This package provides a comprehensive set of tools to simulate, evaluate, and compare model-assisted designs for early-phase (Phase I/II) clinical trials, including: - BOIN12 (Bayesian optimal interval phase 1/11 trial design; Lin et al. (2020) <doi:10.1200/PO.20.00257>), - BOIN-ET (Takeda, K., Taguri, M., & Morita, S. (2018) <doi:10.1002/pst.1864>), - EffTox (Thall, P. F., & Cook, J. D. (2004) <doi:10.1111/j.0006-341X.2004.00218.x>), - Ji3+3 (Joint i3+3 design; Lin, X., & Ji, Y. (2020) <doi:10.1080/10543406.2020.1818250>), - PRINTE (probability intervals of toxicity and efficacy design; Lin, X., & Ji, Y. (2021) <doi:10.1177/0962280220977009>), - STEIN (simple toxicity and efficacy interval design; Lin, R., & Yin, G. (2017) <doi:10.1002/sim.7428>), - TEPI (toxicity and efficacy probability interval design; Li, D. H., Whitmore, J. B., Guo, W., & Ji, Y. (2017) <doi:10.1158/1078-0432.CCR-16-1125>), - uTPI (utility-based toxicity Probability interval design; Shi, H., Lin, R., & Lin, X. (2024) <doi:10.1002/sim.8922>). Includes flexible simulation parameters that allow researchers to efficiently compute operating characteristics under various fixed and random trial scenarios and export the results.

This is a wrapper for the Mercury Parser API. The Mercury Parser is a single API endpoint that takes a URL and gives you back the content reliably and easily. With just one API request, Mercury takes any web article and returns only the relevant content â headline, author, body text, relevant images and more â free from any clutter. Itâ s reliable, easy-to-use and free. See the webpage here: <https://mercury.postlight.com/>.

This package provides tools for fitting periodic coefficients regression models to data where periodicity plays a crucial role. It allows users to model and analyze relationships between variables that exhibit cyclical or seasonal patterns, offering functions for estimating parameters and testing the periodicity of coefficients in linear regression models. For simple periodic coefficient regression model see Regui et al. (2024) <doi:10.1080/03610918.2024.2314662>.

Permutation based non-parametric analysis of CRISPR screen data. Details about this algorithm are published in the following paper published on BMC genomics, Jia et al. (2017) <doi:10.1186/s12864-017-3938-5>: A permutation-based non-parametric analysis of CRISPR screen data. Please cite this paper if you use this algorithm for your paper.

This package provides access to the latest Amazon Mechanical Turk ('MTurk') <https://www.mturk.com> Requester API (version 2017â 01â 17'), replacing the now deprecated MTurkR package.

Create an automated regression table that is well-suited for models that are estimated with multiple dependent variables. panelsummary extends modelsummary (Arel-Bundock, V. (2022) <doi:10.18637/jss.v103.i01>) by allowing regression tables to be split into multiple sections with a simple function call. Utilize familiar arguments such as fmt, estimate, statistic, vcov, conf_level, stars, coef_map, coef_omit, coef_rename, gof_map, and gof_omit from modelsummary to clean the table, and additionally, add a row for the mean of the dependent variable without external manipulation.

Enables the manufacturing, analysis and display of pressure volume curves. From the progression of the curves, turgor loss point, osmotic potential and apoplastic fraction can be derived. Methods adapted from Bartlett, Scoffoni and Sack (2012) <doi:10.1111/j.1461-0248.2012.01751.x>.

The Prais-Winsten estimator (Prais & Winsten, 1954) takes into account AR(1) serial correlation of the errors in a linear regression model. The procedure recursively estimates the coefficients and the error autocorrelation of the specified model until sufficient convergence of the AR(1) coefficient is attained.

Calculates seat allocation using the D-Hondt method, Sainte-Lague method, and Modified Sainte-Lague method, all commonly used in proportional representation electoral systems. For more information on these methods, see Michael Gallagher (1991)<doi:10.1016/0261-3794(91)90004-C>.

This package contains functions to obtain the operational characteristics of bioequivalence studies in Two-Stage Designs (TSD) via simulations.

This package provides tools for examining Rprof profile output.

