This package provides a generalised data structure for fast and efficient loading and data munching of sparse omics data. The OmicFlow requires an up-front validated metadata template from the user, which serves as a guide to connect all the pieces together by aligning them into a single object that is defined as an omics class. Once this unified structure is established, users can perform manual subsetting, visualisation, and statistical analysis, or leverage the automated autoFlow method to generate a comprehensive report.

This package provides a collection of functions that aid in calculating the optimum time to stock hatchery reared fish into a body of water given the growth, mortality and cost of raising a particular number of individuals to a certain length.

This tool was designed to assess the sensitivity of research findings to omitted variables when estimating causal effects using propensity score (PS) weighting. This tool produces graphics and summary results that will enable a researcher to quantify the impact an omitted variable would have on their results. Burgette et al. (2021) describe the methodology behind the primary function in this package, ov_sim. The method is demonstrated in Griffin et al. (2020) <doi:10.1016/j.jsat.2020.108075>.

This package provides a model-agnostic framework for selecting dataset-specific imputation methods for missing values in numerical data related to pain. Lotsch J, Ultsch A (2025) "A model-agnostic framework for dataset-specific selection of missing value imputation methods in pain-related numerical data" Canadian Journal of Pain (in minor revision).

This package provides a novel method to implement cancer subtyping and subtype specific drug targets identification via non-negative matrix tri-factorization. To improve the interpretability, we introduce orthogonal constraint to the row coefficient matrix and column coefficient matrix. To meet the prior knowledge that each subtype should be strongly associated with few gene sets, we introduce sparsity constraint to the association sub-matrix. The average residue was introduced to evaluate the row and column cluster numbers. This is part of the work "Liver Cancer Analysis via Orthogonal Sparse Non-Negative Matrix Tri- Factorization" which will be submitted to BBRC.

This package provides a modified version of alternating logistic regressions (ALR) with estimation based on orthogonalized residuals (ORTH) is implemented, which use paired estimating equations to jointly estimate parameters in marginal mean and within-association models. The within-cluster association between ordinal responses is modeled by global pairwise odds ratios (POR). A finite-sample bias correction is provided to POR parameter estimates based on matrix multiplicative adjusted orthogonalized residuals (MMORTH) for correcting estimating equations, and different bias-corrected variance estimators such as BC1, BC2, and BC3.

This package provides a framework for organizing R projects with a standardized structure. Most analyses consist of three main components: code, results, and data, each with different requirements such as version control, sharing, and encryption. This package provides tools to set up and manage project directories, handle file paths consistently across operating systems, organize results using date-based structures, source code from specified directories, create and manage Quarto documents, and perform file operations safely. It ensures consistency across projects while accommodating different requirements for various types of content.

Compound deconvolution for chromatographic data, including gas chromatography - mass spectrometry (GC-MS) and comprehensive gas chromatography - mass spectrometry (GCxGC-MS). The package includes functions to perform independent component analysis - orthogonal signal deconvolution (ICA-OSD), independent component regression (ICR), multivariate curve resolution (MCR-ALS) and orthogonal signal deconvolution (OSD) alone.

Computes the routing distribution, the expectation of the number of broadcasts, transmissions and receptions considering an Opportunistic transport model. It provides theoretical results and also estimated values based on Monte Carlo simulations.

O-statistics, or overlap statistics, measure the degree of community-level trait overlap. They are estimated by fitting nonparametric kernel density functions to each speciesâ trait distribution and calculating their areas of overlap. For instance, the median pairwise overlap for a community is calculated by first determining the overlap of each species pair in trait space, and then taking the median overlap of each species pair in a community. This median overlap value is called the O-statistic (O for overlap). The Ostats() function calculates separate univariate overlap statistics for each trait, while the Ostats_multivariate() function calculates a single multivariate overlap statistic for all traits. O-statistics can be evaluated against null models to obtain standardized effect sizes. Ostats is part of the collaborative Macrosystems Biodiversity Project "Local- to continental-scale drivers of biodiversity across the National Ecological Observatory Network (NEON)." For more information on this project, see the Macrosystems Biodiversity Website (<https://neon-biodiversity.github.io/>). Calculation of O-statistics is described in Read et al. (2018) <doi:10.1111/ecog.03641>, and a teaching module for introducing the underlying biological concepts at an undergraduate level is described in Grady et al. (2018) <http://tiee.esa.org/vol/v14/issues/figure_sets/grady/abstract.html>.

Observational studies are limited in that there could be an unmeasured variable related to both the response variable and the primary predictor. If this unmeasured variable were included in the analysis it would change the relationship (possibly changing the conclusions). Sensitivity analysis is a way to see how much of a relationship needs to exist with the unmeasured variable before the conclusions change. This package provides tools for doing a sensitivity analysis for regression (linear, logistic, and cox) style models.

