This package provides S7-based infrastructure for fitting mediation models, extracting path coefficients, and performing bootstrap inference. Designed as a foundation package for the mediation analysis ecosystem, supporting probmed', RMediation', and medrobust packages. Implements unified interfaces for model fitting across different engines (currently generalized linear models, with future support for mixed models and Bayesian methods), standardized extraction of mediation paths from various model types, and robust bootstrap inference methods. Mediation inference methods are described in MacKinnon, Lockwood and Williams (2004) <doi:10.1207/s15327906mbr3901_4> and Tofighi and MacKinnon (2011) <doi:10.3758/s13428-011-0076-x>.

Automated calculation and visualization of survey data statistics on a color-coded (choropleth) map.

Friendly implementation of the Mann-Whitney-Wilcoxon test for competitive gene set enrichment analysis.

Fast simulation from ordinary differential equation (ODE) based models typically employed in quantitative pharmacology and systems biology.

Analyzing data under multivariate mixed effects model using multivariate REML and multivariate Henderson3 methods. See Meyer (1985) <doi:10.2307/2530651> and Wesolowska Janczarek (1984) <doi:10.1002/bimj.4710260613>.

Implementation of a next-generation, multi-stock age-structured fisheries assessment model. multiSA is intended for use in mixed fisheries where stock composition can not be readily identified in fishery data alone, e.g., from catch and age/length composition. Models can be fitted to genetic data, e.g., stock composition of catches and close-kin pairs, with seasonal stock availability and movement.

Estimates models that extend the standard GLM to take misclassification into account. The models require side information from a secondary data set on the misclassification process, i.e. some sort of misclassification probabilities conditional on some common covariates. A detailed description of the algorithm can be found in Dlugosz, Mammen and Wilke (2015) <https://ftp.zew.de/pub/zew-docs/dp/dp15043.pdf>.

This package provides tools for general-purpose continuous optimization and feed-forward artificial neural network training using metaheuristic and gradient-based optimization algorithms. The package supports benchmark function optimization, regression, binary classification, and multi-class classification with multilayer perceptrons. The package implements several optimization methods, including particle swarm optimization Kennedy and Eberhart (1995) <doi:10.1109/ICNN.1995.488968>, differential evolution Storn and Price (1997) <doi:10.1023/A:1008202821328>, grey wolf optimizer Mirjalili et al. (2014) <doi:10.1016/j.advengsoft.2013.12.007>, secretary bird optimization Fu et al. (2024) <doi:10.1007/s10462-024-10729-y>, and Adam Kingma and Ba (2015) <doi:10.48550/arXiv.1412.6980>.

This package provides pipe-style interface for data.table'. Package preserves all data.table features without significant impact on performance. let and take functions are simplified interfaces for most common data manipulation tasks. For example, you can write take(mtcars, mean(mpg), by = am) for aggregation or let(mtcars, hp_wt = hp/wt, hp_wt_mpg = hp_wt/mpg) for modification. Use take_if/let_if for conditional aggregation/modification. Additionally there are some conveniences such as automatic data.frame conversion to data.table'.

Generate a stream of pseudo-random numbers generated using the MLS Junk Generator algorithm. Functions exist to generate single pseudo-random numbers as well as a vector, data frame, or matrix of pseudo-random numbers.

Calculates mean cumulative count (MCC) to estimate the expected cumulative number of recurrent events per person over time in the presence of competing risks and censoring. Implements both the Dong-Yasui equation method and sum of cumulative incidence method described in Dong, et al. (2015) <doi:10.1093/aje/kwu289>. Supports inverse probability weighting for causal inference as outlined in Gaber, et al. (2023) <doi:10.1093/aje/kwad031>. Provides S3 methods for printing, summarizing, plotting, and extracting results. Handles grouped analyses and integrates with ggplot2 <https://ggplot2.tidyverse.org/> for visualization.

Provides an interactive toolkit for educational and psychological measurement implemented using the shiny framework. The package supports content validity analysis, dimensionality assessment, and Classical Test Theory using the CTT package (Willse, 2018) <doi:10.32614/CRAN.package.CTT>. Item Response Theory (IRT) analyses are conducted via mirt (Chalmers, 2012) <doi:10.18637/jss.v048.i06>. Exploratory Factor Analysis is performed using psych (Revelle, 2025), while Confirmatory Factor Analysis (CFA) and Structural Equation Modeling (SEM) are based on the lavaan framework (Rosseel, 2012) <doi:10.18637/jss.v048.i02>. The CFA/SEM module features interactive model specification, automatic model comparison, modification indices, comprehensive fit diagnostics, path diagram visualization, and HTML report generation. The application allows users to upload data, evaluate statistical models, visualize results, and export outputs through an intuitive graphical interface without requiring programming experience.

Computation and visualization of matrix correlation coefficients. The main method is the Similarity of Matrices Index, while various related measures like r1, r2, r3, r4, Yanai's GCD, RV, RV2, adjusted RV, Rozeboom's linear correlation and Coxhead's coefficient are included for comparison and flexibility.

