This package provides a new method to implement clustering from multiple modality data of certain samples, the function M2SMjF() jointly factorizes multiple similarity matrices into a shared sub-matrix and several modality private sub-matrices, which is further used for clustering. Along with this method, we also provide function to calculate the similarity matrix and function to evaluate the best cluster number from the original data.

The algorithms implemented here are used to detect the community structure of a network. These algorithms follow different approaches, but are all based on the concept of modularity maximization.

Parameter estimation and classification for Gaussian Mixture Models (GMMs) in the presence of missing data. This package complements existing implementations by allowing for both missing elements in the input vectors and full (as opposed to strictly diagonal) covariance matrices. Estimation is performed using an expectation conditional maximization algorithm that accounts for missingness of both the cluster assignments and the vector components. The output includes the marginal cluster membership probabilities; the mean and covariance of each cluster; the posterior probabilities of cluster membership; and a completed version of the input data, with missing values imputed to their posterior expectations. For additional details, please see McCaw ZR, Julienne H, Aschard H. "Fitting Gaussian mixture models on incomplete data." <doi:10.1186/s12859-022-04740-9>.

Create dummy variables from categorical data. This package can convert categorical data (factor and ordered) into dummy variables and handle multiple columns simultaneously. This package enables to select whether a dummy variable for base group is included (for principal component analysis/factor analysis) or excluded (for regression analysis) by an option. makedummies function accepts data.frame', matrix', and tbl (tibble) class (by tibble package). matrix class data is automatically converted to data.frame class.

Simulation from an mrgsolve <https://cran.r-project.org/package=mrgsolve> model using a parallel backend. Input data sets are split (chunked) and simulated in parallel using mclapply() or future_lapply() <https://cran.r-project.org/package=future.apply>.

This package provides a basic interface for accessing annotation data from the Multi-CAST collection, a database of spoken natural language texts edited by Geoffrey Haig and Stefan Schnell. The collection draws from a diverse set of languages and has been annotated across multiple levels. Annotation data is downloaded on request from the servers of the University of Bamberg. See the Multi-CAST website <https://multicast.aspra.uni-bamberg.de/> for more information and a list of related publications.

Multilevel models (mixed effects models) are the statistical tool of choice for analyzing multilevel data (Searle et al, 2009). These models account for the correlated nature of observations within higher level units by adding group-level error terms that augment the singular residual error of a standard OLS regression. Multilevel and mixed effects models often require specialized data pre-processing and further post-estimation derivations and graphics to gain insight into model results. The package presented here, mlmtools', is a suite of pre- and post-estimation tools for multilevel models in R'. Package implements post-estimation tools designed to work with models estimated using lme4''s (Bates et al., 2014) lmer() function, which fits linear mixed effects regression models. Searle, S. R., Casella, G., & McCulloch, C. E. (2009, ISBN:978-0470009598). Bates, D., Mächler, M., Bolker, B., & Walker, S. (2014) <doi:10.18637/jss.v067.i01>.

Create native charts for Microsoft PowerPoint', Microsoft Excel and Microsoft Word documents. The resulting charts can then be edited and annotated in the host application. It provides functions to create charts and to modify their content and formatting. The chart's underlying data is automatically saved within the Word', Excel or PowerPoint file. It extends the officer package, which does not provide native Microsoft chart production.

Loads, validates, and replays portable mars ModelSpec artifacts from R. The package provides helpers for constructing design matrices, generating predictions, and, when the companion runtime helper is available, fitting portable model specifications for cross-language replay.

Methods-first tooling for reproducing and extending the partial least squares regression studies on incomplete data described in Nengsih et al. (2019) <doi:10.1515/sagmb-2018-0059>. The package provides simulation helpers, missingness generators, imputation wrappers, component-selection utilities, real-data diagnostics, and reproducible study orchestration for Nonlinear Iterative Partial Least Squares (NIPALS)-Partial Least Squares (PLS) workflows.

Matching longitudinal methodology models with complex sampling design. It fits fixed and random effects models and covariance structured models so far. It also provides tools to perform statistical tests considering these specifications as described in : Pacheco, P. H. (2021). "Modeling complex longitudinal data in R: development of a statistical package." <https://repositorio.ufjf.br/jspui/bitstream/ufjf/13437/1/pedrohenriquedemesquitapacheco.pdf>.

Set of utility functions to interact with WeMo Switch', a smart plug that can be remotely controlled via wifi. The provided functions make it possible to turn one or more WeMo Switch plugs on and off in a scriptable fashion. More information about WeMo Switch can be found at <http://www.belkin.com/us/p/P-F7C027/>.

This is an EM algorithm based method for imputation of missing values in multivariate normal time series. The imputation algorithm accounts for both spatial and temporal correlation structures. Temporal patterns can be modeled using an ARIMA(p,d,q), optionally with seasonal components, a non-parametric cubic spline or generalized additive models with exogenous covariates. This algorithm is specially tailored for climate data with missing measurements from several monitors along a given region.

