This package implements multi-factor curve analysis for grouped data in R', replicating and extending the functionality of the the Stata ado mfcurve (Krähmer, 2023) <https://ideas.repec.org/c/boc/bocode/s459224.html>. Related to the idea of specification curve analysis (Simonsohn, Simmons, and Nelson, 2020) <doi:10.1038/s41562-020-0912-z>. Includes data preprocessing, statistical testing, and visualization of results with confidence intervals.

Constructs genetic linkage maps in autopolyploid full-sib populations. Uses pairwise recombination fraction estimation as the first source of information to sequentially position allelic variants in specific homologous chromosomes. For situations where pairwise analysis has limited power, the algorithm relies on the multilocus likelihood obtained through a hidden Markov model (HMM). Methods are described in Mollinari and Garcia (2019) <doi:10.1534/g3.119.400378> and Mollinari et al. (2020) <doi:10.1534/g3.119.400620>.

Estimation of treatment hierarchies in network meta-analysis using a novel frequentist approach based on treatment choice criteria (TCC) and probabilistic ranking models, as described by Evrenoglou et al. (2024) <DOI:10.48550/arXiv.2406.10612>. The TCC are defined using a rule based on the smallest worthwhile difference (SWD). Using the defined TCC, the NMA estimates (i.e., treatment effects and standard errors) are first transformed into treatment preferences, indicating either a treatment preference (e.g., treatment A > treatment B) or a tie (treatment A = treatment B). These treatment preferences are then synthesized using a probabilistic ranking model, which estimates the latent ability parameter of each treatment and produces the final treatment hierarchy. This parameter represents each treatments ability to outperform all the other competing treatments in the network. Here the terms ability to outperform indicates the propensity of each treatment to yield clinically important and beneficial effects when compared to all the other treatments in the network. Consequently, larger ability estimates indicate higher positions in the ranking list.

Model stability and variable inclusion plots [Mueller and Welsh (2010, <doi:10.1111/j.1751-5823.2010.00108.x>); Murray, Heritier and Mueller (2013, <doi:10.1002/sim.5855>)] as well as the adaptive fence [Jiang et al. (2008, <doi:10.1214/07-AOS517>); Jiang et al. (2009, <doi:10.1016/j.spl.2008.10.014>)] for linear and generalised linear models.

This package provides a basic interface for accessing annotation data from the Multi-CAST collection, a database of spoken natural language texts edited by Geoffrey Haig and Stefan Schnell. The collection draws from a diverse set of languages and has been annotated across multiple levels. Annotation data is downloaded on request from the servers of the University of Bamberg. See the Multi-CAST website <https://multicast.aspra.uni-bamberg.de/> for more information and a list of related publications.

This package performs multiple empirical likelihood tests. It offers an easy-to-use interface and flexibility in specifying hypotheses and calibration methods, extending the framework to simultaneous inferences. The core computational routines are implemented using the Eigen C++ library and RcppEigen interface, with OpenMP for parallel computation. Details of the testing procedures are provided in Kim, MacEachern, and Peruggia (2023) <doi:10.1080/10485252.2023.2206919>. A companion paper by Kim, MacEachern, and Peruggia (2024) <doi:10.18637/jss.v108.i05> is available for further information. This work was supported by the U.S. National Science Foundation under Grants No. SES-1921523 and DMS-2015552.

Model evaluation based on a modified version of the recursive feature elimination algorithm. This package is designed to determine the optimal model(s) by leveraging all available features.

Enable operationalized evaluation of disease outcomes in multiple sclerosis. â MSoutcomesâ requires longitudinally recorded clinical data structured in long format. The package is based on the research developed at Clinical Outcomes Research unit (CORe), University of Melbourne and Neuroimmunology Centre, Royal Melbourne Hospital. Kalincik et al. (2015) <doi:10.1093/brain/awv258>. Lorscheider et al. (2016) <doi:10.1093/brain/aww173>. Sharmin et al. (2022) <doi:10.1111/ene.15406>. Dzau et al. (2023) <doi:10.1136/jnnp-2023-331748>.

Pipeline for Genome-Wide Association Study using Multi-Locus Mixed Model from Segura V, Vilhjálmsson BJ et al. (2012) <doi:10.1038/ng.2314>. The pipeline include detection of associated SNPs with MLMM, model selection by lowest eBIC and p-value threshold, estimation of the effects of the SNPs in the selected model and graphical functions.

