation of its structure. For details see Kourentzes et al. (2014) <doi:10.1016/j.ijforecast.2013.09.006>.

This package provides one function, which is a wrapper around purrr::map() with some extras on top, including parallel computation, progress bars, error handling, and result caching.

Create and integrate thematic maps in your workflow. This package helps to design various cartographic representations such as proportional symbols, choropleth or typology maps. It also offers several functions to display layout elements that improve the graphic presentation of maps (e.g. scale bar, north arrow, title, labels). mapsf maps sf objects on base graphics.

This package provides an interface to the Mapbox GL JS (<https://docs.mapbox.com/mapbox-gl-js/guides>) and the MapLibre GL JS (<https://maplibre.org/maplibre-gl-js/docs/>) interactive mapping libraries to help users create custom interactive maps in R. Users can create interactive globe visualizations; layer sf objects to create filled maps, circle maps, heatmaps', and three-dimensional graphics; and customize map styles and views. The package also includes utilities to use Mapbox and MapLibre maps in Shiny web applications.

MAPFX is an end-to-end toolbox that pre-processes the raw data from MPC experiments (e.g., BioLegend's LEGENDScreen and BD Lyoplates assays), and further imputes the ‘missing’ infinity markers in the wells without those measurements. The pipeline starts by performing background correction on raw intensities to remove the noise from electronic baseline restoration and fluorescence compensation by adapting a normal-exponential convolution model. Unwanted technical variation, from sources such as well effects, is then removed using a log-normal model with plate, column, and row factors, after which infinity markers are imputed using the informative backbone markers as predictors. The completed dataset can then be used for clustering and other statistical analyses. Additionally, MAPFX can be used to normalise data from FFC assays as well.

This package provides a variety of functions that make it easy to plot standard choropleth maps as well as choropleth alternatives in ggplot2'.

Regularly spaced grids containing continuous data are transformed to contour polygons. A grid can be defined by a data.frame (x, y, value), an sf object or a raster from terra'.

Topological data analysis (TDA) is a method of data analysis that uses techniques from topology to analyze high-dimensional data. Here we implement Mapper, an algorithm from this area developed by Singh, Mémoli and Carlsson (2007) which generalizes the concept of a Reeb graph <https://en.wikipedia.org/wiki/Reeb_graph>.

Maximum a posteriori (MAP) estimation for topic models (i.e., Latent Dirichlet Allocation) in text analysis, as described in Taddy (2012) On estimation and selection for topic models'. Previous versions of this code were included as part of the textir package. If you want to take advantage of openmp parallelization, uncomment the relevant flags in src/MAKEVARS before compiling.

Estimation methods for phase-type distribution (PH) and Markovian arrival process (MAP) from empirical data (point and grouped data) and density function. The tool is based on the following researches: Okamura et al. (2009) <doi:10.1109/TNET.2008.2008750>, Okamura and Dohi (2009) <doi:10.1109/QEST.2009.28>, Okamura et al. (2011) <doi:10.1016/j.peva.2011.04.001>, Okamura et al. (2013) <doi:10.1002/asmb.1919>, Horvath and Okamura (2013) <doi:10.1007/978-3-642-40725-3_10>, Okamura and Dohi (2016) <doi:10.15807/jorsj.59.72>.

This package provides a genetic analysis tool and variance component model for identifying marginal epistasis between pathways and the rest of the genome. MAPITR uses as input a matrix of genotypes, a vector of phenotypes, and a list of pathways. MAPITR then iteratively tests each pathway for epistasis between any variants within the pathway versus any variants remaining in the rest of the genome. MAPITR returns results in the form of p-values for every pathway indicating whether the null model of there being no epistatic interactions between a pathway and the rest of the genome can be rejected.

This package contains functions for mapping odds ratios, hazard ratios, or other effect estimates using individual-level data such as case-control study data, using generalized additive models (GAMs) or Cox models for smoothing with a two-dimensional predictor (e.g., geolocation or exposure to chemical mixtures) while adjusting linearly for confounding variables, using methods described by Kelsall and Diggle (1998), Webster at al. (2006), and Bai et al. (2020). Includes convenient functions for mapping point estimates and confidence intervals, efficient control sampling, and permutation tests for the null hypothesis that the two-dimensional predictor is not associated with the outcome variable (adjusting for confounders).

This package converts latitude/longitude into projected coordinates.

Suite of interactive functions and helpers for selecting and editing geospatial data.

This is a supplement to the maps package providing the larger and/or higher-resolution databases.

This package provides a set of functions with example data for graphing, pruning, and mapping models. These models are from hierarchical clustering, and classification and regression trees.

This package provides a minimal, light-weight set of tools for producing nice looking maps in R, with support for map projections. See Brown (2016) <doi:10.32614/RJ-2016-005>.

Quickly and conveniently create interactive visualisations of spatial data with or without background maps. Attributes of displayed features are fully queryable via pop-up windows. Additional functionality includes methods to visualise true- and false-color raster images and bounding boxes.

This package provides a mechanism to plot an interactive map using Mapbox GL (<https://docs.mapbox.com/mapbox-gl-js/api/>), a javascript library for interactive maps, and Deck.gl (<https://deck.gl/>), a javascript library which uses WebGL for visualising large data sets.

This package performs maximum a posteriori Bayesian estimation of individual pharmacokinetic parameters from a model defined in mrgsolve', typically for model-based therapeutic drug monitoring. Internally computes an objective function value from model and data, performs optimization and returns predictions in a convenient format. The performance of the package was described by Le Louedec et al (2021) <doi:10.1002/psp4.12689>.

Interface to the Google Maps APIs: (1) routing directions based on the Directions API, returned as sf objects, either as single feature per alternative route, or a single feature per segment per alternative route; (2) travel distance or time matrices based on the Distance Matrix API; (3) geocoded locations based on the Geocode API, returned as sf objects, either points or bounds; (4) map images using the Maps Static API, returned as stars objects.