Calculate morphine milligram equivalents (MME) for opioid dose comparison using standardized methods. Can directly call the NIH HEAL MME Online Calculator <https://research-mme.wakehealth.edu/api> API or replicate API calculations on the user's local machine from the comfort of R'. Creation of the NIH HEAL MME Online Calculator and the MME calculations implemented in this package are described in Adams MCB, Sward KA, Perkins ML, Hurley RW (2025) <doi:10.1097/j.pain.0000000000003529>.

Compose generic monadic function pipelines with %>>% and %>-% based on implementing the S7 generics fmap() and bind(). Methods are provided for the built-in list type and the maybe class from the maybe package. The concepts are modelled directly after the Monad typeclass in Haskell, but adapted for idiomatic use in R.

Background - Traditional gene set enrichment analyses are typically limited to a few ontologies and do not account for the interdependence of gene sets or terms, resulting in overcorrected p-values. To address these challenges, we introduce mulea, an R package offering comprehensive overrepresentation and functional enrichment analysis. Results - mulea employs a progressive empirical false discovery rate (eFDR) method, specifically designed for interconnected biological data, to accurately identify significant terms within diverse ontologies. mulea expands beyond traditional tools by incorporating a wide range of ontologies, encompassing Gene Ontology, pathways, regulatory elements, genomic locations, and protein domains. This flexibility enables researchers to tailor enrichment analysis to their specific questions, such as identifying enriched transcriptional regulators in gene expression data or overrepresented protein domains in protein sets. To facilitate seamless analysis, mulea provides gene sets (in standardised GMT format) for 27 model organisms, covering 22 ontology types from 16 databases and various identifiers resulting in almost 900 files. Additionally, the muleaData ExperimentData Bioconductor package simplifies access to these pre-defined ontologies. Finally, mulea's architecture allows for easy integration of user-defined ontologies, or GMT files from external sources (e.g., MSigDB or Enrichr), expanding its applicability across diverse research areas. Conclusions - mulea is distributed as a CRAN R package. It offers researchers a powerful and flexible toolkit for functional enrichment analysis, addressing limitations of traditional tools with its progressive eFDR and by supporting a variety of ontologies. Overall, mulea fosters the exploration of diverse biological questions across various model organisms.

Interfaces the python library zuko implementing Masked Autoregressive Flows. See Rozet, Divo and Schnake (2023) <doi:10.5281/zenodo.7625672> and Papamakarios, Pavlakou and Murray (2017) <doi:10.48550/arXiv.1705.07057>.

This package implements differential methylation region (DMR) detection using a multistage Markov chain Monte Carlo (MCMC) algorithm based on the alpha-skew generalized normal (ASGN) distribution. Version 0.2.0 removes the Anderson-Darling test stage, improves computational efficiency of the core ASGN and multistage MCMC routines, and adds convenience functions for summarizing and visualizing detected DMRs. The methodology is based on Yang (2025) <https://www.proquest.com/docview/3218878972>.

Correlation coefficients for multivariate data, namely the squared correlation coefficient and the RV coefficient (multivariate generalization of the squared Pearson correlation coefficient). References include Mardia K.V., Kent J.T. and Bibby J.M. (1979). "Multivariate Analysis". ISBN: 978-0124712522. London: Academic Press.

Most multilevel methodologies can only model macro-micro multilevel situations in an unbiased way, wherein group-level predictors (e.g., city temperature) are used to predict an individual-level outcome variable (e.g., citizen personality). In contrast, this R package enables researchers to model micro-macro situations, wherein individual-level (micro) predictors (and other group-level predictors) are used to predict a group-level (macro) outcome variable in an unbiased way.

This package provides two variants of multiple correspondence analysis (ca): multiple ca and ordered multiple ca via orthogonal polynomials of Emerson.

Persistent interface to Macaulay2 <https://www.macaulay2.com> and front-end tools facilitating its use in the R ecosystem. For details see Kahle et. al. (2020) <doi:10.18637/jss.v093.i09>.

This package provides functions to access drug regulatory data from public RESTful APIs including the FDA Open API and the Health Canada Drug Product Database API', retrieving real-time or historical information on drug approvals, adverse events, recalls, and product details. Additionally, the package includes a curated collection of open datasets focused on drugs, pharmaceuticals, treatments, and clinical studies. These datasets cover diverse topics such as treatment dosages, pharmacological studies, placebo effects, drug reactions, misuses of pain relievers, and vaccine effectiveness. The package supports reproducible research and teaching in pharmacology, medicine, and healthcare by integrating reliable international APIs and structured datasets from public, academic, and government sources. For more information on the APIs, see: FDA API <https://open.fda.gov/apis/> and Health Canada API <https://health-products.canada.ca/api/documentation/dpd-documentation-en.html>.

This package implements the Multi-Objective Clustering Algorithm Guided by a-Priori Biological Knowledge ('MOC-GaPBK') proposed by Parraga-Alava and others (2018) <doi:10.1186/s13040-018-0178-4>. The algorithm performs gene clustering using NSGA-II as the underlying multi-objective evolutionary engine, together with Path-Relinking and Pareto Local Search as intensification and diversification strategies. Two versions of the Xie-Beni validity index are used as objective functions, one per distance matrix, so that prior biological knowledge can be incorporated through the second matrix.