DNA methylation is an important epigenetic process that regulates gene activity through chemical modifications of DNA without changing its sequence. OpEnCAST is a plant-specific ensemble-based prediction package that identifies 4mC, 5mC and 6mA methylation sites directly from DNA sequences. It combines multiple machine learning algorithms trained on monocot (Oryza sp.) and dicot (Arabidopsis sp.) reference models to deliver accurate predictions. This methodology is being inspired by the ensemble algorithm for methylation prediction developed by Wang et al. (2022) <doi:10.1186/s12859-022-04756-1>.

An R wrapper for the OneMap.Sg API <https://www.onemap.gov.sg/docs/>. Functions help users query data from the API and return raw JSON data in "tidy" formats. Support is also available for users to retrieve data from multiple API calls and integrate results into single dataframes, without needing to clean and merge the data themselves. This package is best suited for users who would like to perform analyses with Singapore's spatial data without having to perform excessive data cleaning.

This package provides a suite of tools for the comprehensive visualization of multi-omics data, including genomics, transcriptomics, and proteomics. Offers user-friendly functions to generate publication-quality plots, thereby facilitating the exploration and interpretation of complex biological datasets. Supports seamless integration with popular R visualization frameworks and is well-suited for both exploratory data analysis and the presentation of final results. Key formats and methods are presented in Huang, S., et al. (2024) "The Born in Guangzhou Cohort Study enables generational genetic discoveries" <doi:10.1038/s41586-023-06988-4>.

It implements the online Bayesian methods for change point analysis. It can also perform missing data imputation with methods from VIM'. The reference is Yigiter A, Chen J, An L, Danacioglu N (2015) <doi:10.1080/02664763.2014.1001330>. The link to the package is <https://CRAN.R-project.org/package=onlineBcp>.

Allows distance based spatial clustering of georeferenced data by implementing the City Clustering Algorithm - CCA. Multiple versions allow clustering for a matrix, raster and single coordinates on a plain (Euclidean distance) or on a sphere (great-circle or orthodromic distance).

Design and analysis of confirmatory adaptive clinical trials using the optimal conditional error framework according to Brannath and Bauer (2004) <doi:10.1111/j.0006-341X.2004.00221.x>. An extension to the optimal conditional error function using interim estimates as described in Brannath and Dreher (2024) <doi:10.48550/arXiv.2402.00814> and functions to ensure that the resulting conditional error function is non-increasing are also available.

This package provides a novel method to implement cancer subtyping and subtype specific drug targets identification via non-negative matrix tri-factorization. To improve the interpretability, we introduce orthogonal constraint to the row coefficient matrix and column coefficient matrix. To meet the prior knowledge that each subtype should be strongly associated with few gene sets, we introduce sparsity constraint to the association sub-matrix. The average residue was introduced to evaluate the row and column cluster numbers. This is part of the work "Liver Cancer Analysis via Orthogonal Sparse Non-Negative Matrix Tri- Factorization" which will be submitted to BBRC.

High-performance implementation of 36 optimal binning algorithms (16 categorical, 20 numerical) for Weight of Evidence ('WoE') transformation, credit scoring, and risk modeling. Includes advanced methods such as Mixed Integer Linear Programming ('MILP'), Genetic Algorithms, Simulated Annealing, and Monotonic Regression. Features automatic method selection based on Information Value ('IV') maximization, strict monotonicity enforcement, and efficient handling of large datasets via Rcpp'. Fully integrated with the tidymodels ecosystem for building robust machine learning pipelines. Based on methods described in Siddiqi (2006) <doi:10.1002/9781119201731> and Navas-Palencia (2020) <doi:10.48550/arXiv.2001.08025>.

This package provides a tool for visualizing numerical data (e.g., gene expression, protein abundance) on predefined anatomical maps of human/mouse organs and subcellular organelles. It supports customization of color schemes, filtering by organ systems (for organisms) or organelle types, and generation of optional bar charts for quantitative comparison. The package integrates coordinate data for organs and organelles to plot anatomical/subcellular contours, mapping data values to specific structures for intuitive visualization of biological data distribution.The underlying method was described in the preprint by Zhou et al. (2022) <doi:10.1101/2022.09.07.506938>.

This package performs robust cluster analysis allowing for outliers and noise that cannot be fitted by any cluster. The data are modelled by a mixture of Gaussian distributions and a noise component, which is an improper uniform distribution covering the whole Euclidean space. Parameters are estimated by (pseudo) maximum likelihood. This is fitted by a EM-type algorithm. See Coretto and Hennig (2016) <doi:10.1080/01621459.2015.1100996>, and Coretto and Hennig (2017) <https://jmlr.org/papers/v18/16-382.html>.

This package provides tools to process raster data and apply Otsu-based thresholding for burned area mapping and other image segmentation tasks. Implements the method described by Otsu (1979) <doi:10.1109/TSMC.1979.4310076>, a data-driven technique that determines an optimal threshold by maximizing the inter-class variance of pixel intensities. It includes validation functions to assess segmentation accuracy against reference data using standard accuracy metrics such as precision, recall, and F1-score.

