Identify sudden gains based on the three criteria outlined by Tang and DeRubeis (1999) <doi:10.1037/0022-006X.67.6.894> to a selection of repeated measures. Sudden losses, defined as the opposite of sudden gains can also be identified. Two different datasets can be created, one including all sudden gains/losses and one including one selected sudden gain/loss for each case. It can extract scores around sudden gains/losses. It can plot the average change around sudden gains/losses and trajectories of individual cases.

This package provides a toolbox for programming Clinical Data Standards Interchange Consortium (CDISC) compliant Analysis Data Model (ADaM) datasets in R. ADaM datasets are a mandatory part of any New Drug or Biologics License Application submitted to the United States Food and Drug Administration (FDA). Analysis derivations are implemented in accordance with the "Analysis Data Model Implementation Guide" (CDISC Analysis Data Model Team, 2021, <https://www.cdisc.org/standards/foundational/adam>). The package is an extension package of the admiral package for pediatric clinical trials.

Generalized additive model selection via approximate Bayesian inference is provided. Bayesian mixed model-based penalized splines with spike-and-slab-type coefficient prior distributions are used to facilitate fitting and selection. The approximate Bayesian inference engine options are: (1) Markov chain Monte Carlo and (2) mean field variational Bayes. Markov chain Monte Carlo has better Bayesian inferential accuracy, but requires a longer run-time. Mean field variational Bayes is faster, but less accurate. The methodology is described in He and Wand (2024) <doi:10.1007/s10182-023-00490-y>.

An R interface to the MinIO Client. The MinIO Client ('mc') provides a modern alternative to UNIX commands like ls', cat', cp', mirror', diff', find etc. It supports filesystems and Amazon "S3" compatible cloud storage service ("AWS" Signature v2 and v4). This package provides convenience functions for installing the MinIO client and running any operations, as described in the official documentation, <https://min.io/docs/minio/linux/reference/minio-mc.html?ref=docs-redirect>. This package provides a flexible and high-performance alternative to aws.s3'.

Supply functions for the creation and handling of missing data as well as tools to evaluate missing data methods. Nearly all possibilities of generating missing data discussed by Santos et al. (2019) <doi:10.1109/ACCESS.2019.2891360> and some additional are implemented. Functions are supplied to compare parameter estimates and imputed values to true values to evaluate missing data methods. Evaluations of these types are done, for example, by Cetin-Berber et al. (2019) <doi:10.1177/0013164418805532> and Kim et al. (2005) <doi:10.1093/bioinformatics/bth499>.

This package provides functions for evaluating, displaying, and interpreting statistical models. The goal is to abstract the operations on models from the particular architecture of the model. For instance, calculating effect sizes rather than looking at coefficients. The package includes interfaces to both regression and classification architectures, including lm(), glm(), rlm() in MASS', random forests and recursive partitioning, k-nearest neighbors, linear and quadratic discriminant analysis, and models produced by the caret package's train(). It's straightforward to add in other other model architectures.

Evaluate the predictive performance of an existing (i.e. previously developed) prediction/ prognostic model given relevant information about the existing prediction model (e.g. coefficients) and a new dataset. Provides a range of model updating methods that help tailor the existing model to the new dataset; see Su et al. (2018) <doi:10.1177/0962280215626466>. Techniques to aggregate multiple existing prediction models on the new data are also provided; see Debray et al. (2014) <doi:10.1002/sim.6080> and Martin et al. (2018) <doi:10.1002/sim.7586>).

This package provides methods for inference using stacked multiple imputations augmented with weights. The vignette provides example R code for implementation in general multiple imputation settings. For additional details about the estimation algorithm, we refer the reader to Beesley, Lauren J and Taylor, Jeremy M G (2020) â A stacked approach for chained equations multiple imputation incorporating the substantive modelâ <doi:10.1111/biom.13372>, and Beesley, Lauren J and Taylor, Jeremy M G (2021) â Accounting for not-at-random missingness through imputation stackingâ <arXiv:2101.07954>.

