The aim of neo2R is to provide simple and low level connectors for querying neo4j graph databases (<https://neo4j.com/>). The objects returned by the query functions are either lists or data.frames with very few post-processing. It allows fast processing of queries returning many records. And it let the user handle post-processing according to the data model and his needs.

We developed an inference tool based on approximate Bayesian computation to decipher network data and assess the strength of the inferred links between network's actors. It is a new multi-level approximate Bayesian computation (ABC) approach. At the first level, the method captures the global properties of the network, such as a scale-free structure and clustering coefficients, whereas the second level is targeted to capture local properties, including the probability of each couple of genes being linked. Up to now, Approximate Bayesian Computation (ABC) algorithms have been scarcely used in that setting and, due to the computational overhead, their application was limited to a small number of genes. On the contrary, our algorithm was made to cope with that issue and has low computational cost. It can be used, for instance, for elucidating gene regulatory network, which is an important step towards understanding the normal cell physiology and complex pathological phenotype. Reverse-engineering consists in using gene expressions over time or over different experimental conditions to discover the structure of the gene network in a targeted cellular process. The fact that gene expression data are usually noisy, highly correlated, and have high dimensionality explains the need for specific statistical methods to reverse engineer the underlying network.

Estimates of coefficients of lasso penalized linear regression and generalized linear models subject to non-negativity constraints on the parameters using multiplicative iterative algorithm. Entire regularization path for a sequence of lambda values can be obtained. Functions are available for creating plots of regularization path, cross validation and estimating coefficients at a given lambda value. There is also provision for obtaining standard error of coefficient estimates.

Different inference procedures are proposed in the literature to correct for selection bias that might be introduced with non-random selection mechanisms. A class of methods to correct for selection bias is to apply a statistical model to predict the units not in the sample (super-population modeling). Other studies use calibration or Statistical Matching (statistically match nonprobability and probability samples). To date, the more relevant methods are weighting by Propensity Score Adjustment (PSA). The Propensity Score Adjustment method was originally developed to construct weights by estimating response probabilities and using them in Horvitzâ Thompson type estimators. This method is usually used by combining a non-probability sample with a reference sample to construct propensity models for the non-probability sample. Calibration can be used in a posterior way to adding information of auxiliary variables. Propensity scores in PSA are usually estimated using logistic regression models. Machine learning classification algorithms can be used as alternatives for logistic regression as a technique to estimate propensities. The package NonProbEst implements some of these methods and thus provides a wide options to work with data coming from a non-probabilistic sample.

This package performs nonparametric tests for equality of location against ordered alternatives.

The nflverse is a set of packages dedicated to data of the National Football League. This package is designed to make it easy to install and load multiple nflverse packages in a single step. Learn more about the nflverse at <https://nflverse.nflverse.com/>.

Dealing with neutrosophic data of the form N=D+I(where N is a Neutrosophic number ,D is the determinant part of the number and I is the indeterminacy part) using the neutrosophic two way anova test keeps the type I error low. This algorithm calculates the fisher statistics when we have a neutrosophic data, also tests two hypothesizes, first is to test differences between treatments, and second is to test differences between sectors. For more information see Miari, Mahmoud; Anan, Mohamad Taher; Zeina, Mohamed Bisher(2022) <https://www.americaspg.com/articleinfo/21/show/1058>.

Calculation and presentation of decision-invariant bias adjustment thresholds and intervals for Network Meta-Analysis, as described by Phillippo et al. (2018) <doi:10.1111/rssa.12341>. These describe the smallest changes to the data that would result in a change of decision.

This package provides the Arctic Ice Studio's Nord and Group of Seven inspired colour palettes for use with ggplot2 via custom functions.

Run simple direct gravitational N-body simulations. The package can access different external N-body simulators (e.g. GADGET-4 by Springel et al. (2021) <doi:10.48550/arXiv.2010.03567>), but also has a simple built-in simulator. This default simulator uses a variable block time step and lets the user choose between a range of integrators, including 4th and 6th order integrators for high-accuracy simulations. Basic top-hat smoothing is available as an option. The code also allows the definition of background particles that are fixed or in uniform motion, not subject to acceleration by other particles.

Given a failure type, the function computes covariate-specific probability of failure over time and covariate-specific conditional hazard rate based on possibly right-censored competing risk data. Specifically, it computes the non-parametric maximum-likelihood estimates of these quantities and their asymptotic variances in a semi-parametric mixture model for competing-risks data, as described in Chang et al. (2007a).

Indices, heuristics, simulations and strategies to help determine the number of factors/components to retain in exploratory factor analysis and principal component analysis.

