Estimation of pharmacokinetic parameters using non-compartmental theory.

This is a package containing Public Key Infrastructure functions such as verifying certificates, RSA encryption and signing, which can be used to build PKI infrastructure and perform cryptographic tasks.

Fitting and testing probabilistic knowledge structures, especially the basic local independence model (BLIM, Doignon & Flamagne, 1999) and the simple learning model (SLM), using the minimum discrepancy maximum likelihood (MDML) method (Heller & Wickelmaier, 2013 <doi:10.1016/j.endm.2013.05.145>).

Conduct a noncompartmental analysis as closely as possible to the most widely used commercial software. Some features are 1) CDISC SDTM terms 2) Automatic slope selection with the same criterion of WinNonlin(R) 3) Supporting both linear-up linear-down and linear-up log-down method 4) Interval(partial) AUCs with linear or log interpolation method * Reference: Gabrielsson J, Weiner D. Pharmacokinetic and Pharmacodynamic Data Analysis - Concepts and Applications. 5th ed. 2016. (ISBN:9198299107).

Compute standard Non-Compartmental Analysis (NCA) parameters for typical pharmacokinetic analyses and summarize them.

We implement two least-squares estimators under k-monotony constraint using a method based on the Support Reduction Algorithm from Groeneboom et al (2008) <DOI:10.1111/j.1467-9469.2007.00588.x>. The first one is a projection estimator on the set of k-monotone discrete functions. The second one is a projection on the set of k-monotone discrete probabilities. This package provides functions to generate samples from the spline basis from Lefevre and Loisel (2013) <DOI:10.1239/jap/1378401239>, and from mixtures of splines.

This package provides a tool for inferring kinase activity changes from phosphoproteomics data. pKSEA uses kinase-substrate prediction scores to weight observed changes in phosphopeptide abundance to calculate a phosphopeptide-level contribution score, then sums up these contribution scores by kinase to obtain a phosphoproteome-level kinase activity change score (KAC score). pKSEA then assesses the significance of changes in predicted substrate abundances for each kinase using permutation testing. This results in a permutation score (pKSEA significance score) reflecting the likelihood of a similarly high or low KAC from random chance, which can then be interpreted in an analogous manner to an empirically calculated p-value. pKSEA contains default databases of kinase-substrate predictions from NetworKIN (NetworKINPred_db) <http://networkin.info> Horn, et. al (2014) <doi:10.1038/nmeth.2968> and of known kinase-substrate links from PhosphoSitePlus (KSEAdb) <https://www.phosphosite.org/> Hornbeck PV, et. al (2015) <doi:10.1093/nar/gku1267>.

Prepare pharmacokinetic/pharmacodynamic (PK/PD) data for PK/PD analyses. This package provides functions to standardize infusion and bolus dose data while linking it to drug level or concentration data.

This package provides tools from the domain of graph theory can be used to quantify the complexity and vulnerability to failure of a software package. That is the guiding philosophy of this package. pkgnet provides tools to analyze the dependencies between functions in an R package and between its imported packages. See the pkgnet website for vignettes and other supplementary information.

Calculate and compare the prediction probability (PK) values for Anesthetic Depth Indicators. The PK values are widely used for measuring the performance of anesthetic depth and were first proposed by the group of Dr. Warren D. Smith in the paper Warren D. Smith; Robert C. Dutton; Ty N. Smith (1996) <doi:10.1097/00000542-199601000-00005> and Warren D. Smith; Robert C. Dutton; Ty N. Smith (1996) <doi:10.1002/(SICI)1097-0258(19960615)15:11%3C1199::AID-SIM218%3E3.0.CO;2-Y>. The authors provided two Microsoft Excel files in xls format for calculating and comparing PK values. This package provides an easy-to-use API for calculating and comparing PK values in R.

Read R package news files, regardless of whether or not the package is installed.

This provides utilities for creating classed error and warning conditions based on where the error originated.

Statically determine and visualize the function dependencies within and across packages. This may be useful for managing function dependencies across a code base of multiple R packages.

This package simulates the process of installing a package and then attaching it. This is a key part of the devtools package as it allows you to rapidly iterate while developing a package.

Simulate dose regimens for pharmacokinetic-pharmacodynamic (PK-PD) models described by differential equation (DE) systems. Simulation using ADVAN-style analytical equations is also supported (Abuhelwa et al. (2015) <doi:10.1016/j.vascn.2015.03.004>).

This package provides a tool, grammar, and standard to represent and exchange R package source code as text files. Converts one or more source packages to a text file and restores the package structures from the file.

The goal of this package is to generate an attractive and useful website from a source package. pkgdown converts your documentation, vignettes, README file, and more to HTML making it easy to share information about your package online.

Identifies differences between versions of a package. Specifically, the functions help determine if there are breaking changes from one package version to the next. The package also includes a stability assessment, to help you determine the overall stability of a package, or even an entire repository.

Applying the global sensitivity analysis workflow to investigate the parameter uncertainty and sensitivity in physiologically based kinetic (PK) models, especially the physiologically based pharmacokinetic/toxicokinetic model with multivariate outputs. The package also provides some functions to check the convergence and sensitivity of model parameters. The workflow was first mentioned in Hsieh et al., (2018) <doi:10.3389/fphar.2018.00588>, then further refined (Hsieh et al., 2020 <doi:10.1016/j.softx.2020.100609>).

This package provides a new metric named dependency heaviness is proposed that measures the number of additional dependency packages that a parent package brings to its child package and are unique to the dependency packages imported by all other parents. The dependency heaviness analysis is visualized by a customized heatmap. The package is described in <doi:10.1093/bioinformatics/btac449>. We have also performed the dependency heaviness analysis on the CRAN/Bioconductor package ecosystem and the results are implemented as a web-based database which provides comprehensive tools for querying dependencies of individual R packages. The systematic analysis on the CRAN/Bioconductor ecosystem is described in <doi:10.1016/j.jss.2023.111610>. From pkgndep version 2.0.0, the heaviness database includes snapshots of the CRAN/Bioconductor ecosystems for many old R versions.

Metadata and package cache for CRAN-like repositories. This is a utility package to be used by package management tools that want to take advantage of caching.

Implementation of a KL-based (Kullback-Leibler) test for MCAR (Missing Completely At Random) in the context of missing data as introduced in Michel et al. (2021) <arXiv:2109.10150>.

This package provides some low-level utilities to use for R package development. It currently provides managers for multiple package specific options and registries, vignette, unit test and bibtex related utilities.

This package provides functions used to build R packages. It locates compilers needed to build R packages on various platforms and ensures the PATH is configured appropriately so R can use them.