This is a tidy implementation for heatmap. At the moment it is based on the (great) package ComplexHeatmap'. The goal of this package is to interface a tidy data frame with this powerful tool. Some of the advantages are: Row and/or columns colour annotations are easy to integrate just specifying one parameter (column names). Custom grouping of rows is easy to specify providing a grouped tbl. For example: df %>% group_by(...). Labels size adjusted by row and column total number. Default use of Brewer and Viridis palettes.

The web version WebGestalt <https://www.webgestalt.org> supports 12 organisms, 354 gene identifiers and 321,251 function categories. Users can upload the data and functional categories with their own gene identifiers. In addition to the Over-Representation Analysis, WebGestalt also supports Gene Set Enrichment Analysis and Network Topology Analysis. The user-friendly output report allows interactive and efficient exploration of enrichment results. The WebGestaltR package not only supports all above functions but also can be integrated into other pipeline or simultaneously analyze multiple gene lists.

This package provides two functions frameableWidget()', and frameWidget()'. The frameableWidget() is used to add extra code to a htmlwidget which allows is to be rendered correctly inside a responsive iframe'. The frameWidget() is a htmlwidget which displays content of another htmlwidget inside a responsive iframe'. These functions allow for easier embedding of htmlwidgets in content management systems such as wordpress', blogger etc. They also allow for separation of widget content from main HTML content where CSS of the main HTML could interfere with the widget.

Subset of BAM files of human lung tumor and pooled normal samples by targeted panel sequencing. [Zhao et al 2014. Targeted Sequencing in Non-Small Cell Lung Cancer (NSCLC) Using the University of North Carolina (UNC) Sequencing Assay Captures Most Previously Described Genetic Aberrations in NSCLC. In preparation.] Each sample is a 10 percent random subsample drawn from the original sequencing data. The pooled normal sample has been rescaled accroding to the total number of normal samples in the "pool". Here provided is the subsampled data on chr6 (hg19).

This package provides functions to manipulate binary fingerprints of arbitrary length. A fingerprint is represented by an object of S4 class fingerprint. The bitwise logical functions in R are overridden so that they can be used directly with fingerprint objects. A number of distance metrics are also available. Fingerprints can be converted to Euclidean vectors (i.e., points on the unit hypersphere) and can also be folded. Arbitrary fingerprint formats can be handled via line handlers. Currently handlers are provided for CDK, MOE and BCI fingerprint data.

This package provides a suite of functions for analyzing sequences of events. Users can generate and code sequences based on predefined rules, with a special focus on the identification of sequences coded as ABA (when one element appears, followed by a different one, and then followed by the first). Additionally, the package offers the ability to calculate the length of consecutive ABA'-coded sequences sharing common elements. The methods implemented in this package are based on the work by Ziembowicz, K., Rychwalska, A., & Nowak, A. (2022). <doi:10.1177/10464964221118674>.

Bond Pricing and Fixed-Income Valuation of Selected Securities included here serve as a quick reference of Quantitative Methods for undergraduate courses on Fixed-Income and CFA Level I Readings on Fixed-Income Valuation, Risk and Return. CFA Institute ("CFA Program Curriculum 2020 Level I Volumes 1-6. (Vol. 5, pp. 107-151, pp. 237-299)", 2019, ISBN: 9781119593577). Barbara S. Petitt ("Fixed Income Analysis", 2019, ISBN: 9781119628132). Frank J. Fabozzi ("Handbook of Finance: Financial Markets and Instruments", 2008, ISBN: 9780470078143). Frank J. Fabozzi ("Fixed Income Analysis", 2007, ISBN: 9780470052211).