Implementation of network integration approaches comprising unweighted and weighted integration methods. Unweighted integration is performed considering the average, per-edge average, maximum and minimum of networks edges. Weighted integration takes into account a weight for each network during the fusion process, where the weights express the predictiveness strength of each network considering a specific predictive task. Weights can be learned using a machine learning algorithm able to associate the weights to the assessment of the accuracy of the learning algorithm trained on the network itself. The implemented methods can be applied to effectively integrate different biological networks modelling a wide range of problems in bioinformatics (e.g. disease gene prioritization, protein function prediction, drug repurposing, clinical outcome prediction).

Calculates phenological cycle and anomalies using a non-parametric approach applied to time series of vegetation indices derived from remote sensing data or field measurements. The package implements basic and high-level functions for manipulating vector data (numerical series) and raster data (satellite derived products). Processing of very large raster files is supported. For more information, please check the following paper: Chávez et al. (2023) <doi:10.3390/rs15010073>.

This package implements a nonparametric statistical test for rank or score data from partially-balanced incomplete block-design experiments.

Downloading and organizing plant presence and percent cover data from the National Ecological Observatory Network <https://www.neonscience.org>.

This package provides functions to calculate estimates of intrinsic and extrinsic noise from the two-reporter single-cell experiment, as in Elowitz, M. B., A. J. Levine, E. D. Siggia, and P. S. Swain (2002) Stochastic gene expression in a single cell. Science, 297, 1183-1186. Functions implement multiple estimators developed for unbiasedness or min Mean Squared Error (MSE) in Fu, A. Q. and Pachter, L. (2016). Estimating intrinsic and extrinsic noise from single-cell gene expression measurements. Statistical Applications in Genetics and Molecular Biology, 15(6), 447-471.

This package provides a network Maze generator that creates different types of network mazes.

This package provides several direct search optimization algorithms based on the simplex method. The provided algorithms are direct search algorithms, i.e. algorithms which do not use the derivative of the cost function. They are based on the update of a simplex. The following algorithms are available: the fixed shape simplex method of Spendley, Hext and Himsworth (unconstrained optimization with a fixed shape simplex, 1962) <doi:10.1080/00401706.1962.10490033>, the variable shape simplex method of Nelder and Mead (unconstrained optimization with a variable shape simplex made, 1965) <doi:10.1093/comjnl/7.4.308>, and Box's complex method (constrained optimization with a variable shape simplex, 1965) <doi: 10.1093/comjnl/8.1.42>.

Providing a common set of simplified web scraping tools for working with the NHS Data Dictionary <https://datadictionary.nhs.uk/data_elements_overview.html>. The intended usage is to access the data elements section of the NHS Data Dictionary to access key lookups. The benefits of having it in this package are that the lookups are the live lookups on the website and will not need to be maintained. This package was commissioned by the NHS-R community <https://nhsrcommunity.com/> to provide this consistency of lookups. The OpenSafely lookups have now been added <https://www.opencodelists.org/docs/>.

This package provides functions for downloading, calibrating, and analyzing atmospheric isotope data bundled into the eddy covariance data products of the National Ecological Observatory Network (NEON) <https://www.neonscience.org>. Calibration tools are provided for carbon and water isotope products. Carbon isotope calibration details are found in Fiorella et al. (2021) <doi:10.1029/2020JG005862>, and the readme file at <https://github.com/lanl/NEONiso>. Tools for calibrating water isotope products have been added as of 0.6.0, but have known deficiencies and should be considered experimental and unsupported.

Nonparametric efficiency measurement and statistical inference via DEA type estimators (see Färe, Grosskopf, and Lovell (1994) <doi:10.1017/CBO9780511551710>, Kneip, Simar, and Wilson (2008) <doi:10.1017/S0266466608080651> and Badunenko and Mozharovskyi (2020) <doi:10.1080/01605682.2019.1599778>) as well as Stochastic Frontier estimators for both cross-sectional data and 1st, 2nd, and 4th generation models for panel data (see Kumbhakar and Lovell (2003) <doi:10.1017/CBO9781139174411>, Badunenko and Kumbhakar (2016) <doi:10.1016/j.ejor.2016.04.049>). The stochastic frontier estimators can handle both half-normal and truncated normal models with conditional mean and heteroskedasticity. The marginal effects of determinants can be obtained.

The implementation of Markov Model Multiple Imputation with the application to COVID-19 scale, NIAID OS.

Implementation for nFunNN method, which is a novel nonlinear functional principal component analysis method using neural networks. The crucial function of this package is nFunNNmodel().