Regression models can be fitted for multiple outcomes simultaneously. This package computes estimates of parameters across fitted models and returns the matrix of asymptotic covariance. Various applications of this package, including CUPED (Controlled Experiments Utilizing Pre-Experiment Data), multiple comparison adjustment, are illustrated.

Tabulate and plot directional and other multivariate histograms.

Allows the estimation and downstream statistical analysis of the mitochondrial DNA Heteroplasmy calculated from single-cell datasets <https://github.com/ScialdoneLab/MitoHEAR/tree/master>.

Multiple Imputation has been shown to be a flexible method to impute missing values by Van Buuren (2007) <doi:10.1177/0962280206074463>. Expanding on this, random forests have been shown to be an accurate model by Stekhoven and Buhlmann <arXiv:1105.0828> to impute missing values in datasets. They have the added benefits of returning out of bag error and variable importance estimates, as well as being simple to run in parallel.

Create and integrate thematic maps in your workflow. This package helps to design various cartographic representations such as proportional symbols, choropleth or typology maps. It also offers several functions to display layout elements that improve the graphic presentation of maps (e.g. scale bar, north arrow, title, labels). mapsf maps sf objects on base graphics.

Automated calculation and visualization of survey data statistics on a color-coded (choropleth) map.

This package provides functions to access data from public RESTful APIs including REST Countries API', World Bank API', and Nager.Date API', covering Mexico's economic indicators, population statistics, literacy rates, international geopolitical information and official public holidays. The package also includes curated datasets related to Mexico such as air quality monitoring stations, pollution zones, income surveys, postal abbreviations, election studies, forest productivity and demographic data by state. It supports research and analysis focused on Mexico by integrating reliable global APIs with structured national datasets drawn from open and academic sources. For more information on the APIs, see: REST Countries API <https://restcountries.com/>, World Bank API <https://datahelpdesk.worldbank.org/knowledgebase/articles/889392>, and Nager.Date API <https://date.nager.at/Api>.

Regression methods for the meta-SDT model. The package implements methods for cognitive experiments of metacognition as described in Kristensen, S. B., Sandberg, K., & Bibby, B. M. (2020). Regression methods for metacognitive sensitivity. Journal of Mathematical Psychology, 94. <doi:10.1016/j.jmp.2019.102297>.

Model fitting, sampling and visualization for the (Hidden) Markov Random Field model with pairwise interactions and general interaction structure from Freguglia, Garcia & Bicas (2020) <doi:10.1002/env.2613>, which has many popular models used in 2-dimensional lattices as particular cases, like the Ising Model and Potts Model. A complete manuscript describing the package is available in Freguglia & Garcia (2022) <doi:10.18637/jss.v101.i08>.

Computes mutual information matrices from continuous, categorical and survival variables, as well as feature selection with minimum redundancy, maximum relevance (mRMR) and a new ensemble mRMR technique. Published in De Jay et al. (2013) <doi:10.1093/bioinformatics/btt383>.

This is the core functions needed by the tsmp package. The low level and carefully checked mathematical functions are here. These are implementations of the Matrix Profile concept that was created by CS-UCR <http://www.cs.ucr.edu/~eamonn/MatrixProfile.html>.

Enables the creation of Moodle quiz questions using literate programming with R Markdown. This makes it easy to quickly create a quiz that can be randomly replicated with new datasets, questions, and options for answers.

This package provides a causal mediation approach under the counterfactual framework to test the significance of total, direct and indirect effects. In this approach, a group of methylated sites from a predefined region are utilized as the mediator, and the functional transformation is used to reduce the possible high dimension in the region-based methylated sites and account for their location information.

Model selection and averaging for regression and mixtures, inclusing Bayesian model selection and information criteria (BIC, EBIC, AIC, GIC).

An ensemble classifier for multiclass classification. This is a novel classifier that natively works as an ensemble. It projects data on a large number of matrices, and uses very simple classifiers on each of these projections. The results are then combined, ideally via Dempster-Shafer Calculus.