Estimation and plotting of a function's FANOVA graph to identify the interaction structure and fitting, prediction and simulation of a Kriging model modified by the identified structure. The interactive function plotManipulate() can only be run on the RStudio IDE with RStudio package manipulate loaded. RStudio is freely available (<https://rstudio.com/>), and includes package manipulate'. The equivalent function plotTk() bases on CRAN Repository packages only. For further information on the method see Fruth, J., Roustant, O., Kuhnt, S. (2014) <doi:10.1016/j.jspi.2013.11.007>.

This package implements iterative conditional expectation (ICE) estimators of the plug-in g-formula (Wen, Young, Robins, and Hernán (2020) <doi: 10.1111/biom.13321>). Both singly robust and doubly robust ICE estimators based on parametric models are available. The package can be used to estimate survival curves under sustained treatment strategies (interventions) using longitudinal data with time-varying treatments, time-varying confounders, censoring, and competing events. The interventions can be static or dynamic, and deterministic or stochastic (including threshold interventions). Both prespecified and user-defined interventions are available.

William S. Cleveland's book Visualizing Data is a classic piece of literature on Exploratory Data Analysis. Although it was written several decades ago, its content is still relevant as it proposes several tools which are useful to discover patterns and relationships among the data under study, and also to assess the goodness of fit o a model. This package provides functions to produce the ggplot2 versions of the visualization tools described in this book and is thought to be used in the context of courses on Exploratory Data Analysis.

Deconvolution of spatial transcriptomics data based on neural networks and single-cell RNA-seq data. SpatialDDLS implements a workflow to create neural network models able to make accurate estimates of cell composition of spots from spatial transcriptomics data using deep learning and the meaningful information provided by single-cell RNA-seq data. See Torroja and Sanchez-Cabo (2019) <doi:10.3389/fgene.2019.00978> and Mañanes et al. (2024) <doi:10.1093/bioinformatics/btae072> to get an overview of the method and see some examples of its performance.

The Internet Engineering Task Force (IETF) and the Internet Society (ISOC) publish various Internet-related protocols and specifications as "Request for Comments" (RFC) documents and Internet Standard (STD) documents. RFCs and STDs are published in a simple text form. This package provides an Emacs major mode, rfcview-mode, which makes it more pleasant to read these documents in Emacs. It prettifies the text and adds hyperlinks/menus for easier navigation. It also provides functions for browsing the index of RFC documents and fetching them from remote servers or local directories.

This package is a port of the new matplotlib color maps (viridis, magma, plasma and inferno) to R. matplotlib is a popular plotting library for Python. These color maps are designed in such a way that they will analytically be perfectly perceptually-uniform, both in regular form and also when converted to black-and-white. They are also designed to be perceived by readers with the most common form of color blindness. This is the lite version of the more complete viridis package.

Calculates marginal effects based on logistic model objects such as glm or speedglm at the average (default) or at given values using finite differences. It also returns confidence intervals for said marginal effects and the p-values, which can easily be used as input in stargazer. The function only returns the essentials and is therefore much faster but not as detailed as other functions available to calculate marginal effects. As a result, it is highly suitable for large datasets for which other packages may require too much time or calculating power.

Implementation of two sample comparison procedures based on median-based statistical tests for functional data, introduced in Smida et al (2022) <doi:10.1080/10485252.2022.2064997>. Other competitive state-of-the-art approaches proposed by Chakraborty and Chaudhuri (2015) <doi:10.1093/biomet/asu072>, Horvath et al (2013) <doi:10.1111/j.1467-9868.2012.01032.x> or Cuevas et al (2004) <doi:10.1016/j.csda.2003.10.021> are also included in the package, as well as procedures to run test result comparisons and power analysis using simulations.

This package provides a tool for computing network representations of attitudes, extracted from tabular data such as sociological surveys. Development of surveygraph software and training materials was initially funded by the European Union under the ERC Proof-of-concept programme (ERC, Attitude-Maps-4-All, project number: 101069264). Views and opinions expressed are however those of the author(s) only and do not necessarily reflect those of the European Union or the European Research Council Executive Agency. Neither the European Union nor the granting authority can be held responsible for them.