Provide principally an eponymic function that numerically computes the Le Cam's one-step estimator for an independent and identically distributed sample. One-step estimation is asymptotically efficient (see L. Le Cam (1956) <https://projecteuclid.org/euclid.bsmsp/1200501652>) and can be computed faster than the maximum likelihood estimator for large observation samples, see e.g. Brouste et al. (2021) <doi:10.32614/RJ-2021-044>.

Allows performing forwards prediction for the General Unified Threshold model of Survival using compiled ode code. This package was created to avoid dependency with the morse package that requires the installation of JAGS'. This package is based on functions from the morse package v3.3.1: Virgile Baudrot, Sandrine Charles, Marie Laure Delignette-Muller, Wandrille Duchemin, Benoit Goussen, Nils Kehrein, Guillaume Kon-Kam-King, Christelle Lopes, Philippe Ruiz, Alexander Singer and Philippe Veber (2021) <https://CRAN.R-project.org/package=morse>.

Offers a rich collection of data focused on cancer research, covering survival rates, genetic studies, biomarkers, and epidemiological insights. Designed for researchers, analysts, and bioinformatics practitioners, the package includes datasets on various cancer types such as melanoma, leukemia, breast, ovarian, and lung cancer, among others. It aims to facilitate advanced research, analysis, and understanding of cancer epidemiology, genetics, and treatment outcomes.

Assessment and diagnostics for comparing competing clustering solutions, using predictive models. The main intended use is for comparing clustering/classification solutions of ecological data (e.g. presence/absence, counts, ordinal scores) to 1) find an optimal partitioning solution, 2) identify characteristic species and 3) refine a classification by merging clusters that increase predictive performance. However, in a more general sense, this package can do the above for any set of clustering solutions for i observations of j variables.

Sample from the limiting distributions of empirical Wasserstein distances under the null hypothesis and under the alternative. Perform a two-sample test on multivariate data using these limiting distributions and binning.

Represents the basis functions for B-splines in a simple matrix formulation that facilitates, taking integrals, derivatives, and making orthogonal the basis functions.

Summarizes the taxonomic composition, diversity contribution of the rare and abundant community by using OTU (operational taxonomic unit) table which was generated by analyzing pipeline of QIIME or mothur'. The rare biosphere in this package is subset by the relative abundance threshold (for details about rare biosphere please see Lynch and Neufeld (2015) <doi:10.1038/nrmicro3400>).

Supports the definition of sets of properties on objects. Observers can listen to changes on individual properties or the set as a whole. The properties are meant to be fully self-describing. In support of this, there is a framework for defining enumerated types, as well as other bounded types, as S4 classes.

Extract results into R from the Observational Health Data Sciences and Informatics result database (see <https://ohdsi.github.io/Strategus/results-schema/index.html>) and generate reports/presentations via quarto that summarize results in HTML format. Learn more about OhdsiReportGenerator at <https://ohdsi.github.io/OhdsiReportGenerator/>.

Ordered homogeneity pursuit lasso (OHPL) algorithm for group variable selection proposed in Lin et al. (2017) <DOI:10.1016/j.chemolab.2017.07.004>. The OHPL method exploits the homogeneity structure in high-dimensional data and enjoys the grouping effect to select groups of important variables automatically. This feature makes it particularly useful for high-dimensional datasets with strongly correlated variables, such as spectroscopic data.

This package provides simple crosstab output with optional statistics (e.g., Goodman-Kruskal Gamma, Somers d, and Kendall's tau-b) as well as two-way and one-way tables. The package is used within the statistics component of the Masters of Science (MSc) in Social Science of the Internet at the Oxford Internet Institute (OII), University of Oxford, but the functions should be useful for general data analysis and especially for analysis of categorical and ordinal data.

Optimal Subset Cardinality Regression (OSCAR) models offer regularized linear regression using the L0-pseudonorm, conventionally known as the number of non-zero coefficients. The package estimates an optimal subset of features using the L0-penalization via cross-validation, bootstrapping and visual diagnostics. Effective Fortran implementations are offered along the package for finding optima for the DC-decomposition, which is used for transforming the discrete L0-regularized optimization problem into a continuous non-convex optimization task. These optimization modules include DBDC ('Double Bundle method for nonsmooth DC optimization as described in Joki et al. (2018) <doi:10.1137/16M1115733>) and LMBM ('Limited Memory Bundle Method for large-scale nonsmooth optimization as in Haarala et al. (2004) <doi:10.1080/10556780410001689225>). The OSCAR models are comprehensively exemplified in Halkola et al. (2023) <doi:10.1371/journal.pcbi.1010333>). Multiple regression model families are supported: Cox, logistic, and Gaussian.

This package provides a comprehensive set of indexes and tests for social segregation analysis, as described in Tivadar (2019) - OasisR': An R Package to Bring Some Order to the World of Segregation Measurement <doi:10.18637/jss.v089.i07>. The package is the most complete existing tool and it clarifies many ambiguities and errors regarding the definition of segregation indices. Additionally, OasisR introduces several resampling methods that enable testing their statistical significance (randomization tests, bootstrapping, and jackknife methods).