Tests the hypothesis that variances are homogeneous or not using bootstrap. The procedure uses a variance-based statistic, and is derived from a normal-theory test. The test equivalently expressed the hypothesis as a function of the log contrasts of the population variances. A box-type acceptance region is constructed to test the hypothesis. See Cahoy (2010) \doi10.1016/j.csda.2010.04.012.

This package provides a minimalistic, dependency-free alternative to roxygen2'. Reads # comment blocks above R functions and objects and turns them into .Rd documentation files and a NAMESPACE file. tinyroxygen is to roxygen2 what tinytest is to testthat', a lightweight alternative built with base R only, with no recursive dependencies to install. Roxygen stands for R documentation inspired by the Doxygen for C++ documentation tools.

Adding some at-present missing functionality, or functions unlikely to be added to the base xpose package. This includes some diagnostic plots that have been missing in translation from xpose4', but also some useful features that truly extend the capabilities of what can be done with xpose'. These extensions include the concept of a set of xpose objects, and diagnostics for likelihood-based models.

This package defines low-level functions for mass spectrometry data and is independent of any high-level data structures. These functions include mass spectra processing functions (noise estimation, smoothing, binning), quantitative aggregation functions (median polish, robust summarisation, etc.), missing data imputation, data normalisation (quantiles, vsn, etc.) as well as misc helper functions, that are used across high-level data structure within the R for Mass Spectrometry packages.

This package generates graphics with embedded details from statistical tests. Statistical tests included in the plots themselves. It provides an easier syntax to generate information-rich plots for statistical analysis of continuous or categorical data. Currently, it supports the most common types of statistical approaches and tests: parametric, nonparametric, robust, and Bayesian versions of t-test/ANOVA, correlation analyses, contingency table analysis, meta-analysis, and regression analyses.

This package implements the framework of Tiwari and Majumdar (2025) <doi:10.48550/arXiv.2512.07154> for valuing arithmetic and geometric Asian options under transient and permanent market impact. Provides three pricing approaches: Kemna-Vorst frictionless benchmarks, exogenous diffusion pricing (closed-form for geometric, Monte Carlo for arithmetic), and endogenous Hamilton-Jacobi-Bellman valuation via a tree-based Bellman scheme producing indifference bid-ask prices.

The proposed event-driven approach for Bayesian two-stage single-arm phase II trial design is a novel clinical trial design and can be regarded as an extension of the Simonâ s two-stage design with the time-to-event endpoint. This design is motivated by cancer clinical trials with immunotherapy and molecularly targeted therapy, in which time-to-event endpoint is often a desired endpoint.

These experimental expression data (5 leukemic CLL B-lymphocyte of aggressive form from GSE39411', <doi:10.1073/pnas.1211130110>), after B-cell receptor stimulation, are used as examples by packages such as the Cascade one, a modeling tool allowing gene selection, reverse engineering, and prediction in cascade networks. Jung, N., Bertrand, F., Bahram, S., Vallat, L., and Maumy-Bertrand, M. (2014) <doi:10.1093/bioinformatics/btt705>.

Cure dependent censoring regression models for long-term survival multivariate data. These models are based on extensions of the frailty models, capable to accommodating the cure fraction and the dependence between failure and censoring times, with Weibull and piecewise exponential marginal distributions. Theoretical details regarding the models implemented in the package can be found in Schneider et al. (2022) <doi:10.1007/s10651-022-00549-0>.

This package implements the Hatemi-J (2008) cointegration test which allows for two unknown structural breaks (regime shifts) in the cointegrating relationship. The test provides three test statistics: ADF* (Augmented Dickey-Fuller), Zt* (Phillips-Perron Z_t), and Za* (Phillips-Perron Z_alpha), along with endogenously determined break dates. Critical values are based on simulations from Hatemi-J (2008) <doi:10.1007/s00181-007-0175-9>.

This package implements a Bayesian profile regression using a generalized linear mixed model as output model. The package allows for binary (probit mixed model) and continuous (linear mixed model) outcomes and both continuous and categorical clustering variables. The package utilizes RcppArmadillo and RcppDist for high-performance statistical computing in C++. For more details see Amestoy & al. (2025) <doi:10.48550/arXiv.2510.08304>.

This package provides step-by-step derivations of key results in mathematical statistics, including transformations of random variables, order statistics, and sampling distributions. The package combines analytical derivation with Monte Carlo simulation to compare theoretical and empirical results, facilitating deeper understanding of statistical theory and its computational implementation. The methods are motivated by standard treatments in mathematical statistics (Hogg, McKean, and Craig, 2019, ISBN: 9780134686991).

It includes functions like tropical addition, tropical multiplication for vectors and matrices. In tropical algebra, the tropical sum of two numbers is their minimum and the tropical product of two numbers is their ordinary sum. For more information see also I. Simon (1988) Recognizable sets with multiplicities in the tropical semi ring: Volume 324 Lecture Notes I Computer Science, pages 107-120 <doi: 10.1007/BFb0017135>.

