An open source platform for validation and process control. Tools to analyze data from internal validation of forensic short tandem repeat (STR) kits are provided. The tools are developed to provide the necessary data to conform with guidelines for internal validation issued by the European Network of Forensic Science Institutes (ENFSI) DNA Working Group, and the Scientific Working Group on DNA Analysis Methods (SWGDAM). A front-end graphical user interface is provided. More information about each function can be found in the respective help documentation.

Set of tools for evaluating pooled high-throughput screening experiments, typically employing CRISPR/Cas9 or shRNA expression cassettes. Contains methods for interrogating library and cassette behavior within an experiment, identifying differentially abundant cassettes, aggregating signals to identify candidate targets for empirical validation, hypothesis testing, and comprehensive reporting. Version 2.0 extends these applications to include a variety of tools for contextualizing and integrating signals across many experiments, incorporates extended signal enrichment methodologies via the "sparrow" package, and streamlines many formal requirements to aid in interpretablity.

This package provides a varied array of mathematical derivations from various titrimetric and colorimetric methods for analyzing water quality parameters were condensed and integrated for the better physicochemical analysis. It is indispensable for managing any aquatic ecosystem, including aquaculture facilities. By substituting titrant and spectrophotometric absorbance readings, accurate determination of the concentrations of critical parameters such as Dissolved Oxygen, Free Carbon Dioxide, Total Alkalinity, Water Hardness, Hydrogen Sulfide, Total Ammonia Nitrogen, Nitrite, Nitrate, Chlorinity, Salinity, Inorganic Phosphate, and Transparency can be facilitated APHA(2017,ISBN:9780875532875).

Implementation in R of the alpha-shape of a finite set of points in the three-dimensional space. The alpha-shape generalizes the convex hull and allows to recover the shape of non-convex and even non-connected sets in 3D, given a random sample of points taken into it. Besides the computation of the alpha-shape, this package provides users with functions to compute the volume of the alpha-shape, identify the connected components and facilitate the three-dimensional graphical visualization of the estimated set.

This package provides software to facilitate the design, testing, and operation of computer models. It focuses particularly on tools that make it easy to construct and edit a customized graphical user interface ('GUI'). Although our simplified GUI language depends heavily on the R interface to the Tcl/Tk package, a user does not need to know Tcl/Tk'. Examples illustrate models built with other R packages, including PBSmapping', PBSddesolve', and BRugs'. A complete user's guide PBSmodelling-UG.pdf shows how to use this package effectively.

This package provides tools for processing, analyzing, and visualizing spectral data collected from 3D laser-based scanning systems. Supports applications in agriculture, forestry, environmental monitoring, industrial quality control, and biomedical research. Enables evaluation of plant growth, productivity, resource efficiency, disease management, and pest monitoring. Includes statistical methods for extracting insights from multispectral and hyperspectral data and generating publication-ready visualizations. See Zieschank & Junker (2023) <doi:10.3389/fpls.2023.1141554> and Saric et al. (2022) <doi:10.1016/J.TPLANTS.2021.12.003> for related work.

This package provides a collection of parametric quantile regression models for bounded data. At present, the package provides 13 parametric quantile regression models. It can specify regression structure for any quantile and shape parameters. It also provides several S3 methods to extract information from fitted model, such as residual analysis, prediction, plotting, and model comparison. For more computation efficient the [dpqr]'s, likelihood, score and hessian functions are written in C++. For further details see Mazucheli et. al (2022) <doi:10.1016/j.cmpb.2022.106816>.

Bayesian models are used to estimate effect sizes (e.g., gene expression changes, protein abundance differences, drug response effects) while accounting for uncertainty, small sample sizes, and complex experimental designs. However, Bayesian posteriors of models with many parameters are often difficult to interpret at a glance. One way to quickly identify important biological changes based on frequentist analysis are volcano plots (using fold-changes and p-values). Bayesian volcano plots bring together the explicit treatment of uncertainty in Bayesian models and the familiar visualization of volcano plots.

