This package provides a collection of utilities referred to Exponential Power distribution, also known as General Error Distribution (see Mineo, A.M. and Ruggieri, M. (2005), A software Tool for the Exponential Power Distribution: The normalp package. In Journal of Statistical Software, Vol. 12, Issue 4).

This package provides a collection of data structures that represent volumetric brain imaging data. The focus is on basic data handling for 3D and 4D neuroimaging data. In addition, there are function to read and write NIFTI files and limited support for reading AFNI files.

Lite interface for getting data from OSM service Nominatim <https://nominatim.org/release-docs/latest/>. Extract coordinates from addresses, find places near a set of coordinates and return spatial objects on sf format.

An implementation of the Naive Bayes Classifier (NBC) algorithm used for Verbal Autopsy (VA) built on code from Miasnikof et al (2015) <DOI:10.1186/s12916-015-0521-2>.

Interface to NatureServe (<https://www.natureserve.org/>). Includes methods to get data, image metadata, search taxonomic names, and make maps.

Implementation of Narrowest Significance Pursuit, a general and flexible methodology for automatically detecting localised regions in data sequences which each must contain a change-point (understood as an abrupt change in the parameters of an underlying linear model), at a prescribed global significance level. Narrowest Significance Pursuit works with a wide range of distributional assumptions on the errors, and yields exact desired finite-sample coverage probabilities, regardless of the form or number of the covariates. For details, see P. Fryzlewicz (2021) <https://stats.lse.ac.uk/fryzlewicz/nsp/nsp.pdf>.

This package provides routines to compute normalised prediction distribution errors, a metric designed to evaluate non-linear mixed effect models such as those used in pharmacokinetics and pharmacodynamics.

This package provides tools for detecting numeric persistence ("spells") and rigidity patterns in time-ordered numeric data. The package identifies periods of stability, computes spell-based rigidity metrics, and provides plain-language interpretations suitable for policy and applied analysis.

Represent network or igraph objects whose vertices can be represented by features in an sf object as a network graph surmising a sf plot. Fits into ggplot2 grammar.

This package provides a tool for drawing sassy UML (Unified Modeling Language) diagrams based on a simple syntax, see <https://www.nomnoml.com>. Supports styling, R Markdown and exporting diagrams in the PNG format. Note: you need a chromium based browser installed on your system.

These routines create multiple imputations of missing at random categorical data, and create multiply imputed synthesis of categorical data, with or without structural zeros. Imputations and syntheses are based on Dirichlet process mixtures of multinomial distributions, which is a non-parametric Bayesian modeling approach that allows for flexible joint modeling, described in Manrique-Vallier and Reiter (2014) <doi:10.1080/10618600.2013.844700>.

This package provides a framework for systematic exploration of association rules (Agrawal et al., 1994, <https://www.vldb.org/conf/1994/P487.PDF>), contrast patterns (Chen, 2022, <doi:10.48550/arXiv.2209.13556>), emerging patterns (Dong et al., 1999, <doi:10.1145/312129.312191>), subgroup discovery (Atzmueller, 2015, <doi:10.1002/widm.1144>), and conditional correlations (Hájek, 1978, <doi:10.1007/978-3-642-66943-9>). User-defined functions may also be supplied to guide custom pattern searches. Supports both crisp (Boolean) and fuzzy data. Generates candidate conditions expressed as elementary conjunctions, evaluates them on a dataset, and inspects the induced sub-data for statistical, logical, or structural properties such as associations, correlations, or contrasts. Includes methods for visualization of logical structures and supports interactive exploration through integrated Shiny applications.

NONMEM has been a tool for running nonlinear mixed effects models since the 80s and is still used today (Bauer 2019 <doi:10.1002/psp4.12404>). This tool allows you to convert NONMEM models to rxode2 (Wang, Hallow and James (2016) <doi:10.1002/psp4.12052>) and with simple models nlmixr2 syntax (Fidler et al (2019) <doi:10.1002/psp4.12445>). The nlmixr2 syntax requires the residual specification to be included and it is not always translated. If available, the rxode2 model will read in the NONMEM data and compare the simulation for the population model ('PRED') individual model ('IPRED') and residual model ('IWRES') to immediately show how well the translation is performing. This saves the model development time for people who are creating an rxode2 model manually. Additionally, this package reads in all the information to allow simulation with uncertainty (that is the number of observations, the number of subjects, and the covariance matrix) with a rxode2 model. This is complementary to the babelmixr2 package that translates nlmixr2 models to NONMEM and can convert the objects converted from nonmem2rx to a full nlmixr2 fit.

Calculates network measures commonly used in Network Medicine. Measures such as the Largest Connected Component, the Relative Largest Connected Component, Proximity and Separation are calculated along with their statistical significance. Significance can be computed both using a degree-preserving randomization and non-degree preserving.

Optimizing regular numeric problems in optically stimulated luminescence dating, such as: equivalent dose calculation, dose rate determination, growth curve fitting, decay curve decomposition, statistical age model optimization, and statistical plot visualization.

This package implements statistical tools for analyzing, simulating, and computing properties of the New Topp-Leone Kumaraswamy Inverse Exponential (NTLKwIEx) distribution. See Atchadé M, Otodji T, and Djibril A (2024) <doi:10.1063/5.0179458> and Atchadé M, Otodji T, Djibril A, and N'bouké M (2023) <doi:10.1515/phys-2023-0151> for details.

Download data from the Northern Ireland Statistics and Research Agency (NISRA) data portal, accessed at <https://data.nisra.gov.uk>. NISRA is a government agency and the principal source of official statistics and social research on Northern Ireland.

An adaptation of Non-dominated Sorting Genetic Algorithm III for multi objective feature selection tasks. Non-dominated Sorting Genetic Algorithm III is a genetic algorithm that solves multiple optimization problems simultaneously by applying a non-dominated sorting technique. It uses a reference points based selection operator to explore solution space and preserve diversity. See the original paper by K. Deb and H. Jain (2014) <DOI:10.1109/TEVC.2013.2281534> for a detailed description.

This package provides a computational toolkit for analyzing nematode communities in ecological studies. Includes methods to quantify nematode-based ecological indicators such as metabolic footprints, energy flow metrics, and community structure. These tools support assessments of soil health, ecosystem functioning, and trophic interactions, standardizing the use of nematodes as bioindicators.

Retrieve and plot word frequencies through time from the "Google Ngram Viewer" <https://books.google.com/ngrams>.

Utilities for Natural Language Processing.

Efficient tools for preparation, checking and post-processing of data in PK/PD (pharmacokinetics/pharmacodynamics) modeling, with focus on use of Nonmem, including consistency, traceability, and Nonmem compatibility of Data. Rigorously checks final Nonmem datasets. Implemented in data.table', but easily integrated with base and tidyverse'.

Access the United States National Provider Identifier Registry API <https://npiregistry.cms.hhs.gov/api/>. Obtain and transform administrative data linked to a specific individual or organizational healthcare provider, or perform advanced searches based on provider name, location, type of service, credentials, and other attributes exposed by the API.

This package implements methods in Mathur and VanderWeele (in preparation) to characterize global evidence strength across W correlated ordinary least squares (OLS) hypothesis tests. Specifically, uses resampling to estimate a null interval for the total number of rejections in, for example, 95% of samples generated with no associations (the global null), the excess hits (the difference between the observed number of rejections and the upper limit of the null interval), and a test of the global null based on the number of rejections.