Approaches for incorporating time into network analysis. Methods include: construction of time-ordered networks (temporal graphs); shortest-time and shortest-path-length analyses; resource spread calculations; data resampling and rarefaction for null model construction; reduction to time-aggregated networks with variable window sizes; application of common descriptive statistics to these networks; vector clock latencies; and plotting functionalities. The package supports <doi:10.1371/journal.pone.0020298>.

Validates instantiated patient cohorts on an Observational Medical Outcomes Partnership (OMOP) Common Data Model (CDM) database for real-world-evidence (RWE) studies. From a single function call it produces a structured validation report in Hypertext Markup Language (HTML) and JavaScript Object Notation (JSON) covering concept coverage, cohort attrition, temporal data density, and covariate feasibility against a comparator. The checks are aligned with the United States Food and Drug Administration (FDA) guidance on real-world data and evidence, FDA (2023) <https://www.fda.gov/media/171667/download>, the Harmonized Protocol Template to Enhance Reproducibility (HARPER), Wang and others (2022) <doi:10.1002/pds.5507>, and the Reporting of Studies Conducted Using Observational Routinely-Collected Data for Pharmacoepidemiology (RECORD-PE) statement, Langan and others (2018) <doi:10.1136/bmj.k3532>. A self-contained example database is bundled so the checks can be run without a live database connection.

This package provides means to interactively visualize guide RNAs (gRNAs) in GuideSet objects via Shiny application. This GUI can be self-contained or as a module within a larger Shiny app. The content of the app reflects the annotations present in the passed GuideSet object, and includes intuitive tools to examine, filter, and export gRNAs, thereby making gRNA design more user-friendly.

Lineagespot is a framework written in R, and aims to identify SARS-CoV-2 related mutations based on a single (or a list) of variant(s) file(s) (i.e., variant calling format). The method can facilitate the detection of SARS-CoV-2 lineages in wastewater samples using next generation sequencing, and attempts to infer the potential distribution of the SARS-CoV-2 lineages.

MerfishData is an ExperimentHub package that serves publicly available datasets obtained with Multiplexed Error-Robust Fluorescence in situ Hybridization (MERFISH). MERFISH is a massively multiplexed single-molecule imaging technology capable of simultaneously measuring the copy number and spatial distribution of hundreds to tens of thousands of RNA species in individual cells. The scope of the package is to provide MERFISH data for benchmarking and analysis.

# NetActivity enables to compute gene set scores from previously trained sparsely-connected autoencoders. The package contains a function to prepare the data (`prepareSummarizedExperiment`) and a function to compute the gene set scores (`computeGeneSetScores`). The package `NetActivityData` contains different pre-trained models to be directly applied to the data. Alternatively, the users might use the package to compute gene set scores using custom models.

This package provides functions for calibrating, counting, and summarizing actigraphy and activity data into specific metrics and sleep measures. The metrics include activity counts, step counts, activity index, Monitor Independent Movement Summary Unit (MIMS), mean amplitude deviation (MAD), and provides wrappers for sleep estimation from activity counts using Tudor-Locke (2014) <doi:10.1139/apnm-2013-0173> and Sadeh (1994) <doi:10.1093/sleep/17.3.201>.

This package provides functions for creating, modifying, and displaying bitmaps including printing them in the terminal. There is a special emphasis on monochrome bitmap fonts and their glyphs as well as colored pixel art/sprites. Provides native read/write support for the hex and yaff bitmap font formats and if monobit <https://github.com/robhagemans/monobit> is installed can also read/write several additional bitmap font formats.

Functionality to perform adaptive multi-wave sampling for efficient chart validation. Code allows one to define strata, adaptively sample using several types of confidence bounds for the quantity of interest (Lai's confidence bands, Bayesian credible intervals, normal confidence intervals), and sampling strategies (random sampling, stratified random sampling, Neyman's sampling, see Neyman (1934) <doi:10.2307/2342192> and Neyman (1938) <doi:10.1080/01621459.1938.10503378>).

This package provides methods for estimating circular graphical models using maximum likelihood estimation (MLE) and circular mean squared error (CMSE) approaches. The package includes tools for model fitting, network construction, network evaluation, and visualization. The CMSE-based methodology is related to Dar (2023) <https://open.metu.edu.tr/handle/11511/102577>. The package supports both simulated circular data and real-world applications, including gene-expression network analysis.

This package provides a modified boxplot with a new fence coefficient determined by Lin et al. (2025). The traditional fence coefficient k=1.5 in Tukey's boxplot is replaced by a coefficient based on Chauvenet's criterion, as described in their formula (9). The new boxplot can be implemented in base R with function chau_boxplot(), and in ggplot2 with function geom_chau_boxplot().