Provided data containing an outcome variable, compositional variables and additional covariates (optional); linearly regress the outcome variable on an isometric log ratio (ilr) transformation of the linearly dependent compositional variables. The package provides predictions (with confidence intervals) in the change (delta) in the outcome/response variable based on the multiple linear regression model and evenly spaced reallocations of the compositional values. The compositional data analysis approach implemented is outlined in Dumuid et al. (2017a) <doi:10.1177/0962280217710835> and Dumuid et al. (2017b) <doi:10.1177/0962280217737805>.

The geographic dimension plays a fundamental role in multidimensional systems. To define a geographic dimension in a star schema, we need a table with attributes corresponding to the levels of the dimension. Additionally, we will also need one or more geographic layers to represent the data using this dimension. The goal of this package is to support the definition of geographic dimensions from layers of geographic information related to each other. It makes it easy to define relationships between layers and obtain the necessary data from them.

This package provides comprehensive tools for conducting research using the Thinking Grid framework, a psychological measurement approach for understanding the stream of thought. Includes functions for generating Qualtrics surveys with the thinking grid, processing survey responses, calculating quadrant depths, and creating various visualization types including heatmaps, animations, and statistical plots. See Irving, Z. C., Murray, S., Kuvar, V., Urena, M., and Mills, C. (2025) "Consciousness, Just in Time: Fluctuations in the Stream of Consciousness during Tasks and Rest" (manuscript under review, draft available from zci7c@virginia.edu).

This package provides a collection of tools for analyzing the field of vision. It provides a framework for development and use of innovative methods for visualization, statistical analysis, and clinical interpretation of visual-field loss and its change over time. It is intended to be a tool for collaborative research. The package is described in Marin-Franch and Swanson (2013) <doi:10.1167/13.4.10> and is part of the Open Perimetry Initiative (OPI) [Turpin, Artes, and McKendrick (2012) <doi:10.1167/12.11.22>].

This package implements an attribute-weighted aggregation algorithm which leverages peptide-spectrum match (PSM) attributes to provide a more accurate estimate of protein abundance compared to conventional aggregation methods. This algorithm employs pre-trained random forest models to predict the quantitative inaccuracy of PSMs based on their attributes. PSMs are then aggregated to the protein level using a weighted average, taking the predicted inaccuracy into account. Additionally, the package allows users to construct their own training sets that are more relevant to their specific experimental conditions if desired.

Data screening is an important first step of any statistical analysis. dataReporter auto generates a customizable data report with a thorough summary of the checks and the results that a human can use to identify possible errors. It provides an extendable suite of test for common potential errors in a dataset. See Petersen AH, Ekstrøm CT (2019). "dataMaid: Your Assistant for Documenting Supervised Data Quality Screening in R." _Journal of Statistical Software_, *90*(6), 1-38 <doi:10.18637/jss.v090.i06> for more information.

This package provides a collection of multivariate nonparametric methods, selected in part to support an MS level course in nonparametric statistical methods. Methods include adjustments for multiple comparisons, implementation of multivariate Mann-Whitney-Wilcoxon testing, inversion of these tests to produce a confidence region, some permutation tests for linear models, and some algorithms for calculating exact probabilities associated with one- and two- stage testing involving Mann-Whitney-Wilcoxon statistics. Supported by grant NSF DMS 1712839. See Kolassa and Seifu (2013) <doi:10.1016/j.acra.2013.03.006>.

This package provides a collection of functions to facilitate analysis of proteomic data from Olink, primarily NPX data that has been exported from Olink Software. The functions also work on QUANT data from Olink by log- transforming the QUANT data. The functions are focused on reading data, facilitating data wrangling and quality control analysis, performing statistical analysis and generating figures to visualize the results of the statistical analysis. The goal of this package is to help users extract biological insights from proteomic data run on the Olink platform.

This package provides functions to calculate power and sample size for testing main effect or interaction effect in the survival analysis of epidemiological studies (non-randomized studies), taking into account the correlation between the covariate of the interest and other covariates. Some calculations also take into account the competing risks and stratified analysis. This package also includes a set of functions to calculate power and sample size for testing main effect in the survival analysis of randomized clinical trials and conditional logistic regression for nested case-control study.