This package performs (simultaneous) inferences for ratios of linear combinations of coefficients in the general linear model, linear mixed model, and for quantiles in a one-way layout. Multiple comparisons and simultaneous confidence interval estimations can be performed for ratios of treatment means in the normal one-way layout with homogeneous and heterogeneous treatment variances, according to Dilba et al. (2007) <https://cran.r-project.org/doc/Rnews/Rnews_2007-1.pdf> and Hasler and Hothorn (2008) <doi:10.1002/bimj.200710466>. Confidence interval estimations for ratios of linear combinations of linear model parameters like in (multiple) slope ratio and parallel line assays can be carried out. Moreover, it is possible to calculate the sample sizes required in comparisons with a control based on relative margins. For the simple two-sample problem, functions for a t-test for ratio-formatted hypotheses and the corresponding confidence interval are provided assuming homogeneous or heterogeneous group variances.

Data class for increased interoperability working with spatial-temporal data together with corresponding functions and methods (conversions, basic calculations and basic data manipulation). The class distinguishes between spatial, temporal and other dimensions to facilitate the development and interoperability of tools build for it. Additional features are name-based addressing of data and internal consistency checks (e.g. checking for the right data order in calculations).

With high-dimensional omics features, repeated measure ANOVA leads to longitudinal gene-environment interaction studies that have intra-cluster correlations, outlying observations and structured sparsity arising from the ANOVA design. In this package, we have developed robust sparse Bayesian mixed effect models tailored for the above studies (Fan et al. (2025) <doi:10.1093/jrsssc/qlaf027>). An efficient Gibbs sampler has been developed to facilitate fast computation. The Markov chain Monte Carlo algorithms of the proposed and alternative methods are efficiently implemented in C++'. The development of this software package and the associated statistical methods have been partially supported by an Innovative Research Award from Johnson Cancer Research Center, Kansas State University.

Frequently one needs a convenient way to build and tune several models in one go.The goal is to provide a number of machine learning convenience functions. It provides the ability to build, tune and obtain predictions of several models in one function. The models are built using functions from caret with easier to read syntax. Kuhn(2014) <doi:10.48550/arXiv.1405.6974>.

Fused lasso method to cluster and estimate regression coefficients of the same covariate across different data sets when a large number of independent data sets are combined. Package supports Gaussian, binomial, Poisson and Cox PH models.

Builds and interprets multi-response machine learning models using tidymodels syntax. Users can supply a tidy model, and mrIML automates the process of fitting multiple response models to multivariate data and applying interpretable machine learning techniques across them. For more details see Fountain-Jones (2021) <doi:10.1111/1755-0998.13495> and Fountain-Jones et al. (2024) <doi:10.22541/au.172676147.77148600/v1>.

Based on the work of Curi, Converse, Hajewski, and Oliveira (2019) <doi:10.1109/IJCNN.2019.8852333>. This package provides easy-to-use functions which create a variational autoencoder (VAE) to be used for parameter estimation in Item Response Theory (IRT) - namely the Multidimensional Logistic 2-Parameter (ML2P) model. To use a neural network as such, nontrivial modifications to the architecture must be made, such as restricting the nonzero weights in the decoder according to some binary matrix Q. The functions in this package allow for straight-forward construction, training, and evaluation so that minimal knowledge of tensorflow or keras is required.

Pooling estimates reported in meta-analyses (literature-based, LB) and estimates based on individual participant data (IPD) is not straight-forward as the details of the LB nonlinear function estimate are not usually reported. This package pools the nonlinear IPD dose-response estimates based on a natural cubic spline from lm or glm with the pointwise LB estimates and their estimated variances. Details will be presented in Härkänen, Tapanainen, Sares-Jäske, Männistö, Kaartinen and Paalanen (2026) "Novel pooling method for nonlinear cohort analysis and meta-analysis estimates: Predicting health outcomes based on climate-friendly diets" Epidemiology <doi:10.1097/EDE.0000000000001932>.

Using this package, one can determine the minimum sample size required so that the mean square error of the sample mean and the population mean of a distribution becomes less than some pre-determined epsilon, i.e. it helps the user to determine the minimum sample size required to attain the pre-fixed precision level by minimizing the difference between the sample mean and population mean.