Helps calculate statistical values commonly used in meta-analysis. It provides several methods to compute different forms of standardized mean differences, as well as other values such as standard errors and standard deviations. The methods used in this package are described in the following references: Altman D G, Bland J M. (2011) <doi:10.1136/bmj.d2090> Borenstein, M., Hedges, L.V., Higgins, J.P.T. and Rothstein, H.R. (2009) <doi:10.1002/9780470743386.ch4> Chinn S. (2000) <doi:10.1002/1097-0258(20001130)19:22%3C3127::aid-sim784%3E3.0.co;2-m> Cochrane Handbook (2011) <https://www.cochrane.org/authors/handbooks-and-manuals/handbook/archive/v5.1.0> Cooper, H., Hedges, L. V., & Valentine, J. C. (2009) <https://psycnet.apa.org/record/2009-05060-000> Cohen, J. (1977) <https://psycnet.apa.org/record/1987-98267-000> Ellis, P.D. (2009) <https://www.psychometrica.de/effect_size.html> Goulet-Pelletier, J.-C., & Cousineau, D. (2018) <doi:10.20982/tqmp.14.4.p242> Hedges, L. V. (1981) <doi:10.2307/1164588> Hedges L. V., Olkin I. (1985) <doi:10.1016/C2009-0-03396-0> Murad M H, Wang Z, Zhu Y, Saadi S, Chu H, Lin L et al. (2023) <doi:10.1136/bmj-2022-073141> Mayer M (2023) <https://search.r-project.org/CRAN/refmans/confintr/html/ci_proportion.html> Stackoverflow (2014) <https://stats.stackexchange.com/questions/82720/confidence-interval-around-binomial-estimate-of-0-or-1> Stackoverflow (2018) <https://stats.stackexchange.com/q/338043>.

An implementation for multivariate functional additive mixed models (multiFAMM), see Volkmann et al. (2021, <arXiv:2103.06606>). It builds on developed methods for univariate sparse functional regression models and multivariate functional principal component analysis. This package contains the function to run a multiFAMM and some convenience functions useful when working with large models. An additional package on GitHub contains more convenience functions to reproduce the analyses of the corresponding paper (<https://github.com/alexvolkmann/multifammPaper>).

Renders rich inline text (bold, italic, code, links, images) in grid graphics and ggplot2', from markdown or flextable chunks. Provides grobs, theme elements, and geometry layers for styled text rendering. Only works with graphics devices that support systemfonts', such as those provided by ragg', svglite', or ggiraph'. The cairo_pdf device is also supported when fonts are installed at the system level.

This package provides a set of functions to manage data shared on a MOLGENIS Armadillo server.

Various methods for multivariate outlier detection: arw, a Mahalanobis-type method with an adaptive outlier cutoff value; locout, a method incorporating local neighborhood; pcout, a method for high-dimensional data; mvoutlier.CoDa, a method for compositional data. References are provided in the corresponding help files.

Visualize the relationship between linear regression variables and causes of multi-collinearity. Implements the method in Lin et. al. (2020) <doi:10.1080/10618600.2020.1779729>.

Pooling estimates reported in meta-analyses (literature-based, LB) and estimates based on individual participant data (IPD) is not straight-forward as the details of the LB nonlinear function estimate are not usually reported. This package pools the nonlinear IPD dose-response estimates based on a natural cubic spline from lm or glm with the pointwise LB estimates and their estimated variances. Details will be presented in Härkänen, Tapanainen, Sares-Jäske, Männistö, Kaartinen and Paalanen (2026) "Novel pooling method for nonlinear cohort analysis and meta-analysis estimates: Predicting health outcomes based on climate-friendly diets" Epidemiology <doi:10.1097/EDE.0000000000001932>.

This package implements the Mittag-Leffler function, distribution, random variate generation, and estimation. Based on the Laplace-Inversion algorithm by Garrappa, R. (2015) <doi:10.1137/140971191>.

Metadynamics is a state of the art biomolecular simulation technique. Plumed Tribello, G.A. et al. (2014) <doi:10.1016/j.cpc.2013.09.018> program makes it possible to perform metadynamics using various simulation codes. The results of metadynamics done in Plumed can be analyzed by metadynminer'. The package metadynminer reads 1D and 2D metadynamics hills files from Plumed package. It uses a fast algorithm by Hosek, P. and Spiwok, V. (2016) <doi:10.1016/j.cpc.2015.08.037> to calculate a free energy surface from hills. Minima can be located and plotted on the free energy surface. Transition states can be analyzed by Nudged Elastic Band method by Henkelman, G. and Jonsson, H. (2000) <doi:10.1063/1.1323224>. Free energy surfaces, minima and transition paths can be plotted to produce publication quality images.

Effect sizes, diagnostics and performance metrics for multilevel and mixed effects models. Includes marginal and conditional R2 estimates for linear mixed effects models based on Johnson (2014) <doi:10.1111/2041-210X.12225>.

Calculates MeDiA_K (means Mean Distance Association by K-nearest neighbor) in order to detect nonlinear associations.