R functions for the estimation and eigen-decomposition of multivariate autoregressive models.

Likelihood inference based on higher order approximations for linear nonnormal regression models.

Miscellaneous functions and wrappers for development in other packages created, maintained by Jordan Mark Barbone.

Includes functions for conducting univariate and multivariate meta-analysis. This includes the estimation of the asymptotic variance-covariance matrix of effect sizes. For more details see Becker (1992) <doi:10.2307/1165128>, Cooper, Hedges, and Valentine (2019) <doi:10.7758/9781610448864>, and Schmid, Stijnen, and White (2020) <doi:10.1201/9781315119403>.

marr (Maximum Rank Reproducibility) is a nonparametric approach that detects reproducible signals using a maximal rank statistic for high-dimensional biological data. In this R package, we implement functions that measures the reproducibility of features per sample pair and sample pairs per feature in high-dimensional biological replicate experiments. The user-friendly plot functions in this package also plot histograms of the reproducibility of features per sample pair and sample pairs per feature. Furthermore, our approach also allows the users to select optimal filtering threshold values for the identification of reproducible features and sample pairs based on output visualization checks (histograms). This package also provides the subset of data filtered by reproducible features and/or sample pairs.

Computation of various Markovian models for categorical data including homogeneous Markov chains of any order, MTD models, Hidden Markov models, and Double Chain Markov Models.

Multiplicative AR(1) with Seasonal is a stochastic process model built on top of AR(1). The package provides the following procedures for MAR(1)S processes: fit, compose, decompose, advanced simulate and predict.

The MARSS package provides maximum-likelihood parameter estimation for constrained and unconstrained linear multivariate autoregressive state-space (MARSS) models, including partially deterministic models. MARSS models are a class of dynamic linear model (DLM) and vector autoregressive model (VAR) model. Fitting available via Expectation-Maximization (EM), BFGS (using optim), and TMB (using the marssTMB companion package). Functions are provided for parametric and innovations bootstrapping, Kalman filtering and smoothing, model selection criteria including bootstrap AICb, confidences intervals via the Hessian approximation or bootstrapping, and all conditional residual types. See the user guide for examples of dynamic factor analysis, dynamic linear models, outlier and shock detection, and multivariate AR-p models. Online workshops (lectures, eBook, and computer labs) at <https://atsa-es.github.io/>.

Multivariate ARIMA and ARIMA-X estimation using Spliid's algorithm (marima()) and simulation (marima.sim()).

This package contains class definitions for two-color spotted microarray data. It also includes functions for data input, diagnostic plots, normalization and quality checking.

Alternative splicing represents an additional and underappreciated layer of complexity underlying gene expression profiles. Nevertheless, there remains hitherto a paucity of software to investigate splicing dynamics at single-cell resolution. MARVEL enables splicing analysis of single-cell RNA-sequencing data generated from plate- and droplet-based library preparation methods.

Supports visual interpretation of hierarchical composite endpoints (HCEs). HCEs are complex constructs used as primary endpoints in clinical trials, combining outcomes of different types into ordinal endpoints, in which each patient contributes the most clinically important event (one and only one) to the analysis. See Karpefors M et al. (2022) <doi:10.1177/17407745221134949>.

Import xyz data from the NOAA (National Oceanic and Atmospheric Administration, <https://www.noaa.gov>), GEBCO (General Bathymetric Chart of the Oceans, <https://www.gebco.net>) and other sources, plot xyz data to prepare publication-ready figures, analyze xyz data to extract transects, get depth / altitude based on geographical coordinates, or calculate z-constrained least-cost paths.

This package provides a way to estimate and test marginal mediation effects for zero-inflated compositional mediators. Estimates of Natural Indirect Effect (NIE), Natural Direct Effect (NDE) of each taxon, as well as their standard errors and confident intervals, were provided as outputs. Zeros will not be imputed during analysis. See Wu et al. (2022) <doi:10.3390/genes13061049>.

It contains the function to apply MARMoT balancing technique discussed in: Silan, Boccuzzo, Arpino (2021) <DOI:10.1002/sim.9192>, Silan, Belloni, Boccuzzo, (2023) <DOI:10.1007/s10260-023-00695-0>; furthermore it contains a function for computing the Deloof's approximation of the average rank (and also a parallelized version) and a function to compute the Absolute Standardized Bias.

This package provides functions for fitting various models to capture-recapture data including mixed-effects Cormack-Jolly-Seber(CJS) and multistate models and the multi-variate state model structure for survival estimation and POPAN structured Jolly-Seber models for abundance estimation. There are also Hidden Markov model (HMM) implementations of CJS and multistate models with and without state uncertainty and a simulation capability for HMM models.

Estimation of marginal hazard ratios in clustered failure time data. It implements the weighted generalized estimating equation approach based on a semiparametric marginal proportional hazards model (See Niu, Y. Peng, Y.(2015). "A new estimating equation approach for marginal hazard ratio estimation"), accounting for within-cluster correlations. 5 different correlation structures are supported. The package is designed for researchers in biostatistics and epidemiology who require accurate and efficient estimation methods for survival analysis in clustered data settings.

Recently, multiple marginal variable selection methods have been developed and shown to be effective in Gene-Environment interactions studies. We propose a novel marginal Bayesian variable selection method for Gene-Environment interactions studies. In particular, our marginal Bayesian method is robust to data contamination and outliers in the outcome variables. With the incorporation of spike-and-slab priors, we have implemented the Gibbs sampler based on Markov Chain Monte Carlo. The core algorithms of the package have been developed in C++'.

This package provides functions of marginal mean and quantile regression models are used to analyze environmental exposure and biomonitoring data with repeated measurements and non-detects (i.e., values below the limit of detection (LOD)), as well as longitudinal exposure data that include non-detects and time-dependent covariates. For more details see Chen IC, Bertke SJ, Curwin BD (2021) <doi:10.1038/s41370-021-00345-1>, Chen IC, Bertke SJ, Estill CF (2024) <doi:10.1038/s41370-024-00640-7>, Chen IC, Bertke SJ, Dahm MM (2024) <doi:10.1093/annweh/wxae068>, and Chen IC (2025) <doi:10.1038/s41370-025-00752-8>.

An R port of the margins command from Stata', which can be used to calculate marginal (or partial) effects from model objects.

This package provides the mean to parse and render markdown text with grid along with facilities to define the styling of the text.

This package provides tools for manipulating paired ranges and working with Hi-C data in R. Functionality includes manipulating/merging paired regions, generating paired ranges, extracting/aggregating interactions from `.hic` files, and visualizing the results. Designed for compatibility with plotgardener for visualization.

Facilitates tidy calculation of popular quantitative marketing metrics. It also includes functions for doing analysis that will help marketers and data analysts better understand the drivers and/or trends of these metrics. These metrics include Customer Experience Index <https://go.forrester.com/analytics/cx-index/> and Net Promoter Score <https://www.netpromoter.com/know/>.

Analyzing longitudinal clinical data from Electronic Health Records (EHRs) using linear mixed models (LMM) and visualizing the results as networks. It includes functions for fitting LMM, normalizing adjacency matrices, and comparing networks. The package is designed for researchers in clinical and biomedical fields who need to model longitudinal data and explore relationships between variables For more details see Bates et al. (2015) <doi:10.18637/jss.v067.i01>.