This package performs the O2PLS data integration method for two datasets, yielding joint and data-specific parts for each dataset. The algorithm automatically switches to a memory-efficient approach to fit O2PLS to high dimensional data. It provides a rigorous and a faster alternative cross-validation method to select the number of components, as well as functions to report proportions of explained variation and to construct plots of the results. See the software article by el Bouhaddani et al (2018) <doi:10.1186/s12859-018-2371-3>, and Trygg and Wold (2003) <doi:10.1002/cem.775>. It also performs Sparse Group (Penalized) O2PLS, see Gu et al (2020) <doi:10.1186/s12859-021-03958-3> and cross-validation for the degree of sparsity.

This package provides a building block for optimization algorithms based on a simplex. The optimsimplex package may be used in the following optimization methods: the simplex method of Spendley et al. (1962) <doi:10.1080/00401706.1962.10490033>, the method of Nelder and Mead (1965) <doi:10.1093/comjnl/7.4.308>, Box's algorithm for constrained optimization (1965) <doi:10.1093/comjnl/8.1.42>, the multi-dimensional search by Torczon (1989) <https://www.cs.wm.edu/~va/research/thesis.pdf>, etc...

This package provides a set of binary operators for common tasks such as regex manipulation.

Algorithms for D-, A-, I-, and c-optimal designs. For more details, see the package description. Some of the functions in this package require the gurobi software and its accompanying R package. For their installation, please follow the instructions at <https://www.gurobi.com> and the file gurobi_inst.txt, respectively.

This package contains data from the May 2020 Occupational Employment and Wage Statistics data release from the U.S. Bureau of Labor Statistics. The dataset covers employment and wages across occupations, industries, states, and at the national level. Metropolitan data is not included.

We introduce an R function one_two_sample() which can deal with one and two (normal) samples, Ying-Ying Zhang, Yi Wei (2012) <doi:10.2991/asshm-13.2013.29>. For one normal sample x, the function reports descriptive statistics, plot, interval estimation and test of hypothesis of x. For two normal samples x and y, the function reports descriptive statistics, plot, interval estimation and test of hypothesis of x and y, respectively. It also reports interval estimation and test of hypothesis of mu1-mu2 (the difference of the means of x and y) and sigma1^2 / sigma2^2 (the ratio of the variances of x and y), tests whether x and y are from the same population, finds the correlation coefficient of x and y if x and y have the same length.

Clinical reports generated by Oncomine Reporter software contain critical data in unstructured PDF format, making manual extraction time-consuming and error-prone. ORscraper provides a coherent suite of functions to automate this process, allowing researchers to parse reports, identify key biomarkers, extract genetic variant tables, and filter results. It also integrates with the NCBI ClinVar API <https://www.ncbi.nlm.nih.gov/clinvar/> to enrich extracted data.

This package provides tools for multivariate outlier detection based on geometric properties of multivariate data using random directional projections. Observation-level outlier scores are computed by jointly probing radial magnitude and angular alignment through repeated projections onto random directions, with optional robust centering and covariance adjustment. In addition to global outlier scoring, the method produces dimension-level contribution measures to support interpretation of detected anomalies. Visualization utilities are included to summarize directional contributions for extreme observations.

Data integration Web application for biobanks by OBiBa'. Opal is the core database application for biobanks. Participant data, once collected from any data source, must be integrated and stored in a central data repository under a uniform model. Opal is such a central repository. It can import, process, validate, query, analyze, report, and export data. Opal is typically used in a research center to analyze the data acquired at assessment centres. Its ultimate purpose is to achieve seamless data-sharing among biobanks. This Opal client allows to interact with Opal web services and to perform operations on the R server side. DataSHIELD administration tools are also provided.

This package provides implementations of some of the most important outlier detection algorithms. Includes a tutorial mode option that shows a description of each algorithm and provides a step-by-step execution explanation of how it identifies outliers from the given data with the specified input parameters. References include the works of Azzedine Boukerche, Lining Zheng, and Omar Alfandi (2020) <doi:10.1145/3381028>, Abir Smiti (2020) <doi:10.1016/j.cosrev.2020.100306>, and Xiaogang Su, Chih-Ling Tsai (2011) <doi:10.1002/widm.19>.

This package provides a collection of functions to facilitate analysis of proteomic data from Olink, primarily NPX data that has been exported from Olink Software. The functions also work on QUANT data from Olink by log- transforming the QUANT data. The functions are focused on reading data, facilitating data wrangling and quality control analysis, performing statistical analysis and generating figures to visualize the results of the statistical analysis. The goal of this package is to help users extract biological insights from proteomic data run on the Olink platform.

This contains functions and data used by the Open Visualization Academy classes on data processing and visualization. The tutorial included with this package requires the gradethis package which can be installed using "remotes::install_github('rstudio/gradethis')".

Estimation of value and hedging strategy of call and put options, based on optimal hedging and Monte Carlo method, from Chapter 3 of Statistical Methods for Financial Engineering', by Bruno Remillard, CRC Press, (2013).