Perform multivariate modeling of evolved traits, with special attention to understanding the interplay of the multi-factorial determinants of their origins in complex ecological settings (Stephens, 2007 <doi:10.1016/j.tree.2006.12.003>). This software primarily concentrates on phylogenetic regression analysis, enabling implementation of tree transformation averaging and visualization functionality. Functions additionally support information theoretic approaches (Grueber, 2011 <doi:10.1111/j.1420-9101.2010.02210.x>; Garamszegi, 2011 <doi:10.1007/s00265-010-1028-7>) such as model averaging and selection of phylogenetic models. Accessory functions are also implemented for coef standardization (Cade 2015), selection uncertainty, and variable importance (Burnham & Anderson 2000). There are other numerous functions for visualizing confounded variables, plotting phylogenetic trees, as well as reporting and exporting modeling results. Lastly, as challenges to ecology are inherently multifarious, and therefore often multi-dataset, this package features several functions to support the identification, interpolation, merging, and updating of missing data and outdated nomenclature.

This package provides tools for the analysis of population differences using the Major Histocompatibility Complex (MHC) genotypes of samples having a variable number of alleles (1-4) recorded for each individual. A hierarchical Dirichlet-Multinomial model on the genotype counts is used to pool small samples from multiple populations for pairwise tests of equality. Bayesian inference is implemented via the rstan package. Bootstrapped and posterior p-values are provided for chi-squared and likelihood ratio tests of equal genotype probabilities.

This package provides a sample size calculator for micro-randomized trials (MRTs) with binary outcomes based on Cohn et al. (2023) <doi:10.1002/sim.9748>. Also provides a power calculator when the sample size is input by the user.

Multi-criteria design of experiments algorithm that simultaneously optimizes up to six different criteria ('I', Id', D', Ds', A and As'). The algorithm finds the optimal Pareto front and, if requested, selects a possible symmetrical design on it. The symmetrical design is selected based on two techniques: minimum distance with the Utopia point or the TOPSIS approach.

Code to support a systems biology research program from inception through publication. The methods focus on dimension reduction approaches to detect patterns in complex, multivariate experimental data and places an emphasis on informative visualizations. The goal for this project is to create a package that will evolve over time, thereby remaining relevant and reflective of current methods and techniques. As a result, we encourage suggested additions to the package, both methodological and graphical.

This package provides a flexible framework for estimating the variance-covariance matrix of estimated parameters. Estimation relies on unbiased estimating functions to compute the empirical sandwich variance. (i.e., M-estimation in the vein of Tsiatis et al. (2019) <doi:10.1201/9780429192692>.

The tools for MicroRNA Set Enrichment Analysis can identify risk pathways(or prior gene sets) regulated by microRNA set in the context of microRNA expression data. (1) This package constructs a correlation profile of microRNA and pathways by the hypergeometric statistic test. The gene sets of pathways derived from the three public databases (Kyoto Encyclopedia of Genes and Genomes ('KEGG'); Reactome'; Biocarta') and the target gene sets of microRNA are provided by four databases('TarBaseV6.0'; mir2Disease'; miRecords'; miRTarBase';). (2) This package can quantify the change of correlation between microRNA for each pathway(or prior gene set) based on a microRNA expression data with cases and controls. (3) This package uses the weighted Kolmogorov-Smirnov statistic to calculate an enrichment score (ES) of a microRNA set that co-regulate to a pathway , which reflects the degree to which a given pathway is associated with the specific phenotype. (4) This package can provide the visualization of the results.

The inference in multi-state models is traditionally performed under a Markov assumption that claims that past and future of the process are independent given the present state. In this package, we consider tests of the Markov assumption that are applicable to general multi-state models. Three approaches using existing methodology are considered: a simple method based on including covariates depending on the history in Cox models for the transition intensities; methods based on measuring the discrepancy of the non-Markov estimators of the transition probabilities to the Markov Aalen-Johansen estimators; and, finally, methods that were developed by considering summaries from families of log-rank statistics where patients are grouped by the state occupied of the process at a particular time point (see Soutinho G, Meira-Machado L (2021) <doi:10.1007/s00180-021-01139-7> and Titman AC, Putter H (2020) <doi:10.1093/biostatistics/kxaa030>).

This package provides comprehensive tools to scrape and analyze data from the MDPI journals. It allows users to extract metrics such as submission-to-acceptance times, article types, and whether articles are part of special issues. The package can also visualize this information through plots. Additionally, MDPIexploreR offers tools to explore patterns of self-citations within articles and provides insights into guest-edited special issues.

This package provides flexible dictionary-based cleaning that allows users to specify implicit and explicit missing data, regular expressions for both data and columns, and global matches, while respecting ordering of factors. This package is part of the RECON (<https://www.repidemicsconsortium.org/>) toolkit for outbreak analysis.