Statistical framework for comparing sets of trees using hypothesis testing methods. Designed for transmission trees, phylogenetic trees, and directed acyclic graphs (DAGs), the package implements chi-squared tests to compare edge frequencies between sets and PERMANOVA to analyse topological dissimilarities with customisable distance metrics, following Anderson (2001) <doi:10.1111/j.1442-9993.2001.01070.pp.x>.

Hypothesis tests for multivariate data. Tests for one and two mean vectors, multivariate analysis of variance, tests for one, two or more covariance matrices. References include: Mardia K.V., Kent J.T. and Bibby J.M. (1979). Multivariate Analysis. ISBN: 978-0124712522. London: Academic Press.

N>=3 methods are used to measure each of n items. The data are used to estimate simultaneously systematic error (bias) and random error (imprecision). Observed measurements for each method or device are assumed to be linear functions of the unknown true values and the errors are assumed normally distributed. Pairwise calibration curves and plots can be easily generated. Unlike the ncb.od function, the omx function builds a one-factor measurement error model using OpenMx and allows missing values, uses full information maximum likelihood to estimate parameters, and provides both likelihood-based and bootstrapped confidence intervals for all parameters, in addition to Wald-type intervals.

Computes the degrees of freedom of the lasso, elastic net, generalized elastic net and adaptive lasso based on the generalized path seeking algorithm. The optimal model can be selected by model selection criteria including Mallows Cp, bias-corrected AIC (AICc), generalized cross validation (GCV) and BIC.

Producing high-quality documents suitable for publication directly from R is made possible by the R Markdown ecosystem. memoiR makes it easy. It provides templates to knit memoirs, articles and slideshows with helpers to publish the documents on GitHub Pages and activate continuous integration.

Fully parametric Bayesian multiple imputation framework for massive multivariate data of different variable types as seen in Demirtas, H. (2017) <doi:10.1007/978-981-10-3307-0_8>.

This package provides a companion to the Chinese book ``Modern Statistical Graphics''.

Perform a mail merge (mass email) using the message defined in markdown, the recipients in a csv file, and gmail as the mailing engine. With this package you can parse markdown documents as the body of email, and the yaml header to specify the subject line of the email. Any braces in the email will be encoded with glue::glue()'. You can preview the email in the RStudio viewer pane, and send (draft) email using gmailr'.

Designed for analyzing the Medical Information Mart for Intensive Care(MIMIC) dataset, a repository of freely accessible electronic health records. MIMER(MIMIC-enabled Research) package, offers a suite of data wrangling functions tailored specifically for preparing the dataset for research purposes, particularly in antimicrobial resistance(AMR) studies. It simplifies complex data manipulation tasks, allowing researchers to focus on their primary inquiries without being bogged down by wrangling complexities.

This package provides a user-friendly interface for the construction of Makefiles'.

The rapid screening of effective and optimal therapies from large numbers of candidate combinations, as well as exploring subgroup efficacy, remains challenging, which necessitates innovative, integrated, and efficient trial designs(Yuan, Y., et al. (2016) <doi:10.1002/sim.6971>). MIDAS-2 package enables quick and continuous screening of promising combination strategies and exploration of their subgroup effects within a unified platform design framework. We used a regression model to characterize the efficacy pattern in subgroups. Information borrowing was applied through Bayesian hierarchical model to improve trial efficiency considering the limited sample size in subgroups(Cunanan, K. M., et al. (2019) <doi:10.1177/1740774518812779>). MIDAS-2 provides an adaptive drug screening and subgroup exploring framework to accelerate immunotherapy development in an efficient, accurate, and integrated fashion(Wathen, J. K., & Thall, P. F. (2017) <doi: 10.1177/1740774517692302>).

Multiple contrast tests and simultaneous confidence intervals based on normal approximation. With implementations for binomial proportions in a 2xk setting (risk difference and odds ratio), poly-3-adjusted tumour rates, biodiversity indices (multinomial data) and expected values under lognormal assumption. Approximative power calculation for multiple contrast tests of binomial and Gaussian data.

Estimate and test inter-generational social mobility effect on an outcome with cross-sectional or longitudinal data.

The second version (0.2.0) contains implementation for exact matching which is an alternative to propensity score matching (see Glimm & Yau (2025)). The initial version (0.1.2) contains a collection of easy-to-implement tools for checking whether a MAIC can be conducted, as well as an alternative way of calculating weights (see Glimm & Yau (2021) <doi:10.1002/pst.2210>.).

Fitting Multi-Parameter Regression (MPR) models to right-censored survival data. These are flexible parametric regression models which extend standard models, for example, proportional hazards. See Burke & MacKenzie (2016) <doi:10.1111/biom.12625> and Burke et al (2020) <doi:10.1111/rssc.12398>.