The tools for MicroRNA Set Enrichment Analysis can identify risk pathways(or prior gene sets) regulated by microRNA set in the context of microRNA expression data. (1) This package constructs a correlation profile of microRNA and pathways by the hypergeometric statistic test. The gene sets of pathways derived from the three public databases (Kyoto Encyclopedia of Genes and Genomes ('KEGG'); Reactome'; Biocarta') and the target gene sets of microRNA are provided by four databases('TarBaseV6.0'; mir2Disease'; miRecords'; miRTarBase';). (2) This package can quantify the change of correlation between microRNA for each pathway(or prior gene set) based on a microRNA expression data with cases and controls. (3) This package uses the weighted Kolmogorov-Smirnov statistic to calculate an enrichment score (ES) of a microRNA set that co-regulate to a pathway , which reflects the degree to which a given pathway is associated with the specific phenotype. (4) This package can provide the visualization of the results.

Implement Bayesian multilevel modelling for compositional data. Compute multilevel compositional data and perform log-ratio transforms at between and within-person levels, fit Bayesian multilevel models for compositional predictors and outcomes, and run post-hoc analyses such as isotemporal substitution models. References: Le, Stanford, Dumuid, and Wiley (2025) <doi:10.1037/met0000750>, Le, Dumuid, Stanford, and Wiley (2025) <doi:10.1080/00273171.2025.2565598>.

Uses dplyr and tidyeval to fit statistical models inside the database. It currently supports KMeans and linear regression models.

This package provides methods for analyzing and using quartets displayed on a collection of gene trees, primarily to make inferences about the species tree or network under the multi-species coalescent model. These include quartet hypothesis tests for the model, as developed by Mitchell et al. (2019) <doi:10.1214/19-EJS1576>, simplex plots of quartet concordance factors as presented by Allman et al. (2020) <doi:10.1101/2020.02.13.948083>, species tree inference methods based on quartet distances of Rhodes (2019) <doi:10.1109/TCBB.2019.2917204> and Yourdkhani and Rhodes (2019) <doi:10.1007/s11538-020-00773-4>, the NANUQ algorithm for inference of level-1 species networks of Allman et al. (2019) <doi:10.1186/s13015-019-0159-2>, the TINNIK algorithm for inference of the tree of blobs of an arbitrary network of Allman et al.(2022) <doi:10.1007/s00285-022-01838-9>, NANUQ+ routines for resolving multifurcations in the tree of blobs to cycles as in Rhodes et al.(2024) <doi:10.1186/s13015-025-00274-w>, and the ECToBlob algorithm for inference of a network with no anomalous quartets of Allman et al. (2026) (forthcoming). Software announcement by Rhodes et al. (2020) <doi:10.1093/bioinformatics/btaa868>.

Compare microbial co-occurrence networks created from trans_network class of microeco package <https://github.com/ChiLiubio/microeco>. This package is the extension of trans_network class of microeco package and especially useful when different networks are constructed and analyzed simultaneously.

Supports visual interpretation of hierarchical composite endpoints (HCEs). HCEs are complex constructs used as primary endpoints in clinical trials, combining outcomes of different types into ordinal endpoints, in which each patient contributes the most clinically important event (one and only one) to the analysis. See Karpefors M et al. (2022) <doi:10.1177/17407745221134949>.

Imputation of incomplete continuous or categorical datasets; Missing values are imputed with a principal component analysis (PCA), a multiple correspondence analysis (MCA) model or a multiple factor analysis (MFA) model; Perform multiple imputation with and in PCA or MCA.

This package implements three bias-correction techniques from Battaglia et al. (2025 <doi:10.48550/arXiv.2402.15585>) to improve inference in regression models with covariates generated by AI or machine learning.

Constructs and analyzes optimal row-column designs for mixed-level factorial experiments under square and rectangular field layouts. For square field layouts, the package implements direct common-factor constructions by first forming two component treatment arrays, one for each factor or super-factor, and then combining them through a symbolic cell-wise product following Gopinath, Parsad and Mandal (2018) <doi:10.1080/03610926.2017.1376091>. For rectangular field layouts, the package constructs designs by extracting a balanced principal block from a mixed-level block design, treating it as the principal column, taking the complete treatment set as the principal row, and generating the full row-column design by cyclic modular development. The package also includes repair utilities for improving disconnected or partially connected row-column designs through bounded treatment-swap searches while preserving the row-column layout structure. The package provides diagnostic tools for connectedness, orthogonal factorial structure, balance, estimability, and selected optimality criteria for row-column designs.