This package provides functions to interpolate irregularly and regularly spaced data using Multilevel B-spline Approximation (MBA). Functions call portions of the SINTEF Multilevel B-spline Library written by à yvind Hjelle which implements methods developed by Lee, Wolberg and Shin (1997; <doi:10.1109/2945.620490>).

Software to aid in modeling and analyzing mass-spectrometry-based proteome melting data. Quantitative data is imported and normalized and thermal behavior is modeled at the protein level. Methods exist for normalization, modeling, visualization, and export of results. For a general introduction to MS-based thermal profiling, see Savitski et al. (2014) <doi:10.1126/science.1255784>.

This package provides utilities for estimation for the multivariate inverse Gaussian distribution of Minami (2003) <doi:10.1081/STA-120025379>, including random vector generation and explicit estimators of the location vector and scale matrix. The package implements kernel density estimators discussed in Belzile, Desgagnes, Genest and Ouimet (2024) <doi:10.48550/arXiv.2209.04757> for smoothing multivariate data on half-spaces.

Logistic-normal Multinomial (LNM) models are common in problems with multivariate count data. This package gives a simple implementation with a 30 line Stan script. This lightweight implementation makes it an easy starting point for other projects, in particular for downstream tasks that require analysis of "compositional" data. It can be applied whenever a multinomial probability parameter is thought to depend linearly on inputs in a transformed, log ratio space. Additional utilities make it easy to inspect, create predictions, and draw samples using the fitted models. More about the LNM can be found in Xia et al. (2013) "A Logistic Normal Multinomial Regression Model for Microbiome Compositional Data Analysis" <doi:10.1111/biom.12079> and Sankaran and Holmes (2023) "Generative Models: An Interdisciplinary Perspective" <doi:10.1146/annurev-statistics-033121-110134>.

This package provides functions for creating designs for mixture experiments, making ternary contour plots, and making mixture effect plots.

This package provides methods for estimating and utilizing the multivariate generalized propensity score (mvGPS) for multiple continuous exposures described in Williams, J.R, and Crespi, C.M. (2020) <arxiv:2008.13767>. The methods allow estimation of a dose-response surface relating the joint distribution of multiple continuous exposure variables to an outcome. Weights are constructed assuming a multivariate normal density for the marginal and conditional distribution of exposures given a set of confounders. Confounders can be different for different exposure variables. The weights are designed to achieve balance across all exposure dimensions and can be used to estimate dose-response surfaces.

Implementation of Warnes & Raftery's MCGibbsit run-length and convergence diagnostic for a set of (not-necessarily independent) Markov Chain Monte Carlo (MCMC) samplers. It combines the quantile estimate error-bounding approach of the Raftery and Lewis MCMC run length diagnostic `gibbsit` with the between verses within chain approach of the Gelman and Rubin MCMC convergence diagnostic.

The chi-squared test for goodness of fit and independence test.

Magic functions to obtain results from for loops.

Implementation of Matched Wake Analysis (mwa) for studying causal relationships in spatiotemporal event data, introduced by Schutte and Donnay (2014) <doi:10.1016/j.polgeo.2014.03.001>.

This package provides functions to impute missing values using Gaussian copulas for mixed data types as described by Christoffersen et al. (2021) <arXiv:2102.02642>. The method is related to Hoff (2007) <doi:10.1214/07-AOAS107> and Zhao and Udell (2019) <arXiv:1910.12845> but differs by making a direct approximation of the log marginal likelihood using an extended version of the Fortran code created by Genz and Bretz (2002) <doi:10.1198/106186002394> in addition to also support multinomial variables.

This package provides tools for systematic comparison of data frames, offering functionality to identify, quantify, and extract differences. Provides functions with user-friendly and interactive console output for immediate analysis, while also offering options to export differences as structured data frames that can be easily integrated into existing workflows.

This package provides methods for detecting signals related to (adverse event, medical product e.g. drugs, vaccines) pairs, a data generation function for simulating pharmacovigilance datasets, and various utility functions. For more details please see Liu A., Mukhopadhyay R., and Markatou M. <doi:10.48550/arXiv.2410.01168>.

Electronic health records (EHR) linked with biorepositories are a powerful platform for translational studies. A major bottleneck exists in the ability to phenotype patients accurately and efficiently. Towards that end, we developed an automated high-throughput phenotyping method integrating International Classification of Diseases (ICD) codes and narrative data extracted using natural language processing (NLP). Specifically, our proposed method, called MAP (Map Automated Phenotyping algorithm), fits an ensemble of latent mixture models on aggregated ICD and NLP counts along with healthcare utilization. The MAP algorithm yields a predicted probability of phenotype for each patient and a threshold for classifying subjects with phenotype yes/no (See Katherine P. Liao, et al. (2019) <doi:10.1093/jamia/ocz066>.).