This package contains all phrasal verbs listed in <https://www.englishclub.com/ref/Phrasal_Verbs/> as data frame. Useful for educational purpose as well as for text mining.

An implementation of an S3 class based on a double vector for storing and displaying precision teaching measures, representing a growing or a decaying (multiplicative) change between two frequencies. The main format method allows researchers to display measures (including data.frame) that respect the established conventions in the precision teaching community (i.e., prefixed multiplication or division symbol, displayed number <= 1). Basic multiplication and division methods are allowed and other useful functions are provided for creating, converting or inverting precision teaching measures. For more details, see Pennypacker, Gutierrez and Lindsley (2003, ISBN: 1-881317-13-7).

Fits and evaluates three-state partitioned survival analyses (PartSAs) and Markov models (clock forward or clock reset) to progression and overall survival data typically collected in oncology clinical trials. These model structures are typically considered in cost-effectiveness modeling in advanced/metastatic cancer indications. Muston (2024). "Informing structural assumptions for three state oncology cost-effectiveness models through model efficiency and fit". Applied Health Economics and Health Policy.

This package implements entrywise splitting cross-validation (ECV) and its penalized variant (pECV) for selecting the number of factors in generalized factor models.

Run population simulations using an Individual-Based Model (IBM) compiled in C.

This package provides functions and example data to teach and increase the reproducibility of the methods and code underlying the Propensity to Cycle Tool (PCT), a research project and web application hosted at <https://www.pct.bike/>. For an academic paper on the methods, see Lovelace et al (2017) <doi:10.5198/jtlu.2016.862>.

Algorithms to implement various Bayesian penalized survival regression models including: semiparametric proportional hazards models with lasso priors (Lee et al., Int J Biostat, 2011 <doi:10.2202/1557-4679.1301>) and three other shrinkage and group priors (Lee et al., Stat Anal Data Min, 2015 <doi:10.1002/sam.11266>); parametric accelerated failure time models with group/ordinary lasso prior (Lee et al. Comput Stat Data Anal, 2017 <doi:10.1016/j.csda.2017.02.014>).

Computes profile extrema functions for arbitrary functions. If the function is expensive-to-evaluate it computes profile extrema by emulating the function with a Gaussian process (using package DiceKriging'). In this case uncertainty quantification on the profile extrema can also be computed. The different plotting functions for profile extrema give the user a tool to better locate excursion sets.

Inbreeding-purging analysis of pedigreed populations, including the computation of the inbreeding coefficient, partial, ancestral and purged inbreeding coefficients, and measures of the opportunity of purging related to the individual reduction of inbreeding load. In addition, functions to calculate the effective population size and other parameters relevant to population genetics are included. See López-Cortegano E. (2021) <doi:10.1093/bioinformatics/btab599>.

Parallel Constraint Satisfaction (PCS) models are an increasingly common class of models in Psychology, with applications to reading and word recognition (McClelland & Rumelhart, 1981), judgment and decision making (Glöckner & Betsch, 2008; Glöckner, Hilbig, & Jekel, 2014), and several other fields (e.g. Read, Vanman, & Miller, 1997). In each of these fields, they provide a quantitative model of psychological phenomena, with precise predictions regarding choice probabilities, decision times, and often the degree of confidence. This package provides the necessary functions to create and simulate basic Parallel Constraint Satisfaction networks within R.

Speeds up the process of loading raw data from MBA (Multiplex Bead Assay) examinations, performs quality control checks, and automatically normalises the data, preparing it for more advanced, downstream tasks. The main objective of the package is to create a simple environment for a user, who does not necessarily have experience with R language. The package is developed within the project of the same name - PvSTATEM', which is an international project aiming for malaria elimination.

R functions to access provenance information collected by rdt or rdtLite'. The information is stored inside a ProvInfo object and can be accessed through a collection of functions that will return the requested data. The exact format of the JSON created by rdt and rdtLite is described in <https://github.com/End-to-end-provenance/ExtendedProvJson>.

This package provides tools for downloading, reading and analyzing the National Survey of Demographic and Health - PNDS, a household survey from Brazilian Institute of Geography and Statistics - IBGE. The data must be downloaded from the official website <https://www.ibge.gov.br/>. Further analysis must be made using package survey'.