Estimation and bootstrap utilities for single layer and multilayer Mixed Graphical Models, including functions for centrality, bridge metrics, membership stability, and plotting (De Martino et al. (2026) <doi:10.48550/arXiv.2602.05716>).

This package provides a framework to factorise electromyography (EMG) data. Tools are provided for raw data pre-processing, non negative matrix factorisation, classification of factorised data and plotting of obtained outcomes. In particular, reading from ASCII files is supported, along with wide-used filtering approaches to process EMG data. All steps include one or more sensible defaults that aim at simplifying the workflow. Yet, all functions are largely tunable at need. Example data sets are included.

Offers an easy and automated way to scale up individual-level space use analysis to that of groups. Contains a function from the move package to calculate a dynamic Brownian bridge movement model from movement data for individual animals, as well as functions to visualize and quantify space use for individuals aggregated in groups. Originally written with passive acoustic telemetry in mind, this package also provides functionality to account for unbalanced acoustic receiver array designs, and satellite tag data.

Market area models are used to analyze and predict store choices and market areas concerning retail and service locations. This package implements two market area models (Huff Model, Multiplicative Competitive Interaction Model) into R, while the emphases lie on 1.) fitting these models based on empirical data via OLS regression and nonlinear techniques and 2.) data preparation and processing (esp. interaction matrices and data preparation for the MCI Model).

Mask ranges based on expert knowledge or remote sensing layers. These tools can be combined to quantitatively and reproducibly generate a new map or to update an existing map. Methods include expert opinion and data-driven tools to generate thresholds for binary masks.

User-friendly Shiny apps for designing and evaluating phase I cancer clinical trials, with the aim to estimate the maximum tolerated dose (MTD) of a novel drug, using a Bayesian decision procedure based on logistic regression.

Evaluate whether a microbiome sample is a mixture of two samples, by fitting a model for the number of read counts as a function of single nucleotide polymorphism (SNP) allele and the genotypes of two potential source samples. Lobo et al. (2021) <doi:10.1093/g3journal/jkab308>.

Enables preparation of maps to be printed and drawn on. Modified maps can then be scanned back in, and hand-drawn marks converted to spatial objects.

Matrix-Based Flexible Project Planning. This package models, plans, and schedules flexible, such as agile, extreme, and hybrid project plans. The package contains project planning, scheduling, and risk assessment functions. Kosztyan (2022) <doi:10.1016/j.softx.2022.100973>.

Incorporates a Bayesian monotonic single-index mixed-effect model with a multivariate skew-t likelihood, specifically designed to handle survey weights adjustments. Features include a simulation program and an associated Gibbs sampler for model estimation. The single-index function is constrained to be monotonic increasing, utilizing a customized Gaussian process prior for precise estimation. The model assumes random effects follow a canonical skew-t distribution, while residuals are represented by a multivariate Student-t distribution. Offers robust Bayesian adjustments to integrate survey weight information effectively.

This package provides a collection of moment-matching methods for computing the cumulative distribution function of a positively-weighted sum of chi-squared random variables. Methods include the Satterthwaite-Welch method, Hall-Buckley-Eagleson method, Wood's F method, and the Lindsay-Pilla-Basak method.

This package performs Multiple Factor Analysis method for quantitative, categorical, frequency and mixed data, in addition to generating a lot of graphics, also has other useful functions.

Implementation of hypothesis testing procedures described in Hansen (1992) <doi:10.1002/jae.3950070506>, Carrasco, Hu, & Ploberger (2014) <doi:10.3982/ECTA8609>, Dufour & Luger (2017) <doi:10.1080/07474938.2017.1307548>, and Rodriguez Rondon & Dufour (2024) <https://grodriguezrondon.com/files/RodriguezRondon_Dufour_2025_MonteCarlo_LikelihoodRatioTest_MarkovSwitchingModels_20251014.pdf> that can be used to identify the number of regimes in Markov switching models.

Comprehensively identifying states and state-like actors is difficult. This package provides data on states and state-like entities in the international system across time. The package combines and cross-references several existing datasets consistent with the aims and functions of the manydata package. It also includes functions for identifying state references in text, and for generating fictional state names.

This package provides tools for creating and issuing nicely-formatted text within R diagnostic messages and those messages given during warnings and errors. The formatting of the messages can be customized using templating features. Issues with singular and plural forms can be handled through specialized syntax.