This package provides functions for multivariate analysis with compositional data. Includes a function for doing compositional canonical correlation analysis. This analysis requires two data matrices of compositions, which can be adequately transformed and used as entries in a specialized program for canonical correlation analysis, that is able to deal with singular covariance matrices. The methodology is described in Graffelman et al. (2017) <doi:10.1101/144584>. Functions for log-ratio principal component analysis with condition number computations and log-ratio discriminant analysis have been added to the package.

PhyloProfile is a tool for exploring complex phylogenetic profiles. Phylogenetic profiles, presence/absence patterns of genes over a set of species, are commonly used to trace the functional and evolutionary history of genes across species and time. With PhyloProfile we can enrich regular phylogenetic profiles with further data like sequence/structure similarity, to make phylogenetic profiling more meaningful. Besides the interactive visualisation powered by R-Shiny, the package offers a set of further analysis features to gain insights like the gene age estimation or core gene identification.

An imprecise inference presented in the study of Walley (1996) <doi:10.1111/j.2517-6161.1996.tb02065.x> is one of the statistical reasoning methods when prior information is unavailable. Functions and utils needed for illustrating this inferential paradigm are implemented for classroom teaching and further comprehensive research. Two imprecise models are demonstrated using multinomial data and 2x2 contingency table data. The concepts of prior ignorance and imprecision are discussed in lower and upper probabilities. Representation invariance principle, hypothesis testing, decision-making, and further generalization are also illustrated.

This package provides functions to generate incidence matrices and bipartite graphs that have (1) a fixed fill rate, (2) given marginal sums, (3) marginal sums that follow given distributions, or (4) represent bill sponsorships in the US Congress <doi:10.31219/osf.io/ectms>. It can also generate an incidence matrix from an adjacency matrix, or bipartite graph from a unipartite graph, via a social process mirroring team, group, or organization formation <doi:10.48550/arXiv.2204.13670>, or examine the space of binary matrices with fixed marginals.

Maximum likelihood estimation for series systems where the component cause of failure is masked. Implements analytical log-likelihood, score, and Hessian functions for exponential, homogeneous Weibull, and heterogeneous Weibull component lifetimes under masked cause conditions (C1, C2, C3). Supports exact, right-censored, left-censored, and interval-censored observations via composable observation functors. Provides random data generation, model fitting, and Fisher information for asymptotic inference. See Lin, Loh, and Bai (1993) <doi:10.1109/24.257799> and Craiu and Reiser (2006) <doi:10.1111/j.1541-0420.2005.00498.x>.

This package provides a toolkit for calculating topographic distances and identifying and plotting topographic paths. Topographic distances can be calculated along shortest topographic paths (Wang (2009) <doi:10.1111/j.1365-294X.2009.04338.x>), weighted topographic paths (Zhan et al. (1993) <doi:10.1007/3-540-57207-4_29>), and topographic least cost paths (Wang and Summers (2010) <doi:10.1111/j.1365-294X.2009.04465.x>). Functions can map topographic paths on colored or hill shade maps and plot topographic cross sections (elevation profiles) for the paths.

Time Series Segmented Residual Trends is a method for the automated detection of land degradation from remotely sensed vegetation and climate datasets. TSS-RESTREND incorporates aspects of two existing degradation detection methods: RESTREND which is used to control for climate variability, and BFAST which is used to look for structural changes in the ecosystem. The full details of the testing and justification of the TSS-RESTREND method (version 0.1.02) are published in Burrell et al., (2017). <doi:10.1016/j.rse.2017.05.018>. The changes to the method introduced in version 0.2.03 focus on the inclusion of temperature as an additional climate variable. This allows for land degradation assessment in temperature limited drylands. A paper that details this work is currently under review. There are also a number of bug fixes and speed improvements. Version 0.3.0 introduces additional attribution for eCO2, climate change and climate variability the details of which are in press in Burrell et al., (2020). The version under active development and additional example scripts showing how the package can be applied can be found at <https://github.com/ArdenB/TSSRESTREND>.