This package provides a toolkit for medical records data analysis. The naryn package implements an efficient data structure for storing medical records, and provides a set of functions for data extraction, manipulation and analysis.

This package provides functions for revealing what happens when effect size estimates from previous studies are taken into account when evaluating each new dataset in a study sequence. The analyses can be conducted for cumulative meta-analyses and for Bayesian data analyses. The package contains sample data for a wide selection of research topics. Jointly considering previous findings along with new data is more likely to result in correct conclusions than does the traditional practice of not incorporating previous findings, which often results in a back and forth ping-pong of conclusions when evaluating a sequence of studies. O'Connor & Ermacora (2021, <doi:10.1037/cbs0000259>).

Non-linear least squares regression with the Levenberg-Marquardt algorithm using multiple starting values for increasing the chance that the minimum found is the global minimum.

Estimates of coefficients of lasso penalized linear regression and generalized linear models subject to non-negativity constraints on the parameters using multiplicative iterative algorithm. Entire regularization path for a sequence of lambda values can be obtained. Functions are available for creating plots of regularization path, cross validation and estimating coefficients at a given lambda value. There is also provision for obtaining standard error of coefficient estimates.

This permutation based hypothesis test, suited for several types of data supported by the estimateNetwork function of the bootnet package (Epskamp & Fried, 2018), assesses the difference between two networks based on several invariance measures (network structure invariance, global strength invariance, edge invariance, several centrality measures, etc.). Network structures are estimated with l1-regularization. The Network Comparison Test is suited for comparison of independent (e.g., two different groups) and dependent samples (e.g., one group that is measured twice). See van Borkulo et al. (2021), available from <doi:10.1037/met0000476>.

Downloading and organizing plant presence and percent cover data from the National Ecological Observatory Network <https://www.neonscience.org>.

Fit and compare nonlinear mixed-effects models in differential equations with flexible dosing information commonly seen in pharmacokinetics and pharmacodynamics (Almquist, Leander, and Jirstrand 2015 <doi:10.1007/s10928-015-9409-1>). Differential equation solving is by compiled C code provided in the rxode2 package (Wang, Hallow, and James 2015 <doi:10.1002/psp4.12052>).

Optimization for nonlinear objective and constraint functions. Linear or nonlinear equality and inequality constraints are allowed. It accepts the input parameters as a constrained matrix.

Clustering unilayer and multilayer network data by means of finite mixtures is the main utility of netClust.

Based on Natural Earth <https://www.naturalearthdata.com/>, a subset of countries can easily be selected with their administrative boundaries, joined with an external data frame and plotted as a thematic map.

NEON observational data are provided via the NEON Data Portal <https://www.neonscience.org> and NEON API, and can be downloaded and reformatted by the neonUtilities package. NEON observational data (human-observed measurements, and analyses derived from human-collected samples, such as tree diameters and algal chemistry) are published in a format consisting of one or more tabular data files. This package provides tools for performing common operations on NEON observational data, including checking for duplicates and joining tables.

Estimators and variance estimators tailored to the NILS hierarchical design (Adler et al. 2020, <https://res.slu.se/id/publ/105630>; Grafström et al. 2023, <https://res.slu.se/id/publ/128235>). The National Inventories of Landscapes in Sweden (NILS) is a long-term national monitoring program that collects, analyses and presents data on Swedish nature, covering both common and rare habitats <https://www.slu.se/om-slu/organisation/institutioner/skoglig-resurshushallning/miljoanalys/nils/>.

An implementation of the Naive Bayes Classifier (NBC) algorithm used for Verbal Autopsy (VA) built on code from Miasnikof et al (2015) <DOI:10.1186/s12916-015-0521-2>.

This package provides a model library for nlmixr2'. The models include (and plan to include) pharmacokinetic, pharmacodynamic, and disease models used in pharmacometrics. Where applicable, references for each model are included in the meta-data for each individual model. The package also includes model composition and modification functions to make model updates easier.

Implementation of discriminant analysis with network structures in predictors accommodated to do classification and prediction.

This package provides nonparametric CUSUM tests for detecting changes in possibly serially dependent univariate or low-dimensional multivariate observations. Retrospective tests sensitive to changes in the expectation, the variance, the covariance, the autocovariance, the distribution function, Spearman's rho, Kendall's tau, Gini's mean difference, and the copula are provided, as well as a test for detecting changes in the distribution of independent block maxima (with environmental studies in mind). The package also contains a test sensitive to changes in the autocopula and a combined test of stationarity sensitive to changes in the distribution function and the autocopula. The latest additions are an open-end sequential test based on the retrospective CUSUM statistic that can be used for monitoring changes in the mean of possibly serially dependent univariate observations, as well as closed-end and open-end sequential tests based on empirical distribution functions that can be used for monitoring changes in the contemporary distribution of possibly serially dependent univariate or low-dimensional multivariate observations.

This package provides a novel integral estimator for estimating the causal effects with continuous treatments (or dose-response curves) and a localized derivative estimator for estimating the derivative effects. The inference on the dose-response curve and its derivative is conducted via nonparametric bootstrap. The reference paper is Zhang, Chen, and Giessing (2024) <doi:10.48550/arXiv.2405.09003>.

Efficient tools for preparation, checking and post-processing of data in PK/PD (pharmacokinetics/pharmacodynamics) modeling, with focus on use of Nonmem, including consistency, traceability, and Nonmem compatibility of Data. Rigorously checks final Nonmem datasets. Implemented in data.table', but easily integrated with base and tidyverse'.

Designed to automate the calculation of Emergency Medical Service (EMS) quality metrics, nemsqar implements measures defined by the National EMS Quality Alliance (NEMSQA). By providing reliable, evidence-based quality assessments, the package supports EMS agencies, healthcare providers, and researchers in evaluating and improving patient outcomes. Users can find details on all approved NEMSQA measures at <https://www.nemsqa.org/measures>. Full technical specifications, including documentation and pseudocode used to develop nemsqar', are available on the NEMSQA website after creating a user profile at <https://www.nemsqa.org>.

This package provides tools for modelling, ML estimation, validation analysis and simulation of non homogeneous Poisson processes in time.

Offers a rich and diverse collection of datasets focused on the brain, nervous system, and related disorders. The package includes clinical, experimental, neuroimaging, behavioral, cognitive, and simulated data on conditions such as Parkinson's disease, Alzheimer's disease, dementia, epilepsy, schizophrenia, autism spectrum disorder, attention deficit, hyperactivity disorder, Tourette's syndrome, traumatic brain injury, gliomas, migraines, headaches, sleep disorders, concussions, encephalitis, subarachnoid hemorrhage, and mental health conditions. Datasets cover structural and functional brain data, cross-sectional and longitudinal MRI imaging studies, neurotransmission, gene expression, cognitive performance, intelligence metrics, sleep deprivation effects, treatment outcomes, brain-body relationships across species, neurological injury patterns, and acupuncture interventions. Data sources include peer-reviewed studies, clinical trials, military health records, sports injury databases, and international comparative studies. Designed for researchers, neuroscientists, clinicians, psychologists, data scientists, and students, this package facilitates exploratory data analysis, statistical modeling, and hypothesis testing in neuroscience and neuroepidemiology.

Tidied data from the ASA 2006 data expo, as well as a number of useful other related data sets.

Plot, process, and analyze NPO files produced by Nonpareil <http://enve-omics.ce.gatech.edu/nonpareil/>.

This package provides a set of functions to scrape and analyze rugby data. Supports competitions including the National Rugby League, New South Wales Cup, Queensland Cup, Super League, and various representative and women's competitions. Includes functions to fetch player statistics, match results, ladders, venues, and coaching data. Designed to assist analysts, fans, and researchers in exploring historical and current rugby league data. See Woods et al. (2017) <doi:10.1123/ijspp.2016-0187> for an example of rugby